Rethinking Clinical Trials

NOVEMBER 1, 2022

The HERO Registry aimed to create a diverse virtual community of healthcare workers and their families and communities, ready for future COVID-19 research. The HERO Program was fully approved and began recruiting participants on April 22, 2020. pctGR, @Collaboratory1.

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Rethinking Clinical Trials

OCTOBER 2, 2023

Building off the request for proposals process for the Learning Health Network, PROTEUS recognized that institutions caring for vulnerable and underserved populations may face unique challenges when aiming to implement PROs in routine care. With current funding, PROTEUS can address recommendations specifically regarding education materials.

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Pharmaceutical Technology

MAY 2, 2023

IO therapies come with a hefty price tag, with ICI therapies in the US typically exceeding $100,000, while cell therapies can exceed $400,000. There is currently a rich and diverse IO pipeline that aims to address these unmet needs, with 703 IO products currently in clinical trials. Cost-related unmet needs also scored highly.

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Pharmaceutical Technology

FEBRUARY 10, 2023

This is not the first treatment to come with a high price tag. Partly in response to such drugs, risk-sharing agreements (RSAs) have increased in popularity and aim to mitigate the risks of including high-cost drugs on reimbursement lists and healthcare plans.

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Rethinking Clinical Trials

MARCH 15, 2023

An estimand is a precise description of the treatment effect that a researcher aims to estimate from the trial. Tags #pctGR, @Collaboratory1 The post Grand Rounds March 10, 2023: Estimands in Cluster-Randomized Trials: Choosing Analyses that Answer the Right Question (Brennan Kahan, PhD) appeared first on Rethinking Clinical Trials.

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Rethinking Clinical Trials

AUGUST 28, 2023

The new structure aims to provide clarity and better readability. The scope is focused, and the language aims to facilitate innovation in trial design. The principles aim to promote good science and ethics, be clear and concise, be inclusively developed and be progressive and durable.

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Rethinking Clinical Trials

AUGUST 28, 2023

The new structure aims to provide clarity and better readability. The scope is focused, and the language aims to facilitate innovation in trial design. The principles aim to promote good science and ethics, be clear and concise, be inclusively developed and be progressive and durable.

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Drug Discovery World

OCTOBER 31, 2023

The children will continue to receive enzyme replacement therapy during treatment, but once the gene therapy begins to work, the research team say part of the trial aims to remove the need for weekly enzyme replacement therapy over the child’s lifetime, while the other aim is to safely target the brain disease suffered by these patients.

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Rethinking Clinical Trials

FEBRUARY 14, 2024

DCP aimed to recruit 13,500 patients across the U.S. Tags #pctGR, @Collaboratory1 The post Grand Rounds February 9, 2024: Pragmatic Recruitment of Underrepresented Groups – Experience From the Diuretic Comparison Project (Cynthia Hau, MPH) appeared first on Rethinking Clinical Trials.

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Rethinking Clinical Trials

MAY 25, 2023

Researchers aimed to test the safety and effectiveness of Aspirin use as prophylaxis in orthopedic trauma cases. Tags #pctGR, @Collaboratory1 The post Grand Rounds May 19, 2023: Aspirin or Low-Molecular-Weight Heparin for Thromboprophylaxis After a Fracture (Robert O’Toole, MD) appeared first on Rethinking Clinical Trials.

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Rethinking Clinical Trials

AUGUST 3, 2023

As a research community, we need to think about auditing citations because they are used as evidence for claims we make but many are falling short of that aim. Tags #pctGR, @Collaboratory1 The post Grand Rounds July 28, 2023: How Can Researchers Fight Misinformation About Medicine?

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Rethinking Clinical Trials

JULY 13, 2023

There are a lot of programs that are aimed at this type of intervention at Kaiser but not one with a virtual intervention. Tags #pctGR, @Collaboratory1 The post Grand Rounds July 7, 2023: Implementing Virtual Strategies Across an Integrated Healthcare System: The IMPLEMENT-HF Study (Ankeet S.

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XTalks

MAY 1, 2024

This new brand aims to make sophisticated, chef-inspired food products accessible and affordable, catering to the evolving tastes and demands of today’s consumers. In an ambitious move set to redefine grocery shopping, Walmart announced the launch of bettergoods, its most significant private label brand introduction in two decades.

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pharmaphorum

AUGUST 25, 2022

The double-headed antibody binds to CD3 on T cells and redirects them to BCMA-expressing myeloma cells, with the aim of stimulating an immune attack on the tumour, which remains incurable despite a slew of new therapies reaching the market in recent years.

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Rethinking Clinical Trials

OCTOBER 11, 2023

The group considered the project aims, study design, statistical analysis plan, and power analysis for each center until all aspects were aligned. Tags #pctGR, @Collaboratory1 The post Grand Rounds October 6, 2023: Hybrid Studies Should Not Sacrifice Rigorous Methods (David M.

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pharmaphorum

JANUARY 11, 2022

Other DTxs are aimed at people being treated for breast and lung cancers. The post Blue Note leukaemia DTx gets FDA breakthrough tag appeared first on. In 2020, it formed an alliance with Memorial Sloan Kettering Cancer Centre in the US to develop an app that can be used by patients who are living in fear of their cancer, for example.

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Rethinking Clinical Trials

MARCH 1, 2023

The aim of S2302 is to validate the improvement in overall survival in S1800A. Overall survival was significantly improved with a hazard ratio of 0.69, median OS of 14.5 months, for pembrolizumab and ramucirumab vs. standard of care, respectively. We kept coming back to the one thing we want to know, which is the overall survival.

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XTalks

OCTOBER 19, 2023

Despite the premium price tag, the brand has gained a cult following thanks to its inclusion of high quality ingredients and successful word-of-mouth marketing. But for a large corporation aiming to tap into the premium sector, acquiring a top-tier brand can be a strategic move.

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Rethinking Clinical Trials

AUGUST 18, 2022

The Trial Innovation Network Recruitment Innovation Center aims to positively impact human health by improving participant enrollment and retention in multi-center clinical trials. The legacies of these inequities and the structural factors live on and are obvious when we look at the health outcomes of populations in our country.

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pharmaphorum

AUGUST 17, 2020

In this article Joanna Carlish, managing director of financial services at Tag Americas , and Robb DeFilippis, Tag Americas’ managing director, life sciences, go head-to-head to discuss marketing within a regulated industry. Joanna Carlish, managing director, financial services, Tag Americas. Virtual connections.

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Rethinking Clinical Trials

MAY 5, 2023

In 2017 the study team developed a pilot trial with the aim of determining the effect of lower intermediate and higher SpO2 targets on clinical outcomes for mechanically validated critically ill adults. Because of the lack of data about these 3 approaches, the recommended targets vary among 3 international guidelines.

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XTalks

FEBRUARY 8, 2024

Along with the hefty price tag for screen time that may not be perceived to be a worthwhile investment, and despite favoring advertising at other major events like the Grammys, pharma tends to stay somewhat clear of all the Super Bowl hoopla.

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XTalks

MAY 2, 2024

The event spanned two days packed with keynote speeches, panel discussions and networking opportunities aimed at enhancing food safety practices across the country. Sam Davidson, Director of Food Safety at The Acheson Group (TAG) , also emphasized the need for fundamental training for frontline workers in the food industry.

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Rethinking Clinical Trials

SEPTEMBER 22, 2022

The aim is to test communication strategies for optimizing the update of the flu vaccine. The NUDGE-FLU trial is a nationwide implementation study that will randomize all Danish citizens above 65 who receive a free vaccine by Danish government. million citizens will be randomized to receive 10 different communications. Learn more.

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The Pharma Data

MARCH 23, 2022

Instead of targeting Ebola polymerase directly, the researchers aimed to target cellular proteins critical for viral polymerase to function. This special enzyme, once fused to Ebola virus polymerase, enables the polymerase to add a molecular tag to any other protein it interacts with.

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Pharmaceutical Technology

MARCH 22, 2023

The pharmaceutical industry began using radio frequency identification (RFID) tags in the early 2000s. Pfizer was the first to use the tech, adding RFID tags to track a Viagra (sildenafil) shipment circa 2006. Twenty years ago, the cost of implementing RFID tags and the ecosystem (software) was much more expensive than today.

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pharmaphorum

DECEMBER 17, 2021

Aduhelm (aducanumab) was approved by the FDA in June, but has been held back by a glacial rollout as clinicians have questioned the data on which the decision to clear the drug was based, plus a $56,000 per year price tag, which has in turn led to pushback by payers.

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The Pharma Data

MARCH 16, 2022

using SNAP-tag) involves labeling cell proteins with a fluorescent dye, thereby enabling researchers to observe how proteins interact in the living cell and where in the cell they are located. With Spirochrome, he commercialized fluorescent probes for cell biology, while with Covalys, he marketed SNAP-tag and other protein labeling methods.

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World of DTC Marketing

DECEMBER 13, 2021

As cancer survival rates rise, so do the price tags of life-saving treatments. Researchers with the Reproducibility Project: Cancer Biology aimed to replicate 193 experiments from 53 top cancer papers published from 2010 to 2012. OPENING: American cancer patients spent more than $21 billion on their care in 2019.

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pharmaphorum

NOVEMBER 27, 2022

Typically, the pharma industry has aimed to increase throughput while maintaining quality, but under supply chain shock conditions this often results in an excessive production of safety stock. This has been the go-to approach for dealing with foreseeable supply chain shocks in the past.

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The Pharma Data

OCTOBER 9, 2021

This designation is predicated on data showing that gantenerumab significantly reduced brain amyloid pillar, a pathological hallmark of Notice, in the ongoing SCarlet RoAD and Marguerite RoAD open- tag extension trials, as well as other studies. Both trials are expected to be completed in the second half of 2022.

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Delveinsight

FEBRUARY 25, 2021

Cambridge, Massachusetts-based Beam aims to make more precise edits with genetic medicines, which employ base-editing. DNA hypomethylating agents are epigenetic drugs that eliminate specific chemical tags on DNA, hence turning specific genes on and off and changing the cells’ function.

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pharmaphorum

DECEMBER 2, 2020

Others rapidly followed, including Glucotrol, aimed at diabetics, and Procardia, an anti-hypertensive. Indeed, critics feared this redomiciling was the main aim of the merger, and that Pfizer wouldn’t sustain investment in UK R&D in the long term. For all the latest Pfizer news follow pharmaphorum’s Pfizer tag.

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The Pharma Data

NOVEMBER 15, 2020

Clover aims to double its commercial manufacturing capacity in preparation for global Phase 2/3 trials. With promising preliminary safety and immunogenicity results from the Phase 1 clinical study, Clover aims to quickly expand its current 2 x 2000L capacity of the Cytiva FlexFactory, which went into service in January 2020.

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pharmaphorum

AUGUST 26, 2022

million for the one-shot therapy – in other words, after any discounts that it may offer or outcomes-based agreements – aiming to launch first in Germany followed by France. BioMarin has said Roctavian will be available at a ‘net’ price of around €1.5 million spread over five years.

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XTalks

AUGUST 23, 2021

But these aims must be balanced with the third principle of protecting study participants from unnecessary risks, like those that may result from preventing patients from accessing available therapies to maintain the integrity of the treatment and placebo arms of the trial.

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pharmaphorum

OCTOBER 4, 2022

Central to the initiative is the aim to gather data from willing participants that can provide greater insights into cancer development and treatment over time. The Moonshot was started with three aims: to accelerate scientific discovery in cancer, foster greater collaboration between stakeholders, and to improve the sharing of cancer data.

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