Drug Discovery World

APRIL 10, 2023

University of Queensland (UQ) researchers have led a national study on the four main bacteria that cause sepsis, providing new targets for developing antibiotics. The research team set out to find responses common to all four types of bacteria that cause sepsis and discover more about how bacteria survive in the body.

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Drug Discovery World

APRIL 30, 2024

Messenger RNA (mRNA) has come into focus within the drug discovery and development as an exciting tool to deliver genetic information. mRNA is a molecule made up of a single strand of ribonucleic acid (RNA). Today, there are several other categories of RNA therapeutics with drugs already approved or currently in development.

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Scienmag

MAY 7, 2021

Study describes new mechanism for terminating transcription of DNA into RNA in bacteria Credit: Babitzke Laboratory and Dani Zemba, Penn State The protein, known as NusG, pauses the transcription machinery at specific DNA sequences to facilitate what is called “intrinsic termination” and prevent unwanted transcription that could disrupt (..)

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The Pharma Data

JANUARY 19, 2021

A naturally occurring system for tuning CRISPR-Cas9 expressing in bacteria, identified in a study published in Cell , could have implications for gene editing therapies as well. A CRISPR-Cas9 system has two components: the Cas9 guide RNA that directs the system to edit a particular gene, and the CRISPR “scissors” that make the cut.

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Bacteria Gene Editing Research RNA 52

XTalks

DECEMBER 22, 2021

The RNA Revolution: From mRNA Vaccines to RNA Editing. The age of RNA is officially here, and it’s here to stay as more than a passing life science trend. RNA technology is not new nor has its potential been surprising. RNA in the Making. So why did this perceived RNA ‘revolution’ take so long?

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Drug Discovery World

MARCH 21, 2023

In a step forward for genetic engineering and synthetic biology, US researchers have modified E coli bacteria to be immune to infection by all natural viruses tested so far. The team used two safeguard methods to prevent the bacteria and their modified genes from escaping into the wild.

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Drug Discovery World

JANUARY 12, 2024

The top stories: Excitement over new antibiotics that can kill drug-resistant bacteria A novel antibiotic class targeting a major global pathogen and threat to human health has been discovered by scientists from Roche and Harvard University (Cambridge, MA, US).

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XTalks

DECEMBER 14, 2022

The CRISPR-Cas9 gene editing system uses a programmable single guide RNA sequence (sgRNA) to find and bind to specific regions of DNA and the Cas9 nuclease induces double strand breaks at these target regions of the genome. Integrases are used by viruses called bacteriophages to insert their genetic material into bacteria.

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Camargo

JULY 27, 2021

Viruses and bacteria can be first modified to prevent them from causing infectious diseases and then implemented into human tissues as therapeutic gene vectors. For example, it is beneficial to administer RNA treatments for some lung diseases directly to the disease site through inhalation. Route of Administration Considerations.

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pharmaphorum

NOVEMBER 25, 2020

Although at 90% effectiveness AZ’s shot would lag slightly behind RNA-based rivals from Pfizer/BioNTech and Moderna, AZD1222 is easier to handle and can be stored in fridges instead of at ultra-cool temperatures.

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Drug Discovery World

MAY 2, 2023

In the event of an attack from similar bacteriophages, the bacteria can recognise these segments and use this to discern and cleave the viral DNA, which disrupts the viral gene function. Bacterial RNA is replaced by a synthetic guide RNA (gRNA) that can recognise a specific target DNA sequence.

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Drug Discovery World

JULY 18, 2023

CRISPR diagnostics have successfully detected various pathogens, including RNA viruses (eg. Herpesviridae, Polyomaviridae, and Papillomaviridae), bacteria (e.g., In the context of non- infectious diseases, CRISPR diagnostics have been developed to detect RNA species, such as human CXCL9 mRNA, for kidney transplant rejection.

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Roots Analysis

OCTOBER 16, 2023

Membrane Filters: Membrane filters are typically used for sterilization and removal of smaller impurities such as bacteria and viruses. It removes bacteria, viruses and other debris using microfiltration, ultrafiltration and nanofiltration. are used to remove any residual bacteria, viruses, or endotoxins.

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Drug Discovery World

APRIL 27, 2023

million to advance its novel bacteria-based cancer treatment. Storm Therapeutics raised a £24.2 ($30) million Series B to continue its development of RNA-modifying enzymes as a treatment for solid tumours and leukaemias. Akamis Bio , formally known as PsiOxus Therapeutics, raised £25 ($30.9) Prokarium secured £24.9 ($30.8)

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The Pharma Data

JULY 22, 2021

These are the cells that have the potential to form a new tumour mass at a later stage” explains cancer researcher and RNA biologist Eleonora Leucci (KU Leuven).

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Bacteria Research RNA Medicine 52

Roots Analysis

AUGUST 31, 2023

coli bacteria, as well as lambda bacteriophage, can adapt to the alterations in the composition of their nutrient medium. It is worth noting that the transcription factor is responsible for recruiting RNA polymerase to bind to the gene and produce messenger RNA, which is then translated into the protein.

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XTalks

FEBRUARY 11, 2021

coli bacteria. The bacteria are grown in large vats, with the process taking two weeks. The RNA is transcribed from DNA in 40-liter vessels containing enzymes and chemicals over the course of three to four days. Vaccine mRNA: The DNA is then shipped 1,200 miles over to the Andover plant from which mRNA is synthesized.

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The Pharma Data

OCTOBER 19, 2020

The company’s suite of market-leading molecular profiling offerings assesses DNA, RNA and proteins to reveal a molecular blueprint that helps physicians and cancer patients make more precise and personalized treatment decisions.

Life Science 52

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The Pharma Data

JULY 18, 2021

Pneumococcal disease is an infection caused by bacteria called Streptococcus pneumoniae, or pneumococcus. Different strains of this bacteria are called serotypes. Invasive pneumococcal disease (IPD) occurs when the bacteria infect parts of the body that are usually free from germs.

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The Pharma Data

SEPTEMBER 28, 2021

Respiratory infections are caused by a good sort of pathogens, like influenza viruses, respiratory syncytial virus, parainfluenza viruses, metapneumovirus, rhinovirus, enterovirus, coronavirus and adenovirus, and other bacteria pathogens.

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Drug Discovery World

JULY 26, 2023

Microbial NGS methods can range from ribosomal RNA analysis (16S rRNA sequencing), to parallel genomic sequencing or shotgun metagenomic sequencing, to whole genome sequencing, to metatranscriptomics. Genome editing tools such as CRISPR may be employed to create “live biotherapeutics” (drugs composed of living bacteria).

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XTalks

DECEMBER 24, 2020

Doudna, PhD, of the University of California, Berkeley and Emmanuelle Charpentier, PhD, of the Max Planck Unit for the Science of Pathogens Institute for Infection Biology, revolutionized genetic research by helping to identify a natural gene editing mechanism in bacteria. Single-Cell RNA Sequencing.

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Drug Discovery World

AUGUST 10, 2022

The immune system typically identifies foreign entities such as bacteria and viruses and activates lymphocytes such as T cells to destroy them with overwhelming force. Unlike qPCR, which requires users to generate a standard curve to estimate the concentration of DNA or RNA in a sample, ddPCR technology quantifies nucleic acids directly.

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Manufacturing Gene Genome Genomics 98

XTalks

AUGUST 2, 2023

2) Botox Therapeutic/Cosmetic Botox, or botulinum neurotoxin, is a neurotoxic protein produced by the Clostridium botulinum bacteria. 2) Veklury (remdesivir) Veklury, approved by the FDA in 2020, is a SARS-CoV-2 nucleotide analog RNA polymerase inhibitor designed for the treatment of COVID-19. billion in 2022. billion in 2022.

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