Drug Discovery World

JULY 15, 2022

The remaining 8% of the genome was often referred to as the dark matter of the genome or sometimes even ‘Junk DNA’ 2. This technical tour de force will have far reaching implications for our understanding of the human genome and for practical use of this knowledge in clinical medicine.

Genome 52

Genome Genomics DNA Containment 52

Drug Discovery World

NOVEMBER 15, 2022

Rapid and accurate DNA synthesis . Conventional DNA synthesis, typically used for making sequences such as primers, employs phosphoramidite chemistry, a method that was developed in the 1980s and is still considered the gold standard for DNA synthesis. .

DNA 98

DNA Drugs Antibody Engineer 98

The Pharma Data

DECEMBER 23, 2020

” Dr. Stanley Plotkin , Professor Emeritus at The Wistar Institute, said, “INOVIO’s DNA vaccine appeared to be quite safe with few significant reactions but yet induced both antibody and T cell responses to SARS-CoV-2.” About INOVIO’s DNA Medicines Platform. mg and 2.0

DNA 40

DNA Vaccination Vaccine Immune Response 40

Drug Discovery World

MAY 29, 2024

DNA purification “Plasmid DNA is an incredibly important part of molecular biology”, says Hummersone. We are now looking at larger plasmid DNA sequences to carry more genetic material, and so we can get a more delicate endpoint with a much larger plasmid DNA sequence. That’s not the case in CGT.”

Gene Therapy 103

Gene Therapy Gene Genetics DNA 103

Drug Discovery World

MAY 5, 2023

With Exacis’ pipeline of engineered iPSC-derived cell therapy candidates, we believe Eterna is well-positioned to develop more effective, targeted and highly differentiated medicines to treat cancer,” said Matt Angel, Chief Executive Officer and President of Eterna.

Gene Editing 52

Gene Editing Engineer DNA Life Science 52

XTalks

FEBRUARY 11, 2021

For example, British scientist Rosalind Franklin gained recognition for her work after her death, which is not unheard of, but with it came the revelation that her work, which helped demonstrate the double helical structure of DNA, went largely uncredited by famed DNA duo James Watson and Francis Crick.

Genetics 119

Genetics DNA Genome Genomics 119

Scienmag

OCTOBER 6, 2021

In the cell’s power plants, known as mitochondria, the energy contained in our food is converted into the molecule ATP. It serves as a kind of fuel that drives most cellular processes – from muscle contraction to the assembly of our DNA. In order to fulfill their many tasks, cells need energy.

DNA 52

DNA Containment Medicine 52

Drug Discovery World

MAY 4, 2023

Recombinant DNA technology and improved protein purification techniques further contributed to our understanding and explorations of drug targets. The MorCVD database contains all the human proteins that can be potentially involved in heart disease. The post Can artificial intelligence help craft new medicines?

Medicine 52

Medicine Protein Drugs Bioassay 52

pharmaphorum

MAY 11, 2021

Called eRNA for short, this class of medicines is programmable and can continuously express therapeutic proteins inside the body. This makes the body into a “drug factory”, allowing for long-lasting medicines that allow for repeat redosing and can be administered easily by several routes.

RNA 98

RNA Drugs Protein Immune Response 98

Scienmag

OCTOBER 4, 2020

DNA, which carries genetic information in cells, contain biological instructions. CHICAGO – Researchers have identified genetic mutations that appear to protect women from severe bleeding after childbirth, a leading cause of maternal death. A genetic mutation, which is a permanent […].

Genetics 40

Genetics Research DNA Containment 40

Drug Discovery World

AUGUST 14, 2023

Over the past few decades, the incredible progress in personalised medicine has led to the development of life-saving cell and gene therapies (CGT). Within the past year, the sector saw the EU’s landmark approval of the first allogeneic T cell therapy as well as the approval of several new gene therapies in the US.

Gene Therapy 52

Gene Therapy Marketing Gene DNA 52

XTalks

DECEMBER 13, 2023

These efforts encompass programs related to the shingles vaccine, Tdap vaccine and plague vaccine, reinforcing Dynavax’s commitment to advancing the field of vaccines and medicine. The enduring success of Aravive can be attributed to its ongoing investment in R&D and the commercialization of innovative new medicines.

Genetics 111

Genetics Vaccination Vaccine DNA 111

Drug Discovery World

DECEMBER 15, 2022

These platforms all induce double strand cuts in the chromosomal DNA that can be sealed by the cell, leading to a specific gene disruption, or resulting in a new target site for inserting DNA segments. Reduce/eliminate chromosomal disruptions caused by double-strand DNA breaks. In one example, Choi et al.

Gene Editing 52

Gene Editing Gene In-Vivo Genome 52

pharmaphorum

OCTOBER 19, 2022

The dark genome – a loose term that covers non-coding regions of the genome that are capable of regulating the expression of genes, previously rather inaccurately referred to as junk DNA – is increasingly being explored by biopharma companies for new drug targets.

Genome 57

Genome Genomics Gene Gene Expression 57

Pharmaceutical Technology

MAY 24, 2023

Within the emerging innovation stage, cell therapy for ocular disorders, coronavirus vaccine components, and DNA polymerase compositions are disruptive technologies that are in the early stages of application and should be tracked closely.

Protein 130

Protein Antibody Medicine Development 130

Pharmaceutical Technology

MAY 15, 2023

Within the emerging innovation stage, cell therapy for ocular disorders, coronavirus vaccine components, and DNA polymerase compositions are disruptive technologies that are in the early stages of application and should be tracked closely. Its primary focus is on oncology, cardiovascular, immunology, and fibrotic therapeutic projects.

Antibody 130

Antibody DNA Genome Genomics 130

XTalks

JANUARY 19, 2024

Radiobiological and Clinical Considerations from CRO and Emerging Biotech Radiopharmaceuticals are medicinal formulations containing radioisotopes that are used in the field of nuclear medicine primarily for the diagnosis and treatment of various diseases, particularly cancer. There have been more than $1.7

DNA 66

DNA Radiology FDA Approval Development 66

Roots Analysis

SEPTEMBER 18, 2023

Owing to the ability to preserve a wide variety of elements for such a long period of time, including cells, tissues, blood and DNA, cryopreservation has emerged as a key focus area for stakeholders in the biopharmaceutical industry. The above figure presents a general overview of the cryopreservation process.

Engineer 52

Engineer Containment In-Vivo Production 52

pharmaphorum

JANUARY 18, 2023

The DNA of these so-called ‘genetic superheroes’ may contain clues about how to treat severe disease. The idea of ‘genetic superheroes’ and precision medicine is captivating for researchers, but the concept can be abstract and distant for participants. Giving participants something in return. About the author.

Genetic Disease 95

Genetic Disease Genetics Research Genome 95

The Pharma Data

JANUARY 20, 2021

Nasdaq: INO), a biotechnology company focused on bringing to market precisely designed DNA medicines to treat and protect people from infectious diseases, including COVID-19, cancer and HPV-associated diseases, today announced the pricing of an underwritten public offering of 17,700,000 shares of its common stock at a public offering price of $8.50

DNA 40

DNA Containment Immune Response Sales 40

pharmaphorum

DECEMBER 2, 2020

That ignores the fact that the thalidomide tragedy itself was responsible for the introduction of evidence-based medicine and reforms to the regulatory system that keep patients safe today. Other false claims are that RNA-based vaccines like BNT162b can alter a recipient’s DNA and that the shots will contain tissue from aborted foetuses.

Vaccination 104

Vaccination Vaccine Medicine RNA 104

Roots Analysis

FEBRUARY 15, 2022

Specifically, the multi-step process of production of cytotoxic payloads, which are used in ADCs, requires a contained environment, dedicated manufacturing facilities, specialized analytical and purification techniques, and storage facilities. Want additional details on the ADC Payloads / Warheads Developers? Increased Partnership Activity.

Contract Manufacturing 52

Contract Manufacturing Manufacturing Marketing Containment 52

The Pharma Data

MARCH 30, 2021

Targeted radioligand therapy is a type of precision medicine combining two key elements: a targeting compound, or ligand, and a radioactive isotope, causing DNA damage that inhibits tumor growth and replication. We believe this technology has the potential to transform many patients’ lives.”. Disclaimer. Source link:[link].

Protein 52

Protein Licensing Licensing Containment 52

The Pharma Data

MARCH 7, 2022

“Today’s decision underscores our commitment to using a risk and science-based, data-driven process that focuses on safety to the animals containing intentional genomic alterations and safety to the people who eat the food produced by these animals,” said Steven M. director of the FDA’s Center for Veterinary Medicine. “It

Genome 52

Genome Genomics Production Marketing 52

Roots Analysis

AUGUST 31, 2023

Recent advances in DNA sequencing technologies have led to significant developments in healthcare-focused research on precision medicine and diagnostics. Nutritional DNA testing helps in identifying foods that might lead to allergies or intolerance in an individual.

Genome 40

Genome Genomics Genetics Gene 40

The Pharma Data

JANUARY 11, 2021

Neither of the two vaccines approved in the United States — made by Pfizer-BioNTech and Moderna — contains the live virus. “That means it never converts into DNA,” Dr. M. Fahad Khalid, chief of hospital medicine at Penn State Health Hershey Medical Center in Hershey, Pa.,

Vaccination 52

Vaccination Vaccine Allergies Protein 52

The Pharma Data

DECEMBER 2, 2020

Results show the protocol demonstrated a 30Gb+ yield of long DNA reads raw data of an E. The FMv8 protocol introduces a needle-aspirate-based, cell-resuspension step prior to cell lysis that boosts DNA recovery. Elsewhere around the globe: RevoluGen – U.K.-based Horizon Discovery Group – U.K.-based

Drugs 52

Drugs Gene Editing Genome Genomics 52

Drug Discovery World

MARCH 27, 2023

Genetic insights are also guiding healthcare closer to precision medicine, enabling clinicians to tailor medical decisions or therapies to each patient. However, this quantum leap in bioscience comes with the challenge of how to store and manage large volumes of sensitive patient data.

Genome 52

Genome Genomics Research Scientist 52

XTalks

FEBRUARY 4, 2021

The power of leveraging clinical data to decipher disease mechanisms and fuel drug discovery has rapidly grown in the era of genomics and personalized medicine. This includes precision medicine strategies which can be effectively guided through high-level translational research led by clinical data.

Research 98

Research Biobanking Drugs Genome 98

The Pharma Data

NOVEMBER 24, 2020

. “Sadly, the risk of developing prostate cancer is significantly higher for carriers of the BRCA or ATM -gene mutation, which affects roughly 10 per cent of men living with mCRPC,” said Dr. Kim Chi, Medical Oncologist and Professor of Medicine at the University of British Columbia. ” . 3, 4, 5, 6 .

Gene 52

Gene Hormones DNA Medicine 52

Delveinsight

DECEMBER 13, 2020

This discovery led to the development of diagnostic tests and an effective vaccine, and Blumberg was awarded the Nobel Prize in Physiology or Medicine in 1976 for this discovery. Chronic hepatitis B infection is treated with medicines, including oral antiviral agents. HBV DNA can be integrated into the host genome.

Genotype 52

Genotype FDA Approval DNA Drugs 52

Drug Discovery World

AUGUST 10, 2022

To prevent these potentially fatal side effects, the US FDA recommends that manufacturers who generate CAR T cells using retroviral or lentiviral vectors screen out batches that contain more than four transgene copies per cell 13. Meanwhile, droplets that do not contain the template strand only emit weak fluorescence.

Manufacturing 98

Manufacturing Gene Genome Genomics 98

XTalks

APRIL 23, 2021

dMMR occurs when a cell is unable to repair errors made during cellular replication, owing to mutations in DNA mismatch repair genes such as MLH1 or MLH2 , resulting in high-frequency microsatellite instability (H-MSI).

FDA Approval 105

FDA Approval Trials Antibody DNA 105

XTalks

NOVEMBER 7, 2022

Liquid biopsy tests in oncology involve isolating entities such as circulating tumor cells (CTC), circulating tumor DNA (ctDNA) and tumor-derived exosomes. The cfDNA that originates from tumors is called circulating tumor DNA (ctDNA). FoundationOne ® Liquid CDx (Foundation Medicine; end-to-end commercial provider).

Clinical Trials 98

Clinical Trials Clinical Trials Trials FDA Approval 98

Pfizer

JANUARY 27, 2023

In preclinical studies, nirmatrelvir did not demonstrate evidence of mutagenic DNA interactions. One carton contains five blister packs of PAXLOVID, as co-packaged nirmatrelvir tablets with ritonavir tablets, providing all required doses for a full five-day treatment course. Accessed: January 2023. Accessed: January 2023.

Marketing 75

Marketing Production Drugs Licensing 75

The Pharma Data

SEPTEMBER 2, 2021

AstraZeneca will present new data across its diverse portfolio of cancer medicines at the International Association for the Study of Lung Cancer (IASLC) 2021 World Conference on Lung Cancer (WCLC) and the European Society for Medical Oncology (ESMO) Congress 2021. Abstract #P47.04. 8 September 2021. Lead author. Abstract title.

Trials 52

Trials Medicine Antibody Clinical Trials 52

Pfizer

DECEMBER 13, 2022

In preclinical studies, nirmatrelvir did not demonstrate evidence of mutagenic DNA interactions. One carton contains five blister packs of PAXLOVID, as co-packaged nirmatrelvir tablets with ritonavir tablets, providing all required doses for a full five-day treatment course. COVID-19 Medicines Partnerships. COVID-19 Medicines.

Drugs 110

Drugs Licensing Licensing Production 110