Pharmaceutical Technology

AUGUST 29, 2023

On 21 August, the US Food and Drug Administration (FDA) announced that it had granted an orphan drug designation (ODD) to Redx’s zelasudil (RXC007), which is an oral, selective rho-associated coiled-coil containing a protein kinase 2 (ROCK2) inhibitor for the potential treatment of idiopathic pulmonary fibrosis (IPF).

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Drug Discovery World

OCTOBER 26, 2022

A new method to study the proteins released by cells, which could lead to new biomarkers for diseases including cancer, has been developed by scientists at the Francis Crick Institute and Imperial College London. . Identifying the proteins . The new method involves adding chemical tags to sugar molecules which are added to cells.

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XTalks

JULY 26, 2021

But several researchers and experts have brought to light some food safety concerns of plant-based meat, and why it must be treated differently than that of animal protein. Because of their near-neutral pH and high protein and moisture content, plant-based meats are susceptible to microbial growth. Subject to Microbial Growth.

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The Pharma Data

MARCH 23, 2022

Polymerase is a viral protein that directs how Ebola virus replicates its genome as it infects new hosts. Drugs that target polymerase could potentially treat Ebola virus infections and save lives. The researchers discovered that Ebola virus polymerase hijacks a cellular protein called GSPT1. Catching polymerase in the act.

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Protein Genome Genomics Research 52

XTalks

MAY 7, 2021

As Novavax awaits emergency use authorization (EUA) from the US Food and Drug Administration (FDA) for its protein-based COVID-19 vaccine NVX-CoV2373, the company shared new data this week on the vaccine’s efficacy against the South African B.1.351 1.351 variant.

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Drug Discovery World

NOVEMBER 29, 2022

Using artificial intelligence, researchers at Chalmers University of Technology, Sweden have succeeded in designing synthetic DNA that controls the cells’ protein production. . The technology can contribute to the development and production of vaccines and drugs for severe diseases much faster and at lower cost. .

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Pharmaceutical Technology

MARCH 14, 2023

In the last three years alone, there have been over 633,000 patents filed and granted in the pharmaceutical industry, according to GlobalData’s report on Immuno-oncology in Pharmaceuticals: Purine derivatives-based cancer drug compositions. By means of geographic reach, Primmune Therapeutics Inc holds the top position.

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The Pharma Data

AUGUST 15, 2021

Food and Drug Administration were based on mRNA, more conventional protein-based vaccines have also shown promise in clinical trials. Most train the immune system to recognize the RBD, a peptide that is the portion of the SARS-CoV-2 spike protein that binds to the ACE-2 receptor on host cell surfaces. bioRxiv [Preprint].

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Drug Discovery World

JANUARY 31, 2024

Atacicept is an investigational recombinant fusion protein that contains the soluble transmembrane activator and calcium-modulating cyclophilin ligand interactor (TACI) receptor that binds to the cytokines B-cell activating factor (BAFF) and A proliferation-inducing ligand (APRIL).

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pharmaphorum

MAY 11, 2021

Flagship Pioneering, the VC fund run by Moderna’s co-founder Noubar Afeyan has launched a new biotech Laronde , with an ambitious plan to create a new class of drugs based on Endless RNA. Called eRNA for short, this class of medicines is programmable and can continuously express therapeutic proteins inside the body.

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XTalks

AUGUST 27, 2021

Renegade Creamery makes plant-based cheese but adds milk proteins produced in strains of yeast and bacteria and uses an “artisan fermentation process.” Like Renegade Creamery, the company also uses transgenic bacteria and yeast to make the protein because they have a history of being a safe and reliable way of producing animal proteins.

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The Pharma Data

MARCH 30, 2021

Basel, March 30, 2021 — Novartis has obtained exclusive worldwide rights to develop and commercialize therapeutic applications for a library of Fibroblast Activation Protein (FAP) targeting agents including FAPI-46 and FAPI-74, through an assignment agreement with iTheranostics, Inc., an affiliate of SOFIE Biosciences, Inc. Disclaimer.

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FDA Law Blog

JULY 11, 2023

Koblitz — One of the most important questions FDA has to answer is whether a given product is appropriately characterized as a drug, biologic, device, food, cosmetic, or something entirely different. FDA further defined the term “protein” so that it includes any peptide product that has an amino acid sequence greater than 40 amino acids.

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FDA Law Blog

DECEMBER 8, 2022

Food and Drug Administration (FDA) issued two guidance documents, one draft and one final, on food allergen labeling requirements. labeling of major food allergens in bulk foods, dietary supplements, protein-free ingredients, and foods produced through genetic engineering); and. By Sophia R. Gaulkin — Last week, the U.S.

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Scienmag

NOVEMBER 20, 2020

It contains the information for the production of 27 proteins. This is not much compared to the possible 40,000 kinds of protein that a […].

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Drug Discovery World

OCTOBER 21, 2022

The first and only oral contraception containing a new, synthetic version of a naturally occurring oestrogen has been launched in the UK. . Cancer drug shows promise in treating incurable lung disease . The post This week in drug discovery (17-21 October) appeared first on Drug Discovery World (DDW).

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Scienmag

DECEMBER 9, 2021

When the body attempts to fight off an infection, immune cells called neutrophils may shoot out spider web-like networks of toxic proteins to help contain the invaders.

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Drug Discovery World

JANUARY 9, 2024

Thirteen new-to-market therapeutics and drugs poised to launch in 2024 will achieve ‘blockbuster’ status by 2029 or deliver game-changing benefits to patients. The 2024 Drugs to Watch, are: 1. Due to a delayed US launch it remains a drug to watch for 2024.

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Scienmag

JUNE 3, 2022

Researchers at Baylor College of Medicine and Texas Children’s Hospital have identified potent, highly specific compounds that interfere with bromodomain (BD)-containing proteins involved in cancer. The team reports in the Proceedings of the […].

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The Pharma Data

APRIL 7, 2023

CycPeptMPDB, a novel database – created by Tokyo Tech researchers – focused on the membrane permeability of cyclic peptides, could accelerate the development of drugs based on these promising compounds. In principle, these compounds can achieve the fine balance required of modern drugs.

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The Pharma Data

DECEMBER 16, 2020

TWO NOVEL SOLID TUMOUR TARGETS FROM THE PARTNERSHIP TRANSITION INTO DRUG DISCOVERY. This has enabled the generation of a pipeline of novel first-in-class targeted protein degradation projects. Evotec will be responsible for progressing the drug discovery programmes to IND filing.

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Drug Discovery World

MARCH 26, 2024

For example, progress made in developing gene mutant-specific inhibitors, antibody-drug conjugates (ADC), or cellular therapies. The post Conversations from ESMO Targeted Anticancer Therapies Congress 2024 appeared first on Drug Discovery World (DDW). We were there to present the latest findings from our research.

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Drug Discovery World

DECEMBER 14, 2023

With leading academic institutions and significant recent investment, Glasgow is shaping up to be an important centre for drug discovery and development in the UK. Discoveries in these areas will identify new treatments which will become the cancer drugs of the future.” DDW’s Diana Spencer explores the city’s unique ecosystem.

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pharmaphorum

FEBRUARY 24, 2022

Clinical stage pharmaceutical company Cantex Pharmaceuticals has obtained a global licence from Harvard University’s Office of Technology Development to develop the small-molecule drug azeliragon into a treatment for inflammatory lung diseases, including COVID-19.

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Drug Discovery World

JANUARY 27, 2023

The Winter 2022/2023 issue of Drug Discovery World Magazine is out now. Key features of the Winter issue include an overview of the drug discovery landscape in 2023, sector successes and challenges in the Scandinavian market, and how a drug sourced from the aerospace industry could offer treatments for multiple disease targets.

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Pharmaceutical Technology

MARCH 10, 2023

Pharmaceutical and biotechnology industries widely use freeze-drying systems to protect vaccines, antibodies, antibiotics such as penicillin, blood plasma, proteins, enzymes, hormones, viruses, and bacteria from heat and minimise their biological activity. The process eliminates the disadvantages of conventional drying methods or freezing.

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Drug Discovery World

SEPTEMBER 4, 2023

In the third and final part of this series of articles focused on plant-based medicines, DDW’s Megan Thomas evaluates therapeutic breakthroughs using plant-based products in drug discovery. In this study, researchers discovered how EGCG breaks apart tangles of the protein tau, a ‘hallmark’ of Alzheimer’s disease.

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Drug Discovery World

JANUARY 19, 2023

Sustained reduction in endotoxin levels One of the metabolic characteristics of bacterial or virus infections is the strong decrease of circulating lipoprotein and particularly the High-Density Lipoprotein (HDL) with its main containing protein apolipoprotein A-I (apoA-I).

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Drug Discovery World

APRIL 11, 2023

The Spring 2023 issue of Drug Discovery World Magazine is out now. Key features of the Spring issue include a market report on the US drug discovery sector, whether AI can discover new medicines, and why post-Covid-19 cognitive impairment is a new target for drug development.

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XTalks

JANUARY 3, 2024

Wainua is the only FDA-approved drug for the treatment of ATTRv-PN that can be self-administered via an auto-injector. In individuals affected by ATTR, which includes both hereditary and wild-type (non-hereditary) variants, the TTR protein forms fibrils that accumulate in various tissues.

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Worldwide Clinical Trials

SEPTEMBER 29, 2022

Preclinical assays designed to assess drug toxicity and safety must detect total drug. For studies of humanized therapeutics (monoclonal antibodies [mAb], fusion protein, antibody-drug conjugates [ADC], bispecific antibodies, etc.), To measure free drug only, anti-idiotype (anti-ID) mAb testing may be the best choice.

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The Pharma Data

DECEMBER 16, 2020

Currently in Phase 3 clinical testing in the United Kingdom for the prevention of COVID-19, NVX-CoV2373 is a recombinant protein vaccine adjuvanted with Novavax’ proprietary Matrix-M to enhance the immune response. NVX-CoV2373 contains purified protein antigen and can neither replicate, nor can it cause COVID-19.

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Drug Discovery World

AUGUST 9, 2022

Based in Dundee, Cypex manufactures recombinant xenobiotic metabolizing enzymes with its product portfolio covering a wide range of proteins involved in drug metabolism. . This technology enables the expression of human drug-metabolizing enzymes in bacteria, without requiring large modifications to the proteins.?

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pharmaphorum

SEPTEMBER 28, 2020

VWD affects up to 1% of the global population, and is caused by deficiency or dysfunction in the protein known as von Willebrand factor (VWF). Also, unlike many pdVWF products, Veyvondi does not contain any clotting Factor VIII, so that co-dosing does not need to be accounted for and the risk of excess factor building up is reduced.

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XTalks

MAY 13, 2022

A container closure system consists of all the packaging components that contain and protect a pharmaceutical product. Container Closure Systems. A container closure system protects the product from environmental conditions, safeguarding a product’s purity, strength, safety and efficacy.

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Drug Discovery World

NOVEMBER 14, 2022

Early-stage biopharma company Atrogi initiated a Phase I study for its drug candidate ATR-258 targeting type 2 diabetes in Germany, which is expected to announce results at the end of the year. . Australian researchers identified a crucial protein that could prevent type 1 diabetes from taking hold. . Alternative to insulin.

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pharmaphorum

SEPTEMBER 14, 2021

The Cambridge, Massachusetts biotech is focusing specifically on the 60% of DNA sequences that repeat themselves hundreds or thousands of times in the genome, known as the ‘repeatome’, that could contain targets for cancer and autoimmune disorders.

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