The Pharma Data

MARCH 30, 2021

Basel, March 30, 2021 — Novartis has obtained exclusive worldwide rights to develop and commercialize therapeutic applications for a library of Fibroblast Activation Protein (FAP) targeting agents including FAPI-46 and FAPI-74, through an assignment agreement with iTheranostics, Inc., an affiliate of SOFIE Biosciences, Inc. Disclaimer.

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Protein Licensing Licensing Containment 52

Drug Discovery World

APRIL 11, 2023

Key features of the Spring issue include a market report on the US drug discovery sector, whether AI can discover new medicines, and why post-Covid-19 cognitive impairment is a new target for drug development. To download the DDW app for Apple devices click  here.

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Containment Protein Drugs Medicine 52

Pharmaceutical Technology

FEBRUARY 15, 2023

Cas, also called CRISPR associated proteins, are a family of nucleases such as Cas9, Cas12a, Cas12b, and CasX that process these sequences. The eukaryotic genome can be cut at any desired position by introducing plasmids containing Cas genes and specifically constructed CRISPRs into eukaryotic cells.

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In-Vivo Genome Genomics Gene Editing 162

Drug Discovery World

AUGUST 9, 2023

The UK Medicines and Healthcare products Regulatory Agency (MHRA) has granted Aleta Biotherapeutics a clinical trial authorisation (CTA) to evaluate biologic ALETA-001 in a Phase I/II clinical trial in patients with B-cell malignancies who are relapsed/refractory to CD19 CAR T cell therapy.

Clinical Trials 52

Clinical Trials Clinical Trials Trials Licensing 52

XTalks

AUGUST 26, 2020

. “We found that macrophage programming is driven by more than the immune system — it is also driven by the environment in which the macrophages reside,” said lead study author Asrar Malik, the UIC Schweppe Family Distinguished Professor and head of pharmacology and regenerative medicine at the College of Medicine.

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Bacteria Immune Response Protein Medicine 105

Pfizer

AUGUST 3, 2022

We thank the patients, families, investigators and members of the advocacy community who contributed to this research,” said Chris Boshoff, M.D., Detailed data from the REALM-DCM study will be presented at future medical meetings to help inform ongoing research. About REALM-DCM.

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Development Vaccination Vaccine Production 101

Pharmaceutical Technology

MAY 24, 2023

Innovation S-curve for the pharmaceutical industry Tetrapeptide derivatives are a key innovation area in the pharmaceutical industry Tetrapeptides are classified as oligopeptides as they contain only four amino acids linked by peptide bonds. Whilst Abliva and Ambrx Biopharma stand in second and third positions, respectively.

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Protein Antibody Medicine Development 130

Pfizer

AUGUST 11, 2022

The information contained in this statement is as of August 11, 2022. Pfizer assumes no obligation to update forward-looking statements contained in this release as the result of new information or future events or developments. . Pfizer and BioNTech Complete Submission to European Medicines Agency for Omicron BA.1 07.27.2022.

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Containment Vaccination Vaccine Development 49

pharmaphorum

SEPTEMBER 14, 2020

AstraZeneca has resumed UK trials for its coronavirus vaccine, after the country’s medicines regulator gave the all-clear following a safety scare. A UK safety committee has concluded its investigations and recommended to the country’s Medicines and Healthcare products Regulatory Agency (MHRA) that trials are safe to resume.

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Vaccination Vaccine Trials Protein 81

Drug Discovery World

DECEMBER 14, 2023

The new centre represents a flagship investment within the University’s Glasgow Riverside Innovation District (GRID) and will be home to commercial businesses as well as the University of Glasgow-led Living Laboratory for Precision Medicine.

Drugs 76

Drugs Life Science Research Scientist 76

Pharmaceutical Technology

DECEMBER 9, 2022

M&A – Commended PRODUCT LAUNCHES – Commended RESEARCH AND DEVELOPMENT – Commende d. Solvias is a Swiss-based pharmaceutical company focused on contract research, development and manufacturing. Pharmaceutical Technology Excellence Rankings – The Verdict.

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Development Manufacturing Production Vaccination 130

Drug Discovery World

NOVEMBER 14, 2022

Find out more: New human beta cell model enables discoveries in diabetes research . Based on research into adrenergic signaling by professor Tore Bengtsson at Stockholm University, ATR-258 is a small molecule therapy that works by selectively stimulating b2-adrenergic receptors to translocate GLUT4 to the cell membrane. .

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Development Gene Therapy Drugs Gene 52

XTalks

AUGUST 6, 2020

Epidiolex is the only FDA-approved formulation that contains CBD derived from the cannabis plant. CBD is the most abundant non-psychoactive cannabinoid compound found in the cannabis plant, making up about 40 percent of the plant’s extract, which contains over 100 different cannabinoid compounds.

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FDA Approval Protein Containment Genetic Disease 64

The Pharma Data

DECEMBER 10, 2020

executive vice president of research and development. “We Lexicon is a biopharmaceutical company with a mission of pioneering medicines that transform patients’ lives. Through the precise targeting of these proteins, Lexicon is pioneering the discovery and development of innovative medicines to safely and effectively treat disease.

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Containment Clinical Development Development Protein 52

The Pharma Data

DECEMBER 31, 2020

Researchers from the U.S. The researchers saw no signs of the virus in the tissue samples, which they said may mean that the damage was not caused by the virus itself. In 16 patients, the investigators found bright spots, which contained blood vessels that were thinner than normal and sometimes leaking blood proteins into the brain.

Immune Response 52

Immune Response Containment Doctors Doctor 52

The Pharma Data

OCTOBER 20, 2020

Patent and Trademark Office covering the use of Fatty Acid Binding Protein 5 (FABP5) inhibitors for the treatment of psychological disorders such as anxiety and post-traumatic stress disorder (PTSD). We look forward to continuing our research on FABP5 inhibitors in collaboration with Artelo.”. About Artelo Biosciences, Inc.

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Protein Development Research Production 52

The Pharma Data

JANUARY 11, 2021

Neither of the two vaccines approved in the United States — made by Pfizer-BioNTech and Moderna — contains the live virus. They give the body a blueprint to create a bit of the virus that causes COVID-19, called a spike protein. This protein then appears on the surface of the cell and the immune system responds to it. .

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Vaccination Vaccine Allergies Protein 52

Drug Discovery World

MARCH 7, 2023

Within this, Qatar is emerging as a country which is actively seeking to bolster its drug discovery and development sectors, through high levels of spending and investment into local research programmes. Qatar is a small country but faces many of the same healthcare problems that Western countries currently face.

Biobanking 52

Biobanking Drugs Genome Genomics 52

The Pharma Data

DECEMBER 17, 2020

NASDAQ: REGN ) today announced that the New England Journal of Medicine (NEJM) has published initial clinical data from an ongoing seamless Phase 1/2/3 trial of the antibody cocktail casirivimab and imdevimab in non-hospitalized patients with COVID-19. TARRYTOWN, N.Y. , 17, 2020 /PRNewswire/ — Regeneron Pharmaceuticals, Inc.

Antibody 52

Antibody Medicine Production Trials 52

Pfizer

FEBRUARY 16, 2023

GCP is the international ethical and scientific quality standard for clinical trials that all clinical researchers need to follow. OspA is a surface protein expressed by the bacteria when present in a tick. Pfizer Disclosure Notice The information contained in this release is as of February 17, 2023.

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Clinical Trials Clinical Trials Vaccination Vaccine 76

Camargo

APRIL 28, 2021

The typical pathway toward initiating pediatric clinical research begins by gathering data in preclinical in vivo studies and in adult healthy volunteers or patients. If the model does not contain covariates relevant for young patients, they are added to the model based on the known information.

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Clinical Trials Clinical Trials In-Vivo Drugs 130

Roots Analysis

OCTOBER 24, 2023

Owing to the advancement in clinical pharmacology and oncology domain, and the rising demand for targeted therapeutics and precision medicines, high potency active pharmaceutical ingredients (HPAPIs) and cytotoxic drugs have become one of the key areas of interest to researchers and drug manufacturers across the globe.

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Manufacturing Hormones Contamination Contract Manufacturing 40

Pharmaceutical Technology

AUGUST 5, 2022

As per the prevailing prion theory, a misfolded version of a normal cell-surface protein acts as the chief infectious agent. It is ultra-rare,” says Jesús Rodriguez Requena, PhD, associate professor in the Department of Medicine at the University of Santiago de Compostela. And then comes the question of the right target.

Drugs 299

Drugs Protein Vaccination Vaccine 299

Advarra

MARCH 10, 2023

Considered a rare disease, research in finding better therapies – and possibly even a cure – for SCD may be competing for funding with conditions impacting broader populations. SCD’s significant impact on African Americans also means it predominantly impacts a minority community historically underserved by clinical research.

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Clinical Trials Clinical Trials Trials Doctors 98

The Pharma Data

JULY 22, 2021

10 Improving awareness and understanding around this rare and life-threatening blood disorder associated with ADAMTS13 deficiency, 9 together with the development of TAK-755, forms part of Takeda’s commitment to invest in research that has the potential to transform the future care of even more patients affected by rare hematological disorders.

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Containment Production Protein Medicine 52

XTalks

SEPTEMBER 8, 2020

Albany Molecular Research Inc (AMRI), a global provider of advanced drug development and manufacturing solutions, announced that they have signed a supply agreement with AstraZeneca. The genetic material contains SARS-CoV-2 spike protein. Fauci, in a statement.

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Manufacturing Vaccination Vaccine Allergies 83

The Pharma Data

NOVEMBER 29, 2021

deputy director of the Office of Specialty Medicine in the FDA’s Center for Drug Evaluation and Research. “By Ovarian cancer often causes the body to overproduce a specific protein in cell membranes called a folate receptor. Cytalux may cause fetal harm when administered to a pregnant woman.

FDA Approval 52

FDA Approval Drugs Cosmetics Protein 52

XTalks

JANUARY 28, 2022

The company is expecting approval from the European Medicines Agency (EMA) soon as it prepares for a European launch in the second quarter of this year. Related: Cancer Blood Test Developed by University of Oxford Researchers Can Detect Metastasis. Kimmtrak has a price tag of $18,760 per vial, which amounts to a weekly dose.

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FDA Approval Development Licensing Licensing 98

pharmaphorum

OCTOBER 14, 2021

The protein, Programmed Death-Ligand 1 (PD-L1), is found on the surface of many cells throughout the body. Some cancer cells contain large amounts of PD-L1, which helps them to evade the body’s immune system. Patients who received the Keytruda and chemotherapy combination, with or without bevacizumab, enjoyed 19.8

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The Pharma Data

OCTOBER 25, 2020

Moderna is advancing messenger RNA (mRNA) science to create a new class of transformative medicines for patients. mRNA medicines are designed to direct the body’s cells to produce intracellular, membrane or secreted proteins that can have a therapeutic or preventive benefit and have the potential to address a broad spectrum of diseases.

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Vaccination Vaccine Manufacturing Clinical Development 52

The Pharma Data

DECEMBER 21, 2020

Targeted protein degradation (TPD) is an approach whereby the body’s natural process for degrading proteins is diverted using small molecule drugs to eliminate disease-causing proteins. However, there has so far been limited progress in applying this exciting approach to membrane-associated proteins such as GPCRs.

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Drugs Protein Development Production 40

The Pharma Data

APRIL 18, 2022

Takeda today announced that it has received manufacturing and marketing approval from the Japan Ministry of Health, Labour and Welfare (MHLW) for Nuvaxovid ® Intramuscular Injection (Nuvaxovid), a novel recombinant protein-based COVID-19 vaccine, for primary and booster immunization in individuals aged 18 and older.

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Vaccination Vaccine Manufacturing Clinical Trials 52

The Pharma Data

JANUARY 17, 2021

The medicine, an anti-SARS-CoV-2 immunoglobulin, given subcutaneously, would provide immediate protection after exposure to the virus and could be used to protect the elderly and healthcare workers. . It could also help contain outbreaks in places where the vaccination hasn’t begun or is still underway.

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Clinical Trials Clinical Trials Trials Containment 52

Pfizer

FEBRUARY 9, 2023

The gE protein is important for viral replication and the cell-to-cell spread after reactivation of the virus in the nerve cells. We strive to set the standard for quality, safety and value in the discovery, development and manufacture of health care products, including innovative medicines and vaccines.

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Vaccination Vaccine Clinical Trials Clinical Trials 75

The Pharma Data

NOVEMBER 23, 2020

Under the partnership, Evotec will support Rappta’s programme of developing small molecule activators of the enzyme Protein Phosphatase 2A (“PP2A”), which downregulates multiple oncogenic signalling pathways responsible for driving cancer progression.

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Development Protein Regulation Containment 40

The Pharma Data

NOVEMBER 17, 2021

It uses a replication-deficient chimpanzee viral vector based on a weakened version of a common cold virus (adenovirus) that causes infections in chimpanzees and contains the genetic material of the SARS-CoV-2 virus spike protein. 3,4,5,6,7).

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Vaccination Vaccine Clinical Trials Clinical Trials 52

pharmaphorum

MARCH 10, 2021

While the lab study is no guarantee that Comirnaty will be protective against these variants circulating in the real world, it’s an encouraging indication that the changes in the SARS-CoV-2 spike protein in these strains aren’t big enough to dramatically hinder the effectiveness of the current vaccines.

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Vaccination Vaccine Genetic Engineering Engineer 58