Camargo

JULY 27, 2021

How and When to Incorporate PK Design into Your Gene Therapy Development Plan. Gene therapy, which was in its infancy around 30 years ago, is now becoming a more prominent treatment method in many therapeutic areas, from personalized therapy to mass vaccinations against COVID-19. Formulation Considerations.

Gene Therapy 238

Gene Therapy Gene Gene Editing Genetics 238

Drug Discovery World

OCTOBER 4, 2023

Scientists have discovered the link between gene expression, DNA methylation, and brain structural changes in depression, revealing new potential therapeutic targets. Parallel findings in humans underscored the involvement of interferon-related genes in major depressive disorder.

Research 52

Research Gene DNA Gene Expression 52

Scienmag

DECEMBER 22, 2020

Blocking gene expression in mitochondria in mice stops cancer cells from growing Credit: Hauke S. Hillen A newly developed compound starves cancer cells by attacking their “power plants” – the so-called mitochondria. The new compound prevents the genetic information within mitochondria from being read.

Gene Expression 95

Gene Expression Genetics Gene Drugs 95

XTalks

AUGUST 5, 2020

In recent webinars by Genuity Science, formerly known as WuXi NextCODE, experts from the biotech and pharma industries spoke about leveraging the power of single cell RNA sequencing platforms and solutions in conjunction with machine learning technologies such as AI in cell biology and disease research. The Power of Single Cell Technology.

Gene Expression 112

Gene Expression Development RNA Drugs 112

Drug Discovery Today

APRIL 24, 2023

(MIAMI) Researchers at the John P.

Gene 80

Gene Gene Expression Genome Genomics 80

Drug Discovery World

OCTOBER 6, 2023

In celebration of the Nobel Prize for Medicine going to two of the early proponents of mRNA technology for creating therapeutics, Katalin Karikó and Drew Weissman, this week our round-up highlights the importance of genetics, genomics and gene editing in drug discovery.

Drugs 52

Drugs Gene Editing Genome Genomics 52

Drug Discovery World

MARCH 2, 2023

A new paper has solved the 20-year mystery of how epigenetic modifications act as traffic lights to control gene expression and could ultimately speed up the development of a new class of epigenetic cancer drugs. But, until now, scientists lacked an understanding of what the chemical tag does, despite many years of research.

Gene Expression 52

Gene Expression Gene DNA RNA 52

Drug Discovery World

SEPTEMBER 27, 2023

HKG Epitherapeutics is a biotechnology company developing novel tools for the early detection of cancer and promoting healthy aging. Embarking on a new era of medicine The advent of genomics has ushered in the era of personalised medicine, enabling us to analyse the genetic makeup of individuals with unprecedented accuracy.

DNA 115

DNA Genetics Gene Medicine 115

pharmaphorum

NOVEMBER 12, 2021

Researchers in the US have developed an artificial intelligence-based tool that is able to predict COVID-19 symptoms and suggest which FDA-approved drugs might be used to treat patients. The tool meanwhile could also be applied to new outbreaks of other novel viral infections as they emerge, according to the scientists.

Doctors 135

Doctors Doctor Drugs Gene Expression 135

Drug Discovery World

APRIL 17, 2024

It will be presented by Dylan Mooijman, Head of R&D, Single Cell Discoveries and Darina Šikrová, Researcher, Molecular Biology, Single Cell Discoveries. It will also feature an introduction by Melanie Masuda, Director of Market Development, ScaleBio. The event will take place on 25 April 5 PM BST / 6PM CEST / 9AM PST.

Genome 52

Genome Genomics Gene Expression RNA 52

Drug Discovery World

APRIL 3, 2024

It will be presented by Dylan Mooijman, Head of R&D, Single Cell Discoveries and Darina Šikrová, Researcher, Molecular Biology, Single Cell Discoveries. It will also feature an introduction by Melanie Masuda, Director of Market Development, ScaleBio. The event will take place on 25 April 5 PM BST / 6PM CEST / 9AM PST.

Genome 52

Genome Genomics Gene Expression RNA 52

Drug Discovery World

MARCH 21, 2023

So, what are the recent developments and how is the drug discovery sector tackling this common cancer? The researchers confirmed a clinical complete response in all 14 patients who received the immunotherapy treatment dostarlimab as a first-line treatment for mismatch repair-deficient (MMRd) locally advanced rectal cancer.

Drugs 52

Drugs Gene Expression RNA Clinical Trials 52

XTalks

MARCH 13, 2024

Biomarker testing is being pursued to identify biological signs of the disease and provide an approach to develop personalized treatment plans for each patient. As this technology continues to evolve, it is expected to help identify glaucoma in its nascent stages of development.

Gene Therapy 111

Gene Therapy Gene Life Science DNA 111

pharmaphorum

OCTOBER 19, 2022

The dark genome – a loose term that covers non-coding regions of the genome that are capable of regulating the expression of genes, previously rather inaccurately referred to as junk DNA – is increasingly being explored by biopharma companies for new drug targets. Dr Danuta Jeziorska.

Genome 59

Genome Genomics Gene Gene Expression 59

The Pharma Data

JULY 12, 2021

online issue of Nature Communications, researchers at University of California San Diego School of Medicine describe a new approach that uses machine learning to hunt for disease targets and then predicts whether a drug is likely to receive FDA approval. HUMANOID Center of Research Excellence?(CoRE),

Drugs 52

Drugs Gene Expression Big Data Gene 52

The Pharma Data

JUNE 14, 2023

However, researchers at the Georgia Institute of Technology have identified the major mechanism behind the transition between chronic and acute P. Abell Chair in Molecular and Cellular Biology – and Pengbo Cao, a postdoctoral researcher in Whiteley’s lab, discovered a gene that drives the switch. and Nelson D.

RNA 40

RNA Regulation Scientist Bacteria 40

The Pharma Data

JULY 11, 2021

It is believed to be involved in the development of chronic inflammatory intestinal diseases, to trigger diabetes, to be responsible for obesity, even neurological diseases such as multiple sclerosis and Parkinson’s could have their causes here – not to mention depressions and autistic disorders.

Bacteria 52

Bacteria Genetics Regulation Scientist 52

XTalks

NOVEMBER 6, 2020

Canadian clinical-stage biotech company Symvivo Corporation has developed an oral COVID-19 vaccine that entered clinical trials this week. The gene therapy-based vaccine targets mucosal tissues in the gastrointestinal tract, allowing for greater selectivity and targeted delivery compared to traditional vaccines.

Clinical Trials 75

Clinical Trials Clinical Trials Vaccination Vaccine 75

XTalks

MAY 31, 2022

This immune-mediated inflammatory disease has been researched thoroughly. The precise cause of psoriasis is unknown, but risk factors include genetics and a family history of the condition, heavy alcohol consumption, stress, smoking and dry or cold weather. Psoriasis is considered a life-long ailment with no permanent cure.

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FDA Approval Clinical Trials Clinical Trials Trials 98

Drug Discovery World

DECEMBER 12, 2022

DDW highlights the most interesting global news and comments within the drug discovery and development sector this month. . Everyone enjoys a good news story and the drug discovery and development sector is no exception. Lately, there has been a lot of interest in microbiome research. Research news .

Drugs 52

Drugs Gene Editing Genome Genomics 52

pharmaphorum

JANUARY 29, 2021

“Maybe in 50 years’ time we’ll be using gene editing to lower cholesterol, but it won’t replace statins in anyone but those with life threatening mutations for a long time”. They wanted someone who had lots of experience in drug development, was a molecular biologist, and was stubborn enough to take on CRISPR!” billion in funding.

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Gene Editing Gene Gene Therapy In-Vivo 145

The Pharma Data

FEBRUARY 22, 2021

The researcher at the Max Planck Institute for Developmental Biology received the award in a virtual ceremony for her groundbreaking research on the human microbiome – the totality of all microorganisms that naturally colonize a healthy human – which can reach an impressive mass of approximately one kilogram.

Scientist 40

Scientist Life Science Research Gene Expression 40

XTalks

FEBRUARY 11, 2021

This has ushered in a new era of genomics that is fostering rapid, detailed and personalized insights into human genetics. Xtalks is celebrating the International Day of Women and Girls in Science with a special overview of notable female scientists who have made revolutionary contributions to the field of genetics. Rosalind Franklin.

Genetics 119

Genetics DNA Genome Genomics 119

Roots Analysis

AUGUST 31, 2023

It is worth noting that the transcription factor is responsible for recruiting RNA polymerase to bind to the gene and produce messenger RNA, which is then translated into the protein. An additional level of genetic control is provided by gene switches that are located upstream of the promoter region.

Gene 40

Gene Gene Therapy Gene Expression Regulation 40

The Pharma Data

DECEMBER 14, 2020

The test was originally developed at the University of California, San Francisco, in a cohort of 361 patients with non-squamous NSCLC. Oncocyte has also launched DetermaIO , a gene expression test that identifies patients more likely to respond to checkpoint inhibitor immunotherapies, for research and pharma clinical trial use.

Licensing 52

Licensing Licensing Marketing Gene Expression 52

Drug Discovery World

APRIL 30, 2024

Messenger RNA (mRNA) has come into focus within the drug discovery and development as an exciting tool to deliver genetic information. Whilst research into mRNA has been ongoing for decade, interest has sparked in recent years and research has begun to expand into areas of vaccinology, infectious diseases and other indications.

RNA 52

RNA Protein Vaccination Vaccine 52

XTalks

MARCH 7, 2024

Other issues include medical systems that can often be dismissive of women’s health concerns or experiences, and historically less research on women’s health, which together, can lead to late diagnoses or misdiagnoses. Through this, researchers can pinpoint breast cancer cell types and their phenotypic states.

Hormones 115

Hormones Genetics Genome Genomics 115

Roots Analysis

AUGUST 31, 2023

Recent advances in DNA sequencing technologies have led to significant developments in healthcare-focused research on precision medicine and diagnostics. According to a study, around 20,000 genes are present in the human body, all of which interact with the nutrients in the food, either directly or indirectly.

Genome 40

Genome Genomics Genetics Gene 40

XTalks

MAY 4, 2021

Researchers at the University of California San Francisco (UCSF) and the Whitehead Institute have developed a novel CRISPR-based tool called “CRISPRoff” that can switch off genes in human cells through epigenetic editing without altering the genetic sequence itself. It’s a great tool for controlling gene expression.”.

DNA 98

DNA Gene Gene Silencing Genome 98

Drug Discovery World

FEBRUARY 6, 2023

Johannes Goll, Global Head of Emmes’ Biomedical Data Science and Bioinformatics department, explains how big data analytics can deliver improved therapies and bring clinical research one step close to realising the potential of personalised care. Figure 2: Advanced data visualisation examples for transcriptomics data.

Big Data 52

Big Data RNA Bioinformatics Vaccination 52

Roots Analysis

OCTOBER 22, 2023

RNA therapeutics are a novel class of biopharmaceuticals that harness the power of RNA molecules for the treatment and prevention of a wide range of disorders, including oncological, and genetic disorders as well as infectious diseases. These therapeutics are broadly classified into two categories, namely coding RNAs and non-coding RNAs.

RNA 40

RNA Protein Genetics Gene Expression 40

Drug Discovery World

APRIL 21, 2023

Atrandi Biosciences’ novel technology platform enables researchers to gain insights into the biology of single cells, offering immediate applications in single-cell sequencing, drug and antibody discovery, functional metagenomics, microbial analysis, directed evolution, and synthetic biology. It will be led by Björn C.

Doctors 52

Doctors Doctor Genetics In-Vitro 52

XTalks

MAY 4, 2021

Researchers at the University of California San Francisco (UCSF) and the Whitehead Institute have developed a novel CRISPR-based tool called “CRISPRoff” that can switch off genes in human cells without editing the genetic sequence itself. The research was published earlier this month in the journal Cell.

DNA 52

DNA Gene Gene Silencing Genome 52

Drug Discovery World

DECEMBER 15, 2022

As gene editing technologies like CRISPR progress toward clinical study, researchers must continue to advance new approaches and address inherent challenges, explains Jon Chesnut, PhD, Senior Director, Cell Biology R&D, Thermo Fisher Scientific. Topping the list of alternatives are lipid nanoparticles (LNPs) and electroporation.

Gene Editing 52

Gene Editing Gene In-Vivo Genome 52

Drug Discovery World

JULY 18, 2023

Since its discovery in 2012, CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) technology has revolutionised the biomedicine and cell and gene therapy fields, providing a versatile tool for precise and efficient genome editing. CRISPR diagnostics have successfully detected various pathogens, including RNA viruses (eg.

DNA 98

DNA Genome Genomics RNA 98

Drug Discovery World

APRIL 11, 2024

It will be presented by Dylan Mooijman, Head of R&D, Single Cell Discoveries and Darina Šikrová, Researcher, Molecular Biology, Single Cell Discoveries. It will also feature an introduction by Melanie Masuda, Director of Market Development, ScaleBio. The event will take place on 25 April 5 PM BST / 6PM CEST / 9AM PST.

Genome 52

Genome Genomics Gene Expression RNA 52

Drug Discovery World

MARCH 27, 2024

It will be presented by Dylan Mooijman, Head of R&D, Single Cell Discoveries and Darina Šikrová, Researcher, Molecular Biology, Single Cell Discoveries. It will also feature an introduction by Melanie Masuda, Director of Market Development, ScaleBio. The event will take place on 25 April 5 PM BST / 6PM CEST / 9AM PST.

Genome 52

Genome Genomics Gene Expression RNA 52