Drug Discovery World

JULY 15, 2022

The remaining 8% of the genome was often referred to as the dark matter of the genome or sometimes even ‘Junk DNA’ 2. The sequencing technology relied on could only yield sequences of relatively short DNA fragments, so the assembly of sequences from highly repetitive regions was a huge challenge.

Genome 52

Genome Genomics DNA Containment 52

XTalks

MARCH 13, 2024

Related: Transforming Eye Care: Innovating New Glaucoma and Dry Eye Disease Treatments — Featuring Pierre Simon, VP Marketing, Sight Sciences – Xtalks Life Science Podcast Ep. Secondly, other funded research is exploring differential gene expression regulated by DNA methylation.

Gene Therapy 111

Gene Therapy Gene Life Science DNA 111

XTalks

DECEMBER 28, 2023

XTALKS WEBINAR: Impacts of the New IVD Regulation (IVDR) for Manufacturers and Users Live and On-Demand: Tuesday, January 9, 2024, at 10am EST (4pm CET/EU-Central) Register for this free webinar to learn how the new In Vitro Diagnostic Regulation (IVDR) impacts manufacturers and users of diagnostic devices.

Trials 97

Trials Clinical Trials Clinical Trials Antibody 97

XTalks

MAY 4, 2021

The tool targets the epigenome, the collection of DNA modifications in a cell such as methylation and post-translational histone modifications. These modifications regulate gene expression without altering the sequence or structure of DNA. DNA methylation occurs endogenously in all mammalian cells in response to various stimuli.

DNA 52

DNA Gene Gene Silencing Genome 52

Drug Discovery World

JULY 11, 2023

Tim Lowery , President, JSR Life Sciences, asks whether artificial intelligence can do for life sciences what it has done in other sectors and whether these tools can keep up with the complexities of human biology. So, where do we go from here to realise their potential in life sciences?

Big Data 40

Big Data Development Life Science Drugs 40

XTalks

DECEMBER 1, 2020

Circulating DNA. The test is based on the identification of cancer-associated methylation signatures on DNA shed from tumor cells in the blood. The addition of methyl groups to DNA bases — namely cytosine and guanine in so-called ‘CpG islands’ — regulates the expression of genes.

DNA 64

DNA Genome Genomics Regulation 64

Pharmaceutical Technology

FEBRUARY 3, 2023

The established method for this process is a triple transfection using three different DNA plasmids. Another immediate benefit is improved batch-to-batch consistency — something regulators are expected to tighten the rules on in coming years. Cytiva and the Drop logo are trademarks of Life Sciences IP Holdings Corp.

Genome 244

Genome Genomics Medicine Gene Therapy 244

Drug Discovery World

JULY 18, 2023

Rolf Turk , Senior Manager, Genomics Medicine at Integrated DNA Technologies, examines how CRISPR is being used to enhance cancer therapies. parvovirus B19, Flaviviridae, Ebola, and Coronaviridae), DNA viruses (e.g., To achieve cell-specific delivery, many systems rely on using cell-specific DNA aptamers (e.g.,

DNA 98

DNA Genome Genomics RNA 98

pharmaphorum

DECEMBER 9, 2022

The PharmaStars accelerator was set up last year to help bridge the gap between digital health start-ups and potential pharma partners, which can be instrumental in making sure their technologies meet their potential – and help them to navigate the challenges of developing them in the highly regulated healthcare environment.

Life Science 52

Life Science DNA Genome Genomics 52

Drug Discovery World

APRIL 11, 2023

The molecule, known as lissodendoric acid A, appears to counteract other molecules that can damage DNA, RNA and proteins and even destroy whole cells. USP30 is a (de)ubiquitylation (DUB) implicated in neurodegenerative diseases that regulates the clearance of damaged mitochondria in a process called mitophagy.

Research 52

Research Drugs Life Science RNA 52

XTalks

NOVEMBER 23, 2021

During the pandemic, the Government of Canada acknowledged recent shortcomings in the life sciences and biomanufacturing sectors. Biovectra is also working to strike research partnerships and look for new development opportunities for life science professionals and those in the field of biomanufacturing.

Manufacturing 98

Manufacturing Vaccination Vaccine Drugs 98

XTalks

SEPTEMBER 9, 2021

The federal regulator suspended BioMarin’s currently ongoing Phase I/II studies of the gene therapy based on interim safety findings from a preclinical study which revealed that mice treated with the therapy at high doses developed tumors on their liver. Both involve an AAV to deliver a therapeutic gene to patients.

Gene Therapy 105

Gene Therapy Gene Genome Genomics 105

Drug Discovery World

AUGUST 1, 2023

Evonetix will use the funding to brings its semiconductor chips to commercial scale and extend gene assembly capabilities for its binary assembly technology to deliver accurate, gene-length DNA in a benchtop instrument.

Drugs 52

Drugs Gene Expression Engineer Gene 52

XTalks

FEBRUARY 4, 2021

Bernard, executive vice president for research and chief research officer at Vanderbilt University Medical Center, shared his experience in helping set up a DNA and clinical data resource called BioVU. The project began in 2004, in the early days of biobanking for DNA, says Dr. Bernard, and has grown tremendously since.

Research 98

Research Biobanking Drugs Genome 98

Drug Discovery World

FEBRUARY 6, 2024

However, many have cautioned against too great a reliance on these tools and emphasised the importance of checks and balances to ensure the systems are properly regulated and results are verified. By making lab automation as easy as using a smartphone, the Flex robot democratises access to automation in life sciences research.”

Marketing 69

Marketing Medicine Genome Genomics 69

Pharmaceutical Technology

FEBRUARY 20, 2023

About Cerba Research : We offer world-class clinical research that helps life science companies to successfully develop the predictive and precision medicines of the future. We combine the deep expertise and agility of the specialist laboratory with the capacity, breadth and global reach of a central lab. SZ) and Tigermed (300347.SZ

Research 130

Research Clinical Trials Clinical Trials Clinical Research 130

XTalks

FEBRUARY 13, 2023

Radiation causes single and double strand breaks in DNA and radiation damage to cells can occur from a direct or indirect action of radiation on DNA molecules. When radiation directly hits the DNA molecule, this disrupts the molecular structure of the DNA and this structural change to the DNA can lead to cell damage or apoptosis.

Clinical Trials 52

Clinical Trials Clinical Trials Trials DNA 52

Drug Discovery World

APRIL 30, 2024

Patients with argininosuccinic aciduria can also experience an imbalance of glutathione regulation, which is important for liver detoxification. For example, mRNA testing can offer deeper insights compared to DNA and give researchers a better understanding of gene expression in relation to certain cancers. J Biomed Sci 2023;30;84.

RNA 52

RNA Protein Vaccination Vaccine 52

XTalks

NOVEMBER 7, 2022

Liquid biopsy tests in oncology involve isolating entities such as circulating tumor cells (CTC), circulating tumor DNA (ctDNA) and tumor-derived exosomes. The cfDNA that originates from tumors is called circulating tumor DNA (ctDNA). These tumor-derived entities are used to derive genomic and proteomic data.

Clinical Trials 98

Clinical Trials Clinical Trials Trials FDA Approval 98

Drug Discovery World

MARCH 6, 2024

They also involve multiple mutations in non-coding regions of DNA – the ‘dark genome’ which makes up around 98% of our DNA. Mutations in the dark genome affect gene regulation rather than coding, exerting a positive or negative impact on the expression of genes that may be related to disease processes.

Genome 64

Genome Genomics Clinical Trials Clinical Trials 64

Drug Discovery World

AUGUST 3, 2023

Medical cannabis is often a first-thought when regarding plant-based medicines, but there remains public scepticism, arguably due to the regulations relating to the substance. My mission is to see cannabis regulators understand basic science and to consult experienced scientists to refine regulations.

Medicine 52

Medicine Scientist Production Regulation 52

XTalks

NOVEMBER 1, 2022

JAK inhibitors block cell signaling that cause inflammation, providing patients an alternative method to regulating an overactive immune system. Register for this free webinar to learn about the use of state-of-the-art DNA-encoded small molecule library (DEL) technology to uncover compounds that modulate challenging therapeutic targets.

FDA Approval 52

FDA Approval Clinical Trials Clinical Trials Trials 52

XTalks

FEBRUARY 5, 2024

In the dynamic landscape of oncology therapeutics, understanding the trends and performances of leading drugs is crucial for stakeholders across the healthcare and life sciences sectors. Zoladex is an artificial form of a hormone that regulates many processes in the body. Price of Zoladex: The cost of Zoladex (subcutaneous 3.6

FDA Approval 101

FDA Approval Drugs Sales Development 101

XTalks

AUGUST 12, 2020

Unique and diverse patterns of cell surface protein glycosylation (the addition of sugar molecules to proteins) make up specific glycoimmune profiles that have key functional roles in regulating cellular processes and immune functions.

RNA 52

RNA Protein DNA In-Vivo 52

Drug Discovery World

AUGUST 10, 2022

For example, it is challenging to regulate transgene copy numbers in each T cell, posing safety risks. Although transgenes show a preference for certain sites, the CAR transgene could integrate into the T cell genome at any location, including within a sequence that regulates oncogene expression, thereby increasing cancer risk.

Manufacturing 98

Manufacturing Gene Genome Genomics 98

XTalks

APRIL 5, 2021

Specific skills are required to succeed in this job; these include advanced writing skills for scientific literature, developing software tools, working on genome sequencing projects, and designing DNA sequencing libraries. Bioinformatics, unlike other life science-related job paths, is a hybrid between computer studies and science.

Bioinformatics 59

Bioinformatics Engineer Scientist Genome 59

XTalks

SEPTEMBER 30, 2020

Type I interferons are critical molecular immune regulators that are at the forefront of antiviral responses early in an infection. The team sequenced DNA from 659 critically ill COVID-19 patients and 534 controls with mild or asymptomatic disease. Related: Low T Cell Counts Observed in COVID-19 Patients.

Antibody 135

Antibody Genetics Research In-Vitro 135

XTalks

AUGUST 2, 2023

In September 2022, Roche acquired Good Therapeutics for an upfront payment of $250 million, and has access to their PD-1-regulated IL-2 program. The TPO receptor agonist regulates blood platelet production by binding to and activating TPO receptors on megakaryocyte cells and inducing signalling cascades that increase platelet production.

Sales 98

Sales Manufacturing FDA Approval Life Science 98

The Pharma Data

APRIL 11, 2023

About Bayer Bayer is a global enterprise with core competencies in the life science fields of health care and nutrition. The company’s approach to research prioritizes targets and pathways with the potential to impact the way that cancer is treated.

Research 40

Research Clinical Trials Clinical Trials Trials 40

Drug Discovery World

NOVEMBER 13, 2023

The track will be opened by chairperson remarks from Daniel Chen, MD, PhD, Founder, Engenuity Life Sciences, which will be followed by the track’s keynote presentation by Bent Jakobsen, PhD, FMedSci, CEO & Founder, Accession Therapeutics. It is called, ‘An unexpected future for immune oncology therapies?’

Protein 59

Protein Antibody Engineer Scientist 59

XTalks

FEBRUARY 5, 2024

In the dynamic landscape of oncology therapeutics, understanding the trends and performances of leading drugs is crucial for stakeholders across the healthcare and life sciences sectors. Zoladex is an artificial form of a hormone that regulates many processes in the body. Price of Zoladex: The cost of Zoladex (subcutaneous 3.6

FDA Approval 52

FDA Approval Drugs Sales Development 52

Cloudbyz

NOVEMBER 3, 2021

Under this model, the public sector biobanks typically prioritize their own researchers’ needs for Human Biosamples, leaving a narrower array of options for smaller corporations focused on the life sciences. But a new trend is making changes to this model. Reflecting, not directly predicting.

Biobanking 52

Biobanking Clinical Research Contamination Research 52

Delveinsight

SEPTEMBER 2, 2021

This designation was based on positive clinical data from the first 21 Impella ECP patients treated as part of an FDA-regulated early feasibility study and will give priority during the Impella ECP’s regulatory review processes comprising of design iterations, clinical study protocols, and pre-market approval (PMA) application.

Marketing 72

Marketing Radiology Drugs Drug Delivery 72

XTalks

FEBRUARY 26, 2021

In August 2013, the NIH came to an agreement with the family to give them some control over access to the DNA sequence of the two cell lines, along with putting the family in the acknowledgements in the papers. Author Rebecca Skloot set up the Henrietta Lacks Foundation in honor of Lacks and her family.

Scientist 69

Scientist Research Genetics Cosmetics 69

XTalks

OCTOBER 1, 2020

At Nurix, Dr. Hansen focuses on establishing the company’s DNA-encoded library technology platform for small molecule identification and leading the discovery organization. Funding in the Life Science Industry vs. Academia. In industry, things move so much faster.

Scientist 52

Scientist In-Vitro Research Life Science 52

XTalks

SEPTEMBER 14, 2020

Meanwhile, N95 masks are in such short supply that regulators have told healthcare workers they can be used multiple times with little evidence that disinfecting them works. Unlike COVID-19 tests that need to be processed through PCR machines, the new rapid test is processed through a handheld DNA analyzer.

Vaccination 92

Vaccination Vaccine Antibody Life Science 92