Scienmag

OCTOBER 1, 2020

The type and direction of the force on a cell alters gene expression by stretching different regions of DNA, researchers at University of […]. . — Tissues and cells in the human body are subjected to a constant push and pull – strained by other cells, blood pressure and fluid flow, to name a few.

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Medical Xpress

MARCH 13, 2023

Researchers at University of California San Diego School of Medicine and Moores Cancer Center at UC San Diego Health have identified a strong association between the product of a gene expressed in most cancers, including the most common type of head and neck cancer, and elevated levels of white blood cells that produce antibodies within tumors.

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Scienmag

JULY 12, 2021

Researchers at Baylor College of Medicine and Rice University have found a new way to do just that […]. The function of a protein can depend on its abundance in a cell. So, when investigating the properties of a new protein, it is essential to make sure that the same amount is produced by every cell.

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Medical Xpress

FEBRUARY 10, 2023

Individuals with cocaine use disorder exhibit gene expression changes in two brain regions: the nucleus accumbens, a region associated with reward, and the caudate nucleus, a region mediating habit formation, according to research conducted at the Icahn School of Medicine at Mount Sinai and published February 10 in Science Advances.

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BioTech 365

NOVEMBER 25, 2021

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: Study highlights role of disordered protein interactions in gene expression.A

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Drug Discovery World

FEBRUARY 27, 2024

CAR-T Therapies have revolutionised the field of personalised medicine, especially in oncology. Orchestrating the naturally occurring conductors of gene expression can shift the functional state of cells and alter gene expression. Biography Dr Blythe Sather is VP and Head of Research at Tune Therapeutics.

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Medical Xpress

NOVEMBER 22, 2022

A form of blood cancer known as mantle cell lymphoma is critically dependent on a protein that coordinates gene expression, such that blocking its activity with an experimental drug dramatically slows the growth of this lymphoma in preclinical tests, according to a study from Weill Cornell Medicine researchers.

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Scienmag

FEBRUARY 18, 2021

Mount Sinai researchers have discovered that Polycomb complexes, groups of proteins that maintain gene expression patterns, are essential for proper skin development, according to a paper published in Genes & Development on February 18.

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Scienmag

MAY 16, 2022

Just as it’s hard to understand a conversation without knowing its context, it can be difficult for biologists to grasp the significance of gene expression without knowing a cell’s environment.

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Drug Discovery Today

APRIL 24, 2023

(MIAMI) Researchers at the John P.

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Scienmag

JUNE 14, 2021

A discovery from researchers at the University of Illinois Chicago may lead to new treatments for individuals who suffer from alcohol use disorder and depression.

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Scienmag

DECEMBER 22, 2020

Blocking gene expression in mitochondria in mice stops cancer cells from growing Credit: Hauke S. Researchers from the Max Planck Institute for Biology of Ageing in […]. Hillen A newly developed compound starves cancer cells by attacking their “power plants” – the so-called mitochondria.

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Scienmag

NOVEMBER 9, 2020

million National Institute on Aging grant to USC’s Eileen Crimmins supports collaboration of large studies in US, Republic of Ireland and Northern Ireland to answer questions about how life circumstances affect gene expression and health.

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Drug Discovery World

OCTOBER 6, 2023

In celebration of the Nobel Prize for Medicine going to two of the early proponents of mRNA technology for creating therapeutics, Katalin Karikó and Drew Weissman, this week our round-up highlights the importance of genetics, genomics and gene editing in drug discovery.

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Scienmag

MAY 23, 2021

Press release – Abstract 1394: Alterations in clock genes expression in Eutopic and Ectopic Endometrial Tissue New research suggests that night shift work is linked to menstrual irregularity and increased chance of developing endometriosis According to a study being presented at the 23rd European Congress of Endocrinology (e-ECE 2021), on Sunday (..)

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Scienmag

AUGUST 4, 2020

Credit: Henry Ford Health System Findings from a research study, led by scientists at Henry Ford, published in the latest issue of Nature Communications suggest an enzyme could play an important role in the treatment of cancer and autoimmune diseases in the airway.

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Drug Discovery World

JULY 27, 2023

The researchers from Boston University Chobanian & Avedisian School of Medicine in collaboration with the Icahn School of Medicine, Columbia University and the New York State Psychiatric Institute used experimental models to explore the cellular actions of tianeptine. “We appeared first on Drug Discovery World (DDW).

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Scienmag

SEPTEMBER 10, 2020

Findings suggest one factor that may contribute to disparities in COVID-19 infection New York – In a study published in JAMA today, Mount Sinai researchers report findings that shed some light on the disproportionate impact of COVID-19 on Blacks, who have experienced rates of infection and death that are much greater, in some areas twice […]. (..)

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Scienmag

JUNE 9, 2021

First study to show gene expression changes in divers with ‘the bends’ reveals key role of genes for inflammation and immunity For over a century, researchers have known about “the bends”, a serious condition affecting scuba divers. Doctors do not yet have a definitive test […].

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Drug Discovery World

SEPTEMBER 27, 2023

Founder Dr Moshe Szyf Founder shares the potential of harnessing precision medicine. Embarking on a new era of medicine The advent of genomics has ushered in the era of personalised medicine, enabling us to analyse the genetic makeup of individuals with unprecedented accuracy.

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Scienmag

FEBRUARY 23, 2021

Credit: Sorbonne Université Using an innovative computational approach to analyze vast brain cell gene expression datasets, researchers at MIT and Sorbonne Université have found that Huntington’s disease may progress to advanced stages more because of a degradation of the cells’ health maintenance systems than because of increased damage (..)

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Scienmag

SEPTEMBER 28, 2020

Brazilian research group shows that valproic acid (VPA), used to treat epilepsy since the 1960s, modulates gene expression in tumor gene models and acts on DNA conformation and the histones in chromatin Results of recent studies involving valproic acid, used for decades as an anti-convulsant drug, show that it can interact with the conformation of (..)

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XTalks

AUGUST 5, 2020

In recent webinars by Genuity Science, formerly known as WuXi NextCODE, experts from the biotech and pharma industries spoke about leveraging the power of single cell RNA sequencing platforms and solutions in conjunction with machine learning technologies such as AI in cell biology and disease research. The Power of Single Cell Technology.

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Scienmag

MARCH 3, 2021

Using the model organism Caenorhabditis elegans, researchers at the University of Cologne have developed an ‘aging clock’ that reads the biological age of an organism directly from its gene expression, the transcriptome.

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The Pharma Data

FEBRUARY 24, 2022

Researchers at the University of North Carolina at Chapel Hill and the UNC Lineberger Comprehensive Cancer Center have uncovered a new role of a chromatin-modulatory enzyme, termed EZH2, during cancer development. PROTAC addresses this gap,” said Jun Wang, PhD, postdoctoral researcher at UNC Lineberger and co-first author of the work.

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Scienmag

NOVEMBER 9, 2020

Preeclampsia-related gene expression in the placenta may correlate with vitamin D status during pregnancy, report researchers from the Medical University of South Carolina. Credit: Medical University of South Carolina According to the World Health Organization, preeclampsia affects between 2% to 8% of pregnancies.

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Drug Discovery World

AUGUST 1, 2023

At MaxCyte, we are passionate about driving the discovery, development and manufacturing of next-generation, cell-based medicines to tackle complex diseases and cancer. Evonetix hopes the platform can change the way DNA is prepared and delivered to users within synthetic biology and helps accelerate research across life sciences.

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The Pharma Data

JULY 12, 2021

online issue of Nature Communications, researchers at University of California San Diego School of Medicine describe a new approach that uses machine learning to hunt for disease targets and then predicts whether a drug is likely to receive FDA approval. HUMANOID Center of Research Excellence?(CoRE),

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pharmaphorum

OCTOBER 19, 2022

The challenge in unlocking their potential to inform drug discovery is to work out which variants regulate which genes in which cell types and whether they exert a positive or negative impact on gene expression, according to the biotech. Dr Danuta Jeziorska.

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Drug Discovery World

AUGUST 16, 2023

A new study has shed light on the genetic messages encoded by genes within ‘triple negative’ breast cancers (TNBC), and shows they could predict response to chemotherapy. Although immune features remained relatively stable, RNA-based features related to DNA damage repair pathways changed significantly.

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pharmaphorum

NOVEMBER 22, 2022

Founded by prolific biotech entrepreneur and Harvard professor Gregory Verdine (pictured above) – along with WeiQing Zhou, John McGee, Professor Sir David Lane – FogPharma’s approach draws on research carried at Verdine’s Harvard lab on cell-penetrating miniproteins (CPMPs), of which Helicons are one class.

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Camargo

JULY 8, 2021

Researchers at the Broad Center of Regenerative Medicine and Stem Cell Research at UCLA have observed that MAOIs might help the immune system attack cancer. The FDA itself did not produce the assessment but instead contracted the Eastern Research Group to conduct the assessment and produce a report. . ” .

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Drug Discovery World

DECEMBER 12, 2022

The announcement followed the signing of deals to make new medicines available across the country. . Meanwhile, a UAE researcher was selected as a finalist for AstraZeneca’s R&D Postdoctoral Challenge, reported the Khaleej Times 2. Lately, there has been a lot of interest in microbiome research. Research news .

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The Pharma Data

MARCH 7, 2022

By combining CRISPR technology with a protein designed with artificial intelligence (AI), it is possible to awaken individual dormant genes by disabling the chemical “off switches” that silence them. Researchers from the University of Washington School of Medicine in Seattle describe this finding in the journal Cell Reports.

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The Pharma Data

SEPTEMBER 2, 2021

Scientists from the German Cancer Research Center (DKFZ) and the Medical Faculty Mannheim, Heidelberg University, have now identified a new growth factor produced by blood vessels that enables tumor cells to metastatically colonize organs. Science Translational Medicine, 2021. doi: 10.1126/scitranslmed.abe6805. Source link: [link].

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Drug Discovery World

APRIL 16, 2023

“Vaccine strategies over the last 25 years attempted to induce immune responses against tumour-associated antigens that are not absolutely specific to the tumour,” said presenting author Jeffrey Weber, Deputy Director of the NYU Langone Perlmutter Cancer Center and Laura and Isaac Perlmutter Professor of Oncology at NYU Grossman School of Medicine.

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The Pharma Data

FEBRUARY 22, 2021

The researcher at the Max Planck Institute for Developmental Biology received the award in a virtual ceremony for her groundbreaking research on the human microbiome – the totality of all microorganisms that naturally colonize a healthy human – which can reach an impressive mass of approximately one kilogram.

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