Gene, Gene Expression and In-Vivo - Clinical Research Informer

Gene editing: beyond the hype

pharmaphorum

JANUARY 29, 2021

Cutting edge’ is, for once, a truly apt description when it comes to gene editing – both because the field is pushing medicine into areas we might never have dreamed possible, and because these technologies involve literally cutting DNA at a specific point in the genome. Zinc fingers. billion in funding.

Gene Editing

Gene Editing Gene Gene Therapy In-Vivo

Combining the Powers of Single Cell Sequencing and AI in Understanding Disease Biology and Drug Development

XTalks

AUGUST 5, 2020

The detailed complexity of these processes can be captured by creating models that combine correlates of gene and protein expression, providing insight into the molecular composition of tissues. Single cell sequencing has revolutionized the study of biological tissues and systems at the cellular and molecular level.

Gene Expression

Gene Expression Development RNA Drugs

Advances in Genetic Medicine May Be Outpacing Some Clinicians’ Understanding, But Pharmaceutical Marketers Can Do Much to Address the Problem

Pharma Marketing Network

DECEMBER 21, 2020

those that modify the expression of an individual’s genes or repair abnormal genes) has entered clinical practice, including 11 RNA therapeutics, 2 in vivo gene therapies, and 2 gene-modified cell therapies. Almost two decades after the human genome was sequenced, a trickle of new genetic medicines (i.e.,

Genetics

Genetics Medicine Gene Therapy Marketing

Biologics – The Next Step in Revolutionary Medication

Roots Analysis

JANUARY 14, 2024

Expression Systems for Biologics The processes associated with the manufacturing of biopharmaceuticals are complex and require highly sterile and aseptic conditions. This can be attributed to the fact that the production of biopharmaceuticals requires living expression systems.

Contract Manufacturing

Contract Manufacturing Manufacturing Protein Bacteria

Gene Switch: A Novel Platform for Switching Genes On and Off

Roots Analysis

AUGUST 31, 2023

Overview of Gene Switch The notion that genes might be turned on and off was discovered several decades ago when studies revealed that E. Gene switches are sites on genes where regulatory molecules can bind to trigger transcription process, leading to expression of a particular gene.

Gene

Gene Gene Therapy Gene Expression Regulation

Cell-penetrating peptides as a delivery system for oligonucleotides

Drug Discovery World

AUGUST 3, 2022

Currently, only a small number of CPP-based oligonucleotide delivery examples have been reported for in vivo application. 3 positive human cells and silence the targeted genes. Unfortunately, the particles formed though this method are unstable in physiological fluids. The table below includes some of these examples. Nanoparticles 6.

Bioavailability

Bioavailability In-Vivo RNA In-Vitro

Delivering on the promise of gene editing

Drug Discovery World

DECEMBER 15, 2022

As gene editing technologies like CRISPR progress toward clinical study, researchers must continue to advance new approaches and address inherent challenges, explains Jon Chesnut, PhD, Senior Director, Cell Biology R&D, Thermo Fisher Scientific. Early phase clinical trials for gene editing therapies.

Gene Editing

Gene Editing Gene In-Vivo Genome

What the Glycome Can Tell Us About Persistent HIV Infection

XTalks

AUGUST 12, 2020

Despite the effectiveness of anti-retroviral therapy (ART) in significantly improving health, quality of life and reducing mortality among HIV-positive individuals, new research shows that persistent infections may be due to the ability of the virus to take refuge in distinct subsets of immune T cells.

RNA

RNA Protein DNA In-Vivo

Angelman Syndrome Market: Insights Into The Recent Late-Stage Drug Failures And Novel Approaches To Treating This Rare Neurogenetic Disorder

Delveinsight

JANUARY 18, 2021

Angelman syndrome is a result of the missing or dysfunctional gene known as UBE3A. The gene is responsible for the normal and healthy development of an individual physically as well intellectually. Angelman syndrome (AS) is a complex genetic rare disorder that affects the nervous system.

Marketing

Marketing Gene Drugs Protein

Fibrosis research: Advances and challenges

Drug Discovery World

JANUARY 24, 2024

Fibrocor is on track to complete all IND-enabling work to support IND filing and initiation of clinical trials in 2024. Phase I of the clinical program will dose healthy volunteers with single ascending doses of FIB992 before proceeding to a multiple ascending dose study where the drug is administered for a two-week period.

Research

Research Gene Expression Drugs Development

CRISPR breakthroughs: New solutions for common diseases

Drug Discovery World

JULY 18, 2023

Since its discovery in 2012, CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) technology has revolutionised the biomedicine and cell and gene therapy fields, providing a versatile tool for precise and efficient genome editing.

DNA

DNA Genome Genomics RNA

The use of base editing in stem-cell based therapies

Drug Discovery World

JANUARY 23, 2023

Kevin Hemphill, R&D Manager at PerkinElmer’s Horizon Discovery explores how base editing has emerged as an attractive gene editing option for researchers wanting to develop stem cell-based therapies. Adult fibroblasts were cultured in a cocktail of transcription factors to reactivate embryonic gene expression patterns 2.

Gene Editing

Gene Editing Gene Engineer DNA

FAIR Game: making data work harder in the race to market

Drug Discovery World

OCTOBER 17, 2022

For pharma and biotech companies – whether working on small or large molecule drugs, or cell and gene therapies – this means empowering scientists with better and faster data management approaches, best practices, and leading technologies so they can pinpoint new molecules and formulations and modify existing ones more easily and quickly.

Marketing

Marketing Scientist Gene Expression Drugs

Synthetic biology tools advancing and accelerating drug discovery efforts

Drug Discovery World

NOVEMBER 15, 2022

If you want to order gene-length sequences, rather than short oligos for PCR, the waiting times are around two or three weeks at least. Anita Ramanathan outlines four synthetic biology approaches that are improving and accelerating drug discovery. . Improving the quality of the DNA is as important as improving the speed of synthesis.” .

DNA

DNA Drugs Antibody Engineer

Tezepelumab granted Priority Review by U.S. FDA

The Pharma Data

JULY 8, 2021

Amgen (NASDAQ:AMGN) announced that the U.S. Food and Drug Administration (FDA) has accepted a Biologics License Application (BLA) and granted Priority Review for tezepelumab in the treatment of asthma. Tezepelumab is being developed by Amgen in collaboration with AstraZeneca. Reese, M.D., About Severe Asthma. Globally, there are approximately 2.5

Allergies

Allergies Trials In-Vivo Medicine

Clinical Research Informer

Gene editing: beyond the hype

Combining the Powers of Single Cell Sequencing and AI in Understanding Disease Biology and Drug Development

Trending Sources

Advances in Genetic Medicine May Be Outpacing Some Clinicians’ Understanding, But Pharmaceutical Marketers Can Do Much to Address the Problem

Biologics – The Next Step in Revolutionary Medication

Gene Switch: A Novel Platform for Switching Genes On and Off

Cell-penetrating peptides as a delivery system for oligonucleotides

Delivering on the promise of gene editing

What the Glycome Can Tell Us About Persistent HIV Infection

Angelman Syndrome Market: Insights Into The Recent Late-Stage Drug Failures And Novel Approaches To Treating This Rare Neurogenetic Disorder

Fibrosis research: Advances and challenges

CRISPR breakthroughs: New solutions for common diseases

The use of base editing in stem-cell based therapies

FAIR Game: making data work harder in the race to market

Synthetic biology tools advancing and accelerating drug discovery efforts

Tezepelumab granted Priority Review by U.S. FDA

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