BioTech 365

SEPTEMBER 10, 2020

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: GTEx Consortium releases fresh insights into how DNA differences govern gene expression.Scientists from the Genotype-Tissue Expression (GTEx) project, a National Institutes of Health-funded consortium including researchers from (..)

Gene Expression 40

Gene Expression DNA Gene Genotype 40

Drug Discovery World

FEBRUARY 1, 2024

Regulatory agencies consider genotypic identification to be more reliable than phenotypic methods. Per regulatory guidelines, the implementation of an environmental monitoring programme is required to comply with good manufacturing practices and identification of microorganisms to species level is a minimal requirement.

Manufacturing 52

Manufacturing Genotype Gene Therapy Compliance 52

Drug Discovery World

FEBRUARY 22, 2024

Regulatory agencies consider genotypic identification to be more reliable than phenotypic methods. Per regulatory guidelines, the implementation of an environmental monitoring programme is required to comply with good manufacturing practices and identification of microorganisms to species level is a minimal requirement.

Production 52

Production Genotype Manufacturing Gene Therapy 52

Drug Discovery World

FEBRUARY 15, 2024

Regulatory agencies consider genotypic identification to be more reliable than phenotypic methods. Per regulatory guidelines, the implementation of an environmental monitoring programme is required to comply with good manufacturing practices and identification of microorganisms to species level is a minimal requirement.

Production 52

Production Genotype Manufacturing Gene Therapy 52

Drug Discovery World

FEBRUARY 8, 2024

Regulatory agencies consider genotypic identification to be more reliable than phenotypic methods. Per regulatory guidelines, the implementation of an environmental monitoring programme is required to comply with good manufacturing practices and identification of microorganisms to species level is a minimal requirement.

Manufacturing 52

Manufacturing Genotype Gene Therapy Compliance 52

Drug Discovery World

FEBRUARY 1, 2024

Regulatory agencies consider genotypic identification to be more reliable than phenotypic methods. Per regulatory guidelines, the implementation of an environmental monitoring programme is required to comply with good manufacturing practices and identification of microorganisms to species level is a minimal requirement.

Manufacturing 52

Manufacturing Genotype Gene Therapy Compliance 52

Drug Discovery World

JANUARY 20, 2023

Precision medicine uses information about an individual’s genes, proteins, and environment to prevent, diagnose, and treat diseases, including cancer. Standard treatment for some cancers now include genotyping or molecular imaging in living patients.

Medicine 52

Medicine Genotype Protein RNA 52

Drug Discovery World

JULY 3, 2023

PrecisionLife and the University of Oxford have signed a data access agreement to license the Oxford Endometriosis Gene (OXEGENE) dataset to develop new personalised treatments for endometriosis patients. Endometriosis affects 10% of women globally, but on average it takes over seven years for patients to receive a diagnosis.

Genetics 52

Genetics Genotype Medicine Licensing 52

Drug Discovery World

SEPTEMBER 20, 2022

The study also identified similarities with genes that are believed to be associated with multiple sclerosis (MS) and long Covid. Each circle represents a disease-associated SNP genotype, edges represent their co-association in patients in disease signature(s), and colours represent distinct patient sub-populations.

Genetics 52

Genetics Biobanking Genotype Gene 52

XTalks

SEPTEMBER 28, 2020

The test is based on the detection of actionable genes – genes with known driver mutations that can be targeted by an approved therapy (or investigational therapies in clinical trials). The panel of genes in the test only include known NSCLC-associated genes, making the test specific to the disease. Personalized Approach.

Gene 105

Gene DNA Life Science Genotype 105

Bioengineer

JANUARY 16, 2024

In patients with T790M mutant NSCLC receiving osimertinib, 63% experienced loss of T790M at progression, commonly linked to histological transdifferentiation, KRAS mutations, or gene fusions. In the same study, those with T790M loss had a shorter treatment duration (6.1 months vs. 15.2 months, p = 0.01).

Genome 119

Genome Genomics Protein In-Vitro 119

Pharmaceutical Technology

DECEMBER 15, 2022

Therefore, there is also a significant need for new therapies that target the underlying cause of CFD that may offer a cure for patients living with severe disease, or for patients with genotypes such as dysfibrinogenemia and hypodysfibrinogenemia, who are often ineligible for treatment with HFCs.

Marketing 130

Marketing Production Genotype Development 130

pharmaphorum

JANUARY 16, 2023

The study by a team at the Universities of East Anglia and Edinburgh shows that HRT use is associated with better memory, cognition, and larger brain volumes in later life among women carrying the APOE4 gene, a well-established risk factor for Alzheimer’s.

Hormones 74

Hormones Genotype Research Genetics 74

pharmaphorum

JANUARY 24, 2023

Pharma has used this to begin creating targeted treatments, such as gene therapies , which are able to hone in on gene mutations that cause health issues and eradicate or replace the faulty gene. Scientists are able to study the aggregated, de-identified genetics of these individuals.

Genetics 98

Genetics Drugs Genome Project Biobanking 98

The Pharma Data

NOVEMBER 2, 2020

ONWARD is investigating Adial’s lead drug candidate, AD04, as a therapeutic agent for the treatment of Alcohol Use Disorder (AUD) in persons with certain target genotypes related to the serotonin transporter and receptor genes. Key ONWARD highlights include: All 25 planned investigative sites are active.

Trials 52

Trials Genotype Marketing Production 52

Drug Discovery World

FEBRUARY 9, 2024

DDW recently hosted a webinar ‘Discover how iPSC derived cells can be used to support the development of drug and gene therapies’, supported by DefiniGEN. In addition, stable cell lines derived from cancers represent a single and karyotypically abnormal genotype. Are there any ethical boundaries behind the use of iPSCs?

Gene Therapy 52

Gene Therapy Gene Development Drugs 52

pharmaphorum

AUGUST 11, 2022

Pharmacogenomics, the understanding of how genes impact an individual’s response to medications, provides a potential outlet to better optimised therapies. The program is aiming to genotype roughly 150,000 participants over the next few years to demonstrate the impact personalised testing can have on a large scale.

Genome 98

Genome Genomics Drugs Genetics 98

Pharmaceutical Technology

AUGUST 18, 2022

A custom-made, one-dose gene therapy, Zynteglo is indicated for such patients who need red blood cells (RBCs) transfusions on a regular basis. 0 genotypes. An ex-vivo lentiviral vector (LVV) gene therapy, Zynteglo’s every dose is made by genetically modifying the bone marrow stem cells of the patient to produce functional beta-globin.

Gene Therapy 246

Gene Therapy Gene Genotype Genetics 246

Drug Discovery World

SEPTEMBER 19, 2023

In addition, stable cell lines derived from cancers represent a single and karyotypically abnormal genotype. ‘ Discover how iPSC derived cells can be used to support the development of drug and gene therapies’ will take place on 28 September 4PM BST, 5PM CEST, EDT 11AM, PDT 8AM. Register for free here.

Gene Therapy 52

Gene Therapy Gene Development Protein 52

Drug Discovery World

SEPTEMBER 12, 2023

In addition, stable cell lines derived from cancers represent a single and karyotypically abnormal genotype. ‘ Discover how iPSC derived cells can be used to support the development of drug and gene therapies’ will take place on 28 September 4PM BST, 5PM CEST, EDT 11AM, PDT 8AM. Register for free here.

Gene Therapy 52

Gene Therapy Gene Development Drugs 52

pharmaphorum

DECEMBER 9, 2020

bluebird bio has presented long-term data from its Zinteglo one-time gene therapy for the blood disorder beta-thalassaemia, as the company continues talks with payers in Europe to bring the ultra-pricey treatment to market. The post Bluebird trumpets long-term data from beta-thalassaemia gene therapy appeared first on.

Gene Therapy 59

Gene Therapy Gene Genotype Marketing 59

pharmaphorum

OCTOBER 9, 2020

The human history study, which is being funded by the foundation and its supporters, will feed into gene reviews, an international point-of-source for inherited disorders. The team hopes that this study’s scope will also shed light on the gene’s impact on the women who carry it in addition to an elaborative genotype-phenotype correlation.

Research 110

Research Genetics Genotype Nurses 110

XTalks

MARCH 3, 2021

MoCD Type A is an autosomal recessive, inborn error of metabolism caused by mutations in the molybdenum cofactor synthesis 1 gene. In the analysis involving 31 patients, 13 were treated with Nulibry and compared to 18 genotype-matched untreated patients from the history control group. What is Molybdenum Cofactor Deficiency Type A?

FDA Approval 64

FDA Approval Genotype Clinical Trials Clinical Trials 64

pharmaphorum

NOVEMBER 10, 2021

It recommends the National Library of Medicine, which has already published “considerable information” on resistance genes, genome sequences, antimicrobial susceptibility data, and bacterial genomes, establish an open-source, unified AMR database.

Medicine 105

Medicine Genome Genomics Genotype 105

Drug Discovery World

AUGUST 25, 2023

Also, stable cell lines derived from cancers represent a single and karyotypically abnormal genotype. Hepatocellular carcinoma-derived cell lines, such as HepG2s, are less proliferative than CHO or HEK cells but remain readily expandable and retain aspects of hepatocyte function.

Gene Therapy 52

Gene Therapy Gene Development Genotype 52

The Pharma Data

NOVEMBER 18, 2020

such as the integrase gene and assay validation recommendations. The recommended specimen types for HIV drug resistance genotyping are plasma or dried blood spots. Dried blood spots should be used for HIV drug resistance surveys in which plasma cannot. be handled as per WHO recommendations.

Drugs 52

Drugs Genotype Medicine Development 52

XTalks

APRIL 15, 2021

From a total of 30 single-nucleotide polymorphisms (SNPs) in genes previously identified as being associated with blood pressure, many had a relatively neutral effect on the risk of coronary artery disease. Figure 2: Using drug-target MR to validate sympathetic nervous system genes involved in heart failure.

Development 98

Development Drugs Genome Genomics 98

The Pharma Data

DECEMBER 9, 2020

The Chinese biopharmaceutical industry is growing in leaps and bounds, but there is still a huge unmet need when it comes to getting patients access to the breakthrough therapeutic modalities and platforms like RNAi, cell and gene therapy and others. A solution could be at hand with Overland Pharmaceuticals.

In-Vivo 52

In-Vivo In-Vitro Antibody Development 52

Drug Discovery World

MAY 2, 2023

The CRISPR-Cas9 system, awarded the Nobel Prize in Chemistry in 2020 for its applications for gene editing, was initially encountered in the bacterial immune system. These modifications lead to alterations in the function of the proteins expressed by these genes, manifesting in cellular processes dependent on those proteins.

Genome 52

Genome Genomics Gene DNA 52

Drug Discovery World

OCTOBER 30, 2023

RA: You’ve recently announced a collaboration with the University of Oxford to access genotype data on women with endometriosis. We previously conducted a hypothesis-free study using genotype data from the UK Biobank, which resulted in the first mechanism-based stratification of endometriosis patients.

Genome 72

Genome Genomics Genotype Clinical Trials 72

Drug Discovery World

SEPTEMBER 5, 2023

In addition, stable cell lines derived from cancers represent a single and karyotypically abnormal genotype. ‘ Discover how iPSC derived cells can be used to support the development of drug and gene therapies’ will take place on 28 September 4PM BST, 5PM CEST, EDT 11AM, PDT 8AM. Register for free here.

Development 59

Development Drugs Protein Genotype 59

Roots Analysis

AUGUST 31, 2023

According to a study, around 20,000 genes are present in the human body, all of which interact with the nutrients in the food, either directly or indirectly. For instance, carbohydrates increase the expression of genes responsible for the synthesis of enzymes and transporters involved in their metabolism.

Genome 40

Genome Genomics Genetics Gene 40

Worldwide Clinical Trials

DECEMBER 12, 2022

In some cases, the gene associated with a patient’s condition may not yet be discovered or included on the test ordered and the interpretation of genetic variants may change over time as new information is uncovered. single gene testing vs comprehensive panel), the reportable range (e.g.,

Clinical Trials 130

Clinical Trials Clinical Trials Genetics Trials 130

Drug Discovery World

SEPTEMBER 26, 2023

In addition, stable cell lines derived from cancers represent a single and karyotypically abnormal genotype. ‘ Discover how iPSC derived cells can be used to support the development of drug and gene therapies’ will take place on 28 September 4PM BST, 5PM CEST, EDT 11AM, PDT 8AM. Register for free here.

Development 52

Development Drugs Protein Genotype 52

XTalks

NOVEMBER 10, 2020

How many genes need to be scanned in order to determine the presence of a genetic disease? HS: Due to the heterogeneity of the rare disease population, there are many relevant gene lists, and the genomic data analysis of these patients covers almost 2,000 different genetic targets.

Genome 98

Genome Genomics Medicine Genetic Disease 98

Drug Discovery World

DECEMBER 12, 2023

Context and treatment potential AATD is an inherited, autosomal recessive genetic disorder that is most frequently caused by a single nucleotide variant (SNV) mutation in the SERPINA1 gene, the most common of which is the ‘PiZ’ mutation.

RNA 52

RNA In-Vivo Genotype Genetics 52

XTalks

DECEMBER 12, 2023

In some areas, say Alzheimer’s disease, we have growing collections of imaging, gene, cerebrospinal fluid (CSF) and blood markers to follow and look at target engagement of our drugs,” says James Vornov, MD, PhD, Vice President of the Medical Department at Medpace.

Trials 111

Trials Clinical Trials Clinical Trials Genetics 111