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Hormone exposure in the womb potentially linked to migraine risk in later life

Scienmag

Hormone levels in the womb before birth have been potentially linked to the risk of developing migraine in adulthood, reveals a new study of genetic and environmental information from the world’s largest database of twins.

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Genetic biomarkers could personalise therapy for TNBC

Drug Discovery World

A new study has shed light on the genetic messages encoded by genes within ‘triple negative’ breast cancers (TNBC), and shows they could predict response to chemotherapy. They suggest it would be better to use biopsies taken from secondary tumours as the cancers can evolve between first diagnosis and recurrence after initial therapy.

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Exercise hormone may modulate genes associated with replication of novel coronavirus

Scienmag

Brazilian researchers observed that in uninfected adipocytes, the hormone irisin altered the expression of genes that regulate ACE-2, which encodes a protein to which the virus binds in order to invade human cells.

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New genetic target for male contraception identified

Medical Xpress

Discovery of a gene in multiple mammalian species could pave the way for a highly effective, reversible and non-hormonal male contraceptive for humans and animals.

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Genetically modified mice pave the way for customized medicine in a rare disease

Medical Xpress

An international research team led by Dr. Ana Guadaño at the Alberto Sols Biomedical Research Institute (IIBM, a combined CSIC-UAM center) and involving the Complutense University of Madrid (UCM), used CRISPR gene editing techniques to incorporate into mice a mutation of the MCT8 protein responsible for transporting thyroid hormones to the interior (..)

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Researchers show novel device improves blood sugar control in hyperinsulinism patients whose pancreas has been removed

Scienmag

Philadelphia, September 13, 2021—Researchers at Children’s Hospital of Philadelphia (CHOP) have demonstrated that an experimental device can improve blood sugar control in patients who developed diabetes after their pancreas was removed to treat their hyperinsulinism, a genetic disease in which the pancreas produces too much insulin.

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NICE rejects prostate cancer drug due to cost of genetic testing

Drug Discovery World

The Institute of Cancer Research (ICR) has called the decision ‘disappointing’ and ‘frustrating’. NICE has judged olaparib too expensive partly because of the cost of genetic testing to tailor the drug for patients. A “penalty for innovation”. Biomarker testing “should be routine”. I am hopeful it will become a new standard of care.”.