Drug Discovery World

MARCH 30, 2023

Neoantigens are produced by specific tumour viruses, integrated into the genome and are abundantly expressed only in tumour cells with strong immunogenicity and tumour heterogeneity. Vaccines predicated on neoantigens therefore elicit truly tumour-specific T cell responses.

Regulation 52

Regulation Vaccination Vaccine Trials 52

Drug Discovery World

FEBRUARY 6, 2023

The company is co-founded by former team leaders and multi-disciplinary tool builders from 10x Genomics. Taking a human-first approach, Infinimmune is leveraging single-cell technology to create truly human antibody-based therapeutics directly derived from the human immune system. This has consequences for safety and efficacy.

Antibody 52

Antibody Immune Response Genome Genomics 52

Drug Discovery World

OCTOBER 6, 2022

Jarret Glasscock , PhD, CEO of Cofactor Genomics explains how diagnostics are emerging as the key to ensuring the right patients get matched to the right therapy, at the right time. . New classes of therapies have added to this growth, including immune checkpoint inhibitors and genome targeted therapies.

Medicine 52

Medicine Clinical Trials Clinical Trials Genome 52

The Pharma Data

AUGUST 24, 2020

They say genome sequencing shows the two strains of the virus are “clearly different”, making it the world’s first proven case of reinfection. Those infected develop an immune response as their bodies fight off the virus which helps to protect them against it returning. Getty Images.

Immune Response 52

Immune Response Genome Project Genome Genomics 52

The Pharma Data

DECEMBER 30, 2020

The Phase I/II study results, together with recently generated preclinical data, indicate that ARCT-021 leads to a potent immune response to SARS-CoV-2, and demonstrates a differentiated biological profile whereby the immune response increases in the weeks following vaccination, the company said.

Genome 52

Genome Genomics Immune Response Vaccination 52

Drug Discovery World

NOVEMBER 30, 2022

Associate Professor Keith Chappell, co-leader of UQ’s Rapid Response Vaccine Pipeline, said pre-clinical testing had shown the ‘Clamp2’ platform was meeting all expectations, producing stabilised antigens and inducing strong neutralising immune responses. “We Clamp technology .

Vaccination 52

Vaccination Vaccine Immune Response Engineer 52

Drug Discovery World

MAY 30, 2024

In research, it allows us to directly study vaccine-responsive cells, for example their genomic composition and protein expression. KP: Our goal is to use these data for the transformative understanding of the human immune system and how it interacts with vaccines. This is an established test in the clinic.

Vaccination 59

Vaccination Vaccine Scientist Clinical Trials 59

pharmaphorum

JANUARY 6, 2023

BioNTech gets the opportunity to tap into the NHS as a source of subjects for its cancer vaccine studies, as well as access to genomics and health data resources, and in return will open an R&D centre in Cambridge, employing more than 70 scientists, as well as an office in London. It will also cover some infectious disease targets.

Clinical Trials 107

Clinical Trials Clinical Trials Trials Vaccination 107

pharmaphorum

APRIL 28, 2021

“Text mining was also able to highlight new insights into the mechanisms of pancreatic cancer’s immune evasion, which refers to cancer cells’ ability to evade an immune response” . Figure 1: Trending ‘Protein and Genomic’ terms with a semantic relationship to pancreatic cancer.

Immune Response 104

Immune Response Life Science Genome Genomics 104

Drug Discovery World

JULY 17, 2023

While the human genome boasts around 23,000 genes, the average human gut encompasses approximately 2,000,000 genes. One involves sequencing all or part of the 16S gene unique to bacteria, while the other encompasses sequencing the entire bacterial genome—an approach known as “metagenomics.” REFERENCES Rosshart, S.

Bacteria 52

Bacteria Drugs Gene Immune Response 52

Drug Discovery World

NOVEMBER 22, 2022

The Institute of Cancer Research, London, and The Royal Marsden NHS Foundation Trust have revealed plans to direct research against the cells, signals and immune response in the tissue environment that nurtures tumours. . Opening up new lines of attack.

Scientist 52

Scientist Immune Response Research Drugs 52

The Pharma Data

JANUARY 12, 2021

“The T-cell and NK-cell target discovery approach complements our portfolio aimed at turning cold tumors hot and redirecting the innate immune system to elicit a sustained and durable immune response against tumors. For more information, please visit the company’s website at www.ksqtx.com and follow @ksq_tx on Twitter.

Development 52

Development Research In-Vivo Genome 52

Drug Discovery World

FEBRUARY 13, 2023

SB: Transcriptomics is the study of genomic RNA transcripts in a biological system. Diseases ranging from cancer to viral immune response, from cardiovascular to reproductive health, and from metabolic to nervous systems all have the potential to benefit from in-depth transcriptomics.

RNA 52

RNA Drugs Gene Expression Gene 52

XTalks

NOVEMBER 30, 2023

These dual gRNAs target three specific sites within the HIV genome, facilitating the removal of substantial portions of the viral DNA and minimizing the potential for viral escape. The noteworthy candidate, EBT-101, is designed to eliminate HIV proviral DNA using CRISPR-Cas9 along with two guide RNAs (gRNAs).

FDA Approval 111

FDA Approval Gene Therapy Clinical Trials Clinical Trials 111

Cloudbyz

MARCH 6, 2024

For example, monoclonal antibodies, a type of biologic, can selectively bind to specific targets such as proteins or cells involved in disease processes, thereby modulating immune responses or inhibiting disease progression.

Gene 73

Gene Immune Response Manufacturing Gene Therapy 73

The Pharma Data

APRIL 8, 2021

The Company will share a Spotlight Theater Presentation: The Orchestrated Immune Response: Dynamic Forces Guiding Cancer Immunity , introducing a novel framework for understanding the role of the immune system in cancer, with the potential to reshape the way scientists develop medicines to counteract tumour growth.

DNA 52

DNA Medicine Genome Genomics 52

Worldwide Clinical Trials

JUNE 15, 2022

There have been a few cases lately where patients receiving gene therapy had a severe adverse effect because of their immune response to the mechanism of the AAV viral vector, based on their own genomic markers.

Gene Therapy 130

Gene Therapy Gene Clinical Trials Clinical Trials 130

XTalks

NOVEMBER 20, 2020

Traditional antibody tests for uncovering past infections involve detection of antigen-specific antibodies produced during an immune response against a pathogen. The Adaptive Immune System and TCRs. These common TCRs are the reason why the same immune responses are generated in different people.

Antibody 98

Antibody Immune Response Protein In-Vitro 98

Drug Discovery World

SEPTEMBER 29, 2022

After the initial infection, CMV becomes latent, with the genome residing in cells but no virus particles generated to cause detectable damage or illness 7,8. Latent CMV may reactivate occasionally, leading to infection, which is often asymptomatic in individuals with healthy immune systems though still transmissible to others 7. .

Vaccination 52

Vaccination Vaccine Immune Response Protein 52

Drug Discovery World

MAY 6, 2024

Cell and gene therapy is a particular area of focus for the region, centred around the VU LSC-EMBL Partnership for Genome Editing Technologies, a partnership between the Vilnius University Life Sciences Center (VU LSC) and the European Molecular Biology Laboratory (EMBL).

Drugs 59

Drugs Life Science Gene Editing Gene 59

pharmaphorum

NOVEMBER 28, 2021

BioNTech said in a statement that it is waiting on more data from lab tests, due in the next couple of weeks, to see if Omicron could be an “escape variant” – a strain of SARS-CoV-2 that could evade the immune responses stimulated by current vaccines.

Vaccination 96

Vaccination Vaccine Protein Genetics 96

Drug Discovery World

OCTOBER 4, 2023

By analysing gene interactions in mice subjected to behavioural tests, the researchers from Korea University Anam Hospital, Konkuk University, and Sahmyook University identified 141 genes primarily linked to immune responses correlating with depressive behaviours.

Research 52

Research Gene DNA Gene Expression 52

The Pharma Data

DECEMBER 29, 2020

Experts believe brain-related effects may be tied to the body’s immune response to the virus and possibly to vascular problems or surges of inflammation caused by the disease. Colin Smith at Duke University Medical Center in Durham, N.C., told the Times. Most patients have been in their 30s, 40s and 50s.

Genome 52

Genome Genomics Immune Response Doctors 52

The Pharma Data

DECEMBER 31, 2020

“Antibody responses are not likely to be the sole determinant of someone’s outcome,” said Scott Boyd, associate professor of pathology at Stanford. Some of these patients mount a vigorous immune response, and others have a more moderate response. There are also other branches of the immune system involved.

Antibody 52

Antibody Research Bacteria Genetics 52

Drug Discovery World

JULY 29, 2022

The usual suspects for triggering an immune response would be a protein or a sugar,” said Clardy. After discovering the molecular structure of the lipid, the team found that it communicates with a pair of receptors on the surface of many immune cells. muciniphila’s ability to manipulate the immune system and fight disease.

Bacterium 52

Bacterium Research Bacteria Immune Response 52

pharmaphorum

NOVEMBER 24, 2020

Another is the delivery of molecule switches to CAR-NK cells, used to activate biological pathways that can help overcome the immunosuppressive microenvironment around tumours and improve recruitment of other elements of an immune response.

Engineer 52

Engineer Immune Response DNA Genome 52

Drug Discovery World

AUGUST 1, 2023

The NIH states: “This natural mechanism for sequence-specific gene silencing promises to revolutionise experimental biology and may have important practical applications in functional genomics, therapeutic intervention, agriculture and other areas.” There are many examples of ways in which RNAi is impacting drug discovery.

RNA 52

RNA Drugs Gene Silencing Vaccination 52

pharmaphorum

SEPTEMBER 4, 2020

The treatments are developed using cutting- edge technologies such as genomic sequencing and genetic engineering, helping to account for the individual variability in both patient and disease characteristics. This has gained a lot of attention in recent years due to revolutionary breakthroughs in debilitating chronic diseases such as cancer.

Medicine 52

Medicine Production Genetic Engineering Genetics 52

Delveinsight

AUGUST 27, 2020

Moderna’s COVID-19 vaccine triggers an immune response in older adults. Freenome’s diagnostic searches for direct indication of tumors and signs of the immune system’s response, integrating genomics, transcriptomics, methylomics, and proteomics technologies.

Vaccination 53

Vaccination Vaccine Research Trials 53

The Pharma Data

JUNE 19, 2022

Known as “the guardian of the genome,” p53 is a class of proteins tasked with suppressing tumor development. He said that therapies that can increase natural killer cell infiltration and/or activation in tumors are urgently needed. They conducted their first experiment with cultured mouse melanoma cells.

Drugs 52

Drugs Protein Immune Response Dermatology 52

The Pharma Data

JANUARY 11, 2021

Centers for Disease Control and Prevention (CDC) to provide genomic sequencing of SARS-CoV-2 samples. Speaking to the Reuters Next conference, Dale Fisher, chairman of the World Health Organization’s (WHO) Outbreak Alert and Response Network, said that achievement of herd immunity in most countries is unlikely in 2021.

Vaccination 52

Vaccination Vaccine Clinical Trials Clinical Trials 52

Drug Discovery World

MAY 11, 2023

Another dangerous consequence can occur when the therapeutic or vaccine introduces proteins that can activate an uncontrolled immune response. In the case of therapeutics, the aim is usually to avoid patients’ immune responses. Impurities can integrate into the final product at various points during production.

Production 52

Production Gene Protein Vaccination 52

The Pharma Data

APRIL 11, 2021

The scientific rationale for using immunotherapy in the neoadjuvant setting is twofold: it presents the earliest opportunity to treat cancer cells that have spread in the body without detection, and the presence of a tumor during immunotherapy treatment may enable a stronger immune response, potentially making the treatment more effective.

Trials 52

Trials Immune Response Genome Genomics 52

The Pharma Data

JULY 6, 2021

If a virus is disease-causing, the right mutation can allow the virus to escape the immune response by changing the viral pieces the immune system uses to recognize the virus as a threat, pieces scientists call epitopes. The team obtained sequences from the newly circulating B.1.1.7 1.351 Beta, P1 Gamma, and B.1.617.2

Vaccination 52

Vaccination Vaccine Research Immune Response 52

The Pharma Data

MARCH 26, 2021

The study enrolled 572 people, of whom 554 were in the intention-to-treat WT population, which excluded people with EGFR or ALK genomic tumour aberrations, and were randomised 1:1 to receive: Tecentriq monotherapy, until disease progression (or loss of clinical benefit, as assessed by the investigator), unacceptable toxicity or death; or.

HR 52

HR Protein Genome Genomics 52

The Pharma Data

DECEMBER 10, 2020

The vaccine targeted both the inner nucleocapsid (N) and the outer spike (S) proteins of the virus to maximize the immune response. The study showed this broad immune response led to the complete clearance of the virus in a matter of days after infection of previously-vaccinated primates.

Vaccination 52

Vaccination Vaccine Immune Response Protein 52

The Pharma Data

JUNE 30, 2021

Opdivo is a programmed death-1 (PD-1) immune checkpoint inhibitor that is designed to uniquely harness the body’s own immune system to help restore anti-tumor immune response. By harnessing the body’s own immune system to fight cancer, Opdivo has become an important treatment option across multiple cancers.

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Trials Genome Genomics Containment 52