Drug Discovery World

AUGUST 16, 2023

The whole world realised the power of RNA when the Covid-19 pandemic brought us the first mRNA-based vaccines. Decoding ‘junk DNA’ The Human Genome Project and subsequent studies discovered that most of our DNA (approximately 98%) does not actually code for proteins, with humans having approximately 20,000 tox 25,000 protein-coding genes.

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STAT News

FEBRUARY 22, 2023

Moderna is aiming to build a gene editing franchise powered by some of the same technologies used in its COVID-19 vaccines. Moderna will fund preclinical research studies run by the two companies using Life Edit’s tools based on CRISPR technologies that allow scientists to make precise changes to the human genome.

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Drug Discovery World

JULY 22, 2022

Covid-19 vaccines remain effective six months after second dose . Two doses of Covid-19 vaccines were sufficient in providing protection against severe cases of the infectious disease, according to new research.? . An early-stage clinical trial has been launched in the US investigating a vaccine against Nipah virus infection.? .

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Drug Discovery World

OCTOBER 6, 2023

In celebration of the Nobel Prize for Medicine going to two of the early proponents of mRNA technology for creating therapeutics, Katalin Karikó and Drew Weissman, this week our round-up highlights the importance of genetics, genomics and gene editing in drug discovery.

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pharmaphorum

NOVEMBER 17, 2020

Researchers at the Wellcome Sanger Institute in the UK are working on software to monitor the genome of SARS-CoV-2 coronavirus in the hope of spotting changes that could affect the fight against COVID-19. Backed by £12.2

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STAT News

SEPTEMBER 30, 2022

The shortlist includes researchers who elucidated how cells make energy, those who discovered the chemical chatter of bacteria, many of the brilliant minds who shepherded us into the “ era of the genome ,” and most prominently, the pioneers behind the mRNA Covid vaccines. Read the rest…

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The Pharma Data

JANUARY 12, 2021

12, 2021 — President-elect Joe Biden received his second dose of a coronavirus vaccine on Monday and announced that he plans to outline more of his pandemic response plan on Thursday. Biden got his first shot of the Pfizer vaccine on Dec. The Pfizer vaccine requires a second shot about three weeks after the first vaccination.

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The Pharma Data

MAY 22, 2023

WHO launches global network to detect and prevent infectious disease threats WHO and partners are launching a global network to help protect people from infectious disease threats through the power of pathogen genomics. COVID-19 highlighted the critical role pathogen genomics plays in responding to pandemic threats.

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Drug Discovery World

JULY 10, 2023

If there’s one thing I would take from the Summer 2023 issue of Drug Discovery World , it would be that the application of technologies and processes throughout the pharmaceutical industry are changing how scientists pursue the development of therapies. There are myriad ways that this is being enabled.

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pharmaphorum

JANUARY 6, 2023

The UK has formed an partnership with German biotech BioNTech to provide up to 10,000 patients with access to personalised cancer therapies, in another example of the country embracing the mRNA technologies that underpinned COVID-19 vaccines. It will also cover some infectious disease targets.

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pharmaphorum

FEBRUARY 1, 2022

1 strain, and there is somewhat conflicting evidence on its ability to evade the protection from vaccines, according to new studies. That increase was seen regardless of the vaccination status of the secondary cases, and there was an increased risk of spread within vaccinated households with BA.2 The new BA.2 1 and 70% for BA.2

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The Pharma Data

DECEMBER 29, 2020

29, 2020 — Vaccine maker Novavax, along with federal health researchers, announced Monday that a phase 3 trial will begin on the safety and effectiveness of another COVID-19 vaccine — the fifth shot to reach this final stage of development. Uptick in vaccine acceptance. TUESDAY, Dec.

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The Pharma Data

JANUARY 14, 2021

14, 2021 — One month after the United States began what has become a troubled rollout of a national COVID vaccination campaign, the effort is finally gathering real steam. Meanwhile, a number of states have now opened mass vaccination sites in an effort to get larger numbers of people inoculated, CBS News reported. THURSDAY, Jan.

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Scienmag

JANUARY 24, 2021

A group of scientists is calling on governments to consider the continued use of strict control measures as the only way to reduce the evolution and spread of new COVID-19 variants.

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Drug Discovery World

FEBRUARY 6, 2024

Scientific sessions Tuesday’s presentations spanned a range of topics, including functional genomics for target identification, next-generation proteomics, self-driving laboratories, the future of cell culture, and ‘lab on a particle’ technology.

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Drug Discovery World

NOVEMBER 8, 2022

Mutations have enabled the virus to grow stronger and smarter, evading antiviral drugs and vaccines. . The monkeypox virus is very similar to the vaccinia virus, which has been used as a vaccine to treat smallpox. Monkeypox has infected more than 77,000 people in more than 100 countries worldwide.

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Scienmag

SEPTEMBER 30, 2020

Scientists are fighting back with multiple strategies, including vaccines, repurposed drugs developed for other diseases and brand-new therapies. Now, researchers reporting in ACS Central Science have identified small molecules that target a structure within the RNA genome […].

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Drug Discovery World

FEBRUARY 29, 2024

In the first article, Reece Armstrong speaks to Natalia Mateu, Co-Founder, Jelena Aleksic, Co-Founder and Peter Curran, Chemoinformatics Scientist, about utilising 3D chemistry and AI to get small molecule therapies from the clinic to the bedside.

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The Pharma Data

DECEMBER 28, 2020

28, 2020 — When queried in polls conducted earlier this year, only about half of American adults said they planned to get any vaccine against the new coronavirus. “As soon as it is my turn to get the vaccine, I will be there front and center! Still, large pockets of skepticism and resistance to vaccination remain.

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The Pharma Data

DECEMBER 28, 2020

Testing Therapies, Antivirals and Vaccines. The Nanovaccine Institute at Iowa State University (ISU) is using nanotechnology to develop a vaccine will be able to be administered without needles and in one dose. Health Canada granted authorization to the Moderna COVID-19 vaccine on December 23. Other Industry News.

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The Pharma Data

JANUARY 11, 2021

health officials raced to ramp up the delivery of COVID-19 vaccines across the country as both coronavirus case counts and death tallies continued to hit record highs. “We really need to get this vaccine out more quickly, because this is really our only tool,” Dr. Scott Gottlieb, former commissioner of the U.S. .

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Drug Discovery World

APRIL 30, 2024

The biggest growth driver for mRNA therapeutics came from the Covid-19 pandemic, when mRNA-based vaccines proved effective in treating SARS-CoV-2, and pharmaceutical companies such as Pfizer/BioNTech and Moderna were successful in bringing these treatments to market. mRNA is a molecule made up of a single strand of ribonucleic acid (RNA).

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The Pharma Data

DECEMBER 23, 2020

and the Trump Administration were close to a deal on Tuesday that would get more of the company’s coronavirus vaccine to Americans in the coming year. So far, only two pharmaceutical companies — Pfizer and Moderna — have won emergency approval for their COVID-19 vaccines. WEDNESDAY, Dec.

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Delveinsight

DECEMBER 15, 2020

Pfizer, BioNTech COVID-19 Vaccine rolls out in a watershed moment. In a historic first, the US FDA issued an Emergency Use Authorization (EUA) to the COVID-19 mRNA, BNT162b2, vaccine candidate for COVID-19 of Pfizer-BioNTech. The vaccine is the first-ever mRNA vaccine to get to the EUA and is developed in record-time low.

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The Pharma Data

JULY 6, 2021

If a virus is disease-causing, the right mutation can allow the virus to escape the immune response by changing the viral pieces the immune system uses to recognize the virus as a threat, pieces scientists call epitopes. These epitopes could then be used in a vaccine to train T cells, providing protective immunity.

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pharmaphorum

DECEMBER 20, 2022

Genomic profiling has made it possible to diagnose and treat patients with far greater precision. Often, the initial focus is on participating in the data revolution by expanding genomic sequencing capacity, implementing electronic health records (EHRs), and so on.

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Delveinsight

AUGUST 27, 2020

Moderna’s COVID-19 vaccine triggers an immune response in older adults. Moderna showed robust phase 1 results for its COVID-19 vaccine in adults up to 55 last month. It is now following up with data from a small group of older adults, and they look positive. Targeted drug combo attacks breast cancer brain metastases in mice.

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XTalks

OCTOBER 21, 2020

The answer may lie in the genetic code of the virus, which scientists at Duke University have found contains several silent mutations that affect protein folding. At best, it is slowly mutating, which is good news for vaccine developers as they don’t have to contend with potentially multiple strains of the virus.

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pharmaphorum

JANUARY 20, 2021

UK biotech ConserV Bioscience has joined with California’s Lawrence Livermore National Laboratory to develop broad-spectrum coronavirus vaccines as concerns mount over potentially more infectious strains emerging in the UK, South Africa and Brazil.

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XTalks

DECEMBER 24, 2020

From isolating SARS-CoV-2 in early January to sequencing its genome shortly thereafter and having a prototype vaccine against it within days, scientific process and progress have held steadfast throughout the pandemic. For example, investment in mRNA vaccines and viral vectors came well before January, many years before it.

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Drug Discovery World

FEBRUARY 28, 2023

mRNA technology helped us to vaccinate the world against SARS-CoV-2. With only 10% of these conditions indicated for an approved therapy, there is a sizable opportunity for scientists and companies to develop treatments for patients with no other options to turn to.

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Drug Discovery World

AUGUST 1, 2023

The NIH states: “This natural mechanism for sequence-specific gene silencing promises to revolutionise experimental biology and may have important practical applications in functional genomics, therapeutic intervention, agriculture and other areas.” There are many examples of ways in which RNAi is impacting drug discovery.

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pharmaphorum

JANUARY 24, 2022

Some scientists have given it the nickname ‘stealth variant’, because it is more difficult to detect than BA.1 “Our continued genomic surveillance allows us to detect them and assess whether they are significant,” she added. 2, the sub-variant of Omicron (BA.1) 2 causes more severe illness than Omicron BA.1,

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XTalks

JANUARY 14, 2021

False negative results can occur with any molecular test, particularly if a mutation occurs in the part of the virus’s genome assessed by that test. Related: COVID-19 Vaccine and Drug Development Coverage. As scientists learn more about the new B.1.1.7 So far, this does not appear to be the case for the N501Y mutation in the B.1.1.7.

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The Pharma Data

AUGUST 24, 2020

Hong Kong scientists are reporting the case of a healthy man in his 30s who became reinfected with coronavirus four and a half months after his first bout. They say genome sequencing shows the two strains of the virus are “clearly different”, making it the world’s first proven case of reinfection. Image copyright.

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The Pharma Data

OCTOBER 14, 2020

Study May Lead to Biomarkers for Tailoring COVID-19 Vaccines and Therapeutics. Associate Research Scientist at Columbia University Vagelos College of Physicians and Surgeons, has the potential to lead to the isolation and characterization of therapeutically relevant fully human monoclonal antibodies to SARS-CoV-2.

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Drug Discovery World

DECEMBER 12, 2022

Other research updates include a study by NIH 5 researchers using post-mortem brain tissues to understand genomic differences in individuals with attention deficit hyperactivity disorder. The study advances our understanding of ADHD by showing how the condition is tied to changes in how certain genes are expressed in the brain. Analysis .

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