Drug Discovery World

AUGUST 15, 2022

Samantha Kanza, Senior Enterprise Fellow, University of Southampton, will be speaking at the Tech Theatre, ELRIG Drug Discovery 2022, sponsored by DDW. . The Tech Theatre will feature a series of seminars focused on automation and technology for drug discovery. . Click here to register.

Drugs 52

Drugs Research 52

Rethinking Clinical Trials

JULY 13, 2023

Discussion Themes – How diverse were the settings where this was tested? The study team was interested in testing in a setting outside of a large academic hospital. We need to test in systems that might have an enhanced usual care arm. Learn more Read about the IMPLEMENT-HF study in JACC.

Clinical Trials 130

Clinical Trials Clinical Trials Scientist Research 130

Rethinking Clinical Trials

AUGUST 22, 2022

The dosing for the drugs during the trial was Ivermectin 390 (470mcg/kg/day x 3 days), Metformin titration to 1,500mg/day over 7 days, and Fluvoxamine 50mg. We used Google Ads and partnerships with some testing clinics. We started only looking within the participating health system and sites. We also kept equal focus on follow-up.

Trials 130

Trials Clinical Trials Clinical Trials Insulin 130

Drug Discovery World

NOVEMBER 7, 2022

Scientists have uncovered a critical feature that a promising new class of cancer drugs, known as CELMoDs, needs to be effective. . In the study, reported in Science, researchers discovered that these drugs, in order to work, need to cause a critical shape-change in cereblon when they bind to it. Understanding the problem.

Scientist 52

Scientist Drugs Protein Research 52

Drug Discovery World

JANUARY 9, 2023

In this early research, Khalid Shah, Professor of Neurosurgery at Harvard Medical School and Brigham and Women’s Hospital, and colleagues tested the vaccine in an advanced mouse model of brain cancer glioblastoma, with promising results. The findings are published in Science Translational Medicine. .

Scientist 52

Scientist Gene Editing Gene Engineer 52

Rethinking Clinical Trials

SEPTEMBER 22, 2022

The COlchicine Hypertension Trial (COHERENT) is a pragmatic Phase II trial that looked at only hypertension by using registry data to identify patients that receive at least two hypertension drugs. The aim is to test communication strategies for optimizing the update of the flu vaccine. Learn more. Read about DANFLU-1.

Trials 130

Trials Cardiology Vaccination Vaccine 130

pharmaphorum

DECEMBER 23, 2021

Daiichi Sankyo has been granted breakthrough status by the FDA for patritumab deruxtecan, a HER3-targeted antibody-drug conjugate (ADC) in clinical trials for lung cancer. HER3 is expressed in more than 80% of EGFR-mutant NSCLC, and overexpression is associated with poor outcomes, but no HER3-targeted drugs have been approved to date.

Drugs 70

Drugs Antibody Clinical Trials Clinical Trials 70

Rethinking Clinical Trials

AUGUST 28, 2023

 Speakers Prof Sir Martin Landray, FMedSci Professor of Medicine & Epidemiology University of Oxford Chief Executive, Protas Khair ElZarrad, PhD, MPH Director, Office of Medical Policy Center for Drug Evaluation and Research (CDER) U.S. This could stifle innovation and quality when new and different technologies are more relevant.

Clinical Trials 130

Clinical Trials Clinical Trials Trials Development 130

Rethinking Clinical Trials

AUGUST 28, 2023

 Speakers Prof Sir Martin Landray, FMedSci Professor of Medicine & Epidemiology University of Oxford Chief Executive, Protas Khair ElZarrad, PhD, MPH Director, Office of Medical Policy Center for Drug Evaluation and Research (CDER) U.S. This could stifle innovation and quality when new and different technologies are more relevant.

Clinical Trials 130

Clinical Trials Clinical Trials Trials Development 130

pharmaphorum

DECEMBER 12, 2022

Updated results from the ADVANCE IV study of Vyvgart (efgartigimod alfa) showed that more than half of patients with ITP treated with Argenx’ drug showed an improvement in platelet counts, which are dramatically reduced in the disorder. After 24 weeks, 21.8%

Sales 52

Sales Trials Drugs Antibody 52

pharmaphorum

MARCH 23, 2022

Argenx only recently scored FDA approval for its intravenous anti-neonatal FC receptor (FcRn) antibody Vyvgart for generalised myasthenia gravis (gMG), but is already looking to defend its franchise with a new subcutaneous version of the drug. Preliminary results from UCB’s phase 3 RAISE study are expected in the coming weeks.

Antibody 52

Antibody Sales FDA Approval Trials 52

pharmaphorum

NOVEMBER 19, 2020

Novartis/Genentech’s eye drug Lucentis could be the next big blockbuster to face competition from cheaper biosimilars after its US patent expired this year – and Samsung Bioepis and Biogen are closing in after the FDA accepted a filing for their cut-price rival.

FDA Approval 62

FDA Approval Marketing Drugs Clinical Development 62

pharmaphorum

JANUARY 5, 2021

Roche’s closely-watched combination of two checkpoint inhibitors – TIGIT-targeting tiragolumab and PD-L1 drug Tecentriq – has claimed breakthrough status from the FDA. Roche’s drug is already FDA-approved as a monotherapy and in combination with Avastin (bevacizumab) and chemotherapy for previously-untreated NSCLC with high PD-L1 expression.

Immune Response 52

Immune Response FDA Approval Drugs Sales 52

The Pharma Data

MARCH 23, 2022

Drugs that target polymerase could potentially treat Ebola virus infections and save lives. Their investigation reveals that an experimental drug that targets GSPT1 for degradation can also halt Ebola virus infection in human cells. Without this information, researchers cannot move forward with structure-based drug design.

Protein 52

Protein Genome Genomics Research 52

pharmaphorum

JANUARY 11, 2022

It is well-established for conventional drugs and medical devices but has only recently started to be used for DTx. The post Blue Note leukaemia DTx gets FDA breakthrough tag appeared first on. Breakthrough designations can speed up the development of new therapies, making them available to patients sooner.

Development 62

Development Production Drugs 62

pharmaphorum

SEPTEMBER 15, 2020

“Digitally native brands are typically agile businesses from the ground up, and agility and flexibility are part of their core makeup,” says Joe Holmes, vice president, marketing services, US at Tag. They also employ exceptionally high levels of ‘test and learn’ activities to understand which campaigns work and should be upscaled.

Branding 129

Branding Marketing Pharma Companies Life Science 129

Intouch Solutions

APRIL 11, 2024

It has continually evolved, embracing new technologies and methodologies to improve drug discovery, development, and distribution. Pre-Clinical : Deeper comprehension of the impacts and outcomes associated with a particular drug. Clinical : Optimized efficiency, inventory management, and service quality of clinical trials.

Compliance 52

Compliance Marketing Drugs Pharma Companies 52

pharmaphorum

OCTOBER 29, 2021

Gilead’s Trop-2 targeting antibody-drug conjugate Trodelvy (sacituzumab govitecan) will be paired with Merck’s PD-1 inhibitor Keytruda (pembrolizumab) in a new phase 3 trial in previously-untreated subjects with locally advanced or metastatic TNBC. While its headline revenue of $7.4

Trials 52

Trials Sales FDA Approval Production 52

Delveinsight

FEBRUARY 25, 2021

Beam adds to drug delivery stable with USD 120 Million GuideTx buy. GRAIL and Quest collaborate for the cancer blood test. Cancer detection company GRAIL has announced a collaboration with Quest Diagnostics that sees Quest proffering phlebotomy services to bolster GRAIL’s multi-cancer early detection blood test Galleri.

DNA 52

DNA In-Vivo Genetics Medicine 52

XTalks

JANUARY 28, 2022

Kimmtrak has a price tag of $18,760 per vial, which amounts to a weekly dose. Related: Cancer Blood Test Developed by University of Oxford Researchers Can Detect Metastasis. The company is expecting approval from the European Medicines Agency (EMA) soon as it prepares for a European launch in the second quarter of this year.

FDA Approval 98

FDA Approval Development Licensing Licensing 98

XTalks

JUNE 9, 2021

Biogen has been working vigorously over the past couple of years to get its potentially disease-modifying drug Aduhelm (aducanumab) approved for Alzheimer’s disease, and it has finally happened. This Monday, the US Food and Drug Administration (FDA) granted accelerated approval to the drug for the treatment of the disease.

Drugs 98

Drugs Clinical Trials Clinical Trials Trials 98

pharmaphorum

DECEMBER 23, 2022

There’s been huge progress in treatments for blood cancer in recent years – but drawbacks of expensive CAR-T cell and injected antibody therapies have led drug developers to look at novel oral therapies as patient-friendly alternatives. CellCentric, a U.K-based These are particularly important in the progression of certain blood cancers.

Development 52

Development Drugs Clinical Development Antibody 52

Drug Discovery World

JANUARY 10, 2023

Bethyl antibodies are highly regarded for passing strict validation testing before arriving in customer hands. Pillar 5: Protein OE/Epitope Tags. We generate numerous candidates for you to test in your assays and workflows ensuring the antibodies are effective in whatever application they’re being used. Small molecules .

Antibody 52

Antibody Protein Reagent Scientist 52

The Pharma Data

DECEMBER 3, 2020

Preliminary results from stability studies have demonstrated that S-Trimer is stable at 2-8 o C for at least six months (longer-term stability studies are ongoing) and stable at room temperature and 40 o C for at least one month, in line with the adjuvants tested. About Trimer-Tag © Technology. About COVID-19 S-Trimer Vaccine.

Vaccination 52

Vaccination Vaccine Immune Response Protein 52

Roots Analysis

JANUARY 28, 2024

Velocity: Big Data needs to be handled promptly as businesses generate data at an unprecedented speed, driven by the growing adoption of Internet of Things (IoT), and technologies, such as RFID tags, sensors, and smart meters are used to deal with the high velocity of data in real-time. It is loosely arranged into categories using meta tags.

Big Data 40

Big Data Medicine Marketing Clinical Trials 40

Drug Discovery World

JANUARY 30, 2024

Lentivirus strategies are one of the most widely used tools in biomedical research and clinical testing, says Stella Vnook, CEO, Likarda. “Dr Other Challenges: Limited insurance coverage: Many insurance companies are hesitant to cover CGTs due to their high price tags and limited long-term data.

Gene Therapy 71

Gene Therapy Manufacturing Gene Clinical Trials 71

The Pharma Data

OCTOBER 21, 2020

In a trial of 63 patients, researchers found that the drug regimen frequently wiped out all signs of the cancer — a subtype of the blood cancer acute lymphoblastic leukemia (ALL). The drug is given by infusion; each cycle lasts four weeks. When it came to market in 2014, the price tag for one treatment cycle was $89,000.

Drugs 52

Drugs Genetics Trials Research 52

The Pharma Data

OCTOBER 21, 2020

In a trial of 63 patients, researchers found that the drug regimen frequently wiped out all signs of the cancer — a subtype of the blood cancer acute lymphoblastic leukemia (ALL). The drug is given by infusion; each cycle lasts four weeks. When it came to market in 2014, the price tag for one treatment cycle was $89,000.

Drugs 52

Drugs Genetics Trials Research 52

Drug Discovery World

OCTOBER 3, 2022

A series of short seminars focused on automation and technology will be available to visitors at Drug Discovery 2022 which takes place at the ExCel, London 4 and 5 October. will discuss The role of AI and Automation in Personalised Medicine: How can AI Help in the Post- Drug Discovery Process. Fellowship Programme.

Drugs 52

Drugs Scientist Bioinformatics Medicine 52

XTalks

FEBRUARY 27, 2024

Iovance Biotherapeutics’ Amtagvi (lifileucel) won US Food and Drug Administration (FDA) approval last week for the treatment of advanced melanoma, making it the first individualized tumor-infiltrating lymphocyte (TIL) therapy and the first T-cell therapy for a solid tumor to win US regulatory approval.

FDA Approval 52

FDA Approval Manufacturing In-Vivo Trials 52

pharmaphorum

DECEMBER 2, 2020

The company’s first product, a palatable anti-parasitic drug, made to taste like toffee, united Pfizer’s skills as a chemist with Erhart’s training as a confectioner. The “first industrial war” involved drug producers as much as weapons manufacturers. It was a success, and set the pattern for the company’s future development.

Sales 127

Sales Production Drugs Marketing 127

XTalks

AUGUST 23, 2021

AAt this year’s Alzheimer’s Association International Conference ( AAIC ), entire sessions were dedicated to discussions of Biogen’s recently-approved, controversial drug Aduhelm (aducanumab), but their focus wasn’t what you’d expect. More than 125 drugs are still in the [Alzheimer’s disease] drug development pipeline,” said Dr. Grill.

Clinical Trials 52

Clinical Trials Clinical Trials Trials Drugs 52

The Pharma Data

OCTOBER 9, 2021

Food and Drug Administration (FDA) for the treatment of people living with Alzheimer’s fever ( Notice). Roche (SIX RO, ROG; OTCQX RHHBY) now posted that gantenerumab, ananti-amyloid beta antibody developed for subcutaneous administration, has been granted Improvement Rectifier Designation by theU.S.

Antibody 52

Antibody In-Vitro Trials Development 52

XTalks

AUGUST 17, 2020

Immune checkpoint inhibitors : these are drugs that block immune checkpoints, allowing immune cells to elicit enhanced responses to cancer cells. CUE-101 is in the clinic right now, being tested in patients with HPV-driven, recurrent metastatic head and neck cancer in a Phase I dose-escalation and expansion study. 101, 102, 103).

Protein 98

Protein Engineer Immune Response In-Vivo 98

pharmaphorum

NOVEMBER 16, 2022

The advancements made in drug development over the last decade have seen the arrival of a number of treatments that offer one-time cures and more effective therapies for conditions in smaller patient populations. However, with a price tag of €1.58 How to navigate the new climate. At more than $2.1

Gene Therapy 130

Gene Therapy Gene Marketing Development 130

FDA Law Blog

JUNE 27, 2023

Valentine Named Top Lawyer Under 40; Only Food and Drug Lawyer Selected Hyman, Phelps & McNamara, P.C. (HP&M) James was only one of five life sciences attorneys selected and the only food and drug lawyer to make the list. HP&M’s James E. Valentine , as a 2023 Rising Star.

Life Science 81

Life Science FDA Approval Drugs Development 81

Pharmaceutical Technology

JANUARY 27, 2023

On January 18, Sanofi launched a new warranty program for its rare blood disorder drug Cablivi (caplacizumab), which tackles value-based agreements in a slightly different way. Cablivi stops platelets from clumping together, which prevents small clots, and can be used along with other drugs that suppress the immune system.

Manufacturing 130

Manufacturing Drugs Research Analyst FDA Approval 130