Pharmaceutical Technology

MAY 12, 2023

Blood cancer patients with E coli infection are at risk of bacteria infecting the bloodstream. The research team has designed four bacterial viruses which use CRISPR technology to kill the unwanted bacteria precisely. The team then engineered the phages through gene editing to improve their targeting ability.

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Scienmag

JULY 1, 2022

One way cells can control the activities of their genes is by adding small chemical modifications to the DNA that determine which genes are turned on or off. Researchers have found that in bacteria DNA methylation plays a role in regulating virulence, reproduction and gene […].

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Medical Xpress

DECEMBER 7, 2022

Researchers aiming to predict which staph-infection patients might develop a related kidney disease have found a high frequency of gene mutations in the infecting bacteria of affected patients, which suggests these variants may play a role in the body's initiation of the renal damage.

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XTalks

DECEMBER 14, 2022

Expanding upon the CRISPR-Cas9 gene editing system, researchers at MIT have designed a new technique called PASTE gene editing that can cut out defective genes and replace them with new genes in a safer and more efficient way. The PASTE gene editing technique was recently published in Nature Biotechnology.

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Drug Discovery World

FEBRUARY 8, 2024

In 2023, DDW hosted a webinar, ‘A comprehensive guide to using adeno-associated virus (AAV) vectors in gene therapy’, supported by Azenta Life Sciences. AAV is optimal for gene therapy due to its efficiency and safety in humans; however, AAV processes can present obstacles for researchers. How is the titer determined?

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Gene Therapy Gene Bioinformatics Life Science 57

Scienmag

JUNE 24, 2021

NIH scientists discover that bacteria may drive activity of many hallmark aging genes in flies Credit: Courtesy of the Giniger lab NIH/NINDS.

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Scienmag

MAY 12, 2022

BIRMINGHAM, Ala. – Lei Zhang, Ph.D., and Michael Niederweis, Ph.D., of the University of Alabama at Birmingham have made what they call “a major step” in understanding how Mycobacterium tuberculosis acquires iron from its human host — a process essential for the pathogenesis of this bacterium.

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The Pharma Data

MARCH 18, 2022

Columbia Engineering researchers report that they have developed a “cloaking” system that temporarily hides therapeutic bacteria from immune systems, enabling them to more effectively deliver drugs to tumors and kill cancer cells in mice. Using Bacteria For Therapy. ” The Ideal Bacteria.

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Scienmag

JANUARY 8, 2021

Now research reveals that bacteria too have internal clocks that align with the 24-hour cycle of life on Earth. Credit: Professor Ákos Kovács, Technical University of Denmark Humans have them, so do other animals and plants.

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Medical Xpress

JANUARY 4, 2023

Like humans, bacteria and archaea can be attacked by viruses. Bacterial defenses, such as CRISPR-Cas systems, have diverse proteins and functions that help bacteria protect themselves against foreign invaders. These microorganisms have developed their own immune defense strategies against their pathogens.

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Scienmag

DECEMBER 18, 2020

Bacteria often show very strong biogeography – some bacteria are abundant in specific locations while absent from others – leading to major questions when applying microbiology to therapeutics or probiotics: how […].

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Bacteria Genome Genomics Research 52

Drug Discovery World

OCTOBER 3, 2023

Earlier this year, DDW hosted a webinar, ‘A comprehensive guide to using adeno-associated virus (AAV) vectors in gene therapy’, supported by Azenta Life Sciences. AAV is optimal for gene therapy due to its efficiency and safety in humans; however, AAV processes can present obstacles for researchers.

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Gene Therapy Gene Life Science Bioinformatics 52

BioTech 365

APRIL 5, 2021

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: DNA methylation from bacteria and microbiome using nanopore technology.Bacterial DNA methylation occurs in diverse sequence contexts and plays important functional roles in cellular defense and gene regulation.

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Scienmag

FEBRUARY 5, 2021

Membrane-localized phage proteins may also help revitalize, enhance existing antibiotics A study from the Center for Phage Technology, part of Texas A&M’s College of Agriculture and Life Sciences and Texas A&M AgriLife Research, shows how the “hidden” genes in bacteriophages — types of viruses that infect and destroy (..)

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Gene Bacteria Life Science Development 74

Scienmag

JANUARY 12, 2021

Martins Scientists have used gene-editing advances to achieve a tenfold increase in the production of super-bug targeting formicamycin antibiotics. The John Innes Centre researchers used the technology to create a new strain of Streptomyces formicae bacteria which over-produces the medically promising molecules. Credit: Dr Dino J.

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XTalks

NOVEMBER 3, 2023

After spending almost an entire day deliberating the safety of Vertex Pharmaceuticals’ and CRISPR Therapeutics’ CRISPR-based gene therapy exa-cel for sickle cell disease, a US Food and Drug Administration (FDA) advisory panel appears to be satisfied with what it saw. CRISPR works as genetic scissors to edit parts of the genome.

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Drug Discovery World

OCTOBER 18, 2022

The researchers also found that Dynobactin kills Gram-negative bacteria, which include many dangerous and resistant pathogens. . The search for antibiotics against this group of bacteria is far from trivial,” said Hiller. The researchers made use of the fact that many bacteria produce antibiotic peptides to fight each other.

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Scienmag

JUNE 21, 2022

The last two decades have seen the development of sophisticated computational tools that explore the DNA of bacteria. These tools are on the lookout for interesting metabolites (metabolism-related molecules) that illicit a strong biological reaction.

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Bacteria DNA Gene Development 86

Pharmaceutical Technology

DECEMBER 14, 2022

Bacteria naturally develop resistance to antibiotics over time, through genetic mutation, horizontal gene transfer between bacteria, or because of selective pressure. Virus versus bacteria. Phages are viruses of bacteria. Secondly, the relationships between phages and bacteria are very specific.

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Drug Discovery World

JANUARY 23, 2024

Scientists at the King Abdullah University of Science and Technology (KAUST) in Thuwal, Saudi Arabia used the KAUST Metagenomic Analysis Platform (KMAP) to analyse massive amounts of sequencing data to release Global Ocean Gene Catalog 1.0.

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Scienmag

JUNE 7, 2021

Travellers abroad may pick up bacteria and other vectors containing genes conferring antimicrobial resistance which remain in the gut when returning to their home country, according to a study published in Genome Medicine.

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Scienmag

SEPTEMBER 30, 2021

Legumes engage in a unique and beneficial interaction with a group of soil bacteria, collectively called rhizobia. Crop legumes are an integral part of sustainable agriculture, as several of these species represent an important protein source for both human and animal populations.

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BioSpace

JANUARY 19, 2021

A naturally occurring system for tuning CRISPR-Cas9 expressing in bacteria, identified in a study published in Cell, could have implications for gene editing therapies as well.

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Drug Discovery World

JULY 17, 2023

Paul Denslow , CEO, Intus Bio, discusses how a new approach to tracking gut bacteria can revolutionse our understanding of the microbiome and bring about new discoveries for therapeutics. It’s a long-held doctrine that there’s no effective method to track the microbiome during drug research and development.

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Drug Discovery World

APRIL 10, 2023

University of Queensland (UQ) researchers have led a national study on the four main bacteria that cause sepsis, providing new targets for developing antibiotics. The research team set out to find responses common to all four types of bacteria that cause sepsis and discover more about how bacteria survive in the body.

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Drug Discovery World

MARCH 21, 2023

In a step forward for genetic engineering and synthetic biology, US researchers have modified E coli bacteria to be immune to infection by all natural viruses tested so far. The team used two safeguard methods to prevent the bacteria and their modified genes from escaping into the wild.

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The Pharma Data

JUNE 14, 2023

But the bacteria can sometimes change their behavior and enter the bloodstream, causing chronic localized infections to become acute and potentially fatal. Abell Chair in Molecular and Cellular Biology – and Pengbo Cao, a postdoctoral researcher in Whiteley’s lab, discovered a gene that drives the switch.

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Scienmag

SEPTEMBER 23, 2020

In mice, the maternal gut microbiata regulates which genes are activated in the growing brain, UCLA study shows Credit: Reed Hutchinson/UCLA During pregnancy in mice, the billions of bacteria and other microbes that live in a mother’s intestines regulate key metabolites, small molecules that are important for healthy fetal brain development, (..)

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Bacteria Regulation Gene Development 92

Scienmag

SEPTEMBER 30, 2021

The microbiomes of corals — which comprise bacteria, fungi and viruses — play an important role in the ability of corals to tolerate rising ocean temperatures, according to new research led by Penn State. The team also identified several genes within certain corals and the symbiotic photosynthetic algae that live inside […].

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Bacteria Gene Research 69

Scienmag

MAY 26, 2022

A new antibiotic, synthesized at The Rockefeller University and derived from computer models of bacterial gene products, appears to neutralize even drug-resistant bacteria. The compound, named cilagicin, works well in mice and employs a novel mechanism to attack MRSA, C.

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BioTech 365

MARCH 16, 2021

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: Scientists reveal new mechanism of xenogeneic silencing in bacteria.Lateral gene transfer (LGT) plays a prominent role in the genome evolution and environmental adaptation of prokaryotes.

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Scienmag

AUGUST 17, 2020

Credit: Professor Mark Schembri There is new hope for approximately 700,000 people who die each year from antibiotic resistant infections, with University of Queensland researchers discovering how bacteria share antibiotic-resistance genes. “The diminishing […].

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pharmaphorum

OCTOBER 7, 2020

Drs Emmanuelle Charpentier and Jennifer Doudna have won this year’s Nobel Prize for chemistry in recognition of their work on the gene-editing technology CRISPR/Cas9. Charpentier’s early work in this area led to the discovery of tracrRNA, a previously unknown molecule that defends bacteria from viruses by cleaving their DNA.

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Scienmag

MAY 18, 2021

Scientists link genetic makeup of bacteria in the human gut to several human diseases We are truly never alone, not even within our own bodies. Human beings play host to trillions of bacteria, fungi, viruses, and other microorganisms that make up the human microbiome.

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Drug Discovery World

JANUARY 12, 2024

The top stories: Excitement over new antibiotics that can kill drug-resistant bacteria A novel antibiotic class targeting a major global pathogen and threat to human health has been discovered by scientists from Roche and Harvard University (Cambridge, MA, US).

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Scienmag

JUNE 16, 2021

In addition, microplastics can act as breeding grounds for antibiotic-resistant bacteria. Now, researchers reporting in Environmental Science & Technology have analyzed antibiotic-resistance genes (ARGs) on five types of […].

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Bacteria Gene Research 40

Scienmag

FEBRUARY 19, 2021

Microorganisms possess natural product biosynthetic gene clusters (BGCs) that may harbor unique bioactivities for use in drug development and agricultural applications. However, many uncharacterized microbial BGCs remain inaccessible.

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