Drug Discovery World

MARCH 21, 2023

In a step forward for genetic engineering and synthetic biology, US researchers have modified E coli bacteria to be immune to infection by all natural viruses tested so far. The team used two safeguard methods to prevent the bacteria and their modified genes from escaping into the wild.

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Medical Xpress

JANUARY 4, 2023

Like humans, bacteria and archaea can be attacked by viruses. Bacterial defenses, such as CRISPR-Cas systems, have diverse proteins and functions that help bacteria protect themselves against foreign invaders. These microorganisms have developed their own immune defense strategies against their pathogens.

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XTalks

JULY 26, 2021

But several researchers and experts have brought to light some food safety concerns of plant-based meat, and why it must be treated differently than that of animal protein. Because of their near-neutral pH and high protein and moisture content, plant-based meats are susceptible to microbial growth. Subject to Microbial Growth.

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Scienmag

APRIL 26, 2022

Working with tiny bacteria, Michigan State University researchers led by Lee Kroos have made a discovery that could have big implications for biology. EAST LANSING, Mich.

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Scienmag

OCTOBER 19, 2020

New research led by University of Hawai’i at Manoa scientists revealed that, in the mutually beneficial […]. It is now recognized that microbiomes are major drivers of health in all animals, including humans, and that these symbiotic systems often exhibit strong daily rhythms.

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Scienmag

AUGUST 11, 2020

Researchers from Skoltech, Lomonosov Moscow State University, and the Kharkevich Institute for Information Transmission Problems have studied the genomes of some 200 strains of bacteria to determine which proteins in the ribosome, part of the key cell machinery, can be safely lost and why.

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Scienmag

NOVEMBER 22, 2021

Now, a first-of-its-kind Stanford University analysis evaluates the market potential of the approach, in which bacteria fed captured methane grow into protein-rich fishmeal. Like a mirage on the horizon, an innovative process for converting a potent greenhouse gas into a food security solution has been stalled by economic uncertainty.

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Medical Xpress

APRIL 17, 2023

But new research may help explain this link between gum disease and an otherwise disparate condition.

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Drug Discovery World

APRIL 10, 2023

University of Queensland (UQ) researchers have led a national study on the four main bacteria that cause sepsis, providing new targets for developing antibiotics. The research team set out to find responses common to all four types of bacteria that cause sepsis and discover more about how bacteria survive in the body.

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Scienmag

SEPTEMBER 18, 2020

Toxic protein inhibits cell wall synthesis in rival bacteria. Credit: Ethel Bayer-Santos By André Julião | Agência FAPESP – Researchers at the University of São Paulo (USP) in Brazil have characterized a […].

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Scienmag

MAY 18, 2021

Using only a small blood sample, the test detects a protein secreted by Mycobacterium tuberculosis, which causes TB infection Credit: Video by Carolyn Scofield, Tulane University School of Medicine Researchers at Tulane University School of Medicine have developed a highly sensitive blood test that can find traces of the bacteria that causes tuberculosis (..)

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Drug Discovery World

JANUARY 24, 2023

University of Queensland researchers have identified a pathway in cells that could be used to reprogramme the body’s immune system to fight back against both chronic inflammatory and infectious diseases. Coli bacteria from growing,” Dr Das Gupta said. “It

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Drug Discovery World

JULY 29, 2022

But with hundreds of bacterial species populating our gastrointestinal tract, it’s a daunting task to pinpoint which molecules made by which bacteria affect which biological processes—and how they do so. Such knowledge is essential for learning how to manipulate gut bacteria to treat or prevent illness. muciniphila’s cell membrane.

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BioTech 365

MARCH 22, 2021

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: Atomic techniques reveal the evolution of a bacterial protein.Researchers show how bacteria have adapted a sensing mechanism that allows them to live in different environments.

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Scienmag

FEBRUARY 5, 2021

Membrane-localized phage proteins may also help revitalize, enhance existing antibiotics A study from the Center for Phage Technology, part of Texas A&M’s College of Agriculture and Life Sciences and Texas A&M AgriLife Research, shows how the “hidden” genes in bacteriophages — types of viruses that infect and destroy (..)

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The Pharma Data

JUNE 14, 2023

But the bacteria can sometimes change their behavior and enter the bloodstream, causing chronic localized infections to become acute and potentially fatal. However, researchers at the Georgia Institute of Technology have identified the major mechanism behind the transition between chronic and acute P. aeruginosa infections.

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BioTech 365

MAY 7, 2021

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: Study describes new mechanism for terminating transcription of DNA into RNA in bacteria.A bacterial protein helps to stop transcription—the process of making RNA copies of DNA to … Continue reading →

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Drug Discovery World

NOVEMBER 16, 2023

Glox Therapeutics has raised £4.3M ($5.2M) in seed funding to develop targeted therapeutics against antibiotic-resistant Gram-negative bacteria. Glox Therapeutics is developing precision antibiotics using engineered protein bacteriocins.

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Delveinsight

JANUARY 28, 2021

Nirogy plans to use the proceeds to improve its drug discovery platform for generating a pipeline of small-molecule drugs designed to aim the solute carrier family of transporter proteins (SLCTs) embedded in the cell membrane. Gut Bacteria proffer insight into molecules protective against asthma and COVID-19.

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XTalks

NOVEMBER 24, 2021

Here’s how it works: methanotrophic bacteria , which serve as biofilters for the oxidation of methane, transform the greenhouse gas into protein-rich fishmeal for farmed fish. “In That’s why Stanford researchers wanted to make a paradigm shift and create a high-value product using biotechnology.

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XTalks

AUGUST 26, 2020

Macrophages are white blood cells that specialize in the detection, phagocytosis and destruction of bacteria and other harmful organisms. In other words, when fighting bacteria, the macrophages are programmed to be pro-inflammatory. They found a protein called Rspondin3, which is released at high levels during inflammatory injury.

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pharmaphorum

DECEMBER 4, 2020

Valneva has said it plans to accelerate research into its Lyme disease vaccine candidate VLA15, bringing forward a trial including children into the first quarter of 2021. OspA is one of the most dominant surface proteins expressed by the bacteria when present in the ticks that spread the disease.

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XTalks

JANUARY 6, 2021

Researchers at the National Institutes of Health (NIH) in the US have isolated small antibodies called “nanobodies” from a llama named Cormac that can block the SARS-CoV-2 coronavirus. Owing to their size, they can be grown in bacteria as opposed to larger animal or human cells, making them easier and cheaper to produce.

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Roots Analysis

FEBRUARY 27, 2024

Currently, product licensing agreements, technology licensing agreements, research and development agreements and clinical trial agreements are the common types of partnerships inked by developers that are currently focused on the development of ADCs pipeline. In nature, they are made by a group of bacteria known as actinomycetes.

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Drug Discovery World

AUGUST 9, 2022

Based in Dundee, Cypex manufactures recombinant xenobiotic metabolizing enzymes with its product portfolio covering a wide range of proteins involved in drug metabolism. . This technology enables the expression of human drug-metabolizing enzymes in bacteria, without requiring large modifications to the proteins.?

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Pharmaceutical Technology

MARCH 10, 2023

Pharmaceutical and biotechnology industries widely use freeze-drying systems to protect vaccines, antibodies, antibiotics such as penicillin, blood plasma, proteins, enzymes, hormones, viruses, and bacteria from heat and minimise their biological activity.

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XTalks

JANUARY 20, 2021

Researchers at KU Leuven in Belgium have found a potential mechanism underlying irritable bowel syndrome (IBS) that involves activation of immune cells primed by past gastrointestinal infections. The research findings were published in the journal Nature. Related: Monitoring Patients with IBS or Kidney Failure?

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Pharmaceutical Technology

FEBRUARY 15, 2023

The key component in all vaccines is one or more active ingredients made from viruses or bacteria, also called antigens, which generates an immune response. The active component of the Pfizer-BioNTech vaccine tozinameran, contains the genetic code for the coronavirus spike protein, inside a lipid (fat) capsule.

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The Pharma Data

JUNE 22, 2023

They have shown that the mechanism involves a block in proteins called interferons, which promote tissue factor releases. ” The team demonstrated that life-threatening clotting could be prevented in mice infected with the bacteria E. coli and Staph aureus and also in response to SARS-CoV2, the virus that causes COVID-19.

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The Pharma Data

JANUARY 13, 2021

13, 2021 — The bacteria in your gut may play a role in the severity of COVID-19 infection and the strength of your immune system response, a new study suggests. Not only that, imbalances in the microbiome may cause continued inflammatory symptoms, often called “long-haul” COVID, the researchers added. WEDNESDAY, Jan.

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Drug Discovery World

NOVEMBER 17, 2022

Applying the principles of engineering to biology – redesigning organisms and biological parts to create synthetic components with new abilities – fuels the progression of medicine and gives researchers additional ability to tackle scientific issues. . It appears to neutralise even drug-resistant bacteria. .

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Pharmaceutical Technology

FEBRUARY 15, 2023

Innovation S-curve for the pharmaceutical industry CRISPR nuclease is a key innovation area in pharmaceutical development CRISPR, which refers to clustered regularly interspaced short palindromic repeats, are bacteriophage-derived DNA sequences that had previously infected the prokaryote and are found in the genomes of bacteria and archaea.

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XTalks

JANUARY 12, 2022

The innovative food packaging is made from a type of corn protein called zein , starch and other naturally-derived biopolymers, which have been found to be sustainable replacements for PFAS and other plastic-coated paper. The “smart” packaging kills harmful microbes and can extend the shelf life of fresh foods for multiple days.

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Camargo

JULY 27, 2021

The technology of gene therapy is possible due to extensive DNA research and our resulting understanding of many diseases on the genetic level, and it encompasses several mechanisms such as introducing new genes (gene addition) and inactivating or replacing mutated genes (gene editing).

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Delveinsight

JULY 26, 2021

Often the bacteria develop antibiotic resistance to certain drugs, leaving it non-effective for the usage the second time in the case of recurrence of the infection that occurs in approximately 30-35% of the uUTI cases, therefore, leaving a serious dearth of the new antibiotics. coli bacteria called FimH.

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The Pharma Data

MARCH 13, 2022

That’s because the mutations that led to the variant’s emergence aren’t found in the regions of the virus that stimulates one type of cellular immune response, says an international research team from Johns Hopkins Medicine, in collaboration with the National Institute of Allergy and Infectious Diseases (NIAID) and ImmunoScape, a U.S.-Singapore

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The Pharma Data

MARCH 8, 2021

We hope this Phase 2 trial, with a simplified schedule, will provide evidence that the investigational vaccine can be used in populations that are at risk of contracting Lyme disease, potentially including children age five years and older,” said Kathrin Jansen, Senior Vice President and Head of Pfizer Vaccine Research and Development.

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