Drug Discovery World

FEBRUARY 7, 2024

Astellas has submitted a supplemental new drug application (sNDA) in Japan for Padcev (enfortumab vedotin (genetical recombination)) with Keytruda (pembrolizumab (genetical recombination)) for the first-line treatment of advanced bladder cancer. The sNDA is based on results from the Phase III EV-302 clinical trial.

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Pharmaceutical Technology

FEBRUARY 15, 2023

The active component of the Pfizer-BioNTech vaccine tozinameran, contains the genetic code for the coronavirus spike protein, inside a lipid (fat) capsule. The vaccine also contains other inactive ingredients such as cholesterol.

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Drug Discovery World

JULY 3, 2023

PrecisionLife and the University of Oxford have signed a data access agreement to license the Oxford Endometriosis Gene (OXEGENE) dataset to develop new personalised treatments for endometriosis patients. We hope that the analysis of our data will lead to the development of precision medicines to improve the lives of patients.”

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Drug Discovery World

JANUARY 23, 2024

Moreover, the use of marine genetic resources in industrial processes yields an estimated $6 billion annually, a number that doubles every six years as more genes in ocean microbes are found.

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Pharmaceutical Technology

SEPTEMBER 20, 2022

The production of commercial dose non-sterile products such as tablets, capsules, ointments, creams, and powders is rising due to their growing global demand, attributed to increasing demand for anti-ageing products, hereditary factors, genetic mutations, exposure to harmful radiation, and rising geriatric population.

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Medical Xpress

MAY 9, 2023

Leucine-rich repeats containing 4 (LRRC4)—a gene abundantly found in the brain and located on human chromosome 7q31–32—plays a pivotal role in memory formation, autism, spinal cord injury, as well as in determining the malignant potential, development, and progression of glioblastoma (GB), an aggressive cancer involving the brain and/or spinal cord. (..)

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Scienmag

JUNE 9, 2021

Credit: Kazan Federal University Homocysteine (HCY) is a sulfur-containing aminoacid, which attract more and more attention as the increase of homocysteine level associates with a number of pathological conditions. Hyperhomocysteinemia (hHCY) is an elevation of HCY level in plasma and develops due to genetic mutations of enzymes […].

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The Pharma Data

DECEMBER 28, 2020

About Fulgent Genetics. Fulgent Genetics’ proprietary technology platform has created a broad, flexible test menu and the ability to continually expand and improve its proprietary genetic reference library while maintaining accessible pricing, high accuracy and competitive turnaround times. TEMPLE CITY, Calif.,

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Pharmaceutical Technology

MAY 24, 2023

The RMAT designation programme is intended to accelerate the drug’s development and review processes for products, including gene therapies. It can correct several disease elements associated with PKD, a rare, monogenic red blood cell disorder caused by a mutation in the PKLR gene.

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XTalks

MARCH 21, 2024

In this episode of the Xtalks Food Podcast, Sydney talks about the new offerings, which were developed in collaboration with NotCo, a Chilean food-tech firm renowned for its AI-driven approach to crafting plant-based food solutions. The products contain ingredients like bamboo fiber, pea protein and mushrooms.

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Scienmag

FEBRUARY 19, 2021

Undergraduate students explore a more efficient way to measure protein-containing vessels released by cells Credit: DGIST Despite our great progress in understanding various cellular mechanisms over the last decades, many of them remain unclear.

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The Pharma Data

OCTOBER 20, 2020

$1 million in research funding to support PD GENEration, a first-of-its-kind national study offering free genetic testing and counseling for people with Parkinson’s disease (PD). 10-15% of people with Parkinson’s disease have a genetic form of the disease. CAMBRIDGE, Mass.

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Drug Discovery World

DECEMBER 5, 2022

Scientists have unlocked key insights into virus evolution, revealing new information that could help develop treatments for a wide variety of genetic diseases. . Some have even been successfully harnessed as gene therapy vectors for the treatment of genetic diseases. .

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Gene Therapy Gene Genetic Disease Genetics 52

The Pharma Data

NOVEMBER 30, 2020

Nasdaq: NVAX), a late-stage biotechnology company developing next-generation vaccines for serious infectious diseases, today provided an update on its COVID-19 vaccine program. About NVX-CoV2373 NVX-CoV2373 is a protein-based vaccine candidate engineered from the genetic sequence of SARS-CoV-2, the virus that causes COVID-19 disease.

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The Pharma Data

OCTOBER 26, 2020

Sensorion is currently advancing two preclinical gene therapy programs conducted under a broad multi-program research partnership with the Genetics and Physiology of Hearing Unit at Institut Pasteur (Paris). This press release contains certain forward-looking statements concerning Sensorion and its business. About Sensorion.

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Medical Xpress

MARCH 23, 2023

It contains all the information that our cells need to make proteins and other molecules vital for our development, growth and survival. DNA is our body's instruction manual.

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Roots Analysis

FEBRUARY 26, 2024

Whether it was a common cold or a genetic disease, prayers and sacrifices to the gods were the only hope of a remedy at such times. It is possible that the legend of Big Foot may be based on an unfortunate person suffering from elephantiasis or gigantism or some other genetic predisposition that would have rendered him abnormal.

Genetics 52

Genetics Medicine Genetic Engineering Genetic Disease 52

The Pharma Data

MARCH 4, 2021

Takeda will assume sole responsibility for further worldwide development and commercialization, and Ovid will no longer have any financial obligation to Takeda under the original collaboration agreement, including for milestone payments or any future development and commercialization costs.

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Drug Discovery World

SEPTEMBER 14, 2023

This submission, and Janssen’s ongoing study of erdafitinib, reinforces our commitment to deliver much-needed targeted therapies in the areas of high unmet need, including for devastating diseases like metastatic UC,” said Kiran Patel, Vice President, Clinical Development, Solid Tumours, Janssen Research & Development, LLC.

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Drug Discovery World

JULY 21, 2023

Analysts Phesi revealed that a third of clinical development programmes are cancelled during Phase II, and there were significant trial results for drugs for head and neck cancer and Alzheimer’s disease. News round-up for 17-21 July by DDW Digital Content Editor Diana Spencer.

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pharmaphorum

OCTOBER 19, 2022

Oxford-based Nucleome – which is developing an atlas of the dark genome and is focusing initially on finding drugs for autoimmune diseases – notes that the region contains 90% of disease-associated genetic changes, including autoimmune disorders like multiple sclerosis, lupus, and rheumatoid arthritis. Dr Danuta Jeziorska.

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pharmaphorum

DECEMBER 2, 2021

It focuses on the design of AAV capsids, the protein shell of a virus that encloses its genetic material and is used to deliver the payload into cells. Along with improved targeting and safety, the capsids are designed to be able to contain larger genes and be easier to manufacture.

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Gene Therapy Gene Manufacturing Clinical Trials 93

Drug Discovery World

MAY 17, 2024

Cancer trials are notorious because they are dependent on the genetic profile of patients and hence highly-selective. The researchers delved into the genetic makeup of tumours, recognising that genetic mutations heavily influence how tumours respond to drugs. The next challenge is related to the enrollment rates.

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Trials Clinical Trials Clinical Trials Protein 52

XTalks

MAY 1, 2023

This makes Qalsody the first approved treatment to target a genetic cause of ALS. Tofersen was discovered by Ionis Pharmaceuticals, and Biogen licensed tofersen from Ionis under a collaborative development and license agreement. To date, over 200 mutations in the SOD1 gene have been associated with the development of ALS.

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pharmaphorum

OCTOBER 2, 2020

European regulators have started a first ‘rolling review’ of a COVID-19 vaccine, which is being developed by AstraZeneca in collaboration with the University of Oxford. In a separate announcement, AstraZeneca said that a trial of the vaccine has resumed in Japan after a safety scare in the UK.

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XTalks

OCTOBER 21, 2020

The answer may lie in the genetic code of the virus, which scientists at Duke University have found contains several silent mutations that affect protein folding. At best, it is slowly mutating, which is good news for vaccine developers as they don’t have to contend with potentially multiple strains of the virus.

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Camargo

DECEMBER 10, 2021

Each month, Camargo’s “In the News” series highlights important changes and advancements in the regulatory and development space and explores how those changes could impact your program. It incorporates guidance on human cells genetically modified without viral vectors and addresses several key concerns for this new category.

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Drug Discovery World

OCTOBER 26, 2022

A new method to study the proteins released by cells, which could lead to new biomarkers for diseases including cancer, has been developed by scientists at the Francis Crick Institute and Imperial College London. . The researchers genetically modify the cell type they want to study, so that only this type adds the sugar to its proteins.

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Protein Genetics Containment Research 52

pharmaphorum

AUGUST 5, 2021

The issue, however, is developing an effective way of targeting them. . Understanding the mechanism of PPIs and developing methods to target aberrant ones has been a key strategy in drug development. The interface is highly hydrophobic, hence any compounds containing water would be repelled.

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The Pharma Data

MARCH 7, 2022

The IGA results in the equivalent genotype (genetic make-up) and short-hair coat trait seen in some conventionally bred cattle, known as a “slick” coat. This is the FDA’s first low-risk determination for enforcement discretion for an IGA in an animal for food use. Solomon, D.V.M., director of the FDA’s Center for Veterinary Medicine. “It

Genome 52

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The Pharma Data

JANUARY 17, 2021

–( BUSINESS WIRE )– Genus plc (LSE: GNS), a global biotechnology leader in animal genetics, today reported continued strong performance across its operations for the six-months period ending December 31, 2020. 18, 2021 07:00 UTC. BASINGSTOKE, England & MADISON, Wis.–( and £49.0m

Containment 52

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pharmaphorum

MAY 4, 2022

In testing new treatments, what is promising in animal models may not transfer particularly well to humans, which helps to explain why there is a 90% failure rate during clinical development. Quris has taken its technology and used it to develop its own drug candidate pipeline. Organ-on-a-chip.

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The Pharma Data

NOVEMBER 27, 2020

Nasdaq:RYTM), a biopharmaceutical company aimed at developing and commercializing therapies for the treatment of rare genetic diseases of obesity, announced today that the U.S. With this approval, Imcivree becomes the first-ever FDA approved therapy for these rare genetic diseases of obesity. BOSTON, Nov.

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pharmaphorum

APRIL 26, 2022

Compared to a ‘critical organ’ that had been largely ignored, companies working to develop microbiome-based therapies believe there is untapped potential in the area. Ben Hargreaves speaks to companies that are developing therapies not just in gastrointestinal conditions but also in broader areas, such an immuno-oncology.

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pharmaphorum

MARCH 29, 2022

“C9orf72-associated ALS is a complex genetic form of ALS and there are multiple mechanisms by which the scientific community believes the C9orf72 gene causes disease. Based on the results from this study, Biogen and Ionis have confirmed that the BIIB078 clinical development programme will be discontinued.

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XTalks

DECEMBER 1, 2021

Qiagen said it will continue to monitor the potential impact of Omicron on its COVID-19 PCR tests by conducting bi-weekly surveillance of genetic variations. Similarly, Abbott explained that both its rapid antigen and PCR tests do not depend on detection of the genetic material that codes for spike.

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The Pharma Data

SEPTEMBER 17, 2020

It was paused for safety reasons after a participant developed unexplained neurological symptoms that included limb weakness. It is believed they were suffering from transverse myelitis, which is an inflammation of the sheath containing the nerves of the spinal cord. The American trials are still on a hiatus. .

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