Drug Discovery World

FEBRUARY 22, 2024

market capitalisation growth to $3.67 The top 20 global biopharmaceutical companies experienced varied year-on-year (YoY) market capitalisation shifts in 2023 amid the macroeconomic headwinds, steep patent cliffs and the commencement of US drug price negotiations under the Inflation Reduction Act (IRA). billion for 2023.

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Marketing FDA Approval In-Vivo Sales 52

Pharmaceutical Technology

MARCH 29, 2023

Rates of obesity across populations are increasing, and the market for obesity drugs is set to reach $37.1bn across the US, France, Germany, Italy, Spain, UK, and Japan markets, by 2031, according to GlobalData. Other competitors include Novo Nordisk’s semaglutide, marketed as Wegovy for chronic weight management.

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Drugs In-Vivo Marketing Trials 264

Pharmaceutical Technology

FEBRUARY 23, 2023

Moderna has entered a strategic research and development partnership with ElevateBio’s Life Edit Therapeutics to discover and develop new in-vivo mRNA gene editing therapies. Moderna will also assume further development, manufacturing, and commercialisation responsibilities on exercising a target option.

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Gene Editing Gene In-Vivo Gene Therapy 147

Drug Discovery World

APRIL 18, 2023

While the global proteasome inhibitors market is expected to reach nearly $2.3 AVA3996 is in pre-clinical development with the aim of submitting an Investigational New Drug (IND) application to allow clinical development to begin during 2024.

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In-Vivo Clinical Development Development Drugs 97

FDA Law Blog

MARCH 19, 2024

using phantoms, ex vivo animal tissue models, and/or in vivo animal testing), computationally, and/or clinically. When in vivo animal testing is needed, tests should follow good laboratory practices and the animal model should be representative of the intended clinical application.

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In-Vivo Marketing Regulation Development 59

Drug Discovery World

AUGUST 14, 2023

Over the past few decades, the incredible progress in personalised medicine has led to the development of life-saving cell and gene therapies (CGT). Driven by the rapid pace of innovation, the market for CGTs is expected to grow from $4.4 And the robust CGT pipeline suggests there could be an influx of new approvals on the horizon.

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Gene Therapy Marketing Gene DNA 52

pharmaphorum

JUNE 23, 2022

Novartis has shouldered its way into the in vivo gene editing category via a deal with US biotech Precision BioSciences, focused on a therapy for sickle cell disease (SCD). billion in potential milestones if the project advances through development and onto the market. billion agreement that started in 2020.

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Gene Editing In-Vivo Gene Sequencing Gene 92

Pharmaceutical Technology

AUGUST 17, 2022

Merck (MSD outside North America) has entered a partnership agreement with Orna Therapeutics for discovering, developing and marketing various programmes based on next-generation RNA technology. Merck will also make royalty payments on any approved products developed out of the partnership.

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RNA Vaccination Vaccine In-Vivo 147

BioPharma Reporter

AUGUST 30, 2021

Seattle-based Umoja Biopharma, a company looking to reprogram immune cells in-vivo to create next-generation immunotherapies for the treatment of solid tumors and hematologic malignancies, has started work on its new development and manufacturing facility in Colorado.

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Manufacturing In-Vivo Development Regulation 98

The Pharma Data

JANUARY 17, 2021

But that number doesn’t quite reflect the company’s likely market valuation , which is expected to be between $9 billion and $12 billion. Based in Seattle, Washington, Sana focuses on in vivo and ex vivo cell engineering platforms to develop therapies for cancer, diabetes, cardiovascular disease, CNS disorders, and genetic diseases.

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In-Vivo Marketing Engineer Genetics 52

XTalks

DECEMBER 20, 2023

As we step into 2024, the life sciences continue to evolve at an unprecedented pace, driven by technological innovation, a deeper understanding of human biology and the application of new technologies in areas like drug development and health wearables. Regulatory bodies are also taking note of the applications of AI in drug development.

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Life Science Gene Editing Development Clinical Trials 119

Drug Discovery World

JANUARY 18, 2024

Poolbeg Pharma, a biopharmaceutical company focused on the development and commercialisation of medicines targeting diseases with a high unmet medical need, has announced promising in vivo results for POLB 001 in addressing cancer immunotherapy-induced cytokine release syndrome (CRS). million cases of cancer by 2030 1,2.

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In-Vivo Antibody Clinical Trials Clinical Trials 64

Pharmaceutical Technology

OCTOBER 5, 2022

Patients with end-stage CLL have yet to benefit from an approved cell therapy, despite many developers initially trialling autologous CAR-T agents such as Yescarta and Kymriah in CLL during Phase I studies. Although CLL is a B-cell malignancy, patients also suffer from dysfunctional T-cells that exhibit an exhausted phenotype.

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In-Vitro In-Vivo Sales Clinical Trials 279

pharmaphorum

OCTOBER 8, 2021

This year, we’ll be specifically focusing on next generation cell therapies and discussing: Novel in vivo delivery. This year, we’ll be specifically focusing on next generation cell therapies and discussing: Novel in vivo delivery. next generation innovations in cell therapies.

In-Vivo 52

In-Vivo Gene Manufacturing Marketing 52

Camargo

DECEMBER 22, 2021

Informed by today’s competitive drug development landscape, as well as by the sponsor’s strategic goals and capabilities, a portfolio analysis involves assessing product concept and differentiation, strategic planning, factoring in unmet patient needs, and estimating timelines and expenses. Pediatric Research Equity Act (PREA) Requirements.

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Bioequivalency Production Genotoxicity In-Vivo 169

Drug Discovery World

APRIL 15, 2024

Gene therapy will move to ex vivo gene modification and the delivery of gene-modified cell types. DDW’s Megan Thomas speaks to experts from the drug discovery industry about their predictions on the future of stem cells in drug discovery. In addition, I believe we will see more exosome-based therapies enter the clinic in 2024.

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Gene Editing Clinical Trials Clinical Trials In-Vivo 59

Delveinsight

JANUARY 18, 2021

The first sign of a child suffering from Angelman syndrome is a delay in development, such as the inability to sit without support or making incoherent babbling sounds. The gene is responsible for the normal and healthy development of an individual physically as well intellectually.

Marketing 52

Marketing Gene Drugs Protein 52

Drug Discovery World

FEBRUARY 13, 2024

It has demonstrated efficacy in in vitro and in vivo models of fibrosis, as well as favourable safety and pharmacokinetic profiles in Phase I clinical studies. It has demonstrated efficacy in in vitro and in vivo models of fibrosis, as well as favourable safety and pharmacokinetic profiles in Phase I clinical studies.

Drugs 52

Drugs In-Vivo In-Vitro Medicine 52

Pharma Marketing Network

DECEMBER 21, 2020

those that modify the expression of an individual’s genes or repair abnormal genes) has entered clinical practice, including 11 RNA therapeutics, 2 in vivo gene therapies, and 2 gene-modified cell therapies. Here are 5 considerations when developing a communications strategy for a novel genetic medicine. #1.

Genetics 52

Genetics Medicine Gene Therapy Marketing 52

pharmaphorum

JANUARY 29, 2021

California-based Sangamo Therapeutics is one such company that believes in the powerful potential of in vivo genome editing and regulation, together known as genome engineering, and has built up a sizable preclinical pipeline of genome regulation treatments for diseases such as Huntington’s disease and Amyotrophic lateral sclerosis (ALS).

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Gene Editing Gene Gene Therapy In-Vivo 145

The Pharma Data

JUNE 7, 2023

a biotechnology company specializing in the development of lipid nanoparticle (LNP) delivery systems for molecular therapeutics. Acuitas’ LNP technology will support Bayer’s in vivo gene editing and protein replacement programs by specifically delivering RNA payloads to the desired target organ, the liver.

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Gene Therapy Gene Gene Editing In-Vivo 40

Drug Discovery World

MARCH 4, 2024

DDW Editor Reece Armstrong speaks to Abraham Wang , Head of Marketing at Collaborative Drug Discovery (CDD) about annotated assays and the advantages they bring to research teams. RA: What advantages can better analysis into assays bring to drug developers?

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Drugs Bioassay Scientist In-Vivo 59

Drug Discovery World

FEBRUARY 15, 2024

The etherna paradigm for cLNP design is ushering in the rapid generation of novel families of delivery systems for not only vaccination but also for in vivo tolerisation for a host of autoimmune diseases.” The post LNP formulations produce strong immune responses, data shows appeared first on Drug Discovery World (DDW).

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Immune Response In-Vivo Vaccination Vaccine 52

Roots Analysis

FEBRUARY 15, 2023

A study conducted on terminated drug development projects revealed that majority of the drug candidates fail in early drug development phases, due to the problems associated with their pharmacokinetic profiles, ADME ( distribution, metabolism, absorption and excretion ) properties and toxicity-related issues.

Bioavailability 52

Bioavailability In-Vivo Marketing Drugs 52

pharmaphorum

SEPTEMBER 28, 2022

Vertex Pharma and partner CRISPR Therapeutics will start a rolling marketing application in the US for their gene-editing drug for sickle cell disease (SCD) and beta thalassaemia later this year. The time places exa-cel in pole position to become the first drug developed based on CRISPR/Cas9 gene-editing technology to reach the market.

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Gene Editing Gene In-Vivo Clinical Trials 59

The Pharma Data

DECEMBER 9, 2020

Liebisch , Vigil Neuroscience is developing a pipeline of precision-based therapies to combat both rare and common neurodegenerative diseases by restoring the vigilance of microglia. It will if the following five companies, which all launched this year with Series A financing, have anything to say about it. . Vigil Neuroscience.

Marketing 52

Marketing In-Vivo Protein In-Vitro 52

pharmaphorum

FEBRUARY 13, 2022

German drugmaker Merck KGaA has reached an agreement to pilot an artificial intelligence platform developed by Quris that aims to identify potential safety problems with new therapeutic candidates as early as possible in the drug discovery process.

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Drugs In-Vivo In-Vitro Pharma Companies 98

Drug Discovery World

AUGUST 22, 2023

Originator pharma companies are developing ever more complex products, which are transforming the medical landscape, but their cost places an increasing burden on healthcare budgets worldwide. It could also include specialty products that are harder to develop compared to standard generic products. What are complex generics?

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Production Bioequivalency In-Vivo In-Vitro 52

Pharmaceutical Technology

SEPTEMBER 14, 2022

As an autologous cell therapy, manufacturing the infusion product is a highly specialised process involving tumour harvest and the extraction and large-scale ex vivo expansion of TILs. Tumour-infiltrating lymphocyte (TIL) therapy has been investigated as a treatment modality for melanoma for almost 20 years. versus 21.4% respectively.

Immune Response 246

Immune Response In-Vivo Production Manufacturing 246

Pharmaceutical Technology

MARCH 9, 2023

Innovation S-curve for the pharmaceutical industry Transgenic murine models is a key innovation area in pharmaceutical s Transgenic murine models refer to mice that have been genetically altered for the purposes of understanding the in vivo functions of genes. Regeneron Pharmaceuticals is the leading patent filer in transgenic murine models.

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In-Vivo Antibody Genetics Gene 130

pharmaphorum

APRIL 12, 2021

The rest of the money will come in the form of milestone payments if agreed development, regulatory and commercial targets are met. The rest of the money will come in the form of milestone payments if agreed development, regulatory and commercial targets are met.

Drugs 52

Drugs In-Vivo Licensing Licensing 52

Drug Discovery World

APRIL 4, 2023

Read more: New oral option for anaemia of CKD approved in US EA-2353, Endogena Therapeutics The investigation of Endogena Therapeutics’ EA-2353 for the treatment of retinitis pigmentosa (RP) was designated as a Fast Track development programme in February. Here’s a summary. The drug was granted orphan drug designation by the FDA in May 2021.

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FDA Approval In-Vivo Gene Editing Drugs 52

The Pharma Data

JANUARY 11, 2021

a San Diego-based biotechnology company with an array of technology platforms for antibody discovery and optimization, and novel NK and T cell engager generation, today announced licensing of a panel of its anti-SARS-CoV-2 antibody clones to IGM Biosciences for COVID-19 therapy development.

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Antibody Licensing Licensing Development 52

Drug Discovery World

APRIL 10, 2023

It is emerging markets like India that analysts expect to spearhead the global growth of the pharmaceutical sector 1. The pharmacy of the world In the global pharmaceuticals market, India ranks third worldwide for production by volume. India’s domestic pharmaceutical market is expected to reach US$120-130 billion by 2030 2.

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Genome Genomics Drugs Life Science 52

pharmaphorum

MAY 27, 2021

Life sciences tools company Esco Lifesciences Group has scored $200m in a series A and crossover round co-led by Novo Holdings and Vivo Capital. Due to it’s established presence in Asia, Novo Holdings said the investment marked a key milestone in the development of its regional ambitions.

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Life Science In-Vivo Manufacturing Gene Therapy 59

pharmaphorum

NOVEMBER 24, 2021

Norwegian biotech Vaccibody has changed its name to Nykode Therapeutics, and celebrated its new identity with a sizeable deal with Regeneron to develop vaccines for cancer and infectious diseases. The US biotech will cover R&D costs as well as development, regulatory, manufacturing and sales for projects that progress.

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Vaccination Vaccine In-Vivo Manufacturing 52

Drug Discovery World

APRIL 25, 2024

Reece Armstrong offers an overview of cell line development and outlines the benefits the technology is bringing to biopharmaceutical developers. Cell line development is an essential underpinning of the drug development process, enabling teams to test, optimise and manufacture therapeutics at a commercial scale.

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Development Protein In-Vivo Life Science 59