BioSpace

NOVEMBER 10, 2020

This model has the benefit of giving companies direct oversight of their in vivo studies, allowing them to move faster while operationalizing every dollar of their seed financing.

In-Vivo 123

In-Vivo Marketing 123

Pharmaceutical Technology

MARCH 16, 2023

The partnership will use nanotechnology, which was proven in vivo, for providing antibodies inside tumour cells and provides a potential solution to address the medical challenge. These antibodies will be provided to pharma companies for conducting late-stage development and marketing.

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Antibody In-Vivo Pharma Companies Protein 262

FDA Law Blog

MARCH 19, 2024

using phantoms, ex vivo animal tissue models, and/or in vivo animal testing), computationally, and/or clinically. When in vivo animal testing is needed, tests should follow good laboratory practices and the animal model should be representative of the intended clinical application.

In-Vivo 59

In-Vivo Marketing Regulation Development 59

Pharmaceutical Technology

FEBRUARY 23, 2023

Moderna has entered a strategic research and development partnership with ElevateBio’s Life Edit Therapeutics to discover and develop new in-vivo mRNA gene editing therapies. Our novel editing systems have the potential to precisely modify gene targets for both in vivo and ex vivo therapeutic development.”

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Gene Editing Gene In-Vivo Gene Therapy 147

Drug Discovery World

APRIL 18, 2023

While the global proteasome inhibitors market is expected to reach nearly $2.3 Comparison to Velcade In a head-to-head study, AVA2727D killed cancers cells (ex-vivo) as effectively as bortezomib (Takeda’s Velcade) which is one of the approved proteasome inhibitors on the market.

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In-Vivo Clinical Development Development Drugs 97

pharmaphorum

JUNE 23, 2022

Novartis has shouldered its way into the in vivo gene editing category via a deal with US biotech Precision BioSciences, focused on a therapy for sickle cell disease (SCD). billion in potential milestones if the project advances through development and onto the market. billion agreement that started in 2020.

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Gene Editing In-Vivo Gene Sequencing Gene 97

Drug Discovery World

AUGUST 14, 2023

While CGT is still an emerging market, its growth has accelerated over the last five years, resulting in a wave of products approved by the US Food and Drug Administration (FDA) and the European Medicines Agency (EMA). Driven by the rapid pace of innovation, the market for CGTs is expected to grow from $4.4 billion in 2020 to $15.5

Gene Therapy 52

Gene Therapy Marketing Gene DNA 52

The Pharma Data

JANUARY 17, 2021

But that number doesn’t quite reflect the company’s likely market valuation , which is expected to be between $9 billion and $12 billion. Based in Seattle, Washington, Sana focuses on in vivo and ex vivo cell engineering platforms to develop therapies for cancer, diabetes, cardiovascular disease, CNS disorders, and genetic diseases.

In-Vivo 52

In-Vivo Marketing Engineer Genetics 52

BioPharma Reporter

JULY 19, 2021

Celltrion Group has reported that data from an in vivo efficacy study shows that its monoclonal antibody treatment for COVID-19, regdanvimab (CT-P59), has a strong neutralizing effect against the rapidly spreading Delta variant.

Antibody 111

Antibody In-Vivo Regulation Marketing 111

BioPharma Reporter

AUGUST 30, 2021

Seattle-based Umoja Biopharma, a company looking to reprogram immune cells in-vivo to create next-generation immunotherapies for the treatment of solid tumors and hematologic malignancies, has started work on its new development and manufacturing facility in Colorado.

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Manufacturing In-Vivo Development Regulation 98

Drug Discovery World

JANUARY 18, 2024

Poolbeg Pharma, a biopharmaceutical company focused on the development and commercialisation of medicines targeting diseases with a high unmet medical need, has announced promising in vivo results for POLB 001 in addressing cancer immunotherapy-induced cytokine release syndrome (CRS). million cases of cancer by 2030 1,2.

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In-Vivo Antibody Clinical Trials Clinical Trials 64

Pharmaceutical Technology

AUGUST 17, 2022

Merck (MSD outside North America) has entered a partnership agreement with Orna Therapeutics for discovering, developing and marketing various programmes based on next-generation RNA technology. These programmes will include therapies and vaccines in infectious disease and oncology areas.

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RNA Vaccination Vaccine In-Vivo 147

pharmaphorum

OCTOBER 8, 2021

This year, we’ll be specifically focusing on next generation cell therapies and discussing: Novel in vivo delivery. This year, we’ll be specifically focusing on next generation cell therapies and discussing: Novel in vivo delivery. next generation innovations in cell therapies.

In-Vivo 52

In-Vivo Gene Manufacturing Marketing 52

Drug Discovery World

MAY 26, 2023

There are currently no treatments on the market that effectively reverse scarring. AM1476 has been found to ameliorate key fibrotic pathways in vivo and ex vivo with the potential to halt and reverse scarring with potential utility across fibrotic disease.

In-Vivo 52

In-Vivo Trials Marketing Drugs 52

Drug Discovery World

AUGUST 3, 2023

The transaction expands Sygnature’s business operations into the North American market. NuChem Sciences employs over 300 staff in Montreal and Quebec City, Canada, where the company will continue to operate and drive further market expansion across North America.

In-Vivo 52

In-Vivo In-Vitro Protein Marketing 52

Drug Discovery World

APRIL 15, 2024

Gene therapy will move to ex vivo gene modification and the delivery of gene-modified cell types. DDW’s Megan Thomas speaks to experts from the drug discovery industry about their predictions on the future of stem cells in drug discovery. In addition, I believe we will see more exosome-based therapies enter the clinic in 2024.

Gene Editing 59

Gene Editing Clinical Trials Clinical Trials In-Vivo 59

Pharma Marketing Network

DECEMBER 21, 2020

those that modify the expression of an individual’s genes or repair abnormal genes) has entered clinical practice, including 11 RNA therapeutics, 2 in vivo gene therapies, and 2 gene-modified cell therapies. Almost two decades after the human genome was sequenced, a trickle of new genetic medicines (i.e.,

Genetics 52

Genetics Medicine Gene Therapy Marketing 52

Pharmaceutical Technology

OCTOBER 5, 2022

In 2010, two patients with end-stage refractory chronic lymphocytic leukaemia (CLL) were administered Novartis’ autologous anti-CD19 chimeric antigen receptor T-cell (CAR-T) therapy, Kymriah (tisagenlecleucel), as part of a Phase I trial.

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In-Vitro In-Vivo Sales Clinical Trials 279

Drug Discovery World

FEBRUARY 13, 2024

It has demonstrated efficacy in in vitro and in vivo models of fibrosis, as well as favourable safety and pharmacokinetic profiles in Phase I clinical studies. It has demonstrated efficacy in in vitro and in vivo models of fibrosis, as well as favourable safety and pharmacokinetic profiles in Phase I clinical studies.

Drugs 52

Drugs In-Vivo In-Vitro Medicine 52

pharmaphorum

JANUARY 29, 2021

California-based Sangamo Therapeutics is one such company that believes in the powerful potential of in vivo genome editing and regulation, together known as genome engineering, and has built up a sizable preclinical pipeline of genome regulation treatments for diseases such as Huntington’s disease and Amyotrophic lateral sclerosis (ALS).

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Gene Editing Gene Gene Therapy In-Vivo 145

Camargo

DECEMBER 22, 2021

In addition, the size and complexity of a development program can vary significantly depending on product characteristics, market dynamics, and regulatory pathway. Gaining a thorough understanding of these factors can significantly impact development strategy and increase the likelihood of marketplace success. Clinical Pharmacology.

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Bioequivalency Production Genotoxicity In-Vivo 169

Pharmaceutical Technology

SEPTEMBER 14, 2022

As an autologous cell therapy, manufacturing the infusion product is a highly specialised process involving tumour harvest and the extraction and large-scale ex vivo expansion of TILs. Tumour-infiltrating lymphocyte (TIL) therapy has been investigated as a treatment modality for melanoma for almost 20 years. versus 21.4% respectively.

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Immune Response In-Vivo Production Manufacturing 246

Drug Discovery World

APRIL 4, 2023

The designation is the first step to gaining a priority review voucher (PRV), which can accelerate market access for therapeutics. The Food and Drug Administration (FDA) in the US has made several key drug decisions over the last few weeks. Here’s a summary. The drug was granted orphan drug designation by the FDA in May 2021.

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FDA Approval In-Vivo Gene Editing Drugs 52

Pharmaceutical Technology

MARCH 9, 2023

Innovation S-curve for the pharmaceutical industry Transgenic murine models is a key innovation area in pharmaceutical s Transgenic murine models refer to mice that have been genetically altered for the purposes of understanding the in vivo functions of genes. Regeneron Pharmaceuticals is the leading patent filer in transgenic murine models.

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In-Vivo Antibody Genetics Gene 130

pharmaphorum

SEPTEMBER 28, 2022

Vertex Pharma and partner CRISPR Therapeutics will start a rolling marketing application in the US for their gene-editing drug for sickle cell disease (SCD) and beta thalassaemia later this year. The time places exa-cel in pole position to become the first drug developed based on CRISPR/Cas9 gene-editing technology to reach the market.

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Gene Editing Gene In-Vivo Clinical Trials 57

Drug Discovery World

FEBRUARY 15, 2024

The etherna paradigm for cLNP design is ushering in the rapid generation of novel families of delivery systems for not only vaccination but also for in vivo tolerisation for a host of autoimmune diseases.” The post LNP formulations produce strong immune responses, data shows appeared first on Drug Discovery World (DDW).

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Immune Response In-Vivo Vaccination Vaccine 52

The Pharma Data

DECEMBER 9, 2020

Vigil’s $50 million Series A financing, completed this week, was powered by Atlas Ventures and Northpond Ventures, and includes participating investors Hatteras Partners and Alexandria Venture Investments. Atlas cofounded, seeded and incubated Vigil, with pre-clinical stage assets in-licensed from Amgen Inc., which will remain a key shareholder.

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Marketing In-Vivo Protein In-Vitro 52

The Pharma Data

JUNE 7, 2023

Acuitas’ LNP technology will support Bayer’s in vivo gene editing and protein replacement programs by specifically delivering RNA payloads to the desired target organ, the liver. a biotechnology company specializing in the development of lipid nanoparticle (LNP) delivery systems for molecular therapeutics. Source link: [link]

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Gene Therapy Gene Gene Editing In-Vivo 40

Roots Analysis

FEBRUARY 15, 2023

Recent activity in Bioavailability Enhancement Market At present, the bioavailability enhancement technology and service providers are actively trying to consolidate their presence in this field by entering into strategic alliances, to meet the indubitably rising demand for effective therapeutics.

Bioavailability 52

Bioavailability In-Vivo Marketing Drugs 52

Camargo

NOVEMBER 11, 2020

When the FDA requires a product’s labeling to include a boxed warning (also called a “black box warning” because the text is surrounded by black border), the potential market value of the drug often drops severely. The “skinny label” has been used many times previously to enable ANDA applicants to reach the market in similar circumstances.

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Development Bioequivalency Generic Drugs Production 242

pharmaphorum

FEBRUARY 13, 2022

Quris’ BioAI safety prediction platform – which is based on human tissue samples on chips, nanosensors and machine learning – will be compared to traditional in vitro and in vivo laboratory techniques for spotting toxicity. The post Merck will assess Quris’ AI ‘patient-on-a-chip’ drug safety appeared first on.

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Drugs In-Vivo In-Vitro Pharma Companies 98

Drug Discovery World

MARCH 4, 2024

DDW Editor Reece Armstrong speaks to Abraham Wang , Head of Marketing at Collaborative Drug Discovery (CDD) about annotated assays and the advantages they bring to research teams. RA: What advantages can better analysis into assays bring to drug developers? All of these can delay research progress and jeopardise intellectual property claims.

Drugs 59

Drugs Bioassay Scientist In-Vivo 59

pharmaphorum

APRIL 12, 2021

C4XD said it has developed a molecule small enough to be formulated into a pill, which has also been able to block IL-17 in vivo. We believe that our small molecule programme has the potential to create high value, efficacious and convenient oral IL-17 therapeutics for this large market.

Drugs 52

Drugs In-Vivo Licensing Licensing 52

pharmaphorum

MAY 27, 2021

Life sciences tools company Esco Lifesciences Group has scored $200m in a series A and crossover round co-led by Novo Holdings and Vivo Capital. He added that the Asian market had shifted and was no longer purely price reliant. The post Novo Holdings leads $200m financing into Esco Lifesciences Group appeared first on.

Life Science 57

Life Science In-Vivo Manufacturing Gene Therapy 57

Drug Discovery World

APRIL 10, 2023

It is emerging markets like India that analysts expect to spearhead the global growth of the pharmaceutical sector 1. The pharmacy of the world In the global pharmaceuticals market, India ranks third worldwide for production by volume. India’s domestic pharmaceutical market is expected to reach US$120-130 billion by 2030 2.

Genome 52

Genome Genomics Drugs Life Science 52

pharmaphorum

NOVEMBER 24, 2021

The Oslo-based company is getting $50 million upfront from Regeneron – split between cash and an equity investment – with another $875 million on the table if the partnered projects make headway through development and reach the market.

Vaccination 52

Vaccination Vaccine In-Vivo Manufacturing 52

pharmaphorum

JUNE 12, 2022

CTX001 is an ‘ex vivo’ application of gene-editing, in which the technology is used to modify a patient’s own cells outside the body to make foetal haemoglobin (HbF), which can serve as a substitute to regular haemoglobin in both diseases. billion product if it gets approved for both indications.

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Gene Editing Gene Gene Therapy Drugs 57