Drug Discovery World

JANUARY 19, 2024

UK scientists have uncovered the interplay between cancer-driving genetic mutations and inherited genetic variants in a rare type of blood cancer. The study describes how inherited genetic variants can influence whether a spontaneous mutation in a particular gene increases the risk of developing this rare blood cancer.

Genetics 59

Genetics Gene DNA Development 59

XTalks

DECEMBER 14, 2022

Expanding upon the CRISPR-Cas9 gene editing system, researchers at MIT have designed a new technique called PASTE gene editing that can cut out defective genes and replace them with new genes in a safer and more efficient way. The MIT research team turned to a family of enzymes called integrases to meet their goal.

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Gene Editing DNA Gene Gene Sequencing 98

Scienmag

MAY 6, 2021

Jude Children’s Research Hospital scientists have developed a highly efficient method to address a major challenge in biology–identifying the genetic ‘switches’ that regulate gene expression. Jude Children’s Research Hospital St. Credit: St.

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Gene Expression Regulation Gene DNA 97

pharmaphorum

JANUARY 18, 2023

In 2016, scientists behind a study called the Resilience Project analysed genetic data from 589,000+ people and found 13 adults who carried genetic variants that should have resulted in serious – even deadly – childhood disease, but who were apparently healthy. Giving participants something in return. with their priorities.

Genetic Disease 86

Genetic Disease Genetics Research Genome 86

STAT News

OCTOBER 3, 2022

A Swedish scientist won the 2022 Nobel Prize in medicine or physiology on Monday for his groundbreaking research into the evolutionary history of humankind. Pääbo unlocked scientists’ understanding of how genes from these extinct relatives have been passed down to present-day humans.

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Medicine Contamination Research DNA 142

Drug Discovery World

JULY 19, 2022

Non-coding or ‘junk’ DNA could contribute to the development of certain cancers due to how it disrupts the replication of the genome, scientists have discovered. . A team from The Institute of Cancer Research (ICR), London reconstituted the entire process of DNA replication in a test tube in order to understand it more completely.

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DNA Genome Genomics Genetics 52

Scienmag

FEBRUARY 23, 2021

CRISPR gene editing has transformed research, but it is not perfect, and can sometimes target unintended genes; to watch CRISPR enzymes respond to different genes, Leipzig University researchers developed a new method using DNA origami and were able to me Credit: Image courtesy of Julene Madariaga Marcos.

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DNA Gene Gene Editing Scientist 56

Medical Xpress

DECEMBER 1, 2022

Research on understanding the effect of extra chromosomes for conditions like Down syndrome typically involves examining what genes play a role in the symptoms of these conditions. However, researchers from Germany and the U.S. However, researchers from Germany and the U.S.

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Research Scientist DNA Genetics 75

BioTech 365

FEBRUARY 23, 2021

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: Scientists use DNA origami to monitor CRISPR gene targeting.The remarkable genetic scissors called CRISPR/Cas9, the discovery that won the 2020 Nobel Prize in Chemistry, sometimes cut in … Continue reading →

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DNA Scientist Gene Genetics 40

Scienmag

MARCH 11, 2022

March 11, 2022 — In a paper published today in Sciences Advances, researchers in the Department of Chemistry and the Department of Physics & Astronomy at the University of California, Irvine revealed new details about a key enzyme that makes DNA sequencing possible. Irvine, Calif.,

Genetics 60

Genetics Scientist DNA Research 60

STAT News

MARCH 3, 2023

Next week, hundreds of scientists from around the world will convene in London for an international summit on genome editing. That technology, which enables scientists to easily excise, alter, or replace specific sections of DNA, was awarded the 2020 Nobel Prize for Chemistry. Continue to STAT+ to read the full story…

Genome 111

Genome Genomics Gene Editing Genetic Disease 111

pharmaphorum

DECEMBER 3, 2020

Germany’s Merck KGaA has joined with UK-based Artios Pharma in a potential multi-billion dollar deal to investigate novel DNA damage response targets in cancer. The principle of DNA damage response is already being exploited by AstraZeneca and other companies with their poly (ADP-ribose) polymerase (PARP) inhibitor drugs.

DNA 78

DNA Genetics Research Sales 78

Drug Discovery World

AUGUST 16, 2023

Samir Ounzain , PhD, CEO & Co-Founder of HAYA Therapeutics, looks at how a better understanding of our DNA can lead to increased activity for RNA therapeutics. Many scientists are now discovering that this junk DNA plays an essential role in our biology and the epigenetic processes that respond to the environment to drive disease.

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RNA Genome Genomics DNA 52

Drug Discovery World

OCTOBER 4, 2023

Scientists have discovered the link between gene expression, DNA methylation, and brain structural changes in depression, revealing new potential therapeutic targets. Scientists have long known that there may be a genetic component that confers predisposition to depression, but the specific underlying mechanisms have remained elusive.

Research 52

Research Gene DNA Gene Expression 52

Scienmag

OCTOBER 13, 2021

LA JOLLA—(October 13, 2021) For the past fifteen years, cancer researchers have been using DNA sequencing technology to identify the gene mutations that cause the different forms of cancer.

Scientist 52

Scientist Gene DNA Genetics 52

Drug Discovery World

APRIL 17, 2024

The event will feature experts Daniel Jachimowicz, Senior Bioscience Scientist at AstraZeneca BioPharmaceuticals R&D, Sweden, and Bastian Schiffthaler, Senior Data Scientist at AstraZeneca BioPharmaceuticals R&D, Sweden. The event will be supported by Oxford Nanopore Technologies.

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DNA Genome Genomics Gene Therapy 98

BioTech 365

JUNE 2, 2021

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: New approach to DNA research could be key to solving mysteries of deadly diseases.To

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DNA Research Genome Genomics 40

STAT News

FEBRUARY 7, 2023

From the color of our eyes to our odds of developing cancer, we’re all shaped by the genetic legacy of our ancestors. Both these modifications and their metabolic effects were shown to have passed down for at least three to six generations — something scientists once assumed was impossible. Read the rest…

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Gene DNA Genetics Scientist 105

STAT News

JULY 28, 2022

In a little-noticed study published earlier this year, scientists from Oregon Health & Science University reported the birth of three mouse pups that had been created with a never-before-used recipe for reproduction. Read the rest…

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In-Vitro Research DNA Genetics 98

Drug Discovery World

MAY 8, 2024

The event will feature experts Daniel Jachimowicz, Senior Bioscience Scientist at AstraZeneca BioPharmaceuticals R&D, Sweden, and Bastian Schiffthaler, Senior Data Scientist at AstraZeneca BioPharmaceuticals R&D, Sweden. The event will be supported by Oxford Nanopore Technologies.

Gene Therapy 69

Gene Therapy Gene DNA Genome 69

Drug Discovery World

DECEMBER 29, 2023

A new technique to clone and reassemble DNA could simplify and lower the cost of making synthetic chromosomes, according to its creators at University of Southern California (USC) Dornsife. The thing about most synthetic genomics research is that it involves building chromosomes or genomes from scratch using chemically synthesised DNA pieces.

Genome 52

Genome Genomics DNA Scientist 52

The Pharma Data

FEBRUARY 22, 2022

State-of-the-art facility will headquarter research efforts in Boston and New York to accelerate the development of RNA and DNA-based medicines. Adams, vice president of genetic medicine at Lilly and co-director of the Institute. ” The Institute will be headquartered in 334,000 sq.

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Genetics Medicine RNA Scientist 52

Scienmag

DECEMBER 29, 2020

Method will help researchers better understand mitochondrial DNA diseases LOS ANGELES — Scientists from the UCLA Jonsson Comprehensive Cancer Center have developed a simple, high-throughput method for transferring isolated mitochondria and their associated mitochondrial DNA into mammalian cells.

Scientist 40

Scientist Development DNA Genetics 40

Scienmag

FEBRUARY 26, 2021

Computer scientists show benefits of bioinformatics with PlasmidHawk Credit: Tommy LaVergne/Rice University HOUSTON – (Feb. 26, 2021) – Tracking the origin of synthetic genetic code has never been simple, but it can be done through bioinformatic or, increasingly, deep learning computational approaches.

Bioinformatics 64

Bioinformatics DNA Genetics Scientist 64

Scienmag

SEPTEMBER 29, 2020

Hebrew University researchers inch closer to harnessing DNA molecules for disease detection and electronics Credit: Hebrew University We know that DNA molecules express heredity through genetic information. However, in the past few years, scientists have discovered that DNA can conduct electrical currents.

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DNA Genetics Scientist Research 95

STAT News

APRIL 6, 2023

As scientists gain increasing dexterity in manipulating the basic elements of life, they are designing not only other synthetic vaccines, but also therapies for cancer, benign alternatives to fossil fuels, and even novel approaches to protecting endangered species.

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DNA Scientist Vaccination Vaccine 130

Drug Discovery World

APRIL 16, 2024

This webinar will highlight how long-read nanopore sequencing as a comprehensive and sensitive QC method for rAAVs were evaluated — which is supporting internal research activities at AstraZeneca. A live Q&A session follows the webinar presentation.

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Packaging Packaging Genome Genomics 52

Drug Discovery World

MAY 1, 2024

The event will feature experts Daniel Jachimowicz, Senior Bioscience Scientist at AstraZeneca BioPharmaceuticals R&D, Sweden, and Bastian Schiffthaler, Senior Data Scientist at AstraZeneca BioPharmaceuticals R&D, Sweden. The event will be supported by Oxford Nanopore Technologies.

Packaging 52

Packaging Packaging Genome Genomics 52

Drug Discovery World

APRIL 24, 2024

The event will feature experts Daniel Jachimowicz, Senior Bioscience Scientist at AstraZeneca BioPharmaceuticals R&D, Sweden, and Bastian Schiffthaler, Senior Data Scientist at AstraZeneca BioPharmaceuticals R&D, Sweden. The event will be supported by Oxford Nanopore Technologies.

Genome 52

Genome Genomics DNA Gene Therapy 52

XTalks

JANUARY 26, 2024

Technological advancements are revolutionizing cancer research and therapies. This technology, which allows for precise editing of DNA at specific locations, has been a major focus in the field due to its potential to directly target and modify cancer-causing genes.

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Research Gene Editing Gene Genetics 118

Scienmag

APRIL 8, 2021

Credit: IRB Barcelona In cancer, personalised medicine takes advantage of the unique genetic changes in an individual tumour to find its vulnerabilities and fight it. Many tumours have a higher number of mutations due to a antiviral defence mechanism, the APOBEC system, which can accidentally damage DNA and cause mutations.

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Scientist DNA Genetics Medicine 53

Pharmaceutical Technology

FEBRUARY 16, 2023

Rather than viewing ageing as an inevitability, scientists are beginning to perceive it as a disease, one that could be treated, halted, or even reversed. The biology of ageing Ageing is an intensely complex syndrome influenced by environmental, genetic, and epigenetic factors. The idea of ageing is now being challenged.

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Insulin DNA Genetics Life Science 130

XTalks

AUGUST 29, 2022

CRISPR is notable for engineering living cells, allowing scientists to edit, turn off, delete, or replace genes in a cell’s genome. Viral vectors have traditionally been used in gene editing where the shells of viruses carry the template DNA into cells, but this method has its disadvantages.

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Gene Editing DNA Gene Genome 98

Drug Discovery World

FEBRUARY 28, 2024

Lu Rahman selects some of the year’s interesting and noteworthy advances in cancer research drug discovery and development. In the UK, according to Cancer Research UK, around 167,000 people die from cancer in the UK each year. Research into new drugs and therapeutics is on-going and is helping drive mortality rates down.

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Development Research Drugs Antibody 64

Drug Discovery World

OCTOBER 27, 2022

Cancers can evolve to become more aggressive without relying only on DNA mutations, two major studies have revealed. . The research characterises an extra level of control of cancer gene activity within tumours, which the researchers describe as cancer’s ‘dark matter’. . The research . Epigenetic control .

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DNA Drugs Gene Genetics 52

Drug Discovery World

JULY 5, 2023

Global Cancer Segment Market Manager at Agilent Technologies, recently sat down with DDW Editor Reece Armstrong to tell us about the developments in the ‘golden age’ of cancer research. RA: What is the current state of the cancer research industry? Mark Garner, PhD., MG: I am responsible for Agilent’s cancer segment.

Research 98

Research Protein Scientist Immune Response 98

Drug Discovery World

JANUARY 26, 2023

Cancer cells can shrink or super-size themselves to survive drug treatment or other challenges within their environment, researchers have discovered. Study leader Professor Chris Bakal, Professor of Cancer Morphodynamics at The Institute of Cancer Research, London, said: “We think our research has real diagnostic potential.

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DNA Protein Genetics Research 52