Drug Discovery World

FEBRUARY 12, 2024

In the upcoming year, we will see the expansion of new, more complex markets and updated requirements from regulators. The challenge is harnessing the power of AI within a highly regulated industry. However, organisations need to proactively make a shift, or this change will be forced upon them. “In

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Drug Discovery World

MARCH 30, 2023

Likang Life Sciences has been granted implied approval by China’s National Medical Products Administration (NMPA) for the clinical trial of its innovative personalised neoantigen-targeted vaccine LK101 Injection for advanced solid tumours. Vaccines predicated on neoantigens therefore elicit truly tumour-specific T cell responses.

Regulation 52

Regulation Vaccination Vaccine Trials 52

pharmaphorum

MAY 5, 2021

It’s time to take what the UK has learnt about the “Holy Trinity” of government, academia, and industry and apply it to creating a “life sciences superpower”, says health secretary Matt Hancock. It’s about charting a new, better course… and transforming the UK into a life sciences superpower.

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XTalks

DECEMBER 24, 2020

The pandemic propelled the life science and healthcare sectors onto center stage, and they rose to the occasion against the most unprecedented health challenge in recent times. While COVID-19 has undoubtedly been the biggest story in the life science industry in 2020, it was a busy and positive year in many other areas.

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Life Science Vaccination Vaccine Gene 111

Drug Discovery World

JULY 15, 2022

The first complete, gapless sequence of a human genome was published 1 April 2022 in a special issue of the journal Science 1. While The Human Genome Project mapped about 92% of the human genome two decades ago, sequencing the last 8% of the genome proved highly challenging.

Genome 52

Genome Genomics DNA Containment 52

Drug Discovery World

MAY 6, 2024

Thanks to a prestigious academic legacy, Europe has long been a dominant region for life sciences. Europe is traditionally a life sciences powerhouse, with a strong tradition in pharmaceutical discovery. The oldest, still active pharmaceutical company worldwide, Merck, started life in 1668 in Darmstadt, Germany.

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Drugs Life Science Gene Editing Gene 59

XTalks

JULY 14, 2022

However, there is limited knowledge about the upstream regulators of most genes. Although it was expected that numerous connections exist between the genes regulating the three immune genes, the extent of the connectivity was more elaborate than initially thought. All 24 of the regulators affected the levels of IL2RA.

Gene 98

Gene Regulation Protein Gene Editing 98

Drug Discovery World

MARCH 16, 2023

The biopharma industry must industrialise cell and gene therapy manufacturing to bring these life-saving therapies to a larger scale than ever before, says Dominic Clarke, CTO of Cell & Gene Therapies at Discovery Life Sciences. In practice, the first key to CGT manufacturing and production is a consistent starting product.

Gene Therapy 52

Gene Therapy Gene Manufacturing Life Science 52

Drug Discovery World

JULY 11, 2023

Tim Lowery , President, JSR Life Sciences, asks whether artificial intelligence can do for life sciences what it has done in other sectors and whether these tools can keep up with the complexities of human biology. So, where do we go from here to realise their potential in life sciences?

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Big Data Development Life Science Drugs 40

Drug Discovery World

JANUARY 26, 2023

Colin Terry, European Life Sciences R&D leader at Deloitte, explains: “Revitalising today’s clinical trials processes and operations will drastically improve trial efficiency, enhance science-based decisions, and expand collective health equity. “AI

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Development Drugs Clinical Trials Clinical Trials 98

Drug Discovery World

NOVEMBER 27, 2023

By Anis H Khimani , PhD, Senior Strategy Leader, Life Sciences strategy group, Revvity, Inc. In addition, it has stimulated increased collaboration among drug developers, technology providers, supply chain organisations, and regulators. link] About the author Anis is within the strategy group in Life Sciences at Revvity, Inc.

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XTalks

SEPTEMBER 9, 2021

The federal regulator suspended BioMarin’s currently ongoing Phase I/II studies of the gene therapy based on interim safety findings from a preclinical study which revealed that mice treated with the therapy at high doses developed tumors on their liver. The preclinical study was being conducted to assess the durability of the treatment.

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Gene Therapy Gene Genome Genomics 105

XTalks

MAY 4, 2021

These modifications regulate gene expression without changing the sequence or structure of DNA. The tool could also prove to be safer than conventional CRISPR-based gene therapies as it does not involve DNA editing, and thus would not cause potentially harmful off-target genomic changes. Epigenetic Editing with CRISPR.

DNA 98

DNA Gene Gene Silencing Genome 98

Drug Discovery World

MARCH 6, 2024

Guiding neurological drug discovery and development to success The 20 years since the Human Genome Project has seen transformational advances in the molecular understanding of cancers and rare genetic diseases, leading to genetically informed, personalised selection of therapies and massively improved outcomes for many patients.

Genome 64

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Drug Discovery World

JULY 18, 2023

Rolf Turk , Senior Manager, Genomics Medicine at Integrated DNA Technologies, examines how CRISPR is being used to enhance cancer therapies. Although we have seen accelerated development and application of CRISPR in life sciences, further advancements in this technology may resemble more of a marathon than a sprint.

DNA 98

DNA Genome Genomics RNA 98

pharmaphorum

DECEMBER 9, 2022

The PharmaStars accelerator was set up last year to help bridge the gap between digital health start-ups and potential pharma partners, which can be instrumental in making sure their technologies meet their potential – and help them to navigate the challenges of developing them in the highly regulated healthcare environment.

Life Science 52

Life Science DNA Genome Genomics 52

XTalks

OCTOBER 8, 2020

Aizon hopes that the rebrand will help drive its superior AI and ML-driven analytical platforms to help serve a wide range of industries within the life sciences and food sector. As another recent example, genomics data company Wuxi NextCODE underwent restructuring and has emerged under the new name Genuity Science.

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Manufacturing Life Science Cosmetics Regulation 98

pharmaphorum

APRIL 28, 2021

The results of the text mining report bring light to recently trending protein and genomic terms with a semantic relationship to pancreatic cancer, showing the emergence in research in both X-inactive specific transcript (XIST) and lincoo511 ( fig.1. Eric Gilbert is a life sciences consultant at Elsevier. About the author.

Immune Response 104

Immune Response Life Science Genome Genomics 104

pharmaphorum

MARCH 16, 2021

There are a good number of use cases as to why pretty much every big life science company is choosing us these days,” says Medrano. Life sciences companies are interested in understanding the behaviour of the patients and the pathologies where they are working. AI use in the pandemic.

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Doctors Doctor Life Science Clinical Research 112

Drug Discovery World

MARCH 7, 2023

DDW Editor Reece Armstrong takes a look at Qatar’s drug discovery and life sciences market, exploring how the country is utilising innovative technologies in its approach to healthcare. The Middle East represents one of the world’s most lucrative markets for pharmaceuticals.

Biobanking 52

Biobanking Drugs Genome Genomics 52

XTalks

MAY 4, 2021

These modifications regulate gene expression without altering the sequence or structure of DNA. The tool could also prove to be safer than conventional CRISPR-based gene therapies as it does not involve DNA editing, and thus would not cause potentially harmful off-target genomic changes. Epigenome Editing with CRISPR.

DNA 52

DNA Gene Gene Silencing Genome 52

Drug Discovery World

FEBRUARY 6, 2024

However, many have cautioned against too great a reliance on these tools and emphasised the importance of checks and balances to ensure the systems are properly regulated and results are verified. By making lab automation as easy as using a smartphone, the Flex robot democratises access to automation in life sciences research.”

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XTalks

JANUARY 17, 2024

These databases also typically miss critical information like genomic and molecular data. These are designed from the very beginning to capture comprehensive information, including not just clinical but also social, economic and genomic/molecular factors.

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Clinical Trials Clinical Trials Trials Life Science 52

XTalks

FEBRUARY 4, 2021

The power of leveraging clinical data to decipher disease mechanisms and fuel drug discovery has rapidly grown in the era of genomics and personalized medicine. Genuity Science focuses on population genomics as a tool to derive novel biological insights through partnerships with industry-leading pharmaceutical and biotech companies.

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Research Biobanking Drugs Genome 98

Drug Discovery World

JANUARY 19, 2023

Cell engineering is bringing life science into a new era of biotherapeutic discovery and development, disease modelling, and synthetic biology research. Furthermore, evidence of monoclonality must be provided for all cell lines producing biotherapeutic molecules if they are to receive approval from industry regulators.

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Engineer Bioassay Life Science Genome 52

XTalks

APRIL 5, 2021

Bioinformatics jobs are commonly found in the fields of computer information science, pharmaceuticals, biotechnology, medical technology, computational biology, proteomics and medical informatics. The Human Genome Project could not have succeeded without the use of bioinformatics. How to Become a Bioinformatics Analyst.

Bioinformatics 59

Bioinformatics Engineer Scientist Genome 59

pharmaphorum

JULY 4, 2022

And this is where modern technologies and data-driven medical informatics can really bridge the gaps in rare disease research,” said Dr Joanne Hackett, head of Genomic and Precision Medicine at IQVIA, during a recent pharmaphorum webinar. Navigating rare disease research and treatment.

Genome 104

Genome Genomics Research Medicine 104

Drug Discovery World

SEPTEMBER 26, 2022

Panna Sharma is the President and CEO of Lantern Pharma, a company utilising artificial intelligence (AI), machine learning and genomics to advance the timeline of drug discovery and development. Improvements in technology and changes to worldwide regulations in life sciences has led to an increase in the availability of clinical data.

Drugs 52

Drugs Genome Genomics Clinical Trials 52

Drug Discovery World

NOVEMBER 23, 2023

Narain , PhD, President and CEO of BPGbio asks how a better calibre of biobanks in life sciences can lead to more drugs making it to market. In anticipation of the long-awaited personalised medicine revolution, many different types of biobanks have emerged to catalogue samples. But the utility of biobanks varies.

Biobanking 59

Biobanking Drugs Medicine Genome 59

Drug Discovery World

AUGUST 10, 2022

For example, it is challenging to regulate transgene copy numbers in each T cell, posing safety risks. If the gene does not integrate into the genome, the cell will not become a CAR T cell. The gene could also bury itself in a silenced region of the genome, leaving the gene dormant. Plus, regulators are promoting this growth.

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Manufacturing Gene Genome Genomics 98

XTalks

APRIL 24, 2023

Avoiding Issues in Long-Term Follow-Up FDA guidelines suggest that studies using adeno-associated viral vectors follow patients for at least five years, while for integrating vectors and genome-editing products, a minimum 15-year follow-up period is recommended. As a result, there are several EU regulations and directives to follow.

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Gene Therapy Gene Trials Clinical Trials 95

XTalks

FEBRUARY 27, 2024

These regulations offer benefits such as tax credits, grant funding and extended market exclusivity for approved drugs. Advances in Rare Disease Clinical Research Orphan Drug Legislation Many countries have implemented orphan drug acts to incentivize the development of treatments for rare diseases.

Research 59

Research Drugs Gene Therapy Clinical Trials 59

XTalks

DECEMBER 1, 2020

The addition of methyl groups to DNA bases — namely cytosine and guanine in so-called ‘CpG islands’ — regulates the expression of genes. Grail has an ongoing Circulating Cell-free Genome Atlas study that has more than 15,000 participants, both with and without cancer diagnoses.

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DNA Genome Genomics Regulation 64

XTalks

NOVEMBER 7, 2022

These tumor-derived entities are used to derive genomic and proteomic data. Detection of Genomic Alterations from cfDNA: Targeted, Non-Personalized Approaches. Detection of Genomic Alterations from cfDNA: Personalized, Targeted Assays. Non-personalized approaches can be both in-house or through a service provider.

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Clinical Trials Clinical Trials Trials FDA Approval 98

Drug Discovery World

DECEMBER 8, 2023

These measures collectively fortify the foundation upon which AI-powered advancements in healthcare and life sciences can confidently build their future. Also, this type of therapeutic is so new that only a handful of cell and gene therapies have been evaluated and approved by regulators.

Gene Therapy 64

Gene Therapy Gene In-Vitro Development 64

Drug Discovery World

APRIL 30, 2024

Patients with argininosuccinic aciduria can also experience an imbalance of glutathione regulation, which is important for liver detoxification. He has worked in life sciences and pharmaceutical B2B publishing for seven years and was previously Editor of European Pharmaceutical Manufacturer. J Biomed Sci 2023;30;84.

RNA 52

RNA Protein Vaccination Vaccine 52

XTalks

SEPTEMBER 30, 2020

Type I interferons are critical molecular immune regulators that are at the forefront of antiviral responses early in an infection. In the first study , Casanova’s team found that a B cell auto-immune phenocopy of inborn errors of type I IFN immunity underlies life-threatening COVID-19 pneumonia in at least 2.6 percent of women and 12.5

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