pharmaphorum

JANUARY 26, 2023

2022 was a banner year for genomics. In March, the collaborative T2T consortium published the first complete telomere-to-telomere sequence of the human genome, filling in the last 8% of the 3 billion base pairs that make up our DNA.

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Genome Genomics Genome Project Genetics 129

Medical Xpress

MARCH 27, 2023

To develop treatments that may one day entirely rid the body of HIV infection, scientists have long sought to identify all of the places that the virus can hide its genetic code.

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Medical Xpress

FEBRUARY 21, 2023

A large research project, led by scientists at Sylvester Comprehensive Cancer Center in the University of Miami Miller School of Medicine, Memorial Sloan Kettering Cancer Center, and Weill Cornell Medical College, has found that whole genome sequencing (WGS) can provide much more information about classic Hodgkin lymphoma (cHL) than exome sequencing, (..)

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Scienmag

NOVEMBER 16, 2021

17, 2021 – By coupling machine learning with whole genome sequencing, University of Pittsburgh School of Medicine and Carnegie Mellon University scientists greatly improved the quick detection of infectious disease outbreaks within a hospital setting over traditional methods for tracking outbreaks. PITTSBURGH, Nov.

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Medical Xpress

FEBRUARY 10, 2023

They report their findings in npj Genomic Medicine. Researchers at the National Institutes of Health have discovered a new neurological condition characterized by issues with motor coordination and speech.

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Scientist Genome Genomics Medicine 98

Scienmag

SEPTEMBER 30, 2021

LA JOLLA—(September 30, 2021) Salk Assistant Professor Graham McVicker has been awarded a National Human Genome Research Institute (NHGRI) Genomic Innovator Award, which supports early-career scientists who conduct innovative, creative research in genomics. The award, which provides $2.85

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pharmaphorum

OCTOBER 19, 2022

million ($40 million) first-round financing that will be used to explore so-called ‘dark’ regions of the human genome. M Ventures’ Dr Bauke Anninga said that that the startup has a “differentiated platform technology has the potential to fundamentally shift the way we discover and develop precision medicines.

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Genome Genomics Gene Gene Expression 58

Drug Discovery World

NOVEMBER 7, 2022

A new study led by Medical Research Council-funded researchers from UCL has found that tailoring the analysis of whole genome sequencing to individual patients could double the diagnostic rates of rare diseases. . Consequently, the UK has established itself at the forefront of diagnostic whole genome sequencing. Context .

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Drug Discovery World

OCTOBER 26, 2022

A study by the Qatar Genome Research Consortium, led by Dr Lotfi Chouchane from Weill Cornell Medicine-Qatar, has reported the first landscape of cancer germline mutations – hereditary mutations – in the Qatari population. . These variants increase the risk of developing breast cancer in women and prostate cancer in men. .

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XTalks

MAY 20, 2022

If you enjoy working with biological samples and are enthusiastic about healthcare, a career as a clinical scientist might be just right for you. To start applying to clinical scientist jobs today, head over to the Xtalks Job Search platform. Who is a Clinical Scientist? What is it Like to Work as a Clinical Scientist?

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Drug Discovery World

APRIL 17, 2024

Join DDW for this exclusive free event, ‘ rAAV genome sequencing with Oxford Nanopore uncovers transgene integrity and packaging impurities ’. Recombinant adeno-associated viruses (rAAVs) are considered a promising delivery system for gene therapy medicines. The event will be supported by Oxford Nanopore Technologies.

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DNA Genome Genomics Gene Therapy 52

Drug Discovery World

FEBRUARY 12, 2024

Dr Pandora Pound , Fellow Oxford Centre for Animal Ethics explores the hinderances of animal testing in pharma and why new technologies such AI, genomics and synthetic biology c an further drug development. Why has there been so little progress in medicine? Why has it been so unproductive?

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Medicine Genome Genomics Drugs 59

Roots Analysis

JANUARY 22, 2024

This resulted in the discovery of an individualized concept of treatment known as oncology precision medicine which primarily utilizes the patient’s genomic information to provide gene-targeted diagnostics and therapeutics. What is Oncology Precision Medicine?

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Medicine Genetics Genome Genomics 40

STAT News

MARCH 1, 2023

Genome editing summits are generally friendly, nerdy affairs, but for a moment at a Lisbon hotel last June, the conversation at the FASEB genome engineering conference grew tense. ” It was a rare moment: Tessera had raised around $600 million and passed a $1 billion valuation, but published little in academic medical journals.

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Gene Editing Genetic Disease Genome Genomics 119

Scienmag

FEBRUARY 25, 2021

Publication in Science Credit: David Porubsky, University of Washington In 2001, the International Human Genome Sequencing Consortium announced the first draft of the human genome reference sequence. This reference, however, […].

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Genome Genomics Genome Project Genetics 60

XTalks

OCTOBER 19, 2023

An assay development scientist combines deep biological and biochemical expertise with practical laboratory skills to develop tests that can answer specific biological questions or drive the drug discovery process. Related: Pharmaceutical Scientist Jobs: What to Know Before Applying What Does an Assay Development Scientist Do?

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Scientist Development Research Compliance 59

Scienmag

AUGUST 21, 2020

An international team of scientists used genomic analysis to compare the main cellular receptor for the virus in humans — angiotensin converting […].

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Scienmag

OCTOBER 13, 2021

An artificial intelligence (AI)-based technology rapidly diagnoses rare disorders in critically ill children with high accuracy, according to a report by scientists from University of Utah Health and Fabric Genomics, collaborators on a study led by Rady Children’s Hospital in San Diego.

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Genetics Genome Genomics Scientist 87

STAT News

MARCH 9, 2023

LONDON — Scientists at this year’s genome editing summit spent Tuesday showing the world just how far CRISPR -based medicines for treating human diseases have come in a decade. Continue to STAT+ to read the full story…

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Medical Xpress

DECEMBER 13, 2022

It was a good year for medical research as Swedish scientist Svante Paabo won the Nobel Prize in medicine for discoveries he made regarding human evolution—he spearheaded the development of new techniques that will allow researchers to compare the genomes of modern humans and that of other hominins such as Neanderthals and Denisovans.

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Genome Genomics Scientist Medicine 75

Scienmag

MAY 11, 2021

CAMBRIDGE, MA — In early 2020, a few months after the Covid-19 pandemic began, scientists were able to sequence the full genome of the virus that causes the infection, SARS-CoV-2. MIT researchers have determined the virus’ protein-coding gene set and analyzed new mutations’ likelihood of helping the virus adapt.

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pharmaphorum

JANUARY 18, 2023

In 2016, scientists behind a study called the Resilience Project analysed genetic data from 589,000+ people and found 13 adults who carried genetic variants that should have resulted in serious – even deadly – childhood disease, but who were apparently healthy. Giving participants something in return.

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Genetic Disease Genetics Research Genome 97

Scienmag

SEPTEMBER 8, 2020

NEW YORK, NY (September 8, 2020) – Leading cancer scientists working with the New York Genome Center (NYGC) announced today that grants are being awarded to fund six projects that address the role of ethnicity in several major cancer types, taking advantage of the diversity of patients being treated at health care institutions throughout the (..)

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Scienmag

NOVEMBER 30, 2020

Breakthrough brings Temple researchers and their collaborators closer to a cure for human HIV infection Credit: Temple University (Philadelphia, PA) – Taking a major step forward in HIV research, scientists at the Lewis Katz School of Medicine at Temple University have successfully edited SIV – a virus closely related to HIV, the cause (..)

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Scienmag

FEBRUARY 24, 2021

Credit: © DKFZ Heidelberg Genomics, transcriptomics, proteomics, metabolomics, and others… The “omics” technologies keep revolutionizing medicine and biomedical sciences. They generate a lot of valuable data but pose almost as many challenges.

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Genetics Scientist Research Genome 52

Pharmaceutical Technology

FEBRUARY 3, 2023

The field of genomic medicine has reached a true turning point. With scientists fervently developing mRNA vaccines, nucleic acid therapeutics, and viral vector-based gene therapies, clinicians are set to have a growing number of tools available to treat a wide range of conditions, from infectious diseases to genetic disorders and more.

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Drug Discovery World

OCTOBER 6, 2023

In celebration of the Nobel Prize for Medicine going to two of the early proponents of mRNA technology for creating therapeutics, Katalin Karikó and Drew Weissman, this week our round-up highlights the importance of genetics, genomics and gene editing in drug discovery.

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Scienmag

JANUARY 12, 2022

Pacific time to coincide with the study’s publication in The New England Journal of Medicine Media contact: Hanae Armitage at (650) 725-5376 (harmitag@stanford.edu) Fastest DNA sequencing technique helps undiagnosed patients find answers in mere hours A new ultra-rapid genome sequencing approach developed by Stanford Medicine scientists and their collaborators (..)

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DNA Genome Genomics Scientist 62

The Pharma Data

FEBRUARY 24, 2022

To develop pharmacological means of targeting both EZH2 and cMyc, they teamed with the chemical biologists at Icahn School of Medicine at Mount Sinai and designed a new small-molecule, MS177, based on the proteolysis-targeting chimera (PROTAC) technology. MS177 targets both EZH2 and cMyc and thus inhibit cancer growth. .

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Scientist Gene Expression Gene Genome 52

BioTech 365

JUNE 10, 2021

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: New method to untangle 3D cancer genome.Northwestern Medicine scientists have invented a new method for resolving rearranged chromosomes and their 3D structures in cancer cells, which can … Continue reading →

Genome 40

Genome Genomics Scientist Medicine 40

Scienmag

APRIL 15, 2021

Team of Japanese and European scientists identify a novel genetic mitochondrial disorder by analyzing DNA samples from three distinct families Credit: Fujita Health University DNA ligase proteins, which facilitate the formation of bonds between separate strands of DNA, play critical roles in the replication and maintenance of DNA.

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Genetics DNA Genome Genomics 105

Scienmag

APRIL 1, 2021

Salk scientists reveal new insights into neurodegenerative disorders and potential for genetic therapies Credit: Salk Institute/Waitt Advanced Biophotonics Center LA JOLLA–(April 1, 2021) Neurons lack the ability to replicate their DNA, so they’re constantly working to repair damage to their genome.

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DNA Genome Genomics Genetics 77

Scienmag

NOVEMBER 20, 2020

Scientists at Goethe University within the international consortium COVID19-NMR refine previous 2D models The genetic code of the SARS-CoV2 virus is exactly 29,902 characters long, strung through a long RNA molecule. It contains the information for the production of 27 proteins.

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Scienmag

MAY 10, 2021

Scientists have made major advances in understanding and developing treatments for many cancers by identifying genetic mutations that drive the disease.

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DNA Genome Genomics Genetics 50

XTalks

APRIL 23, 2024

Related: Organon’s Commitment to Addressing Contraceptive Deserts The Role of DNA Mapping and Data Mining Further innovation can be seen in the integration of personal DNA genome mapping into medical care. Mangiofico suggests leveraging AI to streamline these processes.

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DNA Genome Genomics Pharmacy 59

Pharmaceutical Technology

JULY 5, 2022

Researchers at the UNC School of Medicine have discovered that hepatitis A virus (HAV) replication needs particular interactions between the human protein ZCCHC14 and TENT4 poly(A) polymerases, a group of enzymes. In addition, the scientists later found that the HAV needs TENT4A/B for its replication.

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Protein RNA Genome Genomics 130

Scienmag

OCTOBER 15, 2020

Scientists in Cambodia have used the new IDseq tool to confirm and sequence the whole genome of the country’s first case of COVID-19 Credit: IDseq.net 15th October 2020, Hong Kong: Published today in the journal GigaScience is a new open source, cloud-based tool called IDseq that makes it possible to rapidly detect, identify, and track […]. (..)

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