Drug Discovery World

NOVEMBER 16, 2022

Juvena Therapeutics, a biotechnology company scaling a computational platform to map the therapeutic potential of secreted proteins, has raised $41 million in an oversubscribed Series A, bringing its total funding to $50 million. This platform is applicable across a wide scope of disease indications.

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Drug Discovery World

DECEMBER 19, 2023

Despite VMS, or hot flushes, being a common symptom of menopause, until now, hormone replacement therapy (HRT) was the only treatment. Lack of scientific advancement Before menopause, there is a balance between oestrogen, and the protein neurokinin B (NKB), which regulates the brain’s temperature control centre.

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Hormones Clinical Trials Clinical Trials Medicine 59

XTalks

MAY 31, 2023

Although studies have associated some diets with lower levels of the Alzheimer’s disease biomarker tau protein, such as the Mediterranean and DASH (Dietary Approaches to Stop Hypertension) diets, this study suggests that high sodium intake contributes to the formation of tau tangles (clusters of tau proteins) in the brain.

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Protein Hormones Containment Branding 111

XTalks

SEPTEMBER 28, 2023

This is because the US has more lenient food ingredient regulations, potentially exposing consumers to carcinogens and harmful chemicals. rBST/rBGH The compound rBST, also referred to as rBGH or bovine somatotropin, is a human-made variant of a hormone naturally produced by cows for managing metabolic activities.

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XTalks

NOVEMBER 2, 2021

The test measures levels of C-peptide protein in the blood, which is a byproduct of insulin synthesis that is released from the pancreas along with the hormone. Moreover, current ultrasensitive C-peptide assays can detect levels of the protein in very low ranges of 0.0015–0.0025 nmol/L.

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Insulin Protein Hormones Regulation 98

Roots Analysis

OCTOBER 24, 2023

This has led to their widespread production and extensive use in the treatment of various indications including hormonal imbalances, oncological disorders and respiratory disorders. The ADCs bind to specific proteins or peptides in cancer cells with very high specificity and efficacy influencing the biological functions.

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XTalks

JULY 2, 2021

Currently, there is no scientific evidence to suggest that the vaccines induce any hormonal changes that would lead to irregular periods. This is because the processes that maintain the uterine lining, including the placenta, during pregnancy are different than those that regulate the normal menstrual cycle.

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pharmaphorum

SEPTEMBER 14, 2020

The drug zeroes in on cancer cells expressing a protein known as LIV-1 and is in phase 1 development for breast cancer and other solid tumours. LIV-1 is a zinc transporter that is regulated by oestrogen and present in increased amounts in oestrogen-receptor positive breast cancer as well as in tumours that have spread to the lymph nodes.

Genetics 52

Genetics Development Drugs Protein 52

Delveinsight

AUGUST 31, 2021

FDA’s Green Flag to Ascendis’s Once-Weekly SKYTROFA for Treatment of Pediatric Growth Hormone Deficiency. Growth Hormone Deficiency , commonly known as dwarfism, can constitute short stature and complications with metabolism, which arise due to inadequate production of growth hormones by the pituitary gland inside the body.

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Hormones FDA Approval Development Drugs 60

XTalks

MARCH 13, 2024

Hormone-based therapeutics aim to delay glaucoma progression by enhancing estrogen’s potential protective effects. Secondly, other funded research is exploring differential gene expression regulated by DNA methylation.

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Gene Therapy Gene Life Science DNA 111

Drug Discovery World

AUGUST 21, 2023

GLP-1 is a hormone that is produced naturally in the brain and the gut in response to food ingestion. Novo Nordisk is currently funding a study at the University of Oxford investigating the effect of semaglutide on the rate of accumulation of tau protein in the brain in Alzheimer’s disease (AD).

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XTalks

SEPTEMBER 17, 2020

Often, the potential patient pool for a given trial is small and the unmet need is high, incentivizing drugmakers and regulators to find innovative ways to make game-changing therapeutics available to those who need them most. Symptoms and Etiology: Caused by an overproduction of growth hormone, acromegaly primarily affects adults.

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Trials Gene Hormones Clinical Trials 98

Pfizer

AUGUST 15, 2022

Current variants of concern can be resistant to treatments that work by binding to the spike protein found on the surface of the SARS-CoV-2 virus. Microsomal triglyceride transfer protein inhibitor: lomitapide. Cystic fibrosis transmembrane conductance regulator potentiators: lumacaftor/ivacaftor. Opioid antagonists: naloxegol.

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Medical Xpress

MARCH 7, 2023

Sex differences exist in the regulation of energy homeostasis. Current studies indicate for instance that female mammals, including humans, are better protected against metabolic diseases during reproductive age. This is particularly important with regard to obesity, whose prevalence has tripled since 1975.

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Hormones Protein Regulation 75

Roots Analysis

AUGUST 31, 2023

Further, the expression of any gene is dependent on the rate at which it is transcribed into mRNA and translated into proteins. There are various regulatory proteins or transcription factors that are responsible for affecting the transcription rate. When activator binds to the operon, it either speeds up or permits gene expression.

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Gene Gene Therapy Gene Expression Regulation 40

The Pharma Data

MAY 15, 2021

Page 311 – Knowing how keeping your body’s PH level normalized is your key to preventing most diseases (cardiovascular, diabetes, cancer, hormone imbalance, immune deficiency, kidney problems, headaches, etc.). Learn a simple method to test your body’s PH level and how you can easily keep it within safe levels.

Doctors 52

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Pfizer

JANUARY 27, 2023

Current variants of concern can be resistant to treatments that work by binding to the spike protein found on the surface of the SARS-CoV-2 virus. Contraception: Use of ritonavir may reduce the efficacy of combined hormonal contraceptives. In preclinical studies, nirmatrelvir did not demonstrate evidence of mutagenic DNA interactions.

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The Pharma Data

FEBRUARY 8, 2021

Metastatic castration-sensitive prostate cancer, also known as metastatic hormone-sensitive prostate cancer (mHSPC), refers to prostate cancer that still responds to hormonal therapy and has spread beyond the prostate to other parts of the body. [4]. About Metastatic Castration-Sensitive Prostate Cancer. About ERLEADA ® (apalutamide).

HR 52

HR Hormones Development Production 52

Drug Discovery World

AUGUST 31, 2023

Could boost immune response to cancer The scientists demonstrated that thymic stem cells contribute to the environment by producing proteins of the extracellular matrix, which functions as their own support system.

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Drug Discovery World

AUGUST 21, 2023

However, because these cancers are not driven by any of the three molecules that can be blocked by targeted hormone receptor drugs, current treatment options are limited. The regulator had already approved the combination treatment in advanced cancers the previous year. months for those who received chemotherapy alone.

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Protein Trials Clinical Trials Clinical Trials 52

The Pharma Data

NOVEMBER 2, 2020

2, 2020 — An experimental antibody drug that targets one of the body’s key metabolism regulators may help obese people lose weight — at least briefly. That’s one finding from an early study that tested the injection drug, which mimics the effects of a natural hormone called fibroblast growth factor 21 (FGF21).

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XTalks

FEBRUARY 8, 2024

for a one-month supply Why it did so well: Jardiance belongs to a class of drugs known as sodium-glucose co-transporter 2 (SGLT2) inhibitors, inhibiting the SGLT2 protein in the kidneys to lead to the excretion of excess glucose through the urine. Jardiance brought in $2.06 billion for Eli Lilly and $6.23 billion for Boehringer Ingelheim.

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Sales Insulin FDA Approval Drugs 52

Pfizer

JANUARY 27, 2023

Working with collaborators, we have conducted research where the original SARS-CoV-2 virus has been used to express the spike protein from new variants of concern. and global regulators for all antiviral products and are carried out by many companies and academic institutions in the U.S. and around the world.

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The Pharma Data

AUGUST 3, 2021

Initial data from LUMAKRAS in combination with a mitogen-activated protein kinase kinase (MEK) inhibitor and LUMAKRAS in combination with an oral EGFR inhibitor are planned to be submitted for presentation at a Q4 2021 medical conference. Bemarituzumab. Tarlatamab (AMG 757). AMG 451 / KHK4083. Rozibafusp alfa (AMG 570).

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Sales Production Antibody Development 52

The Pharma Data

JANUARY 27, 2021

These include in-vitro assays, cell-based phenotypic assays, safety pharmacology and efficacy, ADME toxicology, medicinal chemistry design, synthetic chemistry, and custom proteins and assay development capabilities. The reader is cautioned that assumptions used in the preparation of any forward-looking information may prove to be incorrect.

In-Vitro 52

In-Vitro Containment Drugs Production 52

XTalks

FEBRUARY 5, 2024

Sandostatin (Octreotide) Sandostatin 2022 sales: $1.238 billion Company/Developer: Novartis Date of first FDA approval: October 21, 1988 Indications Sandostatin is FDA-approved for: Sandostatin is a synthetic protein closely resembling the natural hormone somatostatin in the human body. mg implant) is around $1,006.

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FDA Approval Drugs Sales Development 101

Pfizer

DECEMBER 13, 2022

Current variants of concern can be resistant to treatments that work by binding to the spike protein found on the surface of the SARS-CoV-2 virus. Microsomal triglyceride transfer protein inhibitor: lomitapide. Cystic fibrosis transmembrane conductance regulator potentiators: lumacaftor/ivacaftor. Opioid antagonists: naloxegol.

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Drugs Licensing Licensing Production 110

XTalks

AUGUST 2, 2023

5) Ibrance (palbociclib) Ibrance is a chemotherapy drug indicated for hormone receptor positive (HR+), human epidermal growth factor receptor 2-negative (HER2-) metastatic breast cancer. It is a CDK 4/6 inhibitor that is taken in combination with other hormonal therapies to stop the growth of cancer and healthy cells. billion in 2022.

Sales 98

Sales Manufacturing FDA Approval Life Science 98

Pfizer

DECEMBER 20, 2022

Current variants of concern can be resistant to treatments that work by binding to the spike protein found on the surface of the SARS-CoV-2 virus. Microsomal triglyceride transfer protein inhibitor: lomitapide. Cystic fibrosis transmembrane conductance regulator potentiators: lumacaftor/ivacaftor. Opioid antagonists: naloxegol.

Drugs 69

Drugs Licensing Licensing Containment 69

XTalks

FEBRUARY 5, 2024

Sandostatin (Octreotide) Sandostatin 2022 sales: $1.238 billion Company/Developer: Novartis Date of first FDA approval: October 21, 1988 Indications Sandostatin is FDA-approved for: Sandostatin is a synthetic protein closely resembling the natural hormone somatostatin in the human body. mg implant) is around $1,006.

FDA Approval 52

FDA Approval Drugs Sales Development 52

Pfizer

NOVEMBER 23, 2022

Current variants of concern can be resistant to treatments that work by binding to the spike protein found on the surface of the SARS-CoV-2 virus. Microsomal triglyceride transfer protein inhibitor: lomitapide. Cystic fibrosis transmembrane conductance regulator potentiators: lumacaftor/ivacaftor. Opioid antagonists: naloxegol.

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The Pharma Data

MAY 14, 2021

We have many hormones in our bodies, but when they are balanced they keep our bodies and our hair healthy. One of the most important hormones is Testosterone. While it is considered a men’s hormone, both men and women need it to grow and heal bones and muscles.

Production 52

Production Hormones Doctors Doctor 52

The Pharma Data

FEBRUARY 8, 2021

Hypothyroidism — In 2 randomized studies, hypothyroidism was reported for 8% of patients treated with ERLEADA ® and 2% of patients treated with placebo based on assessments of thyroid-stimulating hormone (TSH) every 4 months. The safety profile was consistent with prior studies of ERLEADA ® , with no new safety signals observed.

HR 52

HR In-Vitro Development Clinical Trials 52

The Pharma Data

MAY 13, 2021

Following this program will help you lose weight fast, prevent yo-yoing, stabilize hormonal balance, and get back on track to leading a healthy life – all while never being hungry or having to go to the gym! Effects of glucose-to-fructose ratios in solutions on subjective satiety, food intake, and satiety hormones in young men.

Insulin 52

Insulin Production Hormones Medicine 52

The Pharma Data

JUNE 18, 2021

The BTK protein sends important signals that tell B cells to mature and produce antibodies. About VENCLEXTA ® /VENCLYXTO ® (venetoclax) VENCLEXTA ® /VENCLYXTO ® (venetoclax) is a first-in-class medicine that selectively binds and inhibits the B-cell lymphoma-2 (BCL-2) protein. Isolated growth hormone deficiency. ? N Engl J Med.

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The Pharma Data

JUNE 18, 2021

The BTK protein sends important signals that tell B cells to mature and produce antibodies. VENCLEXTA ® /VENCLYXTO ® (venetoclax) is a first-in-class medicine that selectively binds and inhibits the B-cell lymphoma-2 (BCL-2) protein. VENCLXEXTA/VENCLYXTO targets the BCL-2 protein and works to help restore the process of apoptosis.

Medicine 52

Medicine Production FDA Approval Trials 52

The Pharma Data

MAY 14, 2021

It’s all based on human biology… I refer to it as your “metabolism switch”… But the scientific name for it is AMP-activated protein kinase…. Which is your #1 fat-storing hormone. Their waists got smaller… They also saw an improvement in fat-regulating hormones. How little you exercise….

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