Pharma Times

JULY 22, 2022

Molecular clamp technology is a protein tag that stabilises a wide range of complex viral proteins

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Development Protein Vaccination Vaccine 117

Scienmag

NOVEMBER 17, 2020

Credit: © Andreas Reicher / CeMM Until now, scientists typically studied the changes of proteins and their roles in the cell by using a fluorescent tag to label and follow one protein at a time. This approach limited the number of proteins that could be studied and precluded unbiased discovery approaches.

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The Pharma Data

MARCH 23, 2022

Polymerase is a viral protein that directs how Ebola virus replicates its genome as it infects new hosts. The researchers discovered that Ebola virus polymerase hijacks a cellular protein called GSPT1. To treat Ebola virus infections, researchers are taking a close look at a key piece of the virus: polymerase.

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The Pharma Data

MARCH 7, 2022

By combining CRISPR technology with a protein designed with artificial intelligence (AI), it is possible to awaken individual dormant genes by disabling the chemical “off switches” that silence them. Ruohola-Baker and Levy then fused this designed protein with a disabled version of a protein called Cas9. it can be reawakened.

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Protein Gene Genome Genomics 52

XTalks

JANUARY 7, 2022

The fast-casual pasta chain claims the new noodle has 56 percent fewer net carbs, 30 percent fewer total carbs and 44 percent more protein than traditional wheat noodles, all while maintaining the same taste and appearance as traditional linguine. Related: Better Bagel: The Low-Carb, High-Protein Bagel That’s “Changing the Grain”.

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Scienmag

OCTOBER 19, 2020

A new chemistry technique expands known targets of signaling protein galectin-3, with implications for liver disease and the immune system Credit: Scott Wiseman for Scripps Research October 19, 2020 JUPITER, FL–Human cells are encased by a membrane coated with diverse sugar molecules known as glycans.

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STAT News

JULY 29, 2022

Among the small bunch of billionaires that the local biotech industry has created, Tim Springer may be the only one who regularly rides his bike to work in the Longwood Medical Area, where his ID tag identifies him simply as a “staff scientist.”

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Drug Discovery World

NOVEMBER 7, 2022

CELMoDs are designed to attack cancer by binding to a regulatory protein called cereblon, which then triggers the degradation of key cancer-driving proteins. . One enduring problem for the field has been the fact that some of these drugs bind tightly to cereblon, yet fail to cause sufficient degradation of their protein targets. .

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Drug Discovery World

MARCH 2, 2023

But the new findings answer a fundamental and longstanding question – how epigenetic proteins regulate the processes of transcription and gene expression, through which our genes are read and translated into proteins. But, until now, scientists lacked an understanding of what the chemical tag does, despite many years of research.

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XTalks

OCTOBER 28, 2021

First, while most cake mixes require eggs for structure, color and flavor, the Climate Hero Super Cake mix replaces approximately three eggs with the use of food tech startup Perfect Day’s animal-free milk protein. The resulting protein is then used to make plant-based versions of dairy-based foods. pic.twitter.com/8nWNA5Oya1.

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Protein Packaging Packaging DNA 98

Drug Discovery World

OCTOBER 31, 2022

Click’ chemistry used to tag proteins made by cancer cells. A new method to study the proteins released by cells, which could lead to new biomarkers for diseases including cancer, has been developed by scientists at the Francis Crick Institute and Imperial College London. .

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pharmaphorum

JANUARY 18, 2022

The use of monovalent degraders, which enable the targeted degradation of disease-relevant proteins, offers a new avenue to reach tissue that cannot be targeted with conventional therapeutic agents. Researchers at Almirall have identified several proteins whose abnormal function is associated with inflammatory immune skin diseases.

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The Pharma Data

FEBRUARY 22, 2022

As part of its on-going work to track variants, WHO’s Technical Advisory Group on SARS-CoV-2 Virus Evolution ( TAG-VE ) met yesterday to discuss the latest evidence on the Omicron variant of concern, including its sublineages BA.1 1 in its genetic sequence, including some amino acid differences in the spike protein and other proteins.

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Protein Vaccination Vaccine Genetics 52

The Pharma Data

JANUARY 31, 2021

Utilizing Clover’s proprietary Trimer-Tag© technology, S-Trimer is a trimeric SARS-CoV-2 spike (S)-protein subunit vaccine candidate. Similar to other enveloped RNA viruses such as HIV, RSV and Influenza, SARS-CoV-2 is also an RNA virus that has a trimeric spike (S) protein on its viral envelope.

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XTalks

JULY 16, 2021

But yet, the price tag is still higher than real meat. The basis for the Impossible Burger, for example, is soybean protein, a byproduct of the soybean oil industry. A pound of Beyond Meat’s Beef burgers carries a price tag of $6.25, Vox reported. Sourcing Cheaper Protein. Turning a Profit. The same goes for peas.

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XTalks

JUNE 28, 2023

DMD is caused by the absence of dystrophin, a protein that helps maintain the integrity of muscle cells. Elevidys’ approval was based on data from a randomized trial that showed the therapy increased expression of the Elevidys micro-dystrophin protein, which was used as a surrogate endpoint, in DMD patients aged four to five years of age.

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Gene Therapy Gene Protein FDA Approval 98

Pharmaceutical Technology

FEBRUARY 10, 2023

This is not the first treatment to come with a high price tag. Using this categorization, programmed cell death protein 1 (PD-1)/programmed death ligand 1 (PD-L1) inhibitors saw the greatest percentage of RSAs granted. million, according to GlobalData’s Price Intelligence (POLI), making it the most expensive drug in the world.

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Drug Discovery World

JANUARY 10, 2023

Multiple pillars are used in a complementary fashion to validate each antibody, and the pillars can be variable based on the unique biology of each target protein, or the reagents available for that project. This pillar requires that two or more antibodies directed against different epitopes of a protein generate similar results.

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The Pharma Data

DECEMBER 3, 2020

Utilizing Clover’s proprietary Trimer-Tag © technology, S-Trimer is a trimeric SARS-CoV-2 spike (S)-protein subunit vaccine candidate. Similar to other enveloped RNA viruses such as HIV, RSV and Influenza, SARS-CoV-2 is also an RNA virus that has a trimeric spike (S) protein on its viral envelope. About Trimer-Tag © Technology.

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The Pharma Data

JANUARY 31, 2021

Clover plans to initiate a global Phase 2/3 efficacy trial of its protein-based S-Trimer COVID-19 vaccine candidate adjuvanted with Dynavax’s CpG 1018 plus alum in the first half of 2021 with an interim analysis for vaccine efficacy potentially in the middle of 2021. About Trimer-Tag© Technology.

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The Pharma Data

MARCH 16, 2022

The research scientist at the Max Planck Institute for Medical Research received the award in recognition of his ground-breaking work in establishing various approaches to protein labeling in living cells that have enabled far-reaching advances in chemical and cell biology. Protein labeling (e.g.

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Protein Scientist Gene Development 52

XTalks

JUNE 8, 2021

SMA is caused by mutations in the survival motor neuron 1 ( SMN1) gene, which along with the SMN2 gene, encode the SMN protein. It is administered as a one-time IV administration and expression of the SMN protein from the gene improves muscle movement and function, and ultimately survival. With a price tag of over $2.5

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Gene Therapy Gene Protein Trials 110

Pharmaceutical Technology

APRIL 13, 2023

Although the findings in the report are only preliminary, they shed light at the considerations behind the high price tags of gene therapies. Sickle cell disease is an inherited blood disorder that is caused by mutations in the HBB gene, which codes for the oxygen-carrying protein haemoglobin in red blood cells.

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The Pharma Data

AUGUST 18, 2020

The main focus of the deal is Dragonfly’s monovalent IL-12 immunoglobulin Fc fusion protein known as DF6002, which the company has been investigating in the treatment of both solid and blood cancers.

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Drug Discovery World

NOVEMBER 28, 2023

Importance of healthy mitochondrial function Dysfunctional mitochondria are usually tagged for removal via mitophagy with a protein ‘flag’ called ubiquitin. This paper strongly supports further study of USP30 inhibition as a potential disease-modifying therapy for PD.”

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Pharmaceutical Technology

FEBRUARY 22, 2023

Both drugs are monoclonal antibodies that inhibit the protein PCSK9. Both drugs come with a high price tag. Amgen’s Repatha was greenlit a month later. This lowers the levels of low-density lipoprotein (LDL) cholesterol, which is colloquially known as the “bad” cholesterol.

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XTalks

APRIL 18, 2024

The Elecsys pTau217 assay is designed to detect amyloid pathology, a hallmark of Alzheimer’s disease, by measuring phosphorylated tau protein in human plasma. Previously, Roche secured an FDA breakthrough tag for another one of its Alzheimer’s blood tests that detects levels of pTau-181 and ApoE4 (apolipoprotein e4).

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Clinical Trials Clinical Trials In-Vitro Protein 52

XTalks

AUGUST 17, 2020

protein-based biologics) and vaccine treatments. protein-based biologics) : are those which bind to specific components (i.e. A growing area in the immunotherapy space is the development of biological modulators, which are genetically engineered proteins that target specific components of the immune system.

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pharmaphorum

APRIL 5, 2022

The therapy is a bispecific T cell engager (BiTE) molecule, consisting of a soluble TCR targeting gp100 expressed on cancer cells fused to a protein that binds CD3 receptors on lymphocytes. It’s the first treatment for mUM in the EU, as well as the first BiTE drug to treat a solid tumour.

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XTalks

JANUARY 28, 2022

Kimmtrak has a price tag of $18,760 per vial, which amounts to a weekly dose. Kimmtrak is a bispecific protein that contains a soluble T cell receptor fused to an anti-CD3 immune-effector function. The median treatment time is about 23 weeks (or 5.3 months), so the average cost per patient will be approximately $400,000.

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XTalks

DECEMBER 13, 2023

The disease occurs due to a point mutation in the hemoglobin beta globin ( HBB ) gene that codes for one of the proteins that make up hemoglobin, the oxygen carrier in red blood cells. It also affects Hispanic Americans, but at a lower prevalence. The mutation causes red blood cells to develop a crescent or “sickle” shape.

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Delveinsight

FEBRUARY 9, 2021

The move came not long after healthcare investor giant Deerfield Management has forged a partnership to create the Center for Protein Degradation, investing worth USD 80 million. Deerfield Management has entered into a research agreement with Dana-Farber Cancer Institute to fuel the development of therapeutics and diagnostics for cancer.

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pharmaphorum

DECEMBER 23, 2022

price tag of $475,000 when it was first launched in 2017 – and it becomes apparent that these may not be desirable treatment options for every patient and in every setting. Inobrodib works by targeting twin cancer proteins p300 and CBP, which impacts the expression of cancer drivers including MYC and IRF4.

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Development Drugs Clinical Development Antibody 52

XTalks

AUGUST 25, 2021

But without food sampling, consumers may not be able to justify the $6 price tag, let alone be aware of the brand. . Previously, the brand cut up one of its plant-based, protein-rich bars into four pieces to hand out through an in-store display. But when the pandemic hit, the brand saw the opportunity to partner with local hospitals.

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Branding Marketing Nurses Production 98

XTalks

FEBRUARY 27, 2024

Addressing the high price tag, Iovance’s commercial chief Jim Ziegler said, “Payers have expressed their appreciation for the value proposition for Amtagvi.” TILs can spot tumor antigens derived from intra- or extracellular tumor proteins in the tumor microenvironment. With growing interest in TIL therapies, investors have invested $2.7

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Roots Analysis

JANUARY 28, 2024

Velocity: Big Data needs to be handled promptly as businesses generate data at an unprecedented speed, driven by the growing adoption of Internet of Things (IoT), and technologies, such as RFID tags, sensors, and smart meters are used to deal with the high velocity of data in real-time. It is loosely arranged into categories using meta tags.

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Big Data Medicine Marketing Clinical Trials 40

Delveinsight

FEBRUARY 23, 2021

The company plans to use the capital to expand its pipeline of protein-based vaccines and biologic cancer therapies utilizing its innovative and proprietary Trimer-Tag technology platform. The company develops transformative biologics including vaccines and therapeutics for the world’s most debilitating diseases.

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