The Pharma Data

JULY 11, 2021

Eli Lilly and Company (NYSE: LLY) announced new Phase 2 data showing that gene expression changes induced by mirikizumab in patients with ulcerative colitis (UC) over a 12-week induction treatment were maintained for up to one year. For methodology, see the “About the Studies” section below.

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pharmaphorum

FEBRUARY 9, 2021

InteRNA is focusing on the development of gene-silencing drugs based on microRNA, naturally occurring, non-coding strands of RNA that are thought to regulate gene expression in cells.

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Trials Gene Silencing RNA Gene Expression 59

The Pharma Data

SEPTEMBER 2, 2021

In mice, an antibody directed against this factor was able to slow the growth of metastatic tumors.Blood vessels produce growth factor that promotes metastases. ” With a particular focus on the lung, the researchers performed global gene expression analyses of the metastatic niche.

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The Pharma Data

OCTOBER 15, 2020

On the clinical side, cell and gene therapies must find places where small molecules, antibodies or other traditional approaches may not be the best option. Small molecule and antibody therapies haven’t been able to do that.”. For example, “The era of transplant medicine is unfolding before us,” Culley said.

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Drug Discovery World

AUGUST 3, 2022

This is a common reaction within peptide chemistry and it has been approved by regulatory authorities for various antibody-drug conjugates 4. This work shows great potential for new treatment options for diseases caused by an aberrant gene expression in pancreatic ?-cells, cells, such as diabetes.

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Bioavailability In-Vivo RNA In-Vitro 52

XTalks

MARCH 22, 2021

The biotech acquisition deal includes Five Prime’s prime asset bemarituzumab, which is a first-in-class anti-FGFR2b antibody. The antibody accrued promising data in a randomized, placebo-controlled Phase II study in frontline advanced gastric or gastroesophageal junction (GEJ) cancer, and is now being prepared for Phase III trials.

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Roots Analysis

NOVEMBER 3, 2023

NAD + is involved in a wide range of cellular processes, including energy metabolism, DNA repair, and gene expression. There are several types of NAMPT inhibitors, including small molecules, peptides, and antibodies. NAMPT inhibitors work by blocking the activity of NAMPT, which in turn reduces the production of NAD +.

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Development Drugs Trials FDA Approval 40

pharmaphorum

JANUARY 10, 2023

Xork is designed as a pre-treatment to overcome one of the key limitations to adeno-associated virus (AAV) based gene therapies like AT845, namely that some patients have existing antibodies against the AAV vector that interfere with the treatment. The post Astellas licenses companion drug for Pompe gene therapy appeared first on.

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Gene Therapy Gene Licensing Licensing 119

Drug Discovery World

NOVEMBER 15, 2022

Applications: The ability to synthesise longer, accurate DNA sequences opens up a vast array of application possibilities: generating CRISPR libraries, in situ hybridisation probes, antibody libraries, vaccines, and so on, along with the ability to engineer metabolic pathways, microbes, and plants. .

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DNA Drugs Antibody Engineer 98

Delveinsight

JULY 30, 2020

Roche bets USD 120 Million on UCB’s anti-tau Alzheimer’s antibody. The Swiss pharma, Roche, is handing over USD 120 million upfront for the right of UCB’s anti-tau antibody development. Omega’s platform is designed to adjust gene expression to healthy levels rather than switching genes on and off.

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Genome Genomics Antibody Gene 52

Drug Discovery World

OCTOBER 17, 2023

RA: With spatial biology being cross-disciplinary – in that it uses techniques in both gene expression analysis and immunofluorescence – is expertise in the field limited? Analysing spatial changes during disease progression or treatment response is key to fully understand pathologies. Let’s take CAR T cells as an example.

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Gene Expression Drugs Protein Gene 52

The Pharma Data

DECEMBER 27, 2020

Vir Biotechnology and GlaxoSmithKline dosed the first patient in a new sub-trial of a Phase III study of monoclonal antibody VIR-7831 for hospitalized adults with COVID-19. The drug is a humanized IgG4 monoclonal antibody that blocks CCR5 and is being developed for COVID-19, HIV and metastatic triple-negative breast cancer.

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Trials Antibody Gene Therapy Clinical Trials 52

Roots Analysis

OCTOBER 22, 2023

Coding RNAs include messenger RNA (mRNA) and short interfering RNA (siRNA), which encode proteins and silence gene expression, respectively. RNA interference (RNAi) Therapeutics : Fundamentally, RNAi is a natural process of post-transcriptional gene silencing, involving short strands of nucleic acids.

RNA 40

RNA Protein Genetics Gene Expression 40

Drug Discovery World

FEBRUARY 6, 2023

RNA-Sequencing (RNA-Seq) is a revolutionary technology that enables researchers to assess gene expression changes in thousands of genes over time. This led to better antigen presentation, ultimately improving the efficacy of the vaccine as measured by the degree of protective levels of antibodies post-second dose.

Big Data 52

Big Data RNA Bioinformatics Vaccination 52

Drug Discovery World

APRIL 21, 2023

Atrandi Biosciences’ novel technology platform enables researchers to gain insights into the biology of single cells, offering immediate applications in single-cell sequencing, drug and antibody discovery, functional metagenomics, microbial analysis, directed evolution, and synthetic biology.

Doctors 52

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The Pharma Data

JANUARY 17, 2021

1 and COX-2 gene expression. Preclinical animal models using STP705 have demonstrated a dramatic improvement in T-cell penetration into tumors in the liver with single agent action as well as improvement in the efficacy of an anti-PD-L1 antibody checkpoint inhibitor in an HCC model. About Sirnaomics, Inc.

Gene Expression 52

Gene Expression Trials Production Development 52

The Pharma Data

NOVEMBER 9, 2020

About Tezepelumab Tezepelumab is an investigational, potential first-in-class human monoclonal antibody that works on the primary source of inflammation: the airway epithelium, which is the first point of contact for viruses, allergens, pollutants, and other environmental insults. Amgen will record sales in the U.S. Outside the U.S.,

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Trials Production Sales Manufacturing 52

Drug Discovery World

JULY 18, 2023

It also enables the downregulation of gene expression by directly knocking out the cytoplasmic mRNA transcripts. Another promising approach consists of conjugating antibodies, such as an anti-CD38, to the LNPs for targeted delivery into specific tissues. The system shows potential as a therapy against multiple melanomas.

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The Pharma Data

JULY 8, 2021

“We are proud to advance an innovative, first-in-class monoclonal antibody that targets the top of the inflammatory cascade and represents a potentially transformative treatment option for a broad population of patients with severe asthma. Measures of gene expression in sputum cells can identify TH2-high and TH2-low subtypes of asthma.

Allergies 52

Allergies Trials In-Vivo Medicine 52

XTalks

DECEMBER 24, 2020

Most antibody drugs and vaccines have been developed to target parts of the spike protein. These include remdesivir, baricitinib, dexamethasone and three antibody drugs. Antibody drugs were also developed as targeted COVID-19 treatments. Drug Approvals.

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The Pharma Data

AUGUST 3, 2021

HDACs catalyze the removal of acetyl groups from acetylated lysine residues in histones, resulting in the modulation of gene expression. Istodax ® (romidepsin) for injection is an epigenetic therapy and a member of a class of cancer drugs known as histone deacetylase (HDAC) inhibitors.

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Nurses In-Vitro Gene Expression Medicine 52