Roots Analysis

JANUARY 14, 2024

Biologics activate certain proteins or cells in your immune system to create specific responses to targets, while many conventional systemic drugs activate the entire immune system in a more generalized manner. Insect cell lines have been frequently used as recombinant protein expression systems. cerevisiae) and Pichia pastoris.

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Contract Manufacturing Manufacturing Protein Bacteria 40

Drug Discovery World

NOVEMBER 17, 2022

It is believed that the term synthetic biology was created in 1970 by geneticist, Waclaw Szybalski 1 as work was being carried out on the development of DNA sequencing and synthesis techniques. The Rockefeller University 2 recently reported the development of a synthetic antibiotic that could potentially work against drug-resistant bacteria.

Bacteria 52

Bacteria Engineer Gene Genetics 52

Delveinsight

JULY 26, 2021

Often the bacteria develop antibiotic resistance to certain drugs, leaving it non-effective for the usage the second time in the case of recurrence of the infection that occurs in approximately 30-35% of the uUTI cases, therefore, leaving a serious dearth of the new antibiotics. coli bacteria called FimH.

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Marketing Bacteria Vaccination Vaccine 93

Roots Analysis

OCTOBER 16, 2023

DNA cloning refers to the process of generating multiple copies of a particular DNA segment. DNA and Gene Cloning involves the isolation of a DNA sequence of any species ( often a gene ) and its insertion into a vector to enable growth without any alteration in the original DNA sequence.

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DNA Gene Protein In-Vitro 40

Drug Discovery World

FEBRUARY 6, 2024

Sanofi has stated that it intends to become the first pharma company “powered by AI at scale”, and as part of this ambition, agreed a collaboration with BioMap to co-develop advanced AI models and protein Large Language Models that that it hopes will enable biologics design and multiparametric optimisation 2. Obulytix is not alone.

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Marketing Medicine Genome Genomics 69

The Pharma Data

OCTOBER 19, 2020

The company’s suite of market-leading molecular profiling offerings assesses DNA, RNA and proteins to reveal a molecular blueprint that helps physicians and cancer patients make more precise and personalized treatment decisions.

Life Science 52

Life Science Clinical Trials Clinical Trials RNA 52

XTalks

FEBRUARY 11, 2021

For example, British scientist Rosalind Franklin gained recognition for her work after her death, which is not unheard of, but with it came the revelation that her work, which helped demonstrate the double helical structure of DNA, went largely uncredited by famed DNA duo James Watson and Francis Crick.

Genetics 119

Genetics DNA Genome Genomics 119

Drug Discovery World

APRIL 30, 2024

Its job is to carry coding information that is essential to the translation and processing of functional proteins. This is essential to its use as a therapeutic agent and gives the technology a vast versatility making it suitable to treating a wide range of diseases – especially those that have high protein expression.

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RNA Protein Vaccination Vaccine 52

Drug Discovery World

OCTOBER 11, 2023

Alexander Fleming, the discoverer of penicillin, warned, as early as 1945, against the overuse of antibiotics, suggesting it would select for resistant bacterial species 3 – in fact, penicillin-resistant bacteria were identified before penicillin was approved for use 1,4.

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Bacteria Development Scientist Protein 59

Roots Analysis

AUGUST 31, 2023

coli bacteria, as well as lambda bacteriophage, can adapt to the alterations in the composition of their nutrient medium. Further, the expression of any gene is dependent on the rate at which it is transcribed into mRNA and translated into proteins. When activator binds to the operon, it either speeds up or permits gene expression.

Gene 40

Gene Gene Therapy Gene Expression Regulation 40

Drug Discovery World

APRIL 25, 2024

Grand View Research states that the market for cell lines is currently bolstered by the fact that the majority of biopharma companies use cell lines to synthesise recombinant monoclonal antibodies and proteins. There are a lot of considerations to take when choosing a cell line.

Development 59

Development Protein In-Vivo Life Science 59

Drug Discovery World

MAY 2, 2023

Steve Wowk , VP, Business Unit and General Management of Integrated DNA Technologies, shared with DDW the value of CRISPR-Cas9 in drug discovery. In an effort to defend themselves against viral infection, bacterial cells capture and copy DNA fragments of bacteriophages into their genome. CRISPR libraries: Why do we need them?

Genome 52

Genome Genomics Gene DNA 52

XTalks

FEBRUARY 11, 2021

The drugmaker is targeting various steps in the manufacturing process, beginning right at the DNA stage, which is required as the template from which the mRNA for the SARS-CoV-2 spike protein in the vaccine is made. coli bacteria. The bacteria are grown in large vats, with the process taking two weeks.

Manufacturing 52

Manufacturing Vaccination Vaccine DNA 52

Drug Discovery World

MAY 4, 2023

The magic bullet was the drug, while the specific mark it would reach in the syphilis causing bacteria to eliminate the disease was the drug target. The drug target for Penicillin is a protein that helps bacteria to synthesise its cell wall. Salvarsan was soon overtaken by the Penicillin antibiotics.

Medicine 52

Medicine Protein Drugs Bioassay 52

Roots Analysis

OCTOBER 16, 2023

Biopharmaceutical filtration is a critical step in the production of biopharmaceuticals, including proteins, antibodies, and vaccines. Membrane Filters: Membrane filters are typically used for sterilization and removal of smaller impurities such as bacteria and viruses. are used to remove any residual bacteria, viruses, or endotoxins.

Bacteria 40

Bacteria Production Contamination Protein 40

Drug Discovery World

JULY 18, 2023

Rolf Turk , Senior Manager, Genomics Medicine at Integrated DNA Technologies, examines how CRISPR is being used to enhance cancer therapies. parvovirus B19, Flaviviridae, Ebola, and Coronaviridae), DNA viruses (e.g., Herpesviridae, Polyomaviridae, and Papillomaviridae), bacteria (e.g.,

DNA 98

DNA Genome Genomics RNA 98

Drug Discovery World

AUGUST 10, 2022

The immune system typically identifies foreign entities such as bacteria and viruses and activates lymphocytes such as T cells to destroy them with overwhelming force. To overcome this evasion tactic, the CAR protein was developed to recognise other markers on cancer cells. Identifying the right CAR T cell target.

Manufacturing 98

Manufacturing Gene Genome Genomics 98

pharmaphorum

SEPTEMBER 14, 2020

While there may be just under 20,000 confirmed protein coding genes, it turns out that much of the genome outside of these genes is also important in regulating how the genome is controlled. These technologies directly sequence single molecules of DNA in real time, often without the need for amplification.

Genome 108

Genome Genomics Medicine Gene 108

The Pharma Data

JANUARY 21, 2021

The test valuates mitochondrial DNA levels. When mitochondrial DNA, normally found inside cells, in the mitochondria, spills into the bloodstream, it signals that a particular type of violent cell death is occurring. They measured the patients’ mitochondrial DNA levels on the first day of their hospital stays.

Research 52

Research DNA Hormones Vaccination 52

XTalks

DECEMBER 22, 2021

RNA, and its protein-generating form messenger RNA (mRNA) discovered in 1961 , has quickly transitioned from being an obscure, finicky molecule that is difficult to work with, to becoming a significant cornerstone of therapeutic innovation in pharma and biotech. The RNA Revolution: From mRNA Vaccines to RNA Editing.

Life Science 98

Life Science RNA Vaccination Vaccine 98

XTalks

AUGUST 2, 2023

Johnson & Johnson’s Top 5 Best-Selling Drugs of 2022: 1) Stelara (ustekinumab) Stelara is an immunosuppressant biologic therapy that blocks the IL-12 and IL-23 proteins that play a role in plaque psoriasis and Crohn’s disease. The monoclonal antibody targets CD20, a protein found on the surface of B lymphocytes (B cells).

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Sales Manufacturing FDA Approval Life Science 98

The Pharma Data

OCTOBER 14, 2020

The highly potent and selective payload series represents a powerful new class within ADC development with novel protein alkylating cytotoxicity. -based Iksuda executed its option to secure exclusive, worldwide rights to develop a novel class of tumor-activated prodrug payloads from the University of Goettingen.

Clinical Trials 52

Clinical Trials Clinical Trials Manufacturing Trials 52

XTalks

DECEMBER 24, 2020

SARS-CoV-2 is characterized by an outer surface speckled with spike proteins, giving it a crown-like appearance, hence the name “corona,” which is the Latin word for crown. The spike protein is critical for binding to ACE2 receptors on host cells — this interaction mediates the entry of the virus into cells.

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Life Science Vaccination Vaccine Gene 111