Medical Xpress

JANUARY 12, 2023

A new twin study by researchers from Karolinska Institutet suggests that the same genes may be behind the risk of both cardiometabolic diseases and dementia. Being affected by several cardiometabolic diseases such as diabetes, heart disease and stroke, is linked to a greatly increased risk of dementia and Alzheimer's disease.

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STAT News

JANUARY 6, 2023

… Pfizer told employees it plans to pull back on early-stage research into treatments for rare diseases, including the development of new viral-based gene therapies , Barron’s reports. Among the assets on the chopping block is a gene therapy manufacturing facility in Durham, N.C.,

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Scienmag

MAY 5, 2021

Study published in JAMA Cardiology Credit: UIC/Jenny Fontaine A new mutation found in a gene associated with an increased risk of atrial fibrillation poses a significantly increased risk for heart failure in Black people.

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Medical Xpress

NOVEMBER 7, 2022

A single IV infusion of NTLA-2001, a novel CRISPR/Cas9-based gene editing therapy, significantly reduced circulating transthyretin (TTR) protein levels in patients with ATTR amyloid cardiomyopathy, a progressive and fatal cause of heart failure, according to late-breaking research presented today at the American Heart Association's Scientific Sessions (..)

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Scienmag

FEBRUARY 24, 2021

According to a new study published in The American Journal of Human Genetics, more than one third of genetic variants that increase the risk of coronary artery disease regulate the expression of genes in the liver. These variants have an impact on the expression of genes regulating cholesterol metabolism, among other things. […].

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Scienmag

JANUARY 28, 2021

— In a new study published in Circulation, Mayo Clinic researchers provide the first preclinical, proof-of-concept study for hybrid gene therapy in long QT syndrome, a potentially lethal heart rhythm condition. ROCHESTER, Minn.

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Scienmag

SEPTEMBER 28, 2020

28, 2020 — A veteran’s study identified more than a dozen genes associated with abdominal aortic aneurysm (AAA) that could be used to better identify people at risk for the often-deadly condition, according to new research published today in the American Heart Association’s flagship journal Circulation.

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Scienmag

NOVEMBER 9, 2020

Preeclampsia-related gene expression in the placenta may correlate with vitamin D status during pregnancy, report researchers from the Medical University of South Carolina. Credit: Medical University of South Carolina According to the World Health Organization, preeclampsia affects between 2% to 8% of pregnancies.

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Scienmag

AUGUST 20, 2020

In people with a single-gene variant that puts them at high risk for heart disease, breast cancer, or colorectal cancer, the rest of the genome can alter that risk Life can change dramatically when someone learns they are genetically predisposed to a disease, such as a condition called familial hypercholesterolemia, where a mutated gene can […]. (..)

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Scienmag

DECEMBER 3, 2020

Those two key problems – safety and efficacy – are what continue to hold CRISPR-Cas9 gene targeting back from its full clinical potential, explains co-senior author Y. Eugene Chen, M.D., […].

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Medical Xpress

FEBRUARY 6, 2023

A genetic score may be able to identify higher stroke risk—but only for people living in the most privileged neighborhoods, according to new research that highlights inequities related to wealth and health.

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Scienmag

JANUARY 26, 2021

Authors from the German Center for Diabetes Research (DZD) presented data showing that the longevity gene mammalian Indy (mINDY) is involved in blood pressure regulation in the Journal of Clinical Investigation (JCI) insight.

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Medical Xpress

MARCH 25, 2023

A new study examining the gene expression of gut microbes suggests that the heart-healthy benefits of walnuts may be linked to beneficial changes in the mix of microbes found in our gut. The findings could help identify other foods or supplements with similar nutritional benefits.

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Gene Expression Gene Cardiology 127

STAT News

JULY 12, 2022

Somewhere in New Zealand, the first patient ever has been dosed with a kind of gene-editing treatment known as a base editor, a newer way of utilizing CRISPR for gene editing. The company studying the treatment, Verve Therapeutics, announced the news Tuesday. Continue to STAT+ to read the full story…

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Medical Xpress

JANUARY 20, 2023

A team of researchers at the University of Texas Southwestern Medical Center has found that it is possible in mice to protect the heart from ischemia-reperfusion using the CRISPR-Cas9 gene editing system.

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Medical Xpress

JANUARY 26, 2023

Research in a mouse model of diet-induced obesity has found greater disruption to genes involved in heart function when coupled with vitamin A deficiency using a combined dietary and genetic approach. The study is published ahead of print in the American Journal of Physiology-Heart and Circulatory Physiology.

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Medical Xpress

MAY 10, 2023

In an effort to determine the cause behind a rare condition that causes heart failure in children, University of Maryland School of Medicine (UMSOM) researchers have identified new gene mutations responsible for the disorder in an infant patient.

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XTalks

JULY 19, 2021

The test’s NGS technology achieves a clinical specificity of over 99 percent per condition and the test can detect over 99 percent of potential variants in each gene. As a preventative tool, the test can assist people in taking early action to help mitigate and even prevent health problems.

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Medical Xpress

MARCH 29, 2023

A team of researchers from Ohio University's Heritage College of Osteopathic Medicine has recently discovered a novel role of human-CIDEC gene in improving metabolic dysfunction and cardiovascular health.

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Protein Insulin Research Gene 69

Scienmag

MARCH 25, 2021

Decade-long search uncovers genes responsible for lacunar strokes, a major cause of vascular dementia Scientists have identified new genetic clues in people who’ve had small and often apparently ‘silent’ strokes that are difficult to treat and a major cause of vascular dementia, according to research funded by the British Heart Foundation (..)

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Scienmag

APRIL 28, 2021

— A national, University at Buffalo-led study on genes in pediatric cardiomyopathy demonstrates strong evidence for routine genetic screening in children with the disease. The study, published April 28 in […].

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XTalks

APRIL 15, 2021

Dr. Benoit Tyl, MD, FESC, medical and scientific director, cardiology at Servier, says that the disconnect between correlation and causality in cardiovascular disease trials is partially responsible for the lack of approved HFpEF therapies. However, these drugs have shown limited effectiveness in treating HFpEF.

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Drug Discovery World

NOVEMBER 17, 2023

Asklepios BioPharmaceutical (AskBio), a gene therapy subsidiary of Bayer, has presented first-in-human data from a Phase I trial investigating AB-1002 (also known as NAN-101) for the treatment of patients with congestive heart failure (CHF).

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Gene Therapy Gene Cardiology Trials 105

XTalks

FEBRUARY 16, 2024

Related: Vyjuvek Gets FDA Nod as First Topical Gene Therapy for Rare Skin Disease The active ingredient in Aurlumyn is iloprost, a vasodilator that opens up blood vessels and stops blood from clotting. Blisters, which can affect all layers of skin, typically form 24 hours after exposure and tissue turns black if it starts dying.

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Cardiology Gene Therapy Drugs Branding 59

Scienmag

SEPTEMBER 24, 2020

New light is being shed on a little-known role of Y chromosome genes, specific to males, that could explain why men suffer differently than women from various diseases, including Covid-19.

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Gene Research Cardiology Genetics 60

pharmaphorum

AUGUST 13, 2020

Adding in Regeneron’s antibody resulted in a 49% drop in cholesterol levels from the start of the study compared to patients sticking with their current therapy alone, according to results presented earlier this year at the American College of Cardiology’ congress in March.

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Scienmag

MARCH 31, 2021

Independent of cholesterol, gene variants raise risk of heart disease, diabetes, high blood pressure Credit: In-Hyuk Jung, PhD, Stitziel Lab High cholesterol is the most commonly understood cause of atherosclerosis, a hardening of the arteries that raises the risk of heart attack and stroke.

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The Pharma Data

FEBRUARY 21, 2022

Our leadership in cardiology, radiology and women’s health is recognized worldwide, and we are expanding our presence in oncology, working tirelessly to bring forward new approaches that can change the treatment paradigm for patients,” said Stefan Oelrich, Member of the Board of Management, Bayer AG and President of Bayer’s Pharmaceuticals Division.

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Scienmag

AUGUST 11, 2020

New study identifies frequency of hormone therapy use and predictors of its use in women who underwent preventive oophorectomy as a result of carrying the BRCA gene CLEVELAND, Ohio (August 12, 2020)–Removal of the ovaries before natural menopause (surgical menopause) often exacerbates menopause symptoms and places women at increased risk for (..)

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Scienmag

SEPTEMBER 6, 2020

SCAD is poorly understood, and it’s so far impossible to predict which combination of genes and environmental triggers will lead […].

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Eye on FDA

MARCH 26, 2021

A meeting scheduled for May 8 of the Cellular, Tissue and Gene Therapies Advisory Committee was slated to be a hybrid event – with members of the committee participating virtually and FDA staff appearing onsite at the agency campus, but was altered to become an all-virtual event via Adobe Connect.

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The Pharma Data

MAY 31, 2022

The Company’s cell+gene platform harnesses the power of cells to create new medicines for neurology, cardiology, immunology, and ophthalmology indications.

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The Pharma Data

JANUARY 21, 2021

“While we can’t control our genes, this study gives us more data to promote lifestyle changes early on and have numbers to back us up.” 20 in the journal JAMA Cardiology. 20 in the journal JAMA Cardiology. ” Mora agreed. ” The report was published online Jan. © 2021 HealthDay. .”

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The Pharma Data

OCTOBER 27, 2021

His lab has identified the genes for many of these conditions, for which he uses model systems to elucidate disease mechanisms. He completed a paediatric residency and a cardiology fellowship at The Johns Hopkins University before joining the faculty in 1992. GSK is a science-led global healthcare company.

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Scienmag

MAY 18, 2021

Scientists link genetic makeup of bacteria in the human gut to several human diseases We are truly never alone, not even within our own bodies. Human beings play host to trillions of bacteria, fungi, viruses, and other microorganisms that make up the human microbiome. In recent years, the mix of these resident bacteria, and the […].

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Scienmag

FEBRUARY 10, 2021

Data demonstrates new increased diversity in genetic studies and provides new insights into population-specific diseases Researchers at the University of Maryland School of Medicine (UMSOM) and their colleagues published a new analysis today in the journal Nature from genetic sequencing data of more than 53,000 individuals, primarily from minority (..)

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Genetics Research Medicine Bioinformatics 71

Scienmag

NOVEMBER 19, 2020

Precise treatment leads to resolution of patient’s debilitating symptoms and complete remodeling of her lymphatic system Philadelphia, November 20, 2020–Researchers at Children’s Hospital of Philadelphia (CHOP) have resolved a severe lymphatic disorder in a girl with Noonan Syndrome that had led to upper gastrointestinal bleeding, (..)

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