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Researchers teach AI to tailor artificial DNA for drug development

Drug Discovery World

Using artificial intelligence, researchers at Chalmers University of Technology, Sweden have succeeded in designing synthetic DNA that controls the cells’ protein production. . Now we have succeeded in designing our own DNA that contains the exact instructions to control the quantity of a specific protein,” said Aleksej Zelezniak. .

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Symvivo’s Oral COVID-19 Vaccine Enters Clinical Trials

XTalks

Symvivo’s bacTRL Gene Therapy Platform is designed and optimized to address limitations associated with typical vaccines, including the inability to accommodate large or multiple genes, lack of specificity to targeted tissue and poor control over immune response, says the company.

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Cell-penetrating peptides as a delivery system for oligonucleotides

Drug Discovery World

These peptides typically contain up to 30 amino acids and can be cationic, amphipathic or both. Over the years, a range of different CPPs have been developed, including natural translocating proteins through to newly-designed computer-prediction sequences 3. How are cell-penetrating peptides used? cells, such as diabetes.

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Gene Switch: A Novel Platform for Switching Genes On and Off

Roots Analysis

Further, the expression of any gene is dependent on the rate at which it is transcribed into mRNA and translated into proteins. There are various regulatory proteins or transcription factors that are responsible for affecting the transcription rate.

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US FDA clears Transcenta’s IND for Rett syndrome treatment

Pharmaceutical Technology

The investigational adeno-associated virus (AAV) gene therapy candidate NGN-401 is claimed to be the first to deliver the full-length human MECP2 gene using the company’s Expression Attenuation via Construct Tuning (EXACT) gene regulation technology.

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Epigenetic Editing with CRISPR Might Be Easier Than We Thought

XTalks

These modifications regulate gene expression without changing the sequence or structure of DNA. The CRISPR gene editing system consists of the Cas9 enzyme, which serves as molecular scissors to cleave double-stranded DNA, and a guide RNA template targeted to a specific genomic sequence, which allows for precise editing.

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Synthetic biology tools advancing and accelerating drug discovery efforts

Drug Discovery World

Gene-to-antibody production begins with scientists entering antibody sequences as starting material, after which bioinformatics tools filter out potentially non-viable sequences. The libraries contain only the sequences that occur in the human repertoire, rather than randomly generated sequences,” adds Dr Leproust. .

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