Drug Discovery World

JULY 26, 2023

An industry overview of the role of the microbiome in precision medicine, and its interplay with research tools, diagnostics, and therapeutic development. But what advancements are taking place within microbiome-based precision medicine and how is it being used within oncology?

Medicine 52

Medicine Genome Genomics Bioinformatics 52

Pharmaceutical Technology

FEBRUARY 3, 2023

Only a few weeks into the new year, the prospect of getting a successful advanced HIV vaccine shrank after the discontinuation of yet another late-stage trial. This marks the second time one of Janssen’s HIV vaccines failed after another showed disappointing results in the Phase IIb Imbokodo trial in August 2021.

Vaccination 293

Vaccination Vaccine Antibody Trials 293

XTalks

NOVEMBER 7, 2022

Liquid biopsy tests in oncology involve isolating entities such as circulating tumor cells (CTC), circulating tumor DNA (ctDNA) and tumor-derived exosomes. Gleich, MD, FACS, Senior Vice President, Medical Department, and Dr. Christopher Huth, PhD, Senior Clinical Trial Manager, Clinical Trial Management.

Clinical Trials 98

Clinical Trials Clinical Trials Trials FDA Approval 98

Drug Discovery World

JULY 18, 2023

Rolf Turk , Senior Manager, Genomics Medicine at Integrated DNA Technologies, examines how CRISPR is being used to enhance cancer therapies. These efforts, along with many others, are opening doors for new possibilities in translational medicine. parvovirus B19, Flaviviridae, Ebola, and Coronaviridae), DNA viruses (e.g.,

DNA 98

DNA Genome Genomics RNA 98

The Pharma Data

NOVEMBER 17, 2021

Mount Sinai researchers have developed a new model that uses DNA and RNA sequencing data from hundreds of patients to identify specific genes and genetic alterations responsible for never-before-defined subtypes of a blood cancer called multiple myeloma.

Scientist 52

Scientist RNA DNA Genetics 52

Roots Analysis

JANUARY 28, 2024

Pharmaceutical Research: Big data analytics can be applied in various areas of pharmaceutical research, including drug discovery and development, precision medicine , clinical trial optimization, pharmacovigilance and drug safety, supply chain optimization, and real-time monitoring and surveillance.

Big Data 40

Big Data Medicine Marketing Clinical Trials 40

XTalks

DECEMBER 22, 2021

The RNA Revolution: From mRNA Vaccines to RNA Editing. The age of RNA is officially here, and it’s here to stay as more than a passing life science trend. RNA technology is not new nor has its potential been surprising. RNA in the Making. So why did this perceived RNA ‘revolution’ take so long?

Life Science 98

Life Science RNA Vaccination Vaccine 98

Drug Discovery World

OCTOBER 25, 2023

DDW Editor Reece Armstrong speaks to Dr Darrell Green , Lecturer in RNA Biology Biomedical Research Centre Norwich Medical School University of East Anglia, about his work using next generation sequencing (NGS) and the areas the technology is impacting within drug discovery and development. The second concept is largely in oncology.

Bioinformatics 115

Bioinformatics Genetics RNA Drugs 115

XTalks

DECEMBER 13, 2023

Related: Top 30 Pharma Companies in 2023: Statistics and Trends 1) Moderna Compound annual growth rate: 415 percent Moderna, headquartered in Massachusetts, is a prominent biotechnology company specializing in RNA therapeutics, particularly mRNA vaccines.

Genetics 111

Genetics Vaccination Vaccine DNA 111

Drug Discovery World

AUGUST 16, 2023

Additionally, patients whose cancer has spread but who have not yet received chemotherapy, and whose primary tumours have markers of faults in genes linked to DNA repair pathways, tend to respond better to carboplatin. “Our findings paint a complex picture – with many, dynamic factors driving how tumours respond to treatment.”

Genetics 52

Genetics Gene Hormones RNA 52

pharmaphorum

OCTOBER 31, 2022

The small-molecule PIKfyve inhibitor – called VRG50635 – has been administered to the first subject in the phase 1 trial involving healthy volunteers, according to the San Francisco-based biotech, which was founded in 2015 by Alice Zhang and Jason Chen.

Genome 125

Genome Genomics Drugs RNA 125

Drug Discovery World

DECEMBER 15, 2022

These platforms all induce double strand cuts in the chromosomal DNA that can be sealed by the cell, leading to a specific gene disruption, or resulting in a new target site for inserting DNA segments. Early phase clinical trials for gene editing therapies. Gene editing challenges and potential solutions.

Gene Editing 52

Gene Editing Gene In-Vivo Genome 52

Pharmaceutical Technology

FEBRUARY 20, 2023

If clinical trial participants are representative of the wider disease population, they can help sponsors assess the effectiveness of new and existing therapeutics. of the clinical trial population globally. participation of white subjects. What future developments are you most excited about being part of Cerba Research?

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Research Clinical Trials Clinical Trials Trials 130

Drug Discovery World

APRIL 12, 2023

The pharmaceutical firm also provided promising updates on mRNA-4157/V940, which targets different tumour types, at Moderna’s Vaccines Day on 24 March 2023 2. The first detailed results of the trial will be presented at the American Association for Cancer Research (AACR) in April 2023.

Vaccination 52

Vaccination Vaccine Immune Response RNA 52

The Pharma Data

JANUARY 13, 2021

13, 2021 — A single-shot COVID-19 vaccine from Johnson & Johnson has shown very strong results in early clinical trials, potentially providing a significant boost to U.S. The vaccine produced an immune response of all 805 clinical trial participants within two months of inoculation, according to results published Jan.

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Vaccination Vaccine Trials Immune Response 40

World of DTC Marketing

FEBRUARY 7, 2021

Measuring RNA, DNA quickly. Precision medicine or next-generation sequencing helps in the faster discovery of drugs and tailored medication for individual patients. . Drug Discovery and Manufacturing: It helps in the initial screening of drug compounds to the predicted success rate based on biological factors.

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Doctors Doctor Drugs Marketing 164

The Pharma Data

OCTOBER 19, 2020

Caris’ collaborative network focused on expanding the application of precision medicine in oncology supports Winship’s enterprising approach to research leading to transformative discoveries in cancer care and treatment. The NCTN serves as the NCI’s primary infrastructure to conduct phase II and III clinical trials.

Life Science 52

Life Science Clinical Trials Clinical Trials RNA 52

Drug Discovery World

JANUARY 23, 2023

The combined potential of base editing and PSCs holds great promise for the future of personalised medicine, offering an unlimited supply of universal donor cells that can be tailored to meet the needs of each individual patient. The first in-person iPSC-derived regenerative therapy trial took place at Kyoto University, Japan.

Gene Editing 52

Gene Editing Gene Engineer DNA 52

Drug Discovery World

JANUARY 23, 2023

“Put simply, radioresistant GBM cells prefer to stock up on fatty acids instead of utilising them as an energy source in order to reduce mitochondrial reactive oxygen species that may cause damage to their DNA, RNA, and proteins, and, in turn, cell death,” explains Prof Youn.

FDA Approval 52

FDA Approval Drugs In-Vivo In-Vitro 52

The Pharma Data

MAY 9, 2022

But now Northwestern Medicine scientists, in an international collaboration with scientists at the University of California, San Francisco and the University of Hong Kong, have identified a drug that inhibits growth of the most aggressive meningiomas and how to most accurately identify which meningiomas will respond to the drug. .

Drugs 52

Drugs Scientist DNA Genetics 52

pharmaphorum

FEBRUARY 3, 2021

While achieving the Nobel Prize spotlight would have been enough to impress, CRISPR-Cas9 gene editing is part of a growing list of technologies granted Investigational New Drug (IND) applications with early data from clinical trials supporting its safe use in edited cells re-introduced into a patient.

Gene Editing 87

Gene Editing Gene DNA Engineer 87

Drug Discovery World

APRIL 16, 2023

The clinical benefit was observed regardless of the tumour mutational burden (TMB) status, according to results from the Phase IIb KEYNOTE-942 clinical trial presented at the AACR Annual Meeting 2023, held April 14-19. According to the results of the primary trial analysis, after 18 months, the RFS was 78.6%

Vaccination 52

Vaccination Vaccine Immune Response Gene Expression 52

Drug Discovery World

DECEMBER 21, 2023

Regulatory issues and diversity in clinical trials were also important in 2023, as well as the role that artificial intelligence tools like ChatGPT might play. In a record year for gene therapy approvals, it isn’t surprising that cell & gene therapy (CGT) has been a hot topic.

Gene Therapy 59

Gene Therapy Gene Antibody FDA Approval 59

WCG Clinical

MAY 28, 2024

In contrast to B cell malignancies, a hallmark of lupus is not uncontrolled cellular proliferation, but rather uncontrolled production of antibodies that bind to “self” targets — in particular to nucleic acids (DNA and RNA). WCG has many ways to support cell and gene therapy clinical trials for lupus.

In-Vivo 52

In-Vivo Clinical Trials Clinical Trials FDA Approval 52

Pharmaceutical Technology

MARCH 8, 2023

Caris’s platform combines data obtained from protein analysis, whole exome sequencing, artificial intelligence (AI) models and signatures, and whole transcriptome sequencing for improving patient outcomes through personalised medicine advancement. The company will also use the biomarker-driven patient selection of Caris for clinical trials.

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Research Clinical Trials Clinical Trials Life Science 130

Drug Discovery World

JANUARY 21, 2024

Proximity-inducing drugs: Using technological innovation to build the next generation of medicine Simon Bushell, SVP of Molecular Discovery of Entact Bio, has over two decades of scientific and strategic leadership experience in drug discovery.

Protein 52

Protein Vaccination Vaccine Development 52

pharmaphorum

DECEMBER 21, 2020

Compared with many of the established names in pharma these companies are young upstarts but they have managed to achieve what other big names in the industry have failed to do and harness the power of mRNA to make medicine. This will revolutionise medicine over the next 10-15 years in areas we do not even imagine.”.

Vaccination 84

Vaccination Vaccine Doctors Doctor 84

Drug Discovery World

OCTOBER 17, 2023

RA: Can spatial biology studies help drive advances in precision medicine? BN : Yes, spatial analysis will help develop precision medicine, initially through advancing the speed of research and progression of therapeutic approaches and later as part of the treatment regime. Let’s take CAR T cells as an example.

Gene Expression 52

Gene Expression Drugs Protein Gene 52

The Pharma Data

JANUARY 21, 2021

CABENUVA, a co-packaged kit with two injectable medicines, offers people living with HIV a new approach for maintaining viral suppression. In the ATLAS study, CABENUVA met the primary endpoint for noninferiority (the proportion of participants with plasma HIV-1 RNA ?50 50 c/mL, meeting noninferiority criteria.

FDA Approval 52

FDA Approval RNA Drugs Containment 52

The Pharma Data

MARCH 9, 2021

Nasdaq: GILD) today presented additional results from the Phase 2/3 CAPELLA trial evaluating the company’s investigational, long-acting HIV-1 capsid inhibitor, lenacapavir, in heavily treatment-experienced people with multi-drug resistant HIV-1 infection. Both trials have projected initiation dates in 2021. Gilead Sciences, Inc.

Drugs 52

Drugs RNA Trials Development 52

XTalks

DECEMBER 24, 2020

In addition to pharma and biotech companies who zealously began working to develop COVID-19 drugs and vaccines, companies from areas outside of science and medicine also stepped up to help during the pandemic. The system can be used to precisely edit out portions of DNA flanked by CRISPR sequences.

Life Science 111

Life Science Vaccination Vaccine Gene 111

The Pharma Data

OCTOBER 21, 2020

The pooled analysis examined 1,744 participants across 16 countries currently taking long-acting cabotegravir and rilpivirine as part of the regimen’s ongoing global clinical development programme of six studies, which includes the phase IIb/IIIb LATTE-2, ATLAS, ATLAS-2M, FLAIR, POLAR, and CUSTOMIZE clinical trials.

Clinical Development 52

Clinical Development Development Medicine Clinical Trials 52

Drug Discovery World

AUGUST 8, 2023

Similarly, The Times of India says that branded generic medicines have “long fuelled India’s pharmaceutical exports” 4. Moreover, the India Brand Equity Foundation report reveals that more than half of global demand for various vaccines – 40% of generic demand in the US and 25% of all medicine in the UK – are supplied by India 1.

Research 52

Research Drugs Genome Genomics 52

The Pharma Data

SEPTEMBER 6, 2021

Overview of key presentations featuring Roche medicines. Trial in progress – ASTEFANIA: A phase 3 study of trastuzumab emtansine (T-DM1) plus atezolizumab or placebo as adjuvant therapy in patients with residual invasive breast cancer after neoadjuvant HER2-targeted therapy and chemotherapy. Abstract title. Breast cancer.

Genome 52

Genome Genomics HR Hormones 52

The Pharma Data

JUNE 30, 2021

The submission is supported by data from the Phase 2/3 CAPELLA trial, which evaluated the safety and efficacy of lenacapavir administered subcutaneously every six months in combination with an optimized antiretroviral background regimen. log 10 copies/mL reduction from baseline in HIV-1 RNA at the end of the functional monotherapy period.

Drugs 52

Drugs Trials RNA Development 52

Drug Discovery World

OCTOBER 16, 2023

A company within this ecosystem is STORM Therapeutics, a clinical stage biotechnology company creating novel small molecule therapies that inhibit RNA modifying enzymes (RME) for use in oncology and other diseases. The university aims to identify treatments for life-threatening anti-microbial diseases and metabolic disorders.

Drugs 75

Drugs Life Science Gene Therapy Genome 75

Delveinsight

DECEMBER 13, 2020

This discovery led to the development of diagnostic tests and an effective vaccine, and Blumberg was awarded the Nobel Prize in Physiology or Medicine in 1976 for this discovery. Even though clinical trial results were promising, adverse events and serious complications were observed. HBV DNA can be integrated into the host genome.

Genotype 52

Genotype FDA Approval DNA Drugs 52