Pharmaceutical Technology

JUNE 13, 2023

The combination therapy is intended to treat hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative locally advanced or metastatic breast cancer in adult patients, after recurrence or progression on or after an endocrine-based regimen. AstraZeneca stated that its NDA is being reviewed under Project Orbis.

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Medical Xpress

DECEMBER 12, 2022

An international research team led by Dr. Ana Guadaño at the Alberto Sols Biomedical Research Institute (IIBM, a combined CSIC-UAM center) and involving the Complutense University of Madrid (UCM), used CRISPR gene editing techniques to incorporate into mice a mutation of the MCT8 protein responsible for transporting thyroid hormones to the interior (..)

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Gene Editing Genetics Hormones Medicine 75

Drug Discovery World

AUGUST 1, 2023

Researchers from the University of Liverpool, UK, have created a biomedical compound that has the potential to stop the spread of breast cancer. Scientists from the Chemistry and Biochemistry Departments at the University of Liverpool and Nanjing Medical School in China have discovered a possible way to block proteins that cause metastasis.

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XTalks

NOVEMBER 26, 2020

In addition to innovative new antibody drugs and mRNA vaccines, researchers have found that the sleep-regulating hormone melatonin may also offer protection against COVID-19. Lerner researchers developed a novel artificial intelligence platform to identify potential drugs for COVID-19, finding melatonin to be a promising candidate.

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Research Hormones Protein Regulation 98

pharmaphorum

JULY 22, 2021

Pfizer has pledged a whopping $1 billion upfront for rights to an Arvinas drug for breast cancer from its protein degrader platform, which harnesses cells’ natural protein-denaturing machinery to remove rogue proteins associated with disease.

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Protein Hormones Bioavailability Drugs 115

Trialfacts

NOVEMBER 22, 2022

Research Center: The University of Utah. Lead Researcher: Micah Drummond, Ph.D. That is why researchers at the University of Utah aim to better understand. In this study, researchers want to see how different markers (such as hormones and proteins) in your blood and muscle, respond to physical activity and recovery.

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Research Hormones Protein 52

The Pharma Data

JULY 22, 2021

NYSE: PFE) today announced a global collaboration to develop and commercialize ARV-471, an investigational oral PROTAC® (PROteolysis TArgeting Chimera) estrogen receptor protein degrader. Chief Scientific Officer for Oncology Research and Development at Pfizer. (Nasdaq: ARVN) and Pfizer Inc. Chief Executive Officer at Arvinas.

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Protein Development HR Hormones 52

Drug Discovery World

DECEMBER 9, 2022

The drug capivasertib combined with hormone therapy doubled the time it took for cancer to progress in people with advanced forms of the most common type of breast cancer. . Capivasertib is a potential first-in-class drug that blocks activity of the cancer-driving protein molecule AKT. who received a placebo and hormone therapy. .

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Trials Hormones Drugs Genetics 52

XTalks

JANUARY 23, 2024

Rare diseases, often overlooked in the broader medical research field, affect a small percentage of the population yet carry a significant burden for those diagnosed and their families. Pediatric growth hormone deficiency (PGHD) is one such condition, affecting a child’s growth and development.

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Development Hormones Drugs Trials 72

Pharmaceutical Technology

MAY 31, 2023

The therapeutic candidate targets immune checkpoint, programmed cell death protein 1 (PD1). Les Laboratoires Servier overview Les Laboratoires Servier (Servier) researches, develops, manufactures, and markets drugs for treating various diseases. It is administered as an intravenous infusion.

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Generic Drugs Hormones Manufacturing Development 100

Drug Discovery World

AUGUST 16, 2023

The study, by researchers at The Institute of Cancer Research, London, shows that certain characteristics within patients’ primary tumours can predict how they will respond to different treatments after their tumours have spread around the body.

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Genetics Gene Hormones RNA 52

XTalks

MAY 31, 2023

The research demonstrates that excessive intake of table salt can elevate several indicators for dementia and Alzheimer’s disease. The research team utilized a mouse model, feeding the mice a high sodium solution (two percent sodium chloride) in their drinking water for 12 weeks, and noted their blood pressure throughout the study.

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Protein Hormones Containment Branding 111

Pharmaceutical Technology

MARCH 10, 2023

Pharmaceutical and biotechnology industries widely use freeze-drying systems to protect vaccines, antibodies, antibiotics such as penicillin, blood plasma, proteins, enzymes, hormones, viruses, and bacteria from heat and minimise their biological activity.

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Roots Analysis

MAY 21, 2024

Proteins are the chains of amino acids linked together in different combinations and perform a wide variety of functions. However, continuous regulation of the cellular proteome is essential for maintaining the right balance of different proteins necessary for normal cellular function, survival, and proliferation.

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Protein Marketing Development Antibody 40

Drug Discovery World

DECEMBER 19, 2023

Despite VMS, or hot flushes, being a common symptom of menopause, until now, hormone replacement therapy (HRT) was the only treatment. Lack of scientific advancement Before menopause, there is a balance between oestrogen, and the protein neurokinin B (NKB), which regulates the brain’s temperature control centre.

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Hormones Clinical Trials Clinical Trials Medicine 59

The Pharma Data

NOVEMBER 19, 2020

Researchers with the German Center for Neurodegenerative Diseases (DZNE) working in mice found that Alzheimer’s began much earlier with a fatal chain reaction that results in misfolded beta-amyloid proteins that get out of control and “literally floods the brain.” It is a hormone. Melatonin is produced by the body in darkness.

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Pharmaceutical Technology

FEBRUARY 14, 2023

Alkaloids, natural dyes, drugs, proteins, and enzymes are some of the important classes of natural heterocyclic compounds essential for human life. The company filed heterocyclic composition patents in areas such as PAD4 inhibitors, factor Xa inhibitors, and nuclear hormone receptor modulators.

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XTalks

SEPTEMBER 28, 2023

While the FDA believes the levels of titanium dioxide in US food are safe, the International Agency for Research on Cancer categorizes it as a Group 2B carcinogen , indicating a potential risk to humans if inhaled. There’s been varied research regarding the synthetic hormone’s association with breast cancer.

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Drug Discovery World

JUNE 6, 2023

Researchers hope these results, which were presented at the 2023 American Society of Clinical Oncology (ASCO) Annual Meeting, will lead to a new option for patients with advanced low-grade serous ovarian cancer (LGSOC), a rare form of the disease that has a poor response rate to current treatments.

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Drugs Research Hormones Trials 52

The Pharma Data

DECEMBER 9, 2020

The trial, conducted in nine countries, found that adding chemotherapy to hormone-blocking drugs brought no added benefit to a particular group of patients. Those were postmenopausal women with hormone-sensitive breast cancer that had spread to only one to three lymph nodes, and who had a low risk of recurrence.

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Hormones Trials Medicine Clinical Trials 52

Drug Discovery World

AUGUST 31, 2022

A new therapeutic approach for triple negative breast cancer using nitric oxide is being explored by researchers at the medical research centre CÚRAM. Triple-negative breast cancer is invasive breast cancer that does not respond to hormonal therapy medicines or the current medicines that target the HER2 protein.

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Hormones Doctors Doctor Clinical Trials 52

XTalks

NOVEMBER 2, 2021

The test measures levels of C-peptide protein in the blood, which is a byproduct of insulin synthesis that is released from the pancreas along with the hormone. Related: Researchers Develop World’s First Glucose Saliva Test for Diabetes. Currently, the only treatment for type 1 diabetes is insulin therapy.

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Roots Analysis

OCTOBER 24, 2023

Owing to the advancement in clinical pharmacology and oncology domain, and the rising demand for targeted therapeutics and precision medicines, high potency active pharmaceutical ingredients (HPAPIs) and cytotoxic drugs have become one of the key areas of interest to researchers and drug manufacturers across the globe.

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XTalks

MARCH 13, 2024

Hormone-based therapeutics aim to delay glaucoma progression by enhancing estrogen’s potential protective effects. Secondly, other funded research is exploring differential gene expression regulated by DNA methylation.

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The Pharma Data

SEPTEMBER 28, 2021

“Triple-negative carcinoma grows and spreads faster than other sorts of carcinoma and consequently features a worse prognosis,” said Dr. Vicki Goodman, vice chairman , clinical research, Merck Research Laboratories. Merck has the industry’s largest immuno-oncology clinical research program. About Triple-Negative carcinoma.

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Hormones Medicine Clinical Research Research 52

XTalks

JULY 2, 2021

Currently, there is no scientific evidence to suggest that the vaccines induce any hormonal changes that would lead to irregular periods. Given the growing accounts of the phenomenon, some researchers have started looking into the issue. This had led some to wonder whether period changes may be a potential side effect of the vaccines.

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Trialfacts

NOVEMBER 30, 2023

Stuart Phillips IRB: This study has been reviewed and approved by the Hamilton Integrated Research Ethics Board (HiREB) under Project #16408 About the Study We all know that resistance training is a powerful tool to rebuild lost muscle mass, but did you know that what you eat plays a crucial role in enhancing these effects? Why Participate?

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Protein Research Hormones Containment 52

Delveinsight

AUGUST 31, 2021

FDA’s Green Flag to Ascendis’s Once-Weekly SKYTROFA for Treatment of Pediatric Growth Hormone Deficiency. Growth Hormone Deficiency , commonly known as dwarfism, can constitute short stature and complications with metabolism, which arise due to inadequate production of growth hormones by the pituitary gland inside the body.

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Drug Discovery World

AUGUST 21, 2023

Dr Christian Hendershot, Director of the Clinical and Translational Addiction Research Programme at the University of North Carolina at Chapel Hill, is conducting one of the new trials into addiction. GLP-1 is a hormone that is produced naturally in the brain and the gut in response to food ingestion.

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Clinical Trials Clinical Trials Trials Drugs 52

Roots Analysis

JANUARY 23, 2024

Owing to the challenges involved in the synthesis process and demands of modern drug development, majority of drug developers in this domain prefer to outsource their development and manufacturing operations to peptide therapeutics contract API manufacturers as a strategic solution to streamline their research and peptide synthesis efforts.

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The Pharma Data

JANUARY 7, 2021

Frank Nestle, Sanofi’s chief scientific officer and Global Head of Research, and Dietmar Berger, Sanofi’s chief medical officer and Global Head of Development, provided an overview of the company’s clinical activities and highlighted some of the assets that will be key revenue drives for the company. That’s a significant goal. “In

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Protein Antibody Genetics Gene Therapy 52

Delveinsight

JULY 30, 2020

Adrenoleukodystrophy (ALD/ X-ALD) is a rare, X-linked disorder secondary to a mutation in the ABCD1 gene, which encodes for a peroxisomal membrane protein, resulting in an excessive accumulation of very-long-chain fatty acids (VLCFAs) in the brain and adrenal glands. The disorder can occur at any stage of life and vary with severity.

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Hormones Marketing Gene Trials 52

Pharmaceutical Technology

JANUARY 25, 2023

A researchers’ team from the University of Texas at San Antonio’s (UTSA) Department of Chemistry and its partners are developing compounds to treat Glioblastoma multiforme (GBM) tumours. The National Cancer Institute (NCI) has recently awarded a $3m grant to the researchers’ team.

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Delveinsight

AUGUST 6, 2020

Transthyretin (TTR) is a protein that the liver produces to facilitate the transfer of thyroid hormone and vitamin A in the blood. However, due to specific reasons, the TTR protein begins to misfold and aggregate as fibrils, a process known as amyloidosis of Transthyretin (ATTR). Liver Transplantation.

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Gene Silencing Protein Marketing Gene 52

Pfizer

JANUARY 27, 2023

Pfizer Responds to Research Claims carterda Fri, 01/27/2023 - 19:48 Pfizer Responds to Research Claims Friday, January 27, 2023 - 08:00pm Share New York, N.Y., In the ongoing development of the Pfizer-BioNTech COVID-19 vaccine, Pfizer has not conducted gain of function or directed evolution research.

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Velocity Clinical Research

JUNE 27, 2023

The prolific researchers also had findings simultaneously published in the New England Journal of Medicine and The Lancet. “It’s a chemical, a small molecule that also acts on the GLP-1 receptor, but because it’s not a protein it’s not degraded by enzymes,” said Dr. Frias.

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Insulin Trials Hormones Clinical Trials 52

XTalks

SEPTEMBER 17, 2020

While clinical researchers occasionally need to identify and validate a new surrogate endpoint for a given trial, choosing endpoints that have been previously used as the basis of NDAs and BLAs can clear the path to eventual approval. Symptoms and Etiology: Caused by an overproduction of growth hormone, acromegaly primarily affects adults.

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Trials Gene Hormones Clinical Trials 98