XTalks

SEPTEMBER 17, 2020

In rare disease trials, it’s not always feasible to choose clinically-relevant endpoints to measure the efficacy of a new therapeutic. Symptoms and Etiology: Caused by an overproduction of growth hormone, acromegaly primarily affects adults. Acromegaly. Prevalence: 50 to 70 people per 1 million.

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Trials Gene Hormones Clinical Trials 98

Pharmaceutical Technology

MAY 31, 2023

Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval. The therapeutic candidate targets immune checkpoint, programmed cell death protein 1 (PD1). It is administered as an intravenous infusion. It is developed based on sympress platform technology.

Generic Drugs 100

Generic Drugs Hormones Manufacturing Development 100

XTalks

NOVEMBER 26, 2020

In addition to innovative new antibody drugs and mRNA vaccines, researchers have found that the sleep-regulating hormone melatonin may also offer protection against COVID-19. The study was published in the journal PLOS Biology. Related: Can Vitamin D Be Beneficial for COVID-19 Patients? The list also included melatonin.

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Research Hormones Protein Regulation 98

pharmaphorum

DECEMBER 1, 2021

The French group said that ORI-001, a vaccine based on recombinant proteins from the Cutibacterium acnes (formerly Propionibacterium acnes ) bacterium that is often found in acne lesions, could be the first ever vaccine for the condition.

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Vaccination Vaccine Development Hormones 105

The Pharma Data

DECEMBER 9, 2020

9, 2020 — More women with early-stage breast cancer may be able to safely skip chemotherapy after having surgery, according to initial results from a major clinical trial. The trial, conducted in nine countries, found that adding chemotherapy to hormone-blocking drugs brought no added benefit to a particular group of patients.

Hormones 52

Hormones Trials Medicine Clinical Trials 52

Drug Discovery World

DECEMBER 19, 2023

Despite VMS, or hot flushes, being a common symptom of menopause, until now, hormone replacement therapy (HRT) was the only treatment. Lack of scientific advancement Before menopause, there is a balance between oestrogen, and the protein neurokinin B (NKB), which regulates the brain’s temperature control centre.

Hormones 59

Hormones Clinical Trials Clinical Trials Medicine 59

Drug Discovery World

AUGUST 16, 2023

.” The findings suggest it might be possible to predict who will benefit from carboplatin and docetaxel using a range of different biomarkers and suggest further investigation of these biomarkers in clinical trials is warranted.

Genetics 52

Genetics Gene Hormones RNA 52

Drug Discovery World

JUNE 6, 2023

Approved treatment options available for patients with advanced LGSOC in the UK are currently limited to chemotherapy and hormone therapy, with response rates typically ranging from 0-14%. Avutometinib is a dual RAF and MEK inhibitor, which blocks certain proteins that help control cancer growth and survival.

Drugs 52

Drugs Research Hormones Trials 52

Drug Discovery World

AUGUST 31, 2022

Triple-negative breast cancer is invasive breast cancer that does not respond to hormonal therapy medicines or the current medicines that target the HER2 protein. It is usually more aggressive, harder to treat, and more likely to recur than cancers that are hormone receptor-positive or HER2-positive.

Hormones 52

Hormones Doctors Doctor Clinical Trials 52

Drug Discovery World

AUGUST 21, 2023

Semaglutide manufacturer Novo Nordisk reported earlier this month that the drug reduces the risk of major adverse cardiovascular events by 20% in adults with overweight or obesity, as shown in the SELECT trial. GLP-1 is a hormone that is produced naturally in the brain and the gut in response to food ingestion.

Clinical Trials 52

Clinical Trials Clinical Trials Trials Drugs 52

XTalks

JULY 2, 2021

Currently, there is no scientific evidence to suggest that the vaccines induce any hormonal changes that would lead to irregular periods. However, the similarity between the two proteins is not great enough for anti-spike antibodies to cross-react with placental syncytin-1.

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Vaccination Vaccine Protein Immune Response 105

Velocity Clinical Research

JUNE 27, 2023

Trial results were presented at the ADA sessions and published in NEJM. Dr. Frias is the lead author for Eli Lily’s Phase 2 trial for orforglipron for type 2 diabetes. Trial results were presented at the ADA sessions and published in The Lancet. Trial results were presented at the ADA sessions and published in The Lancet.

Insulin 52

Insulin Trials Hormones Clinical Trials 52

Delveinsight

JULY 30, 2020

Adrenoleukodystrophy (ALD/ X-ALD) is a rare, X-linked disorder secondary to a mutation in the ABCD1 gene, which encodes for a peroxisomal membrane protein, resulting in an excessive accumulation of very-long-chain fatty acids (VLCFAs) in the brain and adrenal glands. The disorder can occur at any stage of life and vary with severity.

Hormones 52

Hormones Marketing Gene Trials 52

The Pharma Data

SEPTEMBER 28, 2021

Recommendation supported Data From Phase 3 KEYNOTE-355 Trial. Triple-negative carcinoma may be a sort of carcinoma that tests negative for estrogen hormone receptors, progesterone hormone receptors and overexpression of human epidermal protein receptor 2 (HER2). About Triple-Negative carcinoma.

Hormones 52

Hormones Medicine Clinical Research Research 52

XTalks

MAY 10, 2023

The exact cause of lupus is not entirely understood, but it is thought to be from a combination of genetic, environmental and hormonal factors. It works by targeting a protein called B-lymphocyte stimulator (BLyS) that is overproduced in people with lupus and contributes to an overactive immune system.

Drugs 52

Drugs Clinical Trials Clinical Trials Antibody 52

XTalks

SEPTEMBER 15, 2020

A vaccine developed by Swedish company Diamyd Medical has demonstrated significant treatment efficacy in a predefined genetic subgroup of individuals with type 1 diabetes in a Phase IIb clinical trial. In the trial, the vaccine was injected directly into the lymph nodes of type 1 diabetic individuals. The DIAGNODE-2 Trial.

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Vaccination Vaccine Insulin Trials 103

XTalks

MARCH 13, 2024

XTALKS WEBINAR: Addressing Ophthalmology Clinical Trial Design and Effective Data Monitoring Committee Strategies On-Demand: Thursday, February 8, 2024 Register for this free webinar gain insights into statistical data strategies for ophthalmology clinical trials and learn best practices for establishing and reporting ophthalmic data.

Gene Therapy 111

Gene Therapy Gene Life Science DNA 111

The Pharma Data

APRIL 27, 2022

6 Currently chemotherapy remains the only treatment option for patients with HR-positive tumours following progression on endocrine (hormone) therapy. The FDA granted the BTD based on data from the pivotal DESTINY-Breast04 Phase III trial which reported positive high-level results in February 2022.

HR 52

HR Trials Protein Medicine 52

Drug Discovery World

JUNE 1, 2023

6 Also in May 2023, Shanghai-native LaNova Medicines entered into an exclusive license agreement with AstraZeneca for LM-305, a pre-clinical stage ADC targeting G protein-coupled receptor, class C, group 5, member D (GPRC5D).

Antibody 98

Antibody Marketing Drugs Licensing 98

Drug Discovery World

JANUARY 9, 2024

The delayed release formulation of budesonide has shown greater efficacy for protein reduction and slowing the decline in kidney function in primary immunoglobulin A (IgA) as well as a much better safety profile than conventional corticosteroids. The therapy has shown positive results in Phase III trials in both breast and lung cancer.

Drugs 69

Drugs Antibody Gene Editing Medicine 69

Find Me Cure

OCTOBER 13, 2019

There currently are drugs that do just that but now they’re in clinical trials for metastatic breast cancer as well. CDK4/6 inhibitors are used alongside hormone therapy. There are antibody drugs targetting those cells that are already FDA approved and there are antibody drugs still in trials. Rosenberg, M.D.

Development 52

Development DNA Clinical Trials Clinical Trials 52

The Pharma Data

MARCH 22, 2021

VISION trial findings to be presented at upcoming medical meeting, with regulatory submissions in the US and EU anticipated in 2021. Results from the VISION trial will be presented at an upcoming medical meeting and included in US and EU regulatory submissions.

Hormones 52

Hormones Gene Therapy Trials Medicine 52

Delveinsight

JANUARY 7, 2021

The immunotherapy pipeline is led by an in-licensed EP4 antagonist that Ikena is testing combined with Keytruda in phase 1b/2 colorectal and non-small cell lung cancer clinical trials. Eli Lilly backed Terns Pharmaceuticals now has two NASH candidates in clinical trials. IND-enabling studies are underway.

RNA 52

RNA Clinical Trials Clinical Trials Bioavailability 52

Delveinsight

DECEMBER 7, 2020

Development in the technology has made it possible for solutions to surface, primarily related to R&D, clinical trials, and diagnostics and treatment, as well as patient management, leading to even more significant innovative potential and promise for AI in the industry. In May 2018, Ava raised about $30 million in a Series B round.

Protein 56

Protein Insulin Hormones FDA Approval 56

Delveinsight

AUGUST 6, 2020

Transthyretin (TTR) is a protein that the liver produces to facilitate the transfer of thyroid hormone and vitamin A in the blood. However, due to specific reasons, the TTR protein begins to misfold and aggregate as fibrils, a process known as amyloidosis of Transthyretin (ATTR). Liver Transplantation.

Gene Silencing 52

Gene Silencing Protein Marketing Gene 52

The Pharma Data

NOVEMBER 19, 2020

Researchers with the German Center for Neurodegenerative Diseases (DZNE) working in mice found that Alzheimer’s began much earlier with a fatal chain reaction that results in misfolded beta-amyloid proteins that get out of control and “literally floods the brain.” It is a hormone. Melatonin is produced by the body in darkness.

Research 52

Research Protein Nurses Immune Response 52

Pfizer

AUGUST 15, 2022

Current variants of concern can be resistant to treatments that work by binding to the spike protein found on the surface of the SARS-CoV-2 virus. Microsomal triglyceride transfer protein inhibitor: lomitapide. Contraception : Use of ritonavir may reduce the efficacy of combined hormonal contraceptives. 07.27.2022. 07.19.2022.

Drugs 99

Drugs Vaccination Vaccine In-Vitro 99

Camargo

NOVEMBER 29, 2021

Like with small molecules, clinical trials of biologics are designed to determine pharmacokinetics (PK), pharmacodynamics (PD), safety, and efficacy. Recombinant therapeutic proteins. Fusion proteins. Gene and cellular therapies. Growth factors. Interferons. Monoclonal antibodies (mAbs).

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Development Protein Production Hormones 180

The Pharma Data

SEPTEMBER 16, 2020

Blueprint Medicines will present new data from the registrational phase I/II ARROW trial, investigating Gavreto TM (pralsetinib) for the treatment of people with RET-mutant medullary thyroid cancer. New integrated analyses from our tumour agnostic Rozlytrek ® (entrectinib) clinical development programme.

HR 52

HR Medicine Hormones Trials 52

Pharmaceutical Technology

JANUARY 25, 2023

The new compounds imitate the sex hormone estrogen activity on a cell protein known as estrogen receptor-beta (ER-beta), which is known to suppress cancer. They aim to complete validation using preclinical models and later evaluate the molecules in clinical trials in the next two to three years.

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Development Research Hormones Gene 246

Pfizer

JANUARY 27, 2023

Current variants of concern can be resistant to treatments that work by binding to the spike protein found on the surface of the SARS-CoV-2 virus. Contraception: Use of ritonavir may reduce the efficacy of combined hormonal contraceptives. In preclinical studies, nirmatrelvir did not demonstrate evidence of mutagenic DNA interactions.

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Marketing Production Drugs Licensing 75

The Pharma Data

MARCH 25, 2021

SG is a first-in-class therapy targeting Trop-2, a protein frequently expressed in multiple types of epithelial tumors, such as TNBC, where high expression is associated with poor survival and relapse. Continued approval for this indication may be contingent upon verification and description of clinical benefit in confirmatory trials.

Genotoxicity 52

Genotoxicity Genotype Containment Protein 52

The Pharma Data

AUGUST 31, 2021

Prostate-Specific AntigenKinetics in Patients from TITAN and SPARTAN (oral presentation): Post-hoc analysis of PSA kinetics in 1,331 patients treated with ERLEADA ® from both the TITAN and SPARTAN trials (Abstract #PD34-11). Adverse Reactions — The most common adverse reactions (?10%) Laboratory Abnormalities — All Grades (Grade 3-4).

Drug Delivery Systems 52

Drug Delivery Systems Drug Delivery Trials Drugs 52

The Pharma Data

AUGUST 30, 2021

KEYTRUDA Now Approved for the Treatment of Patients With PD-L1-Positive, Hormone Receptor-Negative and HER2-Negative, Inoperable or Recurrent Breast Cancer. KEYTRUDA Approved for the Treatment of Patients With PD-L1-Positive, Hormone Receptor-Negative and HER2-Negative, Inoperable or Recurrent Breast Cancer.

Hormones 52

Hormones HR Trials Protein 52

The Pharma Data

FEBRUARY 1, 2021

While multiple factors are at play, Mosconi said, it’s hormones – testosterone in men and estrogen in women – that are the orchestral conductors of the brain. “We are used to thinking of sex hormones as important for fertility and reproduction,” Mosconi said. They are responsible for whether it performs well, or not.

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Hormones Radiology Research Medicine 40

The Pharma Data

FEBRUARY 8, 2021

Metastatic castration-sensitive prostate cancer, also known as metastatic hormone-sensitive prostate cancer (mHSPC), refers to prostate cancer that still responds to hormonal therapy and has spread beyond the prostate to other parts of the body. [4]. 6] ERLEADA ® is being studied in five Phase 3 registrational clinical trials.

HR 52

HR Hormones Development Production 52

XTalks

MARCH 22, 2021

Maverick’s COBRA platform is used to engineer protein-based therapies that target T cells in the tumor microenvironment to trigger their activation. The therapies are designed to induce T cell-mediated killing specifically at the tumor site while sparing healthy cells and tissue.

Life Science 110

Life Science Development Marketing Gene Expression 110