STAT News

JULY 28, 2022

In a little-noticed study published earlier this year, scientists from Oregon Health & Science University reported the birth of three mouse pups that had been created with a never-before-used recipe for reproduction. Read the rest…

In-Vitro 98

In-Vitro Research DNA Genetics 98

Drug Discovery World

JANUARY 18, 2023

Dr Emily Richardson, Lead Scientist at CN Bio, said: “We are extremely pleased with the FDA’s decision to deepen our research collaboration into the multi-organ space. has removed the mandatory requirement for animal testing for toxicity where enhanced performance is proven using in vitro alternatives. .

Bioavailability 52

Bioavailability In-Vitro Research Drugs 52

Drug Discovery World

NOVEMBER 15, 2022

Discover how in vitro assays can be used to model in vivo neurodegeneration. Discover how in vitro assays can be used to model in vivo neurodegeneration. Brought to you by DDW and Malvern Panalytical, the webinar is presented by Dr Elise Malavasi, Principal Scientist at Concept Life Sciences. Watch the webinar now.

In-Vitro 52

In-Vitro Drugs In-Vivo Life Science 52

Pharmaceutical Technology

NOVEMBER 9, 2022

LB-1 will be given along with chemotherapy agents in-vitro, in various cell lines, and in-vivo subcutaneous mouse tumour models in the project. ProPhase Lab CEO Ted Karkus said: “ProPhase Labs is eager to explore new avenues for scientific discovery with these talented scientists as we pursue novel pathways for cancer treatment. “We

In-Vivo 130

In-Vivo Development In-Vitro Scientist 130

Scienmag

DECEMBER 10, 2020

Credit: Nucleic Acids Research Scientists at Tokyo Institute of Technology decipher how to quantitatively assess the effects of specific epigenetic changes on the rate of transcription by developing a mathematical model. For this, they successfully generated reconstituted chromatin bearing histone modifications in vitro.

Gene Expression 52

Gene Expression In-Vitro Gene Scientist 52

Scienmag

SEPTEMBER 28, 2020

Scientists analysed the toxicological impact of one of BAT’s nicotine pouch products, formerly called Lyft and now known as Velo, in an in vitro laboratory-based test. Velo was compared with a reference cigarette […].

Production 52

Production In-Vitro Scientist Research 52

Drug Discovery World

APRIL 8, 2024

The American Association of Cancer Research (AACR) Annual Meeting launched on Sunday 7 April in San Diego with an Opening Plenary Session showcasing cutting-edge technological advances opening new frontiers in cancer science.

In-Vivo 52

In-Vivo In-Vitro Antibody Protein 52

Scienmag

SEPTEMBER 18, 2020

Antibody-like proteins that capture and neutralize SARS-CoV-2 Scientists have used a new high-speed, in vitro selection method to isolate 9 antibody-like proteins (ALPs) that bind to the SARS-CoV-2 virus – 4 of which also exhibited neutralizing activity – within 4 days, according to a new study.

Protein 53

Protein Antibody In-Vitro Scientist 53

Scienmag

MAY 14, 2021

Peer reviewed | experimental study | in vitro/cells Scientists at UCL have identified a new immunotherapy to combat the hepatitis B virus (HBV), the most common cause of liver cancer in the world. The pioneering study used […].

In-Vitro 41

In-Vitro Scientist Medicine 41

Drug Discovery World

NOVEMBER 22, 2022

In this App Note you will learn: How Charles River Laboratories characterised the phenotype of a human iPSC-derived Huntington’s disease model from bit.bio over 38 days in vitro with high-density microelectrode arrays from MaxWell Biosystems.

In-Vitro 52

In-Vitro Genetics Scientist Drugs 52

Drug Discovery World

AUGUST 9, 2022

This work goes towards generating in vitro data showing how a candidate drug will be metabolised in the human body, data often included in new drug applications to regulatory agencies. . ?“We Provider to the life sciences industry BioIVT has acquired enzymes manufacturer Cypex in a bid to enhance its product portfolio. .

In-Vitro 52

In-Vitro Protein Production Bacteria 52

Drug Discovery World

NOVEMBER 22, 2022

Download this new App Note from bit.bio to learn: How Charles River Laboratories characterised the phenotype of a human iPSC-derived Huntington’s disease model from bit.bio over 38 days in vitro with high-density microelectrode arrays from MaxWell Biosystems. Download the App Note now.

Research 52

Research In-Vitro Genetics Scientist 52

Drug Discovery World

JUNE 19, 2023

Anoat will use the funds to conduct additional in vivo and in vitro pharmacology assessments and select a lead candidate. AdBio Partners’ mission is to support founding scientists in the development of new therapeutic approaches,” said Alain Huriez, Managing Partner of AdBio Partners.

Development 52

Development Life Science In-Vivo In-Vitro 52

Drug Discovery World

APRIL 5, 2023

We will be collaborating closely with the consortium’s network of scientists to help fuel the world’s discovery engine in the fight against cancer.” Members contribute their expertise in high throughput screening, structural biology, medicinal chemistry, compound profiling, cancer cell biology, and in vivo and in vitro models for oncology.

Drugs 52

Drugs In-Vivo In-Vitro Engineer 52

pharmaphorum

JANUARY 22, 2021

The mutations identified in these new variants have not significantly altered the part of the virus that remdesivir targets or have any association with known mutations conferring reduced susceptibility of coronaviruses to remdesivir in vitro,” said Gilead in its statement. “We The UK strain – known as B.1.1.7

In-Vitro 140

In-Vitro RNA Licensing Licensing 140

pharmaphorum

JANUARY 18, 2022

Developing Complex, Translatable and Physiologically-Relevant Cellular Models in vitro. Key Benefits of Attending: • Discuss the uses of advanced cell technologies to construct in vitro models of human tissues. Uncover the major benefits of 3D modelling in enhancing clinical translation and predictability. Who Should Attend?

In-Vitro 52

In-Vitro Engineer Drugs Pharma Companies 52

pharmaphorum

JANUARY 17, 2022

Central nervous system-controlled behaviour, such as food intake, is notoriously difficult to explore in vitro. After securing FDA approval for Wegovy last year, Novo Nordisk is strengthening its position in the obesity space through a collaboration with EraCal Therapeutics.

FDA Approval 113

FDA Approval In-Vitro Regulation Hormones 113

Drug Discovery World

JANUARY 17, 2024

Scientists from Fujita Health University have shown that mitochondria play essential roles during muscle development, regeneration and maintenance. The results were consistent with the in vitro experiments. Thus, problems with mitochondria can immediately translate to muscle diseases, including muscle atrophy.

In-Vitro 52

In-Vitro Regulation Protein Gene 52

Drug Discovery World

JUNE 30, 2023

Select mature stem cell lines can then be used in small-scale in vitro assays, and proven biochemical and phenotypic screens supporting target validation and deconvolution studies. Through the use of human induced pluripotent stem cells (iPSCs) derived cells, we can improve translation and reduce risk of clinical failure.

Development 52

Development Drugs In-Vitro Gene Therapy 52

Drug Discovery World

JULY 3, 2023

This was centred around pre-clinical models (in vitro and in vivo) to support discovery and development, re-entering the fray with costimulatory agonists, and clinical development strategies for combinations with immune cell engagers​.

Antibody 52

Antibody In-Vitro Engineer In-Vivo 52

Drug Discovery World

JANUARY 23, 2023

Ubiquigent is supporting a Master’s student at the University of Glasgow (UoG) to undertake a research project on USP30, a (de)ubiquitylation (DUB) implicated in neurodegenerative, renal, and cardiovascular diseases. Overseen by Professor Helen Walden, UoG, and Dr Mehmet Gundogdu, Principal Scientist at Ubiquigent, the project aims to combine biochemistry, (..)

In-Vitro 52

In-Vitro Protein Regulation Scientist 52

Drug Discovery World

FEBRUARY 6, 2024

In vitro and in silico models are becoming increasingly sophisticated in predicting drug safety profiles and preventing costly and time-consuming clinical trials. Her current work focuses on advancing the fields of genome sequencing and analysis, with an emphasis on identifying complex structural variation.

Genome 59

Genome Genomics Genetics In-Vitro 59

pharmaphorum

NOVEMBER 1, 2022

Don’t miss this unmissable opportunity to network with the pharma and biotech community of global experts in the UK and Europe; the two-day agenda offers you peer-to-peer networking with Directors of novel RNA therapies, CEOs, Senior and expert scientists, Chief Medical Officers, Senior Vice Presidents and many more.

RNA 52

RNA Genetics Gene Editing In-Vitro 52

XTalks

JUNE 27, 2022

CerTest Biotec specializes in the development and manufacturing of in vitro diagnostic medical devices and has expertise in the detection of human diseases. In a joint press release , the companies said the aim of the partnership is to design a diagnostic test that can help advance understanding of the global spread of the disease.

Development 83

Development In-Vitro Reagent Vaccination 83

Drug Discovery World

JANUARY 23, 2023

Scientists from Korea and the US have unveiled the mechanism of radioresistance in GBM cells, identifying therapeutic targets to overcome radioresistance. Researchers have discovered a clinical drug that sensitises glioblastoma (GBM) cells to radiotherapy and could replace the current standard of care.

FDA Approval 52

FDA Approval Drugs In-Vivo In-Vitro 52

The Pharma Data

MAY 15, 2023

Human model systems are miniature 2D or 3D living ‘replicas’ of human tissues and organs that scientists create from human stem cells. The IHB is expected to grow to around 250 scientists and bioengineers over the next four years. Matthias Lutolf, Head IHB at Roche.

In-Vitro 40

In-Vitro Medicine Scientist Development 40

Drug Discovery World

NOVEMBER 16, 2022

In April 2021, life sciences solutions provider Molecular Devices launched its Organoid Innovation Centre (OIC), an initiative designed to help scientists leverage the potential of 3D biology throughout the drug discovery process. . 2D vs 3D . 2D biology has been used by pharmaceutical researchers for decades. 2D vs 3D .

Drugs 97

Drugs In-Vivo In-Vitro Scientist 97

pharmaphorum

MARCH 1, 2021

That said, some scientists say that people with low virus levels are less likely to transmit the infection anyway, and the tests are particularly useful for detecting asymptomatic spreaders. The test – which can also be self-collected – showed a sensitivity of 93.8%

In-Vitro 98

In-Vitro RNA Protein Antibody 98

pharmaphorum

JULY 6, 2022

The JV has been formed German pharma companies Boehringer Ingelheim and Evotec with in vitro diagnostics specialist bioMérieux, with the objective of developing new antimicrobial drugs backed by diagnostics to quickly identify pathogens and their resistance patterns and guide treatment.

In-Vitro 58

In-Vitro Development Pharma Companies Drugs 58

XTalks

APRIL 13, 2021

Now, thanks to a study funded by the National Institutes of Health Intramural Research Program, scientists have discovered that ?-synuclein, The scientists found that the amyloid-forming protein is expressed at higher levels in melanoma cells than in normal healthy skin. Additionally, higher levels of ?-synuclein Excessive levels of ?-synuclein

Research 98

Research Protein In-Vitro Gene Therapy 98

XTalks

APRIL 6, 2022

Scientists at the University of Cambridge evaluated the use of a personalized blood test that detects ctDNA to help predict the relapse risk of lung cancer. The personalized ctDNA blood test uses the RaDaR™ assay, a liquid biopsy platform developed by the company Inivata. Photo source: Inivata.

DNA 105

DNA In-Vitro Doctors Doctor 105

XTalks

JANUARY 6, 2021

Related: Scientists Use Llama Antibodies to Neutralize COVID-19. In addition, scientists at the University of Pittsburgh School of Medicine used a cryo-EM method to isolate neutralizing nanobodies from a llama named Wally after it had been immunized with a protein fragment from the SARS-CoV-2 virus. TJ” Esparza, BS, and David L.

Antibody 105

Antibody Protein Bacteria In-Vitro 105

The Pharma Data

AUGUST 15, 2021

Even as several safe and effective COVID-19 vaccines are being administered to people worldwide, scientists are still hard at work developing different vaccine strategies that could provide even stronger or longer-lasting immunity against SARS-CoV-2 and its variants.

Protein 52

Protein Vaccination Vaccine Antibody 52

Camargo

FEBRUARY 10, 2021

Drug development is an extremely cumbersome process, requiring the testing of an agent from in vitro studies to in vivo studies to in silico modeling. Given that it can take up to 20 years for a final product to be approved, it is unsurprising that drug attrition rates are very high. Approaches to Pharmacokinetic Analysis.

Production 133

Production Bioavailability In-Vivo Bioequivalency 133

Drug Discovery World

MAY 25, 2023

Following the Scottish Research and Drug Development Forum meeting, DDW’s Diana Spencer provides a snapshot of drug discovery in Scotland. With over 150 pharma services/supply companies and 19 universities, Scotland is one of the most advanced life science sectors in the UK and the world. There are various other phenomics projects currently ongoing.

Research 52

Research Drugs In-Vitro Insulin 52

Drug Discovery World

JUNE 12, 2023

We’ve been attending AACR 2023 every year for a number of years, which has been a progression of us moving from laboratory studies in tissue culture in vitro to see if we had something, to the animal studies and the pharmacology work, and now we’re reporting on very, very mature clinical trial data.

Research 52

Research In-Vitro Doctors Doctor 52

The Pharma Data

FEBRUARY 25, 2022

Several FDA-approved drugs – including for type 2 diabetes, hepatitis C and HIV – significantly reduce the ability of the Delta variant of SARS-CoV-2 to replicate in human cells, according to new research led by scientists at Penn State. ” The findings published today (Feb. 25) in the journal Communications Biology. .

FDA Approval 52

FDA Approval Drugs Protein In-Vitro 52