Drug Discovery World

JANUARY 10, 2023

For over 50 years, Bethyl Laboratories (now a Fortis Life Sciences brand) has been dedicated to improving lives by supporting scientific discovery through qualified antibody products and custom services. Pillar 5: Protein OE/Epitope Tags. We are vertically-integrated from immunisation through manufacturing and validation.

Antibody 52

Antibody Protein Reagent Scientist 52

The Pharma Data

MARCH 16, 2022

using SNAP-tag) involves labeling cell proteins with a fluorescent dye, thereby enabling researchers to observe how proteins interact in the living cell and where in the cell they are located. With Spirochrome, he commercialized fluorescent probes for cell biology, while with Covalys, he marketed SNAP-tag and other protein labeling methods.

Protein 52

Protein Scientist Gene Development 52

XTalks

NOVEMBER 3, 2022

The company is currently conducting a study to demonstrate Mounjaro’s weight loss effects and secured an FDA Fast Track tag in the obesity indication. Lilly is also looking to pitch Mounjaro as an obesity drug and directly take on Novo’s Wegovy. Lilly plans to begin a rolling submission for Mounjaro in the obesity indication in 2022.

Sales 98

Sales FDA Approval Production Insulin 98

pharmaphorum

JANUARY 21, 2022

And the bottom line is that the patient may not receive a medicine that could save or substantially improve his or her life.”. This evolution is leading to additional health benefits and health gains, but they are accompanied by major concerns, as very high price tags raise questions about their affordability.”.

Medicine 52

Medicine Marketing Manufacturing Production 52

XTalks

JUNE 28, 2023

million price tag of Elevidys, a one-time gene therapy. It has taken Sarepta six years to develop Elevidys with several roadblocks in its journey, including two clinical holds due to safety concerns. In a media call, Sarepta CEO Douglas Ingram revealed the $3.2 He said an analysis suggested that the drug could be cost-effective at $5 million.

Gene Therapy 98

Gene Therapy Gene Protein FDA Approval 98

XTalks

NOVEMBER 30, 2022

Hear more about the therapy and how the high price tag of the new drug is actually lower than the cost of treating Hemophilia B patients over their lifetimes with current conventional treatments. Subscribe to the Xtalks Life Science Podcast to never miss a new episode. million per dose.

Gene Therapy 52

Gene Therapy Life Science Gene FDA Approval 52

Drug Discovery World

MAY 22, 2023

But are these price tags a barrier to access? For instance, apprenticeships are on the rise as technical areas such as bioprocessing become more reliant on unconventional candidates, including training of personnel without a biologics or life science background. million per dose.

Gene Therapy 52

Gene Therapy Gene Drugs Contamination 52

XTalks

JANUARY 28, 2022

Kimmtrak has a price tag of $18,760 per vial, which amounts to a weekly dose. The company is expecting approval from the European Medicines Agency (EMA) soon as it prepares for a European launch in the second quarter of this year. The median treatment time is about 23 weeks (or 5.3

FDA Approval 98

FDA Approval Development Licensing Licensing 98

XTalks

JUNE 8, 2021

With a price tag of over $2.5 One of the main reasons why Zolgensma has such a hefty price tag is because it has a small market size in the drug manufacturing industry and hence limited potential to save lives on a large scale. million, Zolgensma is currently the world’s most expensive drug. Why is Zolgensma So Expensive?

Gene Therapy 110

Gene Therapy Gene Protein Trials 110

XTalks

JULY 12, 2021

On the other hand, Biogen is being aggressively questioned over its tacking on of such a hefty price tag for the drug. Katie Porter, D-California sent a letter to the Department of Health and Human Services in which she charged Biogen with “undue influence” over the FDA’s review process.

Drugs 98

Drugs Clinical Trials Clinical Trials Trials 98

XTalks

OCTOBER 12, 2022

For ASL MR perfusion, water molecules in arterial blood from a feeder artery are magnetically tagged and tracked until they reach the region of interest. Then, the signal difference in the region of interest between the tagged images and control images can be computed to obtain cerebral blood flow (CBF) values ( Figure 3 ).

Clinical Trials 93

Clinical Trials Clinical Trials Trials Drugs 93

Roots Analysis

JANUARY 28, 2024

Velocity: Big Data needs to be handled promptly as businesses generate data at an unprecedented speed, driven by the growing adoption of Internet of Things (IoT), and technologies, such as RFID tags, sensors, and smart meters are used to deal with the high velocity of data in real-time. It is loosely arranged into categories using meta tags.

Big Data 40

Big Data Medicine Marketing Clinical Trials 40

pharmaphorum

NOVEMBER 27, 2022

Fully integrated and automated ingredient to consumer batch tracking using barcoding, RFID tagging, or IoT temperature logging and timestamping significantly reduces the chance of these mix-ups, providing complete traceability records from ingredient manufacturer to patient, and ensures the safety of the product. About the author.

Production 103

Production Manufacturing Drugs Marketing 103

pharmaphorum

SEPTEMBER 29, 2021

Oliver Stohlmann’s Corporate Survival Hacks series draws on his experiences of working in local, regional and global life science communications to offer some little tips for enjoying a big business career. If you need to phrase your message off-business hours, tag your draft for later delivery and release it during office hours.

Life Science 113

Life Science Containment Sales Marketing 113

XTalks

OCTOBER 26, 2021

The treatment came with an initial price tag of $39,000 per vial, which amounts to a total of $575,00 each year. Givlaari was approved by the European Medicines Agency (EMA) in March 2020 and by the US Food and Drug Administration ( FDA ) in 2019.

Gene Silencing 98

Gene Silencing Gene Clinical Trials Clinical Trials 98

XTalks

FEBRUARY 27, 2024

Addressing the high price tag, Iovance’s commercial chief Jim Ziegler said, “Payers have expressed their appreciation for the value proposition for Amtagvi.” Vogt said Iovance set Amtagvi’s price based on its value as the first drug approved in the post-PD-1 melanoma setting, and the company’s analysis of relevant benchmarks.

FDA Approval 52

FDA Approval Manufacturing In-Vivo Trials 52

pharmaphorum

MAY 24, 2021

Robb DeFilippis, managing director, life sciences, for end-to-end global creative production and sourcing partner Tag in the Americas agrees. He’s dedicated the last 10 years of his career to servicing the Life Sciences sector and continues to serve this industry.

Marketing 83

Marketing Branding Sales Life Science 83

XTalks

JUNE 9, 2021

Aducanumab Controversy and Price Tag. While the FDA approval does not indicate that the drug is for a specific group of patients, aducanumab was studied in a specific subset of patients with early disease and who were positive for a component found in amyloid brain plaques. Evidence for aducanumab’s efficacy has been highly contested.

Drugs 98

Drugs Clinical Trials Clinical Trials Trials 98

pharmaphorum

NOVEMBER 16, 2022

However, with a price tag of €1.58 However, a recently released report from the organisation could blow the price tag of Zolgensma out of the water. When even high-income regions like Europe are refusing to meet the price tag of certain gene therapies, it is likely the debate on pricing is set to continue in the long-term.

Gene Therapy 127

Gene Therapy Gene Marketing Development 127

XTalks

FEBRUARY 17, 2023

Here are six key tactics life science marketers should use to drive increased registration numbers for their webinars. 6) Tagging Speakers and Partners It’s a great idea to tag your speakers and partners when promoting your webinar. Target various groups with specific messages that will resonate with them.

Life Science 97

Life Science Marketing Production 97

The Pharma Data

NOVEMBER 15, 2020

16, 2020 /PRNewswire/ — Cytiva , a global life sciences leader, is supporting Clover Biopharmaceuticals , a global clinical-stage biotechnology company, to help accelerate the development and manufacturing of a protein-based S-Trimer subunit vaccine candidate. SHANGHAI , Nov. About Cytiva.

Vaccination 52

Vaccination Vaccine Manufacturing Life Science 52

pharmaphorum

DECEMBER 2, 2020

Unusually, the UK parliament ended up getting involved, perhaps underlining the importance of AZ to the country’s life sciences sector, with both AZ and Pfizer asked to argue for the future of the company in parliamentary hearings. For all the latest Pfizer news follow pharmaphorum’s Pfizer tag.

Sales 127

Sales Production Drugs Marketing 127

XTalks

AUGUST 17, 2020

Using chemistries, we can then tag on different T cell epitopes – [this] is in contrast to the Immuno-STAT where each peptide that is bound to the HLA is made as a fusion protein so it needs its own separate cell line,” Dr.

Protein 98

Protein Engineer Immune Response In-Vivo 98

pharmaphorum

NOVEMBER 28, 2022

Owkin in particular has bagged some high-profile, high-price tag development deals with the likes of Bristol-Myers Squibb and Sanofi. A number of companies have sprung up offering AI models to help pharma companies with drug discovery over the past few years.

Pharma Companies 70

Pharma Companies Life Science Research Development 70

XTalks

AUGUST 23, 2021

With a $56,000 price tag for a year’s worth of treatment, Aduhelm is far from the most expensive drug on the market. But studies investigating both classes of drugs in combination must also consider the potential that the tau-targeting agent might only receive approval to be prescribed alongside an anti-amyloid antibody like aducanumab.

Clinical Trials 52

Clinical Trials Clinical Trials Trials Drugs 52

XTalks

MARCH 22, 2023

In October 2022, Xtalks celebrated two decades of bringing diverse stakeholders in the life science industry together through first holding physical events, then soon after, hosting exclusively online events. In addition, nearly half of all new drugs launched between 2020 and 2021 came with a price tag of $150,000 per year, or more.

Life Science 97

Life Science Drugs FDA Approval Vaccination 97

XTalks

AUGUST 19, 2022

Zynteglo’s hefty price tag of $2.8 Zynteglo’s weighty price tag posed to be an issue in Europe, with bluebird having to pull the drug shortly after it was approved in the EU due to both issues with securing reimbursement payment plans, and manufacturing problems.

Gene Therapy 95

Gene Therapy FDA Approval Gene Clinical Trials 95

pharmaphorum

SEPTEMBER 30, 2022

Life science companies can keep track of where information has been used, re-used, and re-purposed at a very granular level, providing high levels of compliance across all markets and countries. This has to be managed at the data and component level. Key CCMS considerations. Fillable metadata is next added to the templates.

Compliance 52

Compliance Life Science Marketing Production 52

XTalks

FEBRUARY 27, 2024

Despite high price tags of a couple of million dollars, gene therapy makers say they are working to ensure patients are able to access the treatments through patient assistance programs developed in conjunction with the support of governments. Sarepta hopes to clarify Elvidys’ effectiveness in older children in a confirmatory trial.

Research 59

Research Drugs Gene Therapy Clinical Trials 59

XTalks

APRIL 29, 2022

Wegovy had a price tag of $1,297 a month when it was first launched. A year ago, Eli Lilly’s SURPASS-2 study found tirzepatide to be superior to semaglutide in reducing blood sugar and body weight. Results of the trial led Lilly to file for FDA approval of the drug last year for the treatment of adults with type 2 diabetes.

Trials 98

Trials Drugs FDA Approval Clinical Trials 98

pharmaphorum

JUNE 15, 2021

The adoption of New Science – a unique combination of the best in science and health technology that address significant unmet patient needs – is delivering more precise and effective treatments, but often at a higher price tag, according to new research. There are better ways to deliver innovation — 2020 proved that.

Clinical Trials 89

Clinical Trials Clinical Trials Development Marketing 89

XTalks

NOVEMBER 24, 2022

While the price tag of Hemgenix is quite steep, CSL Behring told Fierce Pharma that the cost of treating patients with moderate to severe hemophilia to healthcare systems is more than $20 million over their lifetimes.

Gene Therapy 52

Gene Therapy Gene FDA Approval Genetics 52

Roots Analysis

AUGUST 28, 2022

Furthermore, several live cell imaging and non-destructive fluorescence histological methods measure limited number of biomarkers at a time and the tags introduced may interfere with the natural function of genes and proteins. For more details on this emerging domain, check out the following report : SPATIAL GENOMICS MARKET.

Genome 52

Genome Genomics RNA Genome Project 52

Drug Discovery World

NOVEMBER 13, 2023

The track will be opened by chairperson remarks from Daniel Chen, MD, PhD, Founder, Engenuity Life Sciences, which will be followed by the track’s keynote presentation by Bent Jakobsen, PhD, FMedSci, CEO & Founder, Accession Therapeutics. It is called, ‘An unexpected future for immune oncology therapies?’

Protein 59

Protein Antibody Engineer Scientist 59

XTalks

NOVEMBER 27, 2021

The technical advisory group on SARS-CoV-2 virus evolution (TAG-VE) met on Friday to discuss B.1.1.529, The World Health Organization (WHO) has declared the new variant of SARS-CoV-2 found in South Africa, first referred to as B.1.1.529, 1.1.529, to be a variant of concern (VOC) and has named it after the Greek letter Omicron (O).

Vaccination 97

Vaccination Vaccine Protein Scientist 97

XTalks

JANUARY 19, 2024

This biological variability adds complexity, but with that complexity comes the power to choose the targets, the tags and the payloads and select combinations appropriate to the patient to personalize that therapy. There is also potential for using several radiotherapies in combination therapies.

DNA 66

DNA Radiology FDA Approval Development 66

Drug Discovery World

NOVEMBER 9, 2023

Esperanza Rivera de Torre, PhD, Assistant Professor, Center for Antibody Technologies, Department of Bioengineering, Technical University of Denmark, on: ‘Venom on demand: optimising snake toxin yield, folding, and purity in E coli and P pastoris with biotinylation, solubility, and purification tags’. Crystal Richardson, Ph.D,

Engineer 52

Engineer Antibody Protein In-Vivo 52