Remove tag one-medical-group
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Grand Rounds December 2, 2022: A Randomized Controlled Trial of Mobile Health Intervention in Heart Failure and Diabetes: Lessons Learned (G. Michael Felker, MD, MHS)

Rethinking Clinical Trials

Medication adherence can be a barrier to effectiveness. that focused on patients with heart failure and diabetes, two rapidly growing conditions that are highly morbid. The focus of the study was on physical activity and medication adherence. Both groups received a step counter and weekly text reminder to wear it.

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Grand Rounds July 7, 2023: Implementing Virtual Strategies Across an Integrated Healthcare System: The IMPLEMENT-HF Study (Ankeet S. Bhatt, MD, MBA, ScM)

Rethinking Clinical Trials

They made only one suggestion a day for how to optimize the patient’s care, such as initiation of one therapy or an up titration of an existent therapy. The study team assessed the change in medical therapy from hospital admission to hospital discharge by assigning a guideline directed in-hospital medical therapy score.

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Grand Rounds January 12, 2024: Design and Implementation of a Weighted Lottery to Equitably Allocate Scarce Covid-19 Resources (Erin K. McCreary, PharmD, BCIDP)

Rethinking Clinical Trials

The COVID Therapeutics Committee worked with the state health department to develop a policy for fair allocation of scarce medications to treat COVID-19. UPMC set clear criteria based on the published data at the time for who could and could not receive Remdesivir. The first drug that used the new process was Remdesivir in May 2020.

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Grand Rounds Biostatistics Series January 5, 2024: Methods for Handling Missing Data in Cluster Randomized Trials (Rui Wang, PhD; Moderator: Fan Li, PhD)

Rethinking Clinical Trials

Significant work has been done on individual level missingness, where there is an observed outcome for each cluster, but an outcome is missing for one individual. Discussion Themes -If the cluster size is small, we may have a propensity score estimated at zero or one. Sometimes there is missingness in the outcome.

Trials 275
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Grand Rounds February 9, 2024: Pragmatic Recruitment of Underrepresented Groups – Experience From the Diuretic Comparison Project (Cynthia Hau, MPH)

Rethinking Clinical Trials

One key success factor was having a flexible EHR. Learn more Read more in JAMA Network Discussion Themes -One real takeaway is the incredible amount of preparatory work that was required before a participant was randomized. When people who are external to the VA view it as one homogeneous system, that is not the case.

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Grand Rounds July 14, 2023: Lessons From the COORDINATE-Diabetes Trial (Christopher B. Granger, MD; Neha J. Pagidipati, MD, MPH)

Rethinking Clinical Trials

The objective of COORDINATE-Diabetes trial was to improve the implementation and adoption of these therapies by testing the impact of a clinic-level, multifaceted intervention on the prescription of 3 key groups of evidence-based therapies. The cardiology clinics were randomized to one of two groups. Granger, MD; Neha J.

Trials 130
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Grand Rounds October 7, 2022: Impact Of Handovers Of Anesthesia Care On Morbidity And Mortality (Melanie Meersch-Dini, MD)

Rethinking Clinical Trials

In Germany, there are two levels of anesthesia, in-room anesthesiologists who are either trainees or a medical specialist (non-management). The trial randomized 1,817 patients, with 908 randomized to the handover group and 909 to the no handover group. pctGR, @Collaboratory1.

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