Rethinking Clinical Trials

OCTOBER 2, 2023

The PROTEUS Consortium’s objective is to ensure that patients, clinicians, and other decision-makers have high-quality PRO data from clinical trials and clinical practice to make the best decisions they can about treatment options. In our research, we learned that patients actively do not want to see error bars and P values on graphs.

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Clinical Trials Clinical Trials Research Trials 152

Pharmaceutical Technology

MAY 2, 2023

Immuno-oncology (IO) agents have transformed the cancer therapeutics landscape, driving long-term remissions in a subset of patients who historically had limited options. Although a subset of patients derives long-term benefits from IO therapies, a high percentage of patients still fail to respond or develop resistance to IO therapy.

Genetic Engineering 130

Genetic Engineering Antibody Clinical Trials Clinical Trials 130

Rethinking Clinical Trials

SEPTEMBER 28, 2023

In the initial PARENT trial, intervention families had better performance on receipt of well child care, and patients reported better patient experience and fewer emergency department visits. Parents loved the text messaging service. The average child age was 4 months.

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Trials Clinical Trials Clinical Trials Research 269

Rethinking Clinical Trials

JANUARY 26, 2023

Patient recruitment is through a network of sites in different geographic locations managed by a collaboration of AROs. EVOLVE-MI is enrolling 4,000 patients in 3 countries. So far EVOLVE-MI’s early experience in the trial has been that nearly every site enrolled a patient within days of activation.

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Trials Clinical Trials Clinical Trials Medicine 130

Rethinking Clinical Trials

MARCH 21, 2023

Goldberg Distinguished Professor and Chief of Oncology Physician-in-Chief, North Carolina Cancer Hospital Director, Cancer Outcomes Research Program University of North Carolina Slides Keywords Patient-reported outcomes, Oncology, Clinical Trials Key Points Symptoms are common in cancer care. Quality of life (QOL) was assessed at 6 months.

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Clinical Trials Clinical Trials Trials Research 130

Rethinking Clinical Trials

AUGUST 28, 2023

The American College of Physicians guideline states that “physicians and patients should treat acute, sub-acute and chronic LBP with non-drug therapies.” Patients in the usual care arm clinics are then scheduled to see a PCP. Presenters also shared challenges regarding scheduling and patient insurance coverage.

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Trials Research Medicine Doctors 130

pharmaphorum

APRIL 26, 2021

In 2019 Cognitant and Addenbrook’s Hospital in Cambridge, UK piloted a programme that aimed to educate patients to improve adherence to rheumatoid arthritis medicines. The company halted development before it eventually sold its digital health unit back to Eric Careel, co-founder of Withings, the following year.

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Development Medicine Production Marketing 121

Rethinking Clinical Trials

JUNE 7, 2023

The trial was designed to randomize 1,000 patients who had an On-X aortic valve replacement at least 3 months prior to randomization with either a standard dose of Apixaban (5mg) or continued warfarin (the standard of care). The drugs were administered open label and all patients were given a low dose of aspirin.

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Clinical Trials Clinical Trials Trials Cardiology 130

Rethinking Clinical Trials

OCTOBER 13, 2022

The HandiCAP trial asked the question do intraoperative handovers of anesthesia care have an impact on patient outcomes? Patients were registered and randomized centrally in a 1:1 ratio to receive either a handover of anesthesia care or no handover. Are the results generalizable to all patient cohorts and to other health care systems?

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Trials Clinical Trials Clinical Trials Nurses 130

Rethinking Clinical Trials

DECEMBER 6, 2022

This study asks how can we better facilitate health behaviors in patients with chronic diseases and can we leverage technology? that focused on patients with heart failure and diabetes, two rapidly growing conditions that are highly morbid. Patients did not get text messages about pill adherence.

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Trials Clinical Trials Clinical Trials Compliance 130

Rethinking Clinical Trials

MAY 5, 2023

Yet, even though millions of patients have received oxygen during mechanical ventilation in clinical care for decades, the oxygen target that optimizes outcomes has been unknown. All patients in the ED and ICU were assigned together to an SpO2 target. The sample size was 2,250 patients over 36 months.

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Trials Clinical Trials Clinical Trials Development 130

Rethinking Clinical Trials

MARCH 15, 2023

An example of this is when patients experience better outcomes in a large hospital compared to a small hospital when given the same medication. Two estimands will differ when there is informative cluster size in a trial. Which estimand (participant-average or cluster-average) to use depends on the study question. .

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Trials Clinical Trials Clinical Trials Research 130

XTalks

DECEMBER 13, 2023

Current treatments for sickle cell disease include blood transfusions but patients often have episodes of intense pain and an increased risk of stroke. It can also make patients more susceptible to complications like anemia, jaundice, infections and gallstones.

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Gene Therapy FDA Approval Gene In-Vivo 98

Rethinking Clinical Trials

JULY 6, 2023

For instance, there is no discussion of the role of the health care provider in the DCTs, but it emphasizes the importance of patient voice. Discussion Themes -As an early adopter of DCTs, could you share your experience and perspective on these issues? DCTs can make things easier for patients and the research more efficient.

Trials 130

Trials Clinical Trials Clinical Trials Licensing 130

pharmaphorum

JANUARY 31, 2023

This lack of trust in such a crucial industry can lead to decreased compliance, poor treatment adherence, and negative health outcomes for patients. Additionally, when patients are prescribed medication, they are often unaware of the mechanism of action, potential side effects, interactions, and contraindications.

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Clinical Trials Clinical Trials Trials Vaccination 52

Rethinking Clinical Trials

NOVEMBER 9, 2022

The CardioNerds fellows enrolled 54% women compared to 45% non-fellow enrolled and 71% BIPOC compared to 23% non-fellow enrolled patients. We did not want the fellows to take the place of the site coordinators but to use their experience taking care of the patient. There can be a general level of mistrust.

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Clinical Trials Clinical Trials Trials Development 130

pharmaphorum

AUGUST 17, 2020

In this article Joanna Carlish, managing director of financial services at Tag Americas , and Robb DeFilippis, Tag Americas’ managing director, life sciences, go head-to-head to discuss marketing within a regulated industry. Virtual connections. Engagement channels.

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Regulation Marketing Sales Branding 91

XTalks

OCTOBER 26, 2021

The Phase III trial results show that Givlaari offers sustainable benefit to AIP patients and confirm its favorable safety profile. The treatment came with an initial price tag of $39,000 per vial, which amounts to a total of $575,00 each year. This is a huge development for patients.”. AHP affects 1 in 100,000 people in Europe.

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Gene Silencing Gene Clinical Trials Clinical Trials 98

Drug Discovery World

MARCH 2, 2023

New understanding of epigenetics It has been known for more than 20 years that the enzymes placing H3K4me3, a chemical tag added to DNA, are crucial for normal cell development, as well as being linked to leukaemia, breast, bowel and pancreatic cancers.

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Gene Expression Gene DNA RNA 52

The Pharma Data

AUGUST 18, 2020

Dragonfly CEO and co-Founder Bill Hanley said of the deal: “We are confident that the talent, experience and commitment to science-driven innovation of the Bristol Myers Squibb team will enable DF6002 to discover novel, lifesaving solutions for patients.”.

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Sales Protein Drugs 52

World of DTC Marketing

DECEMBER 13, 2021

OPENING: American cancer patients spent more than $21 billion on their care in 2019. billion and patient time costs of $4.87 As cancer survival rates rise, so do the price tags of life-saving treatments. Some cancer patients may face out-of-pocket costs of nearly $12,000 a year for one drug. ScienceNews.com.

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Drugs FDA Approval Medicine Containment 55

XTalks

DECEMBER 21, 2022

As the world continues to experience the effects and aftermath of the COVID-19 pandemic, lessons learned from the biggest global health crisis in recent times spurred changes and adaptations in the life sciences and healthcare. Gene Therapy Approvals. Manufacturer: Ferring Pharmaceuticals A/S. Manufacturer: bluebird bio, Inc.

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Life Science Gene Therapy Gene Clinical Trials 52

Roots Analysis

JANUARY 28, 2024

Not only in healthcare, but various industries have also adopted big data to enhance their capabilities, improve customer experiences, and strengthen their brand reputation, thereby contributing to overall growth of the company. It is loosely arranged into categories using meta tags.

Big Data 40

Big Data Medicine Marketing Clinical Trials 40

pharmaphorum

DECEMBER 23, 2022

There’s been huge progress in treatments for blood cancer in recent years – but drawbacks of expensive CAR-T cell and injected antibody therapies have led drug developers to look at novel oral therapies as patient-friendly alternatives. Of these patients, seven have been treated at the recommended phase II dose (RP2D) and regimen.

Development 52

Development Drugs Clinical Development Antibody 52

pharmaphorum

JANUARY 18, 2022

The hope is that they will harness and re-programme natural cellular mechanisms to selectively remove the disease driving proteins from human tissues, working by boosting interactions – gluing – between therapeutically relevant proteins and the machinery used by cells to naturally tag and destroy proteins.

Dermatology 52

Dermatology Protein Pharma Companies Research 52

pharmaphorum

SEPTEMBER 15, 2020

The huge rise in the use of telemedicine services during lockdown has brought care directly to patients in their homes, while pharma’s communications with healthcare professionals (HCPs) has experienced a similar push to digital channels. Jeremy Richter, Tag. We’re all trying to find ways to automate. About the interviewees.

Branding 118

Branding Marketing Pharma Companies Life Science 118

The Pharma Data

MARCH 23, 2022

Unfortunately, in a Phase 3 clinical trial, treatment with remdesivir did not make a difference in mortality for Ebola virus disease patients. This special enzyme, once fused to Ebola virus polymerase, enables the polymerase to add a molecular tag to any other protein it interacts with.

Protein 52

Protein Genome Genomics Research 52

Intouch Solutions

AUGUST 25, 2021

This update, iOS 15, will have notable changes regarding user privacy preferences, which is a shift from prior updates focusing on user experience and interface changes. Email to HCPs and patients will not be going away anytime soon; and the iOS 15 update will not slow the development of personalized experiences in email.

Marketing 52

Marketing Regulation Engineer Branding 52

Delveinsight

FEBRUARY 25, 2021

Quest runs 2,200 patient service centers and recruits 5,000 mobile phlebotomists who have experience and expertise in offering phlebotomy services for at-home visits. Working with Quest will help them support convenient access to blood collection for patients and healthcare providers.

DNA 52

DNA In-Vivo Genetics Medicine 52

XTalks

MARCH 22, 2023

Drug Development is More Expensive than Ever Before It was once the aim of big pharma to develop small molecule drugs that collected indications like Pokémon cards in order to have the broadest possible patient population that would benefit. More potential patients equal more prescriptions which equals higher sales and bigger profits.

Life Science 97

Life Science Drugs FDA Approval Vaccination 97

Delveinsight

JULY 22, 2020

Today the tech-based healthcare industry is providing many unique solutions to the patient’s care which are more efficient and effective than the traditional services. IoT relies on the data collected from devices and provides valuable insights that help in providing the best possible healthcare solution to the patient.

Doctors 59

Doctors Doctor Marketing Production 59

XTalks

JANUARY 19, 2024

And if the bar is set too low, patients may not reach optimal exposures and may not get the full benefit of the treatment, explained Dr. Anderson. Some of these include: Patient Models There have been significant improvements in patient models. There is also potential for using several radiotherapies in combination therapies.

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DNA Radiology FDA Approval Development 66

Pharmaceutical Technology

JANUARY 27, 2023

Before Cablivi’s approval, patients relied on a combination of plasma exchange plus corticosteroids and immunomodulators as the standard of care (SOC) for treatment. Sanofi’s eligibility requirements follow a similar model to Pfizer’s previous programs, with refunds being dependent on lack of clinical outcome in patients.

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Manufacturing Drugs Research Analyst FDA Approval 130

The Pharma Data

MARCH 20, 2021

highlight the experiences of. testing platform to process up to 6,000 patient. L volumes, even for notoriously difficult liquid classes like the 100% acetonitrile used to store the Tandem Mass Tags (TMT). In the examples below, we. three different laboratories using the MANTIS liquid handler. samples per day.

Reagent 52

Reagent RNA Bioinformatics Medicine 52

pharmaphorum

MAY 24, 2021

Robb DeFilippis, managing director, life sciences, for end-to-end global creative production and sourcing partner Tag in the Americas agrees. It can be used for sales, marketing and patient communication materials, in print or digital form. About the interviewee.

Marketing 92

Marketing Branding Sales Life Science 92

The Pharma Data

MAY 13, 2021

After all, the ingredients we’ve chosen to include in Spade SB-66 are premium ingredients and come with a hefty price tag. Yet while my track record and the success I’ve had with my patients speaks for itself…. And you’re not just over-the-moon thrilled with your experience using Spade SB-66… Just call or email my U.S.

Packaging 52

Packaging Packaging Containment Production 52

Drug Discovery World

NOVEMBER 13, 2023

Roundtable breakout discussions Breakout Discussions are informal, moderated discussions, which allow participants to exchange ideas and experiences and develop future collaborations around a focused topic. These topics include: Membrane protein discovery challenges, and characterisation of antibodies against membrane proteins.

Protein 59

Protein Antibody Engineer Scientist 59