Scienmag

FEBRUARY 17, 2021

Credit: Mark Bauer/FSU College of Medicine Nearly a half-million people a year die from sudden cardiac death (SCD) in the U.S. A leading cause of SCD in young athletes is arrhythmogenic cardiomyopathy (ACM), a genetic disease in which healthy heart muscle is replaced over time […].

Medicine 55

Medicine Genetic Disease Development Genetics 55

Scienmag

DECEMBER 3, 2020

Associated collaboration with the New York Genome Center to expand patient access to advanced genomic technologies Seeking to advance the scope of precision medicine, Weill Cornell Medicine, NewYork-Presbyterian Hospital, and Illumina, Inc.

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Genome Genomics Medicine Genetics 52

Scienmag

MAY 5, 2021

Study published in JAMA Cardiology Credit: UIC/Jenny Fontaine A new mutation found in a gene associated with an increased risk of atrial fibrillation poses a significantly increased risk for heart failure in Black people.

Cardiology 53

Cardiology Genetics Gene Research 53

Scienmag

APRIL 28, 2021

In a world first study of 390,435 people, University of South Australia researchers found causal genetic evidence that cardio health […].

Genetics 52

Genetics Research Cardiology Gene 52

Scienmag

AUGUST 20, 2020

In people with a single-gene variant that puts them at high risk for heart disease, breast cancer, or colorectal cancer, the rest of the genome can alter that risk Life can change dramatically when someone learns they are genetically predisposed to a disease, such as a condition called familial hypercholesterolemia, where a mutated gene can […]. (..)

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Genetics Gene Genome Genomics 41

Scienmag

MARCH 31, 2021

But now, scientists at Washington University School of Medicine in St. […].

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Scientist Genetics Gene Medicine 62

Scienmag

NOVEMBER 18, 2020

— Research on a genetic heart disease has uncovered a new and unexpected mechanism for heart failure. ROCHESTER, Minn. This landmark discovery found a correlation between the clumping of RNA-binding proteins long linked to neurodegenerative disease ?

Genetics 40

Genetics RNA Protein Research 40

The Pharma Data

OCTOBER 27, 2021

Appointment further strengthens Board scientific capabilities, including in genetics which is central to GSK’s R&D approach. Dietz MD, Professor of Genetic Medicine at The Johns Hopkins University School of Medicine in the United States, will join the Board of the Company as a Non-Executive Director.

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Scienmag

APRIL 20, 2021

Researchers at Penn Medicine uncover more genetic mutations that predispose women to peripartum cardiomyopathy, with implications for the future of increased genetic testing PHILADELPHIA– Researchers at Penn Medicine have identified more genetic mutations that strongly predispose younger, otherwise healthy women to peripartum cardiomyopathy (PPCM), (..)

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Genetics Development Medicine Research 45

Scienmag

SEPTEMBER 7, 2020

Credit: Felix Petermann, MDC Hundreds of innovators, research pioneers, clinicians, industry leaders and policy makers from all around Europe are united by a vision of how to revolutionize healthcare.

Medicine 58

Medicine Research Bioinformatics Allergies 58

Scienmag

AUGUST 31, 2020

Sophia Antipolis, France – 31 Aug 2020: Losing weight could prevent or even reverse diabetes, according to late breaking research presented today at ESC Congress 2020.1 In 2019, approximately 463 million people worldwide had diabetes, of which the vast majority (around 90%) was type 2 diabetes.2

Genetics 72

Genetics Research Cardiology Medicine 72

The Pharma Data

OCTOBER 22, 2020

Pre-pregnancy care for a woman with known aortic disease would include evaluation of maternal and fetal risk, counseling and possible genetic testing, followed by ongoing monitoring and testing, study co-author Dr. Melinda Davis, a cardio-obstetrics expert at University of Michigan Medicine, said in a university news release.

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Cardiology Hormones Genetics Research 52

Scienmag

JUNE 3, 2021

Conducted in partnership with the University of Reading, the world-first study used a genetic-approach to investigate causal […].

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Scienmag

DECEMBER 3, 2020

Using a new variant to repair DNA will improve both safety and effectiveness of the much-touted CRISPR-Cas9 tool in genetic research, Michigan Medicine researchers say. Eugene Chen, M.D., […].

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Gene Editing Gene DNA Genetics 41

Scienmag

FEBRUARY 24, 2021

According to a new study published in The American Journal of Human Genetics, more than one third of genetic variants that increase the risk of coronary artery disease regulate the expression of genes in the liver. Credit: UEF/Raija Törrönen.

Gene 52

Gene Genetics Regulation Cardiology 52

Scienmag

FEBRUARY 17, 2021

In a world first genetic study, researchers from the Australian Centre for Precision Health at the University of South Australia found that that long-term, […].

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Genetics Research Cardiology Medicine 65

Scienmag

MAY 17, 2021

Patients’ genetic profile strongly influences size of effect in early-phase trial People with extremely high levels of triglycerides (a type of fat in the blood) and a specific genetic profile saw a substantial reduction in triglycerides after taking the human monoclonal antibody evinacumab compared with those taking a placebo, in a study presented (..)

Genetics 42

Genetics Antibody Trials Gene Therapy 42

Scienmag

DECEMBER 3, 2020

In a randomized, controlled clinical trial, researchers found that patients who received genetic test results about the side effects of cholesterol-lowering medications did not have worse outcomes after one year A person’s genetic make-up can influence whether they might experience side effects from certain medications.

Clinical Trials 44

Clinical Trials Clinical Trials Trials Genetics 44

Scienmag

MAY 18, 2021

Scientists link genetic makeup of bacteria in the human gut to several human diseases We are truly never alone, not even within our own bodies. Human beings play host to trillions of bacteria, fungi, viruses, and other microorganisms that make up the human microbiome. In recent years, the mix of these resident bacteria, and the […].

Bacteria 74

Bacteria Genetics Scientist Cardiology 74

Scienmag

OCTOBER 15, 2020

Benoit Bruneau and Katie Pollard study DNA folding to identify the genetic causes of congenital heart disease Credit: Photo: Gladstone Institutes SAN FRANCISCO, CA–October 15, 2020–The National Institutes of Health (NIH) has granted a 4D Nucleome award to support research by a group of scientists at Gladstone Institutes led by Benoit Bruneau, (..)

DNA 54

DNA Genetics Scientist Research 54

The Pharma Data

AUGUST 30, 2021

Wilson disease is a rare and progressive genetic condition in which the body’s pathway for removing excess copper is compromised. ALXN1840, a potential new once-daily, oral medicine, demonstrated approximately three times greater copper mobilisation than SoC. Wilson disease. 1 It affects one in 30,000 live births in the US.

Trials 52

Trials Genetics Cardiology Medicine 52

Scienmag

JANUARY 14, 2021

14, 2021 — Adults who smoke or who are genetically predisposed to smoking behaviors are more likely to experience a serious type of stroke called subarachnoid hemorrhage (SAH), according to new research published today in Stroke, a journal of the American Stroke Association, a division of the American Heart Association. […].

Genetics 46

Genetics Research Cardiology Medicine 46

The Pharma Data

DECEMBER 8, 2020

The company’s commercial priorities are three-fold: (1) Initially focusing its commercial efforts on rare diseases within its prolific neurology and cardiology franchises (2) pioneer new markets where there are no available treatments (3) create new standards of care where there has been a lack of innovation to optimize patient care. .

Medicine 52

Medicine RNA Production Marketing 52

The Pharma Data

JANUARY 5, 2021

.” “They are frequently hospitalized and often undergo multiple invasive procedures or surgeries early in childhood and throughout their lifetime,” said Dr. Vincent Gonzalez, a pediatric cardiology fellow at Baylor College of Medicine/Texas Children’s Hospital in Houston.

Cardiology 52

Cardiology Doctors Doctor Genetics 52

Delveinsight

DECEMBER 29, 2020

X-linked myotubular myopathy (XLMTM) is a rare genetic neuromuscular disorder and leads to muscle weakness, respiratory failure, and early death. The ASPIRO trial is a two-part, open-label ascending dose study, and is examining the safety and preliminary efficacy of AT132 in children with XLMTM younger than five years old.

Trials 52

Trials Drugs Hormones Radiology 52

Scienmag

OCTOBER 22, 2020

Scientists cannot be expected to drop everything they’re working on to turn their attention to beating COVID-19, according to the winner of the 2019 Nobel Prize in Physiology or Medicine, Professor Sir Peter Ratcliffe.

Research 41

Research Scientist Medicine Cardiology 41

The Pharma Data

OCTOBER 28, 2020

28, 2020 — There may be a positive causal relationship between elevated birth weight and risk for future atrial fibrillation in adulthood, according to a study presented at the annual Great Wall International Congress of Cardiology, held virtually from Oct. WEDNESDAY, Oct. The genome-wide association study included 321,223 individuals.

Cardiology 40

Cardiology Genetics Genome Genomics 40

Scienmag

SEPTEMBER 6, 2020

Rather than a slow build-up of plaque over time, a heart attack caused by spontaneous coronary artery dissection strikes suddenly, often in younger women who didn’t seem to be at risk for a cardiac event.

Genetics 46

Genetics Gene Cardiology Medicine 46

Scienmag

JULY 19, 2021

May also explain liver fat differences among men & women Credit: Sallam Lab/UCLA FINDINGS A chemical modification that occurs in some RNA molecules as they carry genetic instructions from DNA to cells’ protein-making machinery may offer protection against non-alcoholic fatty liver, a condition that results from a build-up of fat in the liver (..)

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Scienmag

JUNE 17, 2021

Researchers from University of Tsukuba, Japan, collaborating with scientists from Germany, develop a mouse model for restrictive cardiomyopathy and uncover the underlying mechanisms of the disease Ibaraki, Japan – Severe childhood restrictive cardiomyopathy is a condition that causes the muscles in the walls of the heart to become stiff, so that (..)

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Scientist Development Research Cardiology 70

Scienmag

NOVEMBER 25, 2020

Gerszten, MD, Chief of the Division of Cardiovascular Medicine at Beth Israel Deaconess Medical Center (BIDMC) […]. . – Even as tens of thousands of Americans test positive for COVID-19 each day, physicians still aren’t sure why some people experience mild to no symptoms while others become critically ill.

Genetics 49

Genetics Research Medicine Cardiology 49

Scienmag

NOVEMBER 19, 2020

Precise treatment leads to resolution of patient’s debilitating symptoms and complete remodeling of her lymphatic system Philadelphia, November 20, 2020–Researchers at Children’s Hospital of Philadelphia (CHOP) have resolved a severe lymphatic disorder in a girl with Noonan Syndrome that had led to upper gastrointestinal bleeding, (..)

Research 67

Research Cardiology Gene Genetics 67

Scienmag

OCTOBER 8, 2020

M2D2 $200K Challenge provides funding, in-kind support to promising ventures LOWELL, Mass. – A medical-device startup that aims to improve the health of pregnant women is the top winner in an annual pitch contest presented by the Massachusetts Medical Device Development Center (M2D2).

Development 71

Development Clinical Trials Clinical Trials Cardiology 71

Scienmag

NOVEMBER 9, 2020

Preeclampsia-related gene expression in the placenta may correlate with vitamin D status during pregnancy, report researchers from the Medical University of South Carolina. Credit: Medical University of South Carolina According to the World Health Organization, preeclampsia affects between 2% to 8% of pregnancies.

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Gene Gene Expression Research Cardiology 52

Scienmag

AUGUST 7, 2020

Research points to potential to reduce triglyceride levels without the risk of unpleasant and serious side effects in the intestines and liver Credit: Image is courtesy of Navid Marvi.

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Research Cardiology Genetics Medicine 52

Scienmag

SEPTEMBER 24, 2020

New light is being shed on a little-known role of Y chromosome genes, specific to males, that could explain why men suffer differently than women from various diseases, including Covid-19.

Gene 60

Gene Research Cardiology Genetics 60

Scienmag

OCTOBER 7, 2020

Collaborative projects funded by the awards will address important questions about neurodegenerative disease, nucleus biology, and protein turnover Credit: Dollie LaJoie, Huntsman Cancer Institute at the University of Utah Could scientists detect neurodegenerative diseases like Alzheimer’s and ALS years or decades before these disorders manifest (..)

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Protein Scientist Research Cardiology 52