Medical Xpress

MARCH 23, 2023

DNA is our body's instruction manual. It contains all the information that our cells need to make proteins and other molecules vital for our development, growth and survival.

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DNA Containment Protein Development 56

Roots Analysis

OCTOBER 16, 2023

DNA cloning refers to the process of generating multiple copies of a particular DNA segment. DNA and Gene Cloning involves the isolation of a DNA sequence of any species ( often a gene ) and its insertion into a vector to enable growth without any alteration in the original DNA sequence.

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BioTech 365

JANUARY 17, 2022

Targeted Immunotherapy in Oncology Market Research Report 2021: Development of New Targeted Immunotherapies, Particularly Those that Deliver Therapeutic DNA and Proteins – ResearchAndMarkets.com Targeted Immunotherapy in Oncology Market Research Report 2021: Development of New Targeted Immunotherapies, Particularly Those that Deliver … (..)

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Drug Discovery World

APRIL 19, 2023

Scientists at The Institute of Cancer Research, London, are teaming up with small molecule neoantigen immuno-oncology company NeoPhore to develop new potential cancer drugs. Image: Human breast cancer cells stained for DNA (red). New treatments aim to take advantage in cancer cells’ DNA repair mechanisms.

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Drug Discovery World

FEBRUARY 14, 2024

Especially for rapidly-mutating viruses (such as SARS-CoV-2), tools that can help inform the rapid development of vaccines are crucial in being better prepared for future health crises. Unlike other types of vaccines that use viral genetic codes or viral vectors, recombinant protein vaccines use only the antigenic proteins themselves.

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Drug Discovery World

APRIL 25, 2024

Reece Armstrong offers an overview of cell line development and outlines the benefits the technology is bringing to biopharmaceutical developers. Cell line development is an essential underpinning of the drug development process, enabling teams to test, optimise and manufacture therapeutics at a commercial scale.

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Development Protein In-Vivo Life Science 59

Pharmaceutical Technology

JUNE 8, 2023

GenScript ProBio has collaborated with the New York Blood Center Enterprises’ business unit, called Comprehensive Cell Solutions (CCS), to accelerate the development and manufacture of cell and gene therapies. The core objective of the collaboration is to make the therapies affordable and accessible to patients.

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Drug Discovery World

AUGUST 16, 2023

Samir Ounzain , PhD, CEO & Co-Founder of HAYA Therapeutics, looks at how a better understanding of our DNA can lead to increased activity for RNA therapeutics. In actuality, the protein-coding portion of our genome is comparable in identity and number with the humble fruit fly or worm.

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pharmaphorum

AUGUST 23, 2021

The COVID-19 pandemic accelerated the development of mRNA-based vaccines, and its influence has now extended to DNA-based shots as well, with Zydus Cadila’s ZyCoV-D getting emergency use authorisation in India. Proponents of the approach claim that DNA vaccines may have advantages over other technologies like mRNA.

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Drug Discovery World

JANUARY 3, 2023

Matthew Clark , CEO of X-Chem, looks at what the future could hold for DNA-encoded library (DEL) technology. In the 13 years since it was first described, DNA-encoded library (DEL) technology has become a firmly established approach to small molecule hit generation in drug discovery. cytokine-receptor disrupters).

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Pharmaceutical Technology

DECEMBER 7, 2022

Alongside the discourse on what the positive study results could mean for patients, researchers are prioritising the development of more biomarkers to identify potential responders and improve patient outcomes. Developing treatment biomarkers and diagnostic biomarkers may help achieve these goals. Amyloid-targeting therapies.

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BioTech 365

AUGUST 2, 2021

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: Atomic-level, 3-D structure of MUTYH protein opens small window into DNA repair mechanism.Researchers have analyzed the three-dimensional structure of a protein that suppresses the development of colorectal … Continue reading (..)

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Scienmag

JANUARY 11, 2022

Enhancers are regions of DNA that do not code for proteins, but control how genes are expressed. Jude Children’s Research Hospital studied the Vsx2 super-enhancer and its role in the development of the retina. Super-enhancers are clusters of enhancers that together regulate genes with important roles in cell identity.

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Roots Analysis

JUNE 1, 2022

DNA cloning is the field of synthetic biology which can be helpful to understand the effect of mutation on a particular gene. Many diseases that can be treated using DNA cloning, such as leukemia and sickle cell anemia, involving the replacement of defected gene. DNA Cloning Kit Providers – Current Market Landscape.

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Pharmaceutical Technology

DECEMBER 7, 2022

Alongside the discourse on what the positive study results could mean for patients, researchers are prioritising the development of more biomarkers to identify potential responders and improve patient outcomes. Developing treatment biomarkers and diagnostic biomarkers may help achieve these goals. Amyloid-targeting therapies.

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Development Drugs Clinical Trials Clinical Trials 246

Scienmag

MAY 17, 2022

These small, circular DNA molecules are used by scientists to introduce new genes into a target organism. Well known for their applications in the production of therapeutic proteins like insulin, plasmids are broadly used in the large-scale production of many bioproducts. Plasmids have extensive use in basic and applied biology.

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Roots Analysis

DECEMBER 12, 2021

DNA data storage involves encoding and decoding binary data to and from synthesized strands of DNA. DNA data storage is an innovative technology that works by encoding large digital data sequences of binary form (0s and 1s) into DNA sequences (Adenine (A), Guanine (G), Cytosine (C) and Thymine (T)). DNA Storage.

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pharmaphorum

OCTOBER 7, 2022

Uniting Technical Personnel to Expand Assay Capabilities for Next Generation Protein Degraders. The post TPD Assay Development & Screening Summit appeared first on. View the full event guide here.

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Drug Discovery World

NOVEMBER 15, 2022

Known for its ability to offer precision and flexibility while expanding the experimental scale, synthetic biology tools can reduce development timelines and costs, and lend a competitive advantage over traditional methods. . Rapid and accurate DNA synthesis .

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DNA Drugs Antibody Engineer 98

Scienmag

JANUARY 28, 2022

A protein that masterminds the way DNA is wrapped within chromosomes has a major role in the healthy functioning of blood stem cells, which produce all blood cells in the body, according to a new study from researchers at Weill Cornell Medicine. The protein, known as histone H3.3,

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Regulation DNA Research Development 57

Drug Discovery World

JUNE 21, 2023

Hosted by DDW and sponsored by Elegen, “Where are the breakthroughs in mRNA drug discovery and development?” Join this free webinar to learn about the opportunities in mRNA drug discovery and development. What you will learn: What are the challenges in relation to the development of mRNA therapeutics and how can they be overcome?

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Development Drugs DNA Engineer 52

FDA Law Blog

MARCH 5, 2024

Gaulkin & Riëtte van Laack — As readers of this blog know, there is a lot of contention about the naming of alternative protein products (APPs), including both plant-based and cell-cultured alternatives for (traditional) animal products. By Sophia R. We’ve previously blogged about this ongoing battle here , here , here , and here.

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Protein Production DNA Containment 59

The Pharma Data

MARCH 7, 2022

By combining CRISPR technology with a protein designed with artificial intelligence (AI), it is possible to awaken individual dormant genes by disabling the chemical “off switches” that silence them. Ruohola-Baker and Levy then fused this designed protein with a disabled version of a protein called Cas9. it can be reawakened.

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Protein Gene Genome Genomics 52

The Pharma Data

MARCH 15, 2022

The p53 protein protects our cells from cancer and is an interesting target for cancer treatments. Researchers at Karolinska Institutet in Sweden have now found an unusual way of stabilising the protein and making it more potent. Researchers around the world are therefore trying to develop cancer treatments that in some way target p53.

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Protein Research Genetics DNA 52

Scienmag

APRIL 27, 2022

CHAPEL HILL, NC – Inside embryonic cells, specific proteins control the rate at which genetic information is transcribed from DNA to messenger RNA – a crucial regulatory step before proteins are created. Then, organs develop and hopefully function properly.

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Pharmaceutical Technology

JUNE 21, 2023

Life sciences venture capital firm Flagship Pioneering has unveiled Empress Therapeutics, a small molecule drug development startup. This will support development of its proprietary Chemilogics platform and drug discovery pipeline. The Moderna -backed venture fund has launched Empress with a $50m investment.

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Drug Discovery World

MARCH 20, 2023

Scientists from Korea have developed a new biosensor that uses fluorescence resonance energy transfer (FRET) to detect DNA double-strand breaks in living specimens in real time. This biosensor has the potential to aid the development of new treatments for DNA damage-related diseases by revealing how our bodies repair damaged DNA.

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Pharmaceutical Technology

JUNE 23, 2022

Mpro has become the main focus of intense research and treatment development as it is vital for viral replication. It functions as a molecular scissor by slicing long chains of virus’ polypeptide proteins into smaller component proteins. These smaller segments can subsequently fold and develop to create new virus particles.

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Drug Discovery World

JUNE 22, 2023

In a new paper published in Nature , researchers at the Francis Crick Institute in the UK have outlined the structure and function of a protein complex which is required to repair damaged DNA and protect against cancer. We now understand its crucial role in DNA repair, which explains why mutations can lead to cancer.”

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Scienmag

MARCH 15, 2021

The first vaccine has been administered in a comparative adjuvant trial of DNA prime/protein boost HIV vaccine regimens in Kericho, Kenya Credit: U.S. Military HIV Research Program SILVER SPRING, Md.

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Drug Discovery World

MAY 29, 2024

Marc Hummersone, Senior Director of Research and Development (R&D) at Astrea Bioseparations, shares insight on the challenges and opportunities in cell and gene therapy (CGT) with DDW’s Megan Thomas. DNA purification “Plasmid DNA is an incredibly important part of molecular biology”, says Hummersone.

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Gene Therapy Gene Genetics DNA 109

Drug Discovery World

MAY 25, 2023

DNA Script: SYNTAX DNA printing platform Using the company’s EDS technology, the SYNTAX platform can synthesise up to 96 highly accurate, ready-to-use DNA oligos with maximum lengths of up to 120nt in less than 24 hours in the laboratory.

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XTalks

FEBRUARY 11, 2021

For example, British scientist Rosalind Franklin gained recognition for her work after her death, which is not unheard of, but with it came the revelation that her work, which helped demonstrate the double helical structure of DNA, went largely uncredited by famed DNA duo James Watson and Francis Crick.

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Pharmaceutical Technology

SEPTEMBER 7, 2022

Yet when it comes to the crucial step of harvest clarification – the first step when impurities start getting removed – existing technologies are struggling to keep pace with developments in the upstream process, leading to product losses and increased complexity. It is important to evaluate the process holistically. Dr El-Sabbahy: “Yes.

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Scienmag

JUNE 16, 2022

To develop new drugs and vaccines, detailed knowledge about nature’s smallest biological building blocks – the biomolecules – is required.

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Drug Discovery World

AUGUST 21, 2023

SBIR fast-track grant from the NIH to apply its proprietary Multiplexed Assays for the Rational Modulation Of Transcription Factors (MARMOT) platform to their deep learning AI model and accelerate the development of transcription factor drugs. Talus Bio was also awarded a $2.0M The post $4.3

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Pharmaceutical Technology

MARCH 1, 2023

Nedisertib is under clinical development by Merck and currently in Phase I for Neuroendocrine Tumors. GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. It is a new chemical entity.

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